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  1. Article ; Online: Severe Esophageal Lichen Planus Treated With Tofacitinib.

    Kozlov, Michael / Levit, Eyal K / Silvers, David N / Brichkov, Igor

    Cutis

    2022  Volume 111, Issue 3, Page(s) 155–163

    Abstract: Lichen planus is a chronic inflammatory immune disorder that most commonly affects the skin and mucous membranes. Esophageal lichen planus (ELP) is a frequently misdiagnosed and poorly understood form of lichen planus that can be asymptomatic or present ... ...

    Abstract Lichen planus is a chronic inflammatory immune disorder that most commonly affects the skin and mucous membranes. Esophageal lichen planus (ELP) is a frequently misdiagnosed and poorly understood form of lichen planus that can be asymptomatic or present with dysphagia and odynophagia caused by the formation of erosions and strictures in the esophagus. These strictures often reduce a patient's quality of life and may lead to emaciation in more severe cases. We present the case of an 89-year-old woman with a history of cutaneous lichen planus (CLP) and mucosal lichen planus that were successfully managed with topical corticosteroids and oral cyclosporine rinses who presented with an esophageal stricture and erosions that were treated unsuccessfully with surgery. Our patient's condition continued to worsen until she presented in an emaciated state and was treated with tofacitinib, which resulted in complete resolution of oral lichen planus (OLP), ELP, and genital lichen planus.
    MeSH term(s) Female ; Humans ; Aged, 80 and over ; Constriction, Pathologic ; Quality of Life ; Lichen Planus/diagnosis ; Lichen Planus/drug therapy ; Esophagus
    Chemical Substances tofacitinib (87LA6FU830)
    Language English
    Publishing date 2022-11-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Longitudinal melanonychia and skin hyperpigmentation associated with hydroxychloroquine therapy.

    Ricardo, Jose W / Chikeka, Ijeuru / Silvers, David N / Lipner, Shari R

    JAAD case reports

    2020  Volume 7, Page(s) 23–25

    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Re: Cut it out.

    Silvers, David N

    Journal of cutaneous pathology

    2011  Volume 38, Issue 3, Page(s) 320

    MeSH term(s) Humans ; Melanoma/pathology ; Melanoma/therapy ; Nevus, Pigmented/pathology ; Nevus, Pigmented/therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/j.1600-0560.2010.01631.x
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  4. Article ; Online: Fingerprint CD34 immunopositivity to distinguish neurofibroma from an early/paucicellular desmoplastic melanoma can be misleading.

    Husain, Sameera / Silvers, David N

    Journal of cutaneous pathology

    2013  Volume 40, Issue 11, Page(s) 985–987

    MeSH term(s) Antigens, CD34/metabolism ; Humans ; Melanoma/diagnosis ; Neurofibroma/diagnosis ; Skin Neoplasms/diagnosis
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.12206
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  5. Article: Atypical Still disease with necrotic keratinocytes: A histologic mimicker of erythema multiforme.

    Khanna, Trisha / Yang, Christine C / Yamany, Tarek / Silvers, David N / Lauren, Christine T / Lewin, Jesse M

    JAAD case reports

    2018  Volume 4, Issue 4, Page(s) 301–304

    Language English
    Publishing date 2018-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.12.009
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  6. Article: Clinical efficacy of short contact topical 5-Fluorouracil in the treatment of keratoacanthomas: a retrospective analysis.

    Thompson, Bobbye J / Ravits, Margaret / Silvers, David N

    The Journal of clinical and aesthetic dermatology

    2014  Volume 7, Issue 11, Page(s) 35–37

    Abstract: Objective: To determine the efficacy of treating patients with a recent onset, biopsy-proven keratoacanthoma with short-contact topical 5% 5-fluorouracil cream twice daily until resolution.: Design: Chart review of 10 patients who applied 5% 5- ... ...

