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Article ; Online: Myxopapillary Ependymoma in an 11-Year-Old Patient With Right-Sided Nocturnal Thigh Pain.

Sim, Don / Groswald, Michael / Watters, Aaron

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2023

Abstract: Abstract: This case report highlights a rare type of primary spinal cord tumor, myxopapillary ependymoma, in a pediatric patient who presented to clinic with worsening chronic unilateral thigh pain and neurologic deficits. He was appropriately treated ... ...

Abstract	Abstract: This case report highlights a rare type of primary spinal cord tumor, myxopapillary ependymoma, in a pediatric patient who presented to clinic with worsening chronic unilateral thigh pain and neurologic deficits. He was appropriately treated with total gross resection of the tumor and adjuvant radiotherapy and was cleared for competitive sports without any restriction within 1 year of his diagnosis and treatment. Although most musculoskeletal complaints among pediatric patients are of benign etiology, as evidenced by our case, clinicians should have a low threshold to further investigate with advanced imaging modalities should the clinical history and examination be consistent with a more concerning pathologic process.
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000001141
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Article ; Online: Peptide-Functionalized Carbon Nanotube Chemiresistors: The Effect of Nanotube Density on Gas Sensing.

Sim, Daniel / Huang, Tiffany / Kim, Steve S

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 20

Abstract: Biorecognition element (BRE)-based carbon nanotube (CNT) chemiresistors have tremendous potential to serve as highly sensitive, selective, and power-efficient volatile organic compound (VOC) sensors. While many research groups have studied BRE- ... ...

Abstract	Biorecognition element (BRE)-based carbon nanotube (CNT) chemiresistors have tremendous potential to serve as highly sensitive, selective, and power-efficient volatile organic compound (VOC) sensors. While many research groups have studied BRE-functionalized CNTs in material science and device development, little attention has been paid to optimizing CNT density to improve chemiresistor performance. To probe the effect of CNT density on VOC detection, we present the chemiresistor-based sensing results from two peptide-based CNT devices counting more than 60 different individual measurements. We find that a lower CNT density shows a significantly higher noise level and device-to-device variation while exhibiting mildly better sensitivity. Further investigation with SEM images suggests that moderately high CNT density with a stable connection of the nanotube network is desirable to achieve the best signal-to-noise ratio. Our results show an essential design guideline for tuning the nanotube density to provide sensitive and stable chemiresistors.
Language	English
Publishing date	2023-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23208469
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Article ; Online: Unveiling the Potential of Natural Compounds: A Comprehensive Review on Adipose Thermogenesis Modulation.

Shin, Jaeeun / Lee, Yeonho / Ju, Seong Hun / Jung, Young Jae / Sim, Daehyeon / Lee, Sung-Joon

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: The process of adipocyte browning has recently emerged as a novel therapeutic target for combating obesity and obesity-related diseases. Non-shivering thermogenesis is the process of biological heat production in mammals and is primarily mediated via ... ...

Abstract	The process of adipocyte browning has recently emerged as a novel therapeutic target for combating obesity and obesity-related diseases. Non-shivering thermogenesis is the process of biological heat production in mammals and is primarily mediated via brown adipose tissue (BAT). The recruitment and activation of BAT can be induced through chemical drugs and nutrients, with subsequent beneficial health effects through the utilization of carbohydrates and fats to generate heat to maintain body temperature. However, since potent drugs may show adverse side effects, nutritional or natural substances could be safe and effective as potential adipocyte browning agents. This review aims to provide an extensive overview of the natural food compounds that have been shown to activate brown adipocytes in humans, animals, and in cultured cells. In addition, some key genetic and molecular targets and the mechanisms of action of these natural compounds reported to have therapeutic potential to combat obesity are discussed.
MeSH term(s)	Thermogenesis/drug effects ; Humans ; Animals ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/drug effects ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Obesity/drug therapy ; Obesity/metabolism ; Adipocytes, Brown/metabolism ; Adipocytes, Brown/drug effects
Chemical Substances	Biological Products
Language	English
Publishing date	2024-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094915
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Article ; Online: Weak grip strength predicts higher unplanned healthcare utilization among patients with heart failure.

Poco, Louisa Camille / Finkelstein, Eric / Sim, David / Malhotra, Chetna

ESC heart failure

2023 Volume 11, Issue 1, Page(s) 306–314

Abstract: Aims: Frailty increases healthcare utilization and costs for patients with heart failure but is challenging to assess in clinical settings. Hand grip strength (GS) is a single-item measure of frailty yet lacks evidence as a potential screening tool to ... ...

