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  1. Article ; Online: Antibody responses induced by Sputnik V vaccine in individuals previously infected with SARS-CoV-2

    Silvina Raiden / Jorge Geffner

    The Lancet Regional Health. Americas, Vol 6, Iss , Pp 100172- (2022)

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Children hospitalized for COVID-19 during the first winter of the pandemic in Buenos Aires, Argentina

    Silvina Raiden / Héctor Cairoli / Javier Potasnik / Sandra Di Lalla / María J. Chiolo / Fernando Torres / Paula Domínguez / Fernando Ferrero

    Boletín Médico del Hospital Infantil de México, Vol 78, Iss

    2021  Volume 6

    Abstract: Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe ... ...

    Abstract Background: Although there are reports on COVID-19 in pediatrics, the characteristics of the population of each country, its health systems, and how the pandemic was addressed could give the disease distinctive features worldwide. We aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital in the City of Buenos Aires, Argentina. Methods: We conducted a descriptive study, including all patients hospitalized for COVID-19 from 04/26/2020 to 10/31/2020 in a tertiary pediatric hospital. We described the demographic, clinical, and epidemiological characteristics of the patients. Results: During the period studied, 578 patients were hospitalized with COVID-19. The median age was 4.2 years, and 83% reported close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, and 60.4% showed mild, 7.4% moderate, and 1.4% severe symptoms. Among symptomatic patients, fever was the most frequent symptom, followed by sore throat and cough. Conclusions: We reported 578 cases of children and adolescents hospitalized with COVID-19, of which the majority showed mild or asymptomatic disease.
    Keywords Coronavirus infection. COVID-19. Pneumonia. Hospitalization. Children ; Pediatrics ; RJ1-570 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Antibody response against SARS-CoV-2 variants of concern in children infected with pre-Omicron variants

    Vanesa Seery / Silvina Raiden / Constanza Russo / Mauricio Borda / Largión Herrera / Macarena Uranga / Augusto Varese / María Marcó del Pont / Carina Chirino / Constanza Erramuspe / Laura Silvana Álvarez / Melisa Lenoir / Laura Daniela Morales / Carolina Davenport / Alexsa Alarcón Flores / Soledad Huespe Auchter / Yanina Ruiz / Liliana Monsalvo / Laura Sastoque /
    Magalí Gavazzi / Ignacio Mazzitelli / Facundo Di Diego / Yesica Longueira / Bianca Mazzitelli / Inés Sananez / Norberto De Carli / Mirna Marcela Biglione / Juan Martín Gómez Penedo / Ana Ceballos / Natalia Laufer / Fernando Ferrero / Jorge Geffner / Lourdes Arruvito

    EBioMedicine, Vol 83, Iss , Pp 104230- (2022)

    An observational cohort study

    2022  

    Abstract: Summary: Background: Despite that pediatric COVID-19 is usually asymptomatic or mild, SARS-CoV-2 infection typically results in the development of an antibody response. Contradictory observations have been reported when the antibody response of children ... ...

    Abstract Summary: Background: Despite that pediatric COVID-19 is usually asymptomatic or mild, SARS-CoV-2 infection typically results in the development of an antibody response. Contradictory observations have been reported when the antibody response of children and adults were compared in terms of strength, specificity and perdurability. Methods: This observational study includes three cohorts infected with SARS-CoV-2 between March 2020-July 2021: unvaccinated infected children (n=115), unvaccinated infected adults (n=62), and vaccinated infected children (n=76). Plasma anti-spike IgG antibodies and neutralising activity against Wuhan, Delta and Omicron variants after 7-17 months post-infection were analysed. Findings: More than 95% of unvaccinated infected children and adults remained seropositive when evaluated at 382-491 and 386-420 days after infection, respectively. Anti-spike IgG titers and plasma neutralising activity against Wuhan, Delta and Omicron variants were higher in children compared to adults. No differences were found when unvaccinated infected children were stratified by age, gender or presence/absence of symptoms in the acute phase of SARS-CoV-2 infection, but a slight decrease in the antibody response was observed in those with comorbidities. Vaccination of previously infected children with two doses of the inactivated BBIBP-CorV or the mRNA vaccines, BNT162b2 and/or mRNA-1273, further increased anti-spike IgG titers and neutralising activity against Wuhan, Delta and Omicron variants. Interpretation: Unvaccinated infected children mount a more potent and sustained antibody response compared with adults, which is significantly increased after vaccination. Further studies including not only the analysis of the immune response but also the effectiveness to prevent reinfections by the different Omicron lineages are required to optimise vaccination strategy in children. Funding: National Agency for Scientific and Technological Promotion from Argentina (PICTO-COVID-SECUELAS-00007 and PMO-BID-PICT2018-2548).
    Keywords Pediatric COVID-19 ; SARS-CoV-2 ; Variants ; Vaccines ; Antibodies ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Epithelial cells activate plasmacytoid dendritic cells improving their anti-HIV activity.

