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  1. Article ; Online: Expanding gliogenesis.

    Baldwin, Katherine T / Silver, Debra L

    Science (New York, N.Y.)

    2021  Volume 372, Issue 6547, Page(s) 1151–1152

    MeSH term(s) Animals ; Brain ; Mice ; Neurogenesis ; Neuroglia ; Stem Cells
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj1139
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  2. Article ; Online: Uncovering the HARbingers of human brain evolution.

    Mosti, Federica / Silver, Debra L

    Neuron

    2021  Volume 109, Issue 20, Page(s) 3231–3233

    Abstract: During evolution, humans acquired extensive genomic changes that collectively define unique features of our species, yet functions for these sequence variants are largely unknown. In this issue of Neuron, Girskis et al. comprehensively screen human ... ...

    Abstract During evolution, humans acquired extensive genomic changes that collectively define unique features of our species, yet functions for these sequence variants are largely unknown. In this issue of Neuron, Girskis et al. comprehensively screen human accelerated regions (HARs) for enhancer activity in human-specific cortical development, creating a valuable online resource.
    MeSH term(s) Brain ; Genome ; Genomics ; Humans ; Neurogenesis
    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.09.022
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  3. Article ; Online: Founder cells shape brain evolution.

    Liu, Jing / Silver, Debra L

    Cell

    2021  Volume 184, Issue 8, Page(s) 1965–1967

    Abstract: Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids ... ...

    Abstract Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids derived across great apes to implicate neuroepithelial progenitor shape transitions in human cortical expansion.
    MeSH term(s) Animals ; Brain ; Cerebral Cortex ; Hominidae ; Organoids ; Primates
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.03.045
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  4. Article: Founder cells shape brain evolution

    Liu, Jing / Silver, Debra L

    Cell. 2021 Apr. 15, v. 184, no. 8

    2021  

    Abstract: Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids ... ...

    Abstract Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids derived across great apes to implicate neuroepithelial progenitor shape transitions in human cortical expansion.
    Keywords cerebral cortex ; evolution ; humans ; organoids
    Language English
    Dates of publication 2021-0415
    Size p. 1965-1967.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.03.045
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  5. Article ; Online: Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.

    Hoye, Mariah L / Silver, Debra L

    Current opinion in neurobiology

    2020  Volume 66, Page(s) 93–102

    Abstract: Regulation of stem cell fate decisions is elemental to faithful development, homeostasis, and organismal fitness. Emerging data demonstrate pluripotent stem cells exhibit a vast transcriptional landscape, which is refined as cells differentiate. In the ... ...

    Abstract Regulation of stem cell fate decisions is elemental to faithful development, homeostasis, and organismal fitness. Emerging data demonstrate pluripotent stem cells exhibit a vast transcriptional landscape, which is refined as cells differentiate. In the developing neocortex, transcriptional priming of neural progenitors, coupled with post-transcriptional control, is critical for defining cell fates of projection neurons. In particular, radial glial progenitors exhibit dynamic post-transcriptional regulation, including subcellular mRNA localization, RNA decay, and translation. These processes involve both cis-regulatory and trans-regulatory factors, many of which are implicated in neurodevelopmental disease. This review highlights emerging post-transcriptional mechanisms which govern cortical development, with a particular focus on translational control of neuronal fates, including those relevant for disease.
    MeSH term(s) Cell Differentiation ; Gene Expression Regulation, Developmental ; Neocortex ; Neurogenesis ; Neurons
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2020.10.001
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  6. Article ; Online: Evolution: Does More Time Buy More Neurons?

    Lupan, Bianca M / Silver, Debra L

    Current biology : CB

    2020  Volume 30, Issue 21, Page(s) R1316–R1318

    Abstract: Brain expansion and increased neuronal number are hallmarks of cortical evolution, particularly in humans. A new study establishes a link between the length of gestation, neurogenesis, the maternal environment, and key features associated with more ... ...

    Abstract Brain expansion and increased neuronal number are hallmarks of cortical evolution, particularly in humans. A new study establishes a link between the length of gestation, neurogenesis, the maternal environment, and key features associated with more complex brains.
    MeSH term(s) Animals ; Biological Evolution ; Brain ; Hominidae ; Humans ; Neocortex ; Neurogenesis ; Neurons
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.08.098
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  7. Article: The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis.