Abstract	Aims: Frailty increases healthcare utilization and costs for patients with heart failure but is challenging to assess in clinical settings. Hand grip strength (GS) is a single-item measure of frailty yet lacks evidence as a potential screening tool to identify patients at risk of higher unplanned events and related healthcare costs. We examined the association of baseline and longitudinal GS measurements with healthcare utilization and costs among patients with advanced heart failure. Methods and results: Between July 2017 and April 2019, we enrolled 251 patients with symptoms of advanced heart failure (New York Heart Association class III or IV) in a prospective cohort study in Singapore. We measured GS at baseline and every 4 months for 2 years and linked patients' survey data with their medical and billing records. We categorized patients as having weak GS if their GS measurement was below the 5th percentile of the age- and gender-specific normative GS values in Singapore. We assessed the association between baseline GS and healthcare utilization (unplanned and planned events and healthcare costs, total costs, and length of inpatient stay) over the next 2 years using regression models. We investigated the association between longitudinal 4-monthly GS assessments and the ensuing 4 months of healthcare utilization and costs using mixed-effects logistic and two-part regression models. At baseline, 22.5% of patients had weak GS. Baseline and longitudinal GS measurements were significantly associated with longer length of inpatient stay, greater likelihood of unplanned events, and higher related costs. Patients with weak GS had higher odds of an unplanned event occurring by 8 percentage points [95% confidence interval (CI) (0.01, 0.14), P = 0.026], incurred longer inpatient stays by 4 days [95% CI (1.97, 6.79), P = 0.003], and additional SG$ 4792 [US$ ~ 3594, 95% CI (1894, 7689), P = 0.014] in unplanned healthcare costs over the next 4 months. Conclusions: GS is a simple tool to identify and monitor heart failure patients at risk of unplanned events, longer inpatient stays, and higher related healthcare costs. Findings support its routine use in clinical settings.
MeSH term(s)	Humans ; Frailty ; Prospective Studies ; Hand Strength ; Heart Failure/epidemiology ; Heart Failure/therapy ; Patient Acceptance of Health Care
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14573
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Article ; Online: Microfluidic Thermal Flowmeters for Drug Injection Monitoring.

Doh, Il / Sim, Daniel / Kim, Steve S

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 9

Abstract: This paper presents a microfluidic thermal flowmeter for monitoring injection pumps, which is essential to ensure proper patient treatment and reduce medication errors that can lead to severe injury or death. The standard gravimetric method for flow-rate ...

Abstract	This paper presents a microfluidic thermal flowmeter for monitoring injection pumps, which is essential to ensure proper patient treatment and reduce medication errors that can lead to severe injury or death. The standard gravimetric method for flow-rate monitoring requires a great deal of preparation and laboratory equipment and is impractical in clinics. Therefore, an alternative to the standard method suitable for remote, small-scale, and frequent infusion-pump monitoring is in great demand. Here, we propose a miniaturized thermal flowmeter consisting of a silicon substrate, a platinum heater layer on a silicon dioxide thin-membrane, and a polymer microchannel to provide accurate flow-rate measurement. The present thermal flowmeter is fabricated by the micromachining and micromolding process and exhibits sensitivity, linearity, and uncertainty of 0.722 mW/(g/h), 98.7%, and (2.36 ± 0.80)%, respectively, in the flow-rate range of 0.5-2.5 g/h when the flowmeter is operated in the constant temperature mode with the channel width of 0.5 mm. The measurement range of flow rate can be easily adjusted by changing the cross-sectional microchannel dimension. The present miniaturized thermal flowmeter shows a high potential for infusion-pump calibration in clinical settings.
MeSH term(s)	Calibration ; Cross-Sectional Studies ; Flowmeters ; Humans ; Microfluidics ; Temperature
Language	English
Publishing date	2022-04-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22093151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Forestry extension methods

Sim, D. / Hilmi, H. A.

(FAO forestry paper ; 80)

1987

Author's details	by D. Sim and H. A. Hilmi
Series title	FAO forestry paper ; 80
Collection
Language	English
Size	IX, 155 S. : Ill.
Publisher	Food and Agriculture Organization of the United Nations
Publishing place	Rome
Publishing country	Italy
Document type