    Christian Rodriguez Rodrigues / Mercedes Cabrini / Federico Remes Lenicov / Juan Sabatté / Ana Ceballos / Carolina Jancic / Silvina Raiden / Matías Ostrowski / Claudia Silberstein / Jorge Geffner

    PLoS ONE, Vol 6, Iss 12, p e

    2011  Volume 28709

    Abstract: Plasmacytoid dendritic cells (pDCs) play a major role in anti-viral immunity by virtue of their ability to produce high amounts of type I interferons (IFNs) and a variety of inflammatory cytokines and chemokines in response to viral infections. Since ... ...

    Abstract Plasmacytoid dendritic cells (pDCs) play a major role in anti-viral immunity by virtue of their ability to produce high amounts of type I interferons (IFNs) and a variety of inflammatory cytokines and chemokines in response to viral infections. Since recent studies have established that pDCs accumulate at the site of virus entry in the mucosa, here we analyzed whether epithelial cells were able to modulate the function of pDCs. We found that the epithelial cell lines HT-29 and Caco-2, as well as a primary culture of human renal tubular epithelial cells (HRTEC), induced the phenotypic maturation of pDCs stimulating the production of inflammatory cytokines. By contrast, epithelial cells did not induce any change in the phenotype of conventional or myeloid DCs (cDCs) while significantly stimulated the production of the anti-inflammatory cytokine IL-10. Activation of pDCs by epithelial cells was prevented by Bafilomycin A1, an inhibitor of endosomal acidification as well as by the addition of RNase to the culture medium, suggesting the participation of endosomal TLRs. Interestingly, the cross-talk between both cell populations was shown to be associated to an increased expression of TLR7 and TLR9 by pDCs and the production of LL37 by epithelial cells, an antimicrobial peptide able to bind and transport extracellular nucleic acids into the endosomal compartments. Interestingly, epithelium-activated pDCs impaired the establishment of a productive HIV infection in two susceptible target cells through the stimulation of the production of type I IFNs, highlighting the anti-viral efficiency of this novel activation pathway.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile.

    Julian Maggini / Gerardo Mirkin / Ianina Bognanni / Josefina Holmberg / Isabel M Piazzón / Irene Nepomnaschy / Héctor Costa / Cristian Cañones / Silvina Raiden / Mónica Vermeulen / Jorge R Geffner

    PLoS ONE, Vol 5, Iss 2, p e

    2010  Volume 9252

    Abstract: In recent years it has become clear that the therapeutic properties of bone marrow-derived mesenchymal stromal cells (MSC) are related not only to their ability to differentiate into different lineages but also to their capacity to suppress the immune ... ...

    Abstract In recent years it has become clear that the therapeutic properties of bone marrow-derived mesenchymal stromal cells (MSC) are related not only to their ability to differentiate into different lineages but also to their capacity to suppress the immune response. We here studied the influence of MSC on macrophage function. Using mouse thioglycolate-elicited peritoneal macrophages (M) stimulated with LPS, we found that MSC markedly suppressed the production of the inflammatory cytokines TNF-alpha, IL-6, IL-12p70 and interferon-gamma while increased the production of IL-10 and IL-12p40. Similar results were observed using supernatants from MSC suggesting that factor(s) constitutively released by MSC are involved. Supporting a role for PGE(2) we observed that acetylsalicylic acid impaired the ability of MSC to inhibit the production of inflammatory cytokines and to stimulate the production of IL-10 by LPS-stimulated M. Moreover, we found that MSC constitutively produce PGE2 at levels able to inhibit the production of TNF-alpha and IL-6 by activated M. MSC also inhibited the up-regulation of CD86 and MHC class II in LPS-stimulated M impairing their ability to activate antigen-specific T CD4+ cells. On the other hand, they stimulated the uptake of apoptotic thymocytes by M. Of note, MSC turned M into cells highly susceptible to infection with the parasite Trypanosoma cruzi increasing more than 5-fold the rate of M infection. Using a model of inflammation triggered by s.c. implantation of glass cylinders, we found that MSC stimulated the recruitment of macrophages which showed a low expression of CD86 and the MHC class II molecule Ia(b) and a high ability to produce IL-10 and IL-12p40, but not IL-12 p70. In summary, our results suggest that MSC switch M into a regulatory profile characterized by a low ability to produce inflammatory cytokines, a high ability to phagocyte apoptotic cells, and a marked increase in their susceptibility to infection by intracellular pathogens.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Expresión de L-selectina en linfocitos T y neutrófilos de niños infectados con HIV L-selectin expression on T lymphocytes and neutrophils in HIV infected children

