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  1. Article ; Online: The role of visual spatial frequencies in newborns' processing of dynamic facial expressions of emotion.

    Silvestri, Valentina / Arioli, Martina / Colombo, Lorenzo / Porro, Matteo / Macchi Cassia, Viola

    Developmental psychology

    2024  

    Abstract: Evidence on newborns' discrimination of emotional facial expressions is scarce, and the question of what is the nature of the visual information that newborns rely on to perform such discrimination remains open. Here, we manipulated the spatial frequency ...

    Abstract Evidence on newborns' discrimination of emotional facial expressions is scarce, and the question of what is the nature of the visual information that newborns rely on to perform such discrimination remains open. Here, we manipulated the spatial frequency (SF) content of the stimuli by selectively removing low spatial frequency (LSF) and high spatial frequency bands using newborn-appropriate cutoffs to investigate what information newborns use when preferring and discriminating between dynamic displays showing happy and fearful expressions unfolding over time. Using a preferential looking paradigm, in Study 1 (
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066223-3
    ISSN 1939-0599 ; 0012-1649
    ISSN (online) 1939-0599
    ISSN 0012-1649
    DOI 10.1037/dev0001757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Touch me or touch me not: Emotion regulation by affective touch in human adults.

    Silvestri, Valentina / Giraud, Michelle / Macchi Cassia, Viola / Nava, Elena

    Emotion (Washington, D.C.)

    2023  

    Abstract: In mammals, including humans, affective touch (AT) supports the establishment and maintenance of social connections and mitigates the effects of social conflict and ostracism. AT is used to describe slowly moving, low-forced mechanical stimulation that ... ...

    Abstract In mammals, including humans, affective touch (AT) supports the establishment and maintenance of social connections and mitigates the effects of social conflict and ostracism. AT is used to describe slowly moving, low-forced mechanical stimulation that is frequently perceived as pleasant. In humans, AT has been addressed particularly for its role in promoting bonding and emotional regulation during early development; however, more recent studies have suggested that AT also preserves physical and emotional well-being in adulthood. Here, we investigated whether AT can buffer adults' experience of negative emotions as reflected in their behavioral and physiological responses to emotionally arousing stimuli. Participants were stimulated on their forearms using AT or tapping (T) while they viewed a series of emotionally arousing and neutral images, and we measured their skin conductance response and their explicit rating of the images' unpleasantness. We found that AT, but not T, reduced the arousal and perceived unpleasantness of the emotional stimuli but not the neutral ones, revealing the soothing role of AT in emotional contexts. The second aim of the study was to explore the possibility that AT might benefit some individuals more than others, according to their individual differences. To this aim, we assessed individuals' empathy and sensory processing sensitivity, as well as their perception of AT itself. Results revealed that while empathy did not predict changes in emotional processing irrespective of tactile stimulation, individuals with higher sensitivity reported AT as less pleasant. We discuss the possible factors mediating the observed interindividual variability in AT perception. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102391-8
    ISSN 1931-1516 ; 1528-3542
    ISSN (online) 1931-1516
    ISSN 1528-3542
    DOI 10.1037/emo0001320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mitral annular disjunction and Pickelhaube sign in children with mitral valve prolapse: A prospective cohort study.

    Vaksmann, Guy / Bouzguenda, Ivan / Guillaume, Marie-Paule / Gras, Pauline / Silvestri, Valentina / Richard, Adélaïde

    Archives of cardiovascular diseases

    2023  

    Abstract: Background: Mitral annular disjunction (MAD) and the Pickelhaube sign are identified as risk factors for malignant ventricular arrhythmias (VAs) and sudden cardiac death in adults with mitral valve prolapse (MVP); their prevalence and consequences in ... ...

    Abstract Background: Mitral annular disjunction (MAD) and the Pickelhaube sign are identified as risk factors for malignant ventricular arrhythmias (VAs) and sudden cardiac death in adults with mitral valve prolapse (MVP); their prevalence and consequences in children have never been studied.
    Objectives: To determine the proportion of MAD in children with MVP, and its potential link with VAs.
    Methods: A cohort of 49 consecutive children (mean age 12.8±3.0 years; 33 females) with MVP and comprehensive clinical arrhythmia (24-hour monitoring) and Doppler echocardiographic characterization, including pulsed-wave tissue Doppler (PWTD) of the lateral mitral annulus, was identified. The relationship between clinical and echocardiographic data and presence of VAs was studied.
    Results: MAD was common (n=25; 51%). Only five patients had significant VAs (Lown grade>2) characterized by polymorphic premature ventricular contractions or couplets. MAD was not associated with VAs on 24-hour Holter monitoring, but an association was found between VAs and spiked high-velocity midsystolic signal>16cm/s on PWTD (Pickelhaube sign) (P=0.004), myxomatous mitral valve (P=0.004) and left ventricular dilatation (P=0.01). T-wave inversion in inferolateral leads on electrocardiogram was more frequent in patients with versus without the Pickelhaube sign (P=0.03). No difference was found between patients with or without MAD regarding sex, history of palpitation, severity of mitral regurgitation, aortic root diameter and incidence of connective tissue disorders. Myocardial fibrosis was detected in two of three patients who underwent a complementary cardiac magnetic resonance examination.
    Conclusions: MAD is common in children with MVP; its presence was not associated with significant VAs on 24-hour Holter monitoring, but the Pickelhaube sign and presence of myxomatous mitral valve may help to detect patients prone to significant VAs. Myocardial fibrosis can be detected by cardiac magnetic resonance in children with significant VAs.
    Language English
    Publishing date 2023-09-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2023.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs 8: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Sensitivity to trustworthiness cues in own- and other-race faces: The role of spatial frequency information.

