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  1. Article ; Online: Postinfectious Encephalomyelitis Associated With Myelin Oligodendrocyte Glycoprotein Antibody in a Pediatric Patient With COVID-19.

    Cay-Martínez, Karla C / Shen, Min Ye / Silver, Wendy G / Vargas, Wendy S

    Pediatric neurology

    2021  Volume 124, Page(s) 40–41

    MeSH term(s) Autoantibodies/blood ; Autoantibodies/immunology ; COVID-19/blood ; COVID-19/complications ; COVID-19/therapy ; Child ; Encephalomyelitis, Acute Disseminated/blood ; Encephalomyelitis, Acute Disseminated/etiology ; Encephalomyelitis, Acute Disseminated/therapy ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Methylprednisolone/therapeutic use ; Myelin-Oligodendrocyte Glycoprotein/blood ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Plasmapheresis/methods
    Chemical Substances Autoantibodies ; Immunoglobulins, Intravenous ; Myelin-Oligodendrocyte Glycoprotein ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2021.08.001
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  2. Article ; Online: How Providers in Child Neurology Transitioned to Telehealth During COVID-19 Pandemic.

    Bain, Jennifer M / Dyer, Codi-Ann / Galvin, Megan / Goldman, Sylvie / Selman, Jay / Silver, Wendy G / Tom, Sarah E

    Child neurology open

    2021  Volume 8, Page(s) 2329048X211022976

    Abstract: To understand child neurology care practices in telehealth (TH), we conducted an online survey interested in identifying which patients should be triaged for in-person evaluations in lieu of telehealth management. We also sought to identify provider and ... ...

    Abstract To understand child neurology care practices in telehealth (TH), we conducted an online survey interested in identifying which patients should be triaged for in-person evaluations in lieu of telehealth management. We also sought to identify provider and patient/parent limitations of the TH experience. One hundred fourteen clinicians completed the online survey. The majority of child neurologists transitioned within 3 weeks of the pandemic onset and found it inappropriate to evaluate a child under 1 year of age via TH. We identified specific disorders considered inappropriate for initial evaluation via TH, including neuromuscular disease, neuropathy, weakness, autoimmune disease and autism spectrum disorders. Patient and parent technical and economic issues are significant limitations of TH. We suggest quality improvement measures to provide additional training, focusing on particular disorders and increased access for those patients currently excluded from or limited in using or accessing TH.
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785453-X
    ISSN 2329-048X ; 2329-048X
    ISSN (online) 2329-048X
    ISSN 2329-048X
    DOI 10.1177/2329048X211022976
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  3. Article ; Online: Neurobiological basis of autism.

    Silver, Wendy G / Rapin, Isabelle

    Pediatric clinics of North America

    2012  Volume 59, Issue 1, Page(s) 45–61, x

    Abstract: Autism (autism spectrum disorders) is a complex, strongly genetically influenced, behaviorally defined disorder of the immature brain associated with very uneven intellectual abilities. Among its most salient and potentially treatable neurologic features ...

    Abstract Autism (autism spectrum disorders) is a complex, strongly genetically influenced, behaviorally defined disorder of the immature brain associated with very uneven intellectual abilities. Among its most salient and potentially treatable neurologic features that this article focuses on are epilepsy, disorganized sleep patterns, and sensory and motor deficits. Its many causes and wide range of severity means that there is no symptom, no pathology, imaging, electroencephalography, or other biologic feature, and no biologic treatment that is universal or diagnostic of this developmental syndrome.
    MeSH term(s) Adolescent ; Brain/physiopathology ; Child ; Child Development Disorders, Pervasive/complications ; Child Development Disorders, Pervasive/diagnosis ; Child Development Disorders, Pervasive/genetics ; Child Development Disorders, Pervasive/physiopathology ; Child, Preschool ; Diagnostic Imaging ; Epilepsy/complications ; Epilepsy/physiopathology ; Humans ; Infant ; Infant, Newborn ; Motor Skills Disorders/complications ; Motor Skills Disorders/physiopathology ; Sensation Disorders/complications ; Sensation Disorders/physiopathology ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/physiopathology
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2011.10.010
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  4. Article ; Online: Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19.