    Abstract Objective: To determine the efficacy of treating patients with a recent onset, biopsy-proven keratoacanthoma with short-contact topical 5% 5-fluorouracil cream twice daily until resolution.
    Design: Chart review of 10 patients who applied 5% 5-fluorouracil for the treatment of biopsy-proven keratoacanthoma.
    Setting: Outpatient clinic of a board-certified dermatologist.
    Participants: The study population was 90-percent women (9/10), 10-percent men (1/10) and ranged in ages from 52 to 92 years old with a mean age of 74.4.
    Measurements: Patients were followed for weekly visits for the duration of their treatment and at varying, less-frequent intervals after resolution of the lesion clinically. Photographs were taken at each visit.
    Results: The authors performed a retrospective analysis of 10 patients with biopsy-confirmed keratoacanthomas treated with topical 5-fluorouracil. One patient elected to have Mohs surgery after one week of topical 5-fluorouracil due to personal concern and cosmetic appearance and did not complain of any side effects due to the drug. Of the nine patients that remained on topical 5-fluorouracil, all patients had complete resolution of the lesion within six weeks. The range in the number of weeks to resolution was four to six weeks. Two patients required a one- to two-week drug holiday secondary to erythema, which resolved without any further complication or patient discomfort. All nine patients who continued therapy reported satisfaction with the results and showed excellent compliance with treatment.
    Conclusion: Short-contact topical 5% 5-fluorouracil appears to provide excellent cosmetic results and is well-tolerated by patients. This should be an initial consideration for the treatment of keratoacanthomas and does not preclude future surgical intervention if deemed necessary.
    Language English
    Publishing date 2014-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 1941-2789
    ISSN 1941-2789
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  7. Article ; Online: Human Polyomavirus 9-An Emerging Cutaneous and Pulmonary Pathogen in Solid Organ Transplant Recipients.

    Mishra, Nischay / Ng, James / Strom, Mark A / Jain, Komal / Thakkar, Riddhi / Joshi, Shreyas / Pereira, Marcus / Shah, Lori / Grossman, Marc E / Lee, Michael J / De Michele, Simona / Silvers, David N / Faust, Phyllis L / Lipkin, W Ian / Gallitano, Stephanie M

    JAMA dermatology

    2022  Volume 158, Issue 3, Page(s) 293–298

    Abstract: Importance: We describe the first report to our knowledge of cutaneous and systemic pathogenicity of human polyomavirus 9 in solid organ transplant recipients.: Objective: Three solid organ transplant recipients developed a widespread, progressive, ... ...

    Abstract Importance: We describe the first report to our knowledge of cutaneous and systemic pathogenicity of human polyomavirus 9 in solid organ transplant recipients.
    Objective: Three solid organ transplant recipients developed a widespread, progressive, violaceous, and hyperkeratotic skin eruption. All died from pulmonary and multiorgan failure around 1 year from onset of the rash. Routine clinical diagnostic testing could not identify any causative agent; therefore, samples and autopsies were investigated for novel pathogens using high-throughput sequencing.
    Design, setting, and participants: This case series, including 3 solid organ transplant recipients who developed characteristic pink, violaceous, or brown hyperkeratotic papules and plaques throughout the body, was conducted at the Columbia University Medical Center. Lesional skin biopsies were collected from all 3 patients and subjected to high-throughput illumina sequencing for identification of microbial pathogens. Human polyomavirus 9 was identified in lesional skin biopsies. We subsequently collected ocular swabs, oral swabs, urine samples, and blood samples from patients, and organ tissues at autopsy in 1 patient. We investigated these samples for the presence of human polyomavirus 9 using in situ hybridization and quantitative polymerase chain reaction (PCR) assays.
    Main outcomes and measures: A description of the clinical and pathologic findings of 3 patients.
    Results: This case series study found that human polyomavirus 9 was detected in the skin biopsies of all 3 patients by a capture-based high-throughput sequencing method platform (VirCapSeq-VERT). Human polyomavirus 9 was also detected in blood, oral, ocular swabs, and urine by real-time polymerase chain reaction (PCR) assay. In situ hybridization and quantitative PCR assays were performed on the skin biopsies from 3 patients and lung autopsy of 1 patient, which showed the presence of human polyomavirus 9 messenger RNA transcripts, indicating active viral replication and pathogenesis in the skin and lungs.
    Conclusions and relevance: Human polyomavirus 9 was associated with the widespread cutaneous eruption. All 3 patients had progression of cutaneous disease, accompanied by clinical deterioration, pulmonary failure, and death. One patient underwent autopsy and human polyomavirus 9 was identified in the lungs and paratracheal soft tissue. These findings suggest that human polyomavirus 9 may be associated with cutaneous and possibly pulmonary infection and death in solid organ transplant recipients.
    MeSH term(s) DNA, Viral/analysis ; Exanthema ; Humans ; Lung ; Organ Transplantation/adverse effects ; Polyomaviridae ; Polyomavirus/genetics ; Polyomavirus Infections ; Real-Time Polymerase Chain Reaction ; Skin Diseases ; Transplant Recipients
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2021.5853
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  8. Article ; Online: Fulminant lipid storage myopathy due to multiple acyl-coenzyme a dehydrogenase deficiency.