    Gaddi Eduardo / Héctor Quiroz / Jeanette Balbaryski / Graciela Barboni / Claudio Cantisano / Marcela Candi / Silvina Raiden / Vera Giraudi

    Medicina (Buenos Aires), Vol 65, Iss 2, Pp 131-

    2005  Volume 137

    Abstract: La capacidad de los leucocitos de abandonar la circulación y migrar hacia los tejidos es un paso crítico de la respuesta inmune. La L-selectina, selectina leucocitaria (CD62L), media la unión de linfocitos a las vénulas endoteliales altas de los ganglios ...

    Abstract La capacidad de los leucocitos de abandonar la circulación y migrar hacia los tejidos es un paso crítico de la respuesta inmune. La L-selectina, selectina leucocitaria (CD62L), media la unión de linfocitos a las vénulas endoteliales altas de los ganglios linfáticos periféricos, y también participa en la adhesión de linfocitos, neutrófilos y monocitos al endotelio vascular activado en los sitios de inflamación. En este trabajo se estudiaron los niveles de expresión de L-selectina sobre los linfocitos T y polimorfonucleares neutrófilos en 25 niños HIV(+) sin tratamiento antirretroviral y 25 niños sanos HIV(-), evaluando además su comportamiento en 10 de los pacientes, luego de 6 meses de iniciada la terapéutica específica para el HIV. El número de linfocitos TCD3+, CD4+ y CD8+ que expresan CD62L se encontró significativamente disminuido en los niños HIV(+) con respecto al grupo control. El porcentaje de neutrófilos que expresan CD62L se encontró significativamente disminuido en los pacientes con mayor compromiso inmunológico. Se observó una correlación positiva entre los niveles de LTCD4+ y el porcentaje de neutrófilos que expresan CD62L. Luego de 6 meses de tratamiento antirretroviral no hubo cambios significativos en los niveles de expresión de CD62L sobre LTCD4+ y LTCD8+. La reducción en los niveles de expresión de L-selectina en estos tipos celulares sugiere que durante la infección por HIV las funciones leucocitarias tales como la migración y el asentamiento linfocitario son anormales, contribuyendo al progresivo deterioro inmune. The ability of leukocytes to leave the circulation and migrate into tissues is a critical feature of the immune response. L-selectin (CD62L), the leukocyte selectin, mediates the binding of lymphocytes to high endothelial venules of peripheral lymph nodes and is also involved in lymphocyte, neutrophil and monocyte attachment to vascular endothelium at sites of inflammation. In this study L-selectin expression on peripheral T cells and neutrophils was evaluated in 25 HIV infected children, who had not received antiretroviral therapy, and 25 healthy controls. The expression level of L-selectin on T cells was also evaluated in 10 out 25 patients after 6 months of antiretroviral therapy. L-selectin expression on CD3+, CD4+ and CD8+ T cells were significantly lower in HIV infected children than in the control group. The percentage of neutrophils expressing CD62L was significantly reduced in patients with severe immunologic suppression. A positive correlation between the number of CD4+ T cells and the percentage of neutrophils CD62L+ was found. L-selectin expression on both CD4+ and CD8+ T cells did not significantly vary after 6 months of treatment. Altered leukocyte functions such as migration and homing resulting from reduced expression of CD62L may be an important contributor of the progressive dysfunction of the immune system in HIV infected children.
    Keywords L-selectina (CD62L) ; leucocitos ; infección pediátrica por HIV ; L-selectin (CD62L) ; leukocytes ; HIV pediatric infection ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2005-04-01T00:00:00Z
    Publisher Fundación Revista Medicina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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