    Lupan, Bianca M / Solecki, Rachel A / Musso, Camila Manso / Alsina, Fernando C / Silver, Debra L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mutations in components of the exon junction complex (EJC) are associated with neurodevelopment and disease. In particular, reduced levels of the RNA helicase : Summary statement: This study shows that EIF4A3 mediates neurogenesis by controlling ... ...

    Abstract Mutations in components of the exon junction complex (EJC) are associated with neurodevelopment and disease. In particular, reduced levels of the RNA helicase
    Summary statement: This study shows that EIF4A3 mediates neurogenesis by controlling mitosis duration in both mouse and human neural progenitors, implicating new mechanisms underlying neurodevelopmental disorders.
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.13.524010
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  8. Article ; Online: A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X.

    Jowhar, Ziad / Xu, Albert / Venkataramanan, Srivats / Dossena, Francesco / Hoye, Mariah L / Silver, Debra L / Floor, Stephen N / Calviello, Lorenzo

    Molecular systems biology

    2024  Volume 20, Issue 3, Page(s) 276–290

    Abstract: The road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression. A fundamental player in mRNA biology is DDX3X, an RNA binding protein that canonically ... ...

    Abstract The road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression. A fundamental player in mRNA biology is DDX3X, an RNA binding protein that canonically regulates mRNA translation. By monitoring dynamics of mRNA abundance and translation following DDX3X depletion, we observe stabilization of translationally suppressed mRNAs. We use interpretable statistical learning models to uncover GC content in the coding sequence as the major feature underlying RNA stabilization. This result corroborates GC content-related mRNA regulation detectable in other studies, including hundreds of ENCODE datasets and recent work focusing on mRNA dynamics in the cell cycle. We provide further evidence for mRNA stabilization by detailed analysis of RNA-seq profiles in hundreds of samples, including a Ddx3x conditional knockout mouse model exhibiting cell cycle and neurogenesis defects. Our study identifies a ubiquitous feature underlying mRNA regulation and highlights the importance of quantifying multiple steps of the gene expression cascade, where RNA abundance and protein production are often uncoupled.
    MeSH term(s) Animals ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Base Composition ; Gene Expression Regulation ; RNA ; Cell Cycle/genetics
    Chemical Substances RNA, Messenger ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.1038/s44320-024-00013-0
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  9. Article ; Online: Damage Control in the Developing Brain: Tradeoffs and Consequences.

    Alsina, Fernando C / Silver, Debra L

    Trends in neurosciences

    2019  Volume 42, Issue 10, Page(s) 661–663

    Abstract: Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these ... ...

    Abstract Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these questions and examines the consequences of both inducing genomic instability and suppressing safeguard mechanisms for the development of the cerebral cortex.
    MeSH term(s) Aneuploidy ; Brain ; Genomic Instability ; Humans
    Language English
    Publishing date 2019-08-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2019.08.004
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  10. Article ; Online: Human brain evolution: Emerging roles for regulatory DNA and RNA.

    Liu, Jing / Mosti, Federica / Silver, Debra L

    Current opinion in neurobiology

    2021  Volume 71, Page(s) 170–177

    Abstract: Humans diverge from other primates in numerous ways, including their neuroanatomy and cognitive capacities. Human-specific features are particularly prominent in the cerebral cortex, which has undergone an expansion in size and acquired unique cellular ... ...

    Abstract Humans diverge from other primates in numerous ways, including their neuroanatomy and cognitive capacities. Human-specific features are particularly prominent in the cerebral cortex, which has undergone an expansion in size and acquired unique cellular composition and circuitry. Human-specific gene expression is postulated to explain neocortical anatomical differences across evolution. In particular, noncoding regulatory loci are strongly linked to human traits, including progenitor proliferation and cortical size. In this review, we highlight emerging noncoding elements implicated in human cortical evolution, including roles for regulatory DNA and RNA. Further, we discuss the association of human-specific genetic changes with neurodevelopmental diseases.
    MeSH term(s) Animals ; Biological Evolution ; Brain/metabolism ; Cerebral Cortex ; DNA/metabolism ; Humans ; Primates ; RNA/metabolism
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2021.11.005
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