    Abel, Dori / Shen, Min Ye / Abid, Zaynah / Hennigan, Claire / Boneparth, Alexis / Miller, Emily Happy / Uhlemann, Anne-Catrin / McBrian, Danielle K / Thakur, Kiran / Silver, Wendy / Bain, Jennifer M

    Neurology

    2020  Volume 95, Issue 16, Page(s) 745–748

    MeSH term(s) Betacoronavirus ; Brain Diseases/pathology ; Brain Diseases/virology ; COVID-19 ; Child, Preschool ; Coronavirus Infections/pathology ; Humans ; Male ; Pandemics ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/pathology ; Thalamus/pathology
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010652
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  5. Article ; Online: Neurological issues in children with COVID-19.

    Lin, Jieru E / Asfour, Arsenoi / Sewell, Taylor B / Hooe, Benjamin / Pryce, Patrice / Earley, Chelsea / Shen, Min Ye / Kerner-Rossi, Mallory / Thakur, Kiran T / Vargas, Wendy S / Silver, Wendy G / Geneslaw, Andrew S

    Neuroscience letters

    2020  Volume 743, Page(s) 135567

    Abstract: Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in ... ...

    Abstract Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at NewYork-Presbyterian Morgan Stanley Children's Hospital.
    MeSH term(s) COVID-19/complications ; Child ; Child, Preschool ; Female ; Humans ; Male ; Nervous System Diseases/virology ; SARS-CoV-2
    Language English
    Publishing date 2020-12-19
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135567
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  6. Article ; Online: Rates of Positive M-CHAT-R Screenings by Pandemic Birth and Prenatal SARS-CoV-2 Exposure

    Firestein, Morgan R. / Manessis, Angela Gigliotti / Warmingham, Jen / Hu, Yunzhe / Finkel, Morgan A. / Kyle, Margaret / Hussain, Maha / Ahmed, Imaal / Lavallée, Andréane / Solis, Ana / Chaves, Vitoria / Rodriguez, Cynthia / Goldman, Sylvie / Muhle, Rebecca A. / Lee, Seonjoo / Austin, Judy / Silver, Wendy G. / O’Reilly, Kally C. / Bain, Jennifer M. /
    Penn, Anna A. / Veenstra-VanderWeele, Jeremy / Stockwell, Melissa S. / Fifer, William P. / Marsh, Rachel / Monk, Catherine / Shuffrey, Lauren C. / Dumitriu, Dani

    medRxiv

    Abstract: Maternal stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Children born during the COVID-19 pandemic, including those exposed prenatally to maternal SARS-CoV-2 infections, are reaching the ... ...

    Abstract Maternal stress and viral illness during pregnancy are associated with neurodevelopmental conditions in offspring. Children born during the COVID-19 pandemic, including those exposed prenatally to maternal SARS-CoV-2 infections, are reaching the developmental age for the assessment of risk for neurodevelopmental conditions. We examined associations between birth during the COVID-19 pandemic, prenatal exposure to maternal SARS-CoV-2 infection, and rates of positive screenings on the Modified Checklist for Autism in Toddlers-Revised (M-CHAT-R). Data were drawn from the COVID-19 Mother Baby Outcomes (COMBO) Initiative. Participants completed the M-CHAT-R as part of routine clinical care (COMBO-EHR cohort) or for research purposes (COMBO-RSCH cohort). Maternal SARS-CoV-2 status during pregnancy was determined through electronic health records. The COMBO-EHR cohort includes n=1664 children (n=442 historical cohort, n=1222 pandemic cohort; n=997 SARS-CoV-2 unexposed prenatally, n=130 SARS-CoV-2 exposed prenatally) who were born at affiliated hospitals between 2018-2023 and who had a valid M-CHAT-R score in their health record. The COMBO-RSCH cohort consists of n=359 children (n=268 SARS-CoV-2 unexposed prenatally, n=91 SARS-CoV-2 exposed prenatally) born at the same hospitals who enrolled into a prospective cohort study that included administration of the M-CHAT-R at 18-months. Birth during the pandemic was not associated with greater likelihood of a positive M-CHAT-R screen in the COMBO-EHR cohort. Maternal SARS-CoV-2 was associated with lower likelihood of a positive M-CHAT-R screening in adjusted models in the COMBO-EHR cohort (OR=0.40, 95% CI=0.22 - 0.68, p=0.001), while analyses in the COMBO-RSCH cohort yielded similar but non-significant results (OR=0.67, 95% CI=0.31-1.37, p=0.29). These results suggest that children born during the first 18 months of the COVID-19 pandemic and those exposed prenatally to a maternal SARS-CoV-2 infection are not at greater risk for screening positive on the M-CHAT-R.
    Keywords covid19
    Language English
    Publishing date 2024-02-22
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.02.20.24302892
    Database COVID19

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  7. Article ; Online: Increased Intracranial Pressure in the Setting of Multisystem Inflammatory Syndrome in Children, Associated With COVID-19.