    Whitaker, Charles H / Felice, Kevin J / Silvers, David / Wu, Qian

    Muscle & nerve

    2015  Volume 52, Issue 2, Page(s) 289–293

    Abstract: Introduction: The lipid storage myopathies, primary carnitine deficiency, neutral lipid storage disease, and multiple acyl coenzyme A dehydrogenase deficiency (MADD), are progressive disorders that cause permanent weakness. These disorders of fatty acid ...

    Abstract Introduction: The lipid storage myopathies, primary carnitine deficiency, neutral lipid storage disease, and multiple acyl coenzyme A dehydrogenase deficiency (MADD), are progressive disorders that cause permanent weakness. These disorders of fatty acid metabolism and intracellular triglyceride degradation cause marked fat deposition and damage to muscle cells.
    Methods: We describe a rapidly progressive myopathy in a previously healthy 33-year-old woman. Over 4 months, she developed a proximal and axial myopathy associated with diffuse myalgia and dysphagia, ultimately leading to respiratory failure and death.
    Results: Muscle biopsy showed massive accumulation of lipid. Plasma acylcarnitine and urine organic acid analysis was consistent with MADD. This was confirmed by molecular genetic testing, which revealed 2 pathogenic mutations in the ETFDH gene.
    Conclusions: This report illustrates a late-onset case of MADD and reviews the differential diagnosis and evaluation of patients with proximal myopathy and excessive accumulation of lipid on muscle biopsy.
    MeSH term(s) Adult ; Female ; Humans ; Lipid Metabolism, Inborn Errors/diagnosis ; Lipid Metabolism, Inborn Errors/etiology ; Multiple Acyl Coenzyme A Dehydrogenase Deficiency/complications ; Multiple Acyl Coenzyme A Dehydrogenase Deficiency/diagnosis ; Muscular Dystrophies/diagnosis ; Muscular Dystrophies/etiology
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.24552
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    Zs.MO 551: Show issues

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  9. Article: Bullous drug eruption with leukemic cell infiltrate in the setting of new-onset acute myeloid leukemia.

    Khanna, Trisha / Vance, Stephen L / Silvers, David N / Husain, Sameera / Lewin, Jesse M

    JAAD case reports

    2017  Volume 3, Issue 6, Page(s) 529–531

    Language English
    Publishing date 2017-11-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.07.015
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  10. Article: Delayed-onset vemurafenib-induced panniculitis.

    Vance, Stephen L / Singer, Hannah M / Silvers, David / Husain, Sameera / Kabigting, Filamer

    JAAD case reports

    2017  Volume 3, Issue 5, Page(s) 384–386

    Language English
    Publishing date 2017-08-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2017.06.001
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