    Silvestri, Valentina / Arioli, Martina / Baccolo, Elisa / Macchi Cassia, Viola

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0272256

    Abstract: Research has shown that adults are better at processing faces of the most represented ethnic group in their social environment compared to faces from other ethnicities, and that they rely more on holistic/configural information for identity ... ...

    Abstract Research has shown that adults are better at processing faces of the most represented ethnic group in their social environment compared to faces from other ethnicities, and that they rely more on holistic/configural information for identity discrimination in own-race than other-race faces. Here, we applied a spatial filtering approach to the investigation of trustworthiness perception to explore whether the information on which trustworthiness judgments are based differs according to face race. European participants (N = 165) performed an online-delivered pairwise preference task in which they were asked to select the face they would trust more within pairs randomly selected from validated White and Asian broad spectrum, low-pass filter and high-pass filter trustworthiness continua. Results confirmed earlier demonstrations that trustworthiness perception generalizes across face ethnicity, but discrimination of trustworthiness intensity relied more heavily on the LSF content of the images for own-race faces compared to other-race faces. Results are discussed in light of previous work on emotion discrimination and the hypothesis of overlapping perceptual mechanisms subtending social perception of faces.
    MeSH term(s) Adult ; Asians ; Cues ; Humans ; Judgment ; Social Perception ; Trust/psychology
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0272256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gender-Specific Genetic Predisposition to Breast Cancer:

    Valentini, Virginia / Bucalo, Agostino / Conti, Giulia / Celli, Ludovica / Porzio, Virginia / Capalbo, Carlo / Silvestri, Valentina / Ottini, Laura

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Among neoplastic diseases, breast cancer (BC) is one of the most influenced by gender. Despite common misconceptions associating BC as a women-only disease, BC can also occur in men. Additionally, transgender individuals may also experience BC. Genetic ... ...

    Abstract Among neoplastic diseases, breast cancer (BC) is one of the most influenced by gender. Despite common misconceptions associating BC as a women-only disease, BC can also occur in men. Additionally, transgender individuals may also experience BC. Genetic risk factors play a relevant role in BC predisposition, with important implications in precision prevention and treatment. The genetic architecture of BC susceptibility is similar in women and men, with high-, moderate-, and low-penetrance risk variants; however, some sex-specific features have emerged. Inherited high-penetrance pathogenic variants (PVs) in
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030579
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  6. Article: HER2-Low Expression in Male Breast Cancer: Results from a Multicenter Series in Italy.

    Silvestri, Valentina / Valentini, Virginia / Bucalo, Agostino / Conti, Giulia / Manzella, Livia / Turchetti, Daniela / Russo, Antonio / Capalbo, Carlo / Ottini, Laura

    Cancers

    2024  Volume 16, Issue 3

    Abstract: In the field of breast cancer care, a significant breakthrough has occurred with the recognition of HER2-low expression as a target for novel anti-HER2 antibody-drug conjugates (ADC). This discovery is reshaping the treatment landscape, challenging ... ...

    Abstract In the field of breast cancer care, a significant breakthrough has occurred with the recognition of HER2-low expression as a target for novel anti-HER2 antibody-drug conjugates (ADC). This discovery is reshaping the treatment landscape, challenging previous perceptions that considered HER2-low as clinically insignificant. The ability to target HER2-low expression is expected to have substantial clinical implications, irrespective of gender, including in cases of male breast cancer (MBC). However, an estimate of the prevalence of the HER2-low subtype in MBC is missing. This retrospective, observational, multicenter study was aimed at characterizing the HER2-low subtype in MBC. For the purpose of this study, the three-tiered categorization of HER2 (HER2-0, HER2-low, and HER2-positive) was used to reclassify the HER2-negative group into HER-0 or HER2-low subtypes. In the whole series of 144 invasive MBCs, 79 (54.9%) were HER2-0 (IHC scores of 0), 39 (27.1%) HER2-low (IHC scores of 1+/2+ with negative ISH), and 26 (18.0%) HER2-positive (IHC scores of 3+/2+ with positive ISH). Specifically, among hormone receptor-positive (HR+) HER2-negative invasive MBCs, 34.8% were HER2-low and 65.2% HER2-0. Compared with HER2-0, HER2-low subtype was associated with a positive lymph node involvement (
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030548
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  7. Article ; Online: Face in collision: emotional looming stimuli modulate interpersonal space across development and gender.