    Baccarella, Alyssa / Linder, Alexandra / Spencer, Robert / Jonokuchi, Alexander J / King, Paul Benjamin / Maldonado-Soto, Angel / Boneparth, Alexis / Hooe, Benjamin S / Schweickert, Adam J / Carlin, Rebecca F / Kingery, Francesca / Vargas, Wendy S / Sewell, Taylor B / Silver, Wendy G

    Pediatric neurology

    2020  Volume 115, Page(s) 48–49

    MeSH term(s) Abdominal Pain/etiology ; Abducens Nerve Diseases/etiology ; Antibodies, Viral/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19 Nucleic Acid Testing ; COVID-19 Serological Testing ; Cerebrospinal Fluid/virology ; Child ; Delayed Diagnosis ; Diplopia/etiology ; False Negative Reactions ; Headache/etiology ; Humans ; Intracranial Hypertension/cerebrospinal fluid ; Intracranial Hypertension/etiology ; Intracranial Hypertension/physiopathology ; Nasopharynx/virology ; Papilledema/etiology ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/physiopathology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2020-11-22
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2020.11.008
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  8. Article ; Online: Treatment outcomes of West syndrome in infants with Down syndrome.

    Sanmaneechai, Oranee / Sogawa, Yoshimi / Silver, Wendy / Ballaban-Gil, Karen / Moshé, Solomon L / Shinnar, Shlomo

    Pediatric neurology

    2013  Volume 48, Issue 1, Page(s) 42–47

    Abstract: West syndrome constitutes the most frequent of all seizure types in infants with Down syndrome. We retrospectively reviewed records of 12 infants with Down syndrome and West syndrome, accounting for 5% of 239 infants with West syndrome from a ... ...

    Abstract West syndrome constitutes the most frequent of all seizure types in infants with Down syndrome. We retrospectively reviewed records of 12 infants with Down syndrome and West syndrome, accounting for 5% of 239 infants with West syndrome from a comprehensive epilepsy database during a 17-year period. All demonstrated classic hypsarrhythmia on video electroencephalograms. One had clinically responded to clonazepam, and one was not treated because the parents refused any treatment. Seven of 10 infants demonstrated a complete response to high-dose natural adrenocorticotrophic hormone. Four (57%) of these seven infants relapsed. Relapses occurred as long as 2 years after cessation of the initial presentation of infantile spasms. At most recent follow-up (median age, 5 years), 8/12 (67%) were seizure-free, and seven were off any medications. Two of three nonresponders manifested intractable epilepsy and profound mental retardation. Developmentally, 6/8 who could be assessed met criteria for autistic spectrum disorder. Close follow-up is necessary even after successful initial treatment, because relapses are frequent and can occur as long as 2 years later.
    MeSH term(s) Adrenocorticotropic Hormone/therapeutic use ; Anticonvulsants/therapeutic use ; Cognition Disorders/etiology ; Cognition Disorders/therapy ; Databases, Factual/statistics & numerical data ; Down Syndrome/complications ; Electroencephalography ; Female ; Humans ; Infant ; Longitudinal Studies ; Male ; Neuropsychological Tests ; Outcome Assessment (Health Care) ; Retrospective Studies ; Spasms, Infantile/etiology ; Spasms, Infantile/therapy ; Treatment Outcome ; Video Recording
    Chemical Substances Anticonvulsants ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2012.09.006
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  9. Article: Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19

    Abel, Dori / Shen, Min Ye / Abid, Zaynah / Hennigan, Claire / Boneparth, Alexis / Miller, Emily Happy / Uhlemann, Anne-Catrin / McBrian, Danielle K / Thakur, Kiran / Silver, Wendy / Bain, Jennifer M

    Neurology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733014
    Database COVID19

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  10. Article ; Online: Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19

    Abel, Dori / Shen, Min Ye / Abid, Zaynah / Hennigan, Claire / Boneparth, Alexis / Miller, Emily Happy / Uhlemann, Anne-Catrin / McBrian, Danielle K. / Thakur, Kiran / Silver, Wendy / Bain, Jennifer M.

    Neurology

    2020  Volume 95, Issue 16, Page(s) 745–748

    Keywords Clinical Neurology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000010652
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