    Silvestri, Valentina / Grassi, Massimo / Nava, Elena

    Psychological research

    2021  Volume 86, Issue 5, Page(s) 1591–1598

    Abstract: Basic visual functions have evolved to allow for rapid detection of dynamic stimuli in our surrounding environment. In particular, looming stimuli are of relevance because they are expected to enter the individual's interpersonal space representing a ... ...

    Abstract Basic visual functions have evolved to allow for rapid detection of dynamic stimuli in our surrounding environment. In particular, looming stimuli are of relevance because they are expected to enter the individual's interpersonal space representing a potential threat. Different studies showed that emotions can modulate the perception of visual looming stimuli and the borders of interpersonal space, defined as the area around the body that individuals maintain between themselves and others during social interactions. Here, we investigated how emotions modulate the perception and the physiological correlates of interpersonal space and whether such indexes change across age and gender. Children and adults were asked to quickly react to emotional looming stimuli while measuring their skin conductance response (SCR). We found that emotional looming stimuli shrink the borders of interpersonal space of males more than females, and that this pattern does not change with age. In addition, adults reacted faster to angry than happy and neutral faces, which is in line with the notion that threatening stimuli capture attention more quickly than other types of emotional stimuli. However, this was not observed in children, suggesting that experience with negative stimuli, rather than the evolutionary meaning they possess, may influence the boundaries of interpersonal space. Overall, our study suggests that interpersonal space is modulated by emotions, but this appears to be modulated by gender and age: while behavioural responses to emotional looming stimuli refine with age, physiological responses are adult-like as early as 5 years of age.
    MeSH term(s) Adult ; Anger/physiology ; Attention/physiology ; Child ; Child, Preschool ; Emotions/physiology ; Facial Expression ; Female ; Happiness ; Humans ; Male
    Language English
    Publishing date 2021-09-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1463034-5
    ISSN 1430-2772 ; 0340-0727
    ISSN (online) 1430-2772
    ISSN 0340-0727
    DOI 10.1007/s00426-021-01590-7
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  8. Article: Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care.

    Casolino, Raffaella / Corbo, Vincenzo / Beer, Philip / Hwang, Chang-Il / Paiella, Salvatore / Silvestri, Valentina / Ottini, Laura / Biankin, Andrew V

    Cancers

    2022  Volume 14, Issue 13

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis and represents a major public health issue, as both its incidence and mortality are expecting to increase steeply over the next years. Effective screening strategies are lacking, and ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis and represents a major public health issue, as both its incidence and mortality are expecting to increase steeply over the next years. Effective screening strategies are lacking, and most patients are diagnosed with unresectable disease precluding the only chance of cure. Therapeutic options for advanced disease are limited, and the treatment paradigm is still based on chemotherapy, with a few rare exceptions to targeted therapies. Germline variants in cancer susceptibility genes-particularly those involved in mechanisms of DNA repair-are emerging as promising targets for PDAC treatment and prevention. Hereditary PDAC is part of the spectrum of several syndromic disorders, and germline testing of PDAC patients has relevant implications for broad cancer prevention. Germline aberrations in
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133239
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  9. Article ; Online: Reply to V. Fallet et al.

    Li, Shuai / Silvestri, Valentina / Rebbeck, Timothy R / Neuhausen, Susan L / Hopper, John L / Nielsen, Henriette Roed / Ottini, Laura / Antoniou, Antonis C

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 22, Page(s) 2509–2510

    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.00782
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  10. Article: A Possible Link between Gut Microbiome Composition and Cardiovascular Comorbidities in Psoriatic Patients.

    Valentini, Virginia / Silvestri, Valentina / Bucalo, Agostino / Marraffa, Federica / Risicato, Maria / Grassi, Sara / Pellacani, Giovanni / Ottini, Laura / Richetta, Antonio Giovanni

    Journal of personalized medicine

    2022  Volume 12, Issue 7

    Abstract: Cardiovascular disease (CVD) is one of the most common comorbidities that may affect psoriatic patients. Several exogenous and endogenous factors are involved in the etiology and progression of both psoriasis and CVD. A potential genetic link between the ...

    Abstract Cardiovascular disease (CVD) is one of the most common comorbidities that may affect psoriatic patients. Several exogenous and endogenous factors are involved in the etiology and progression of both psoriasis and CVD. A potential genetic link between the two diseases has emerged; however, some gaps remain in the understanding of the CVD prevalence in psoriatic patients. Recently, the role of the gut microbiome dysbiosis was documented in the development and maintenance of both diseases. To investigate whether gut microbiome dysbiosis might influence the occurrence of CVD in psoriatic patients, 16S rRNA gene sequencing was performed to characterize the gut microbiome of 28 psoriatic patients, including 17 patients with and 11 without CVD. The comparison of the gut microbiome composition between patients with and without CVD showed a higher prevalence of
    Language English
    Publishing date 2022-07-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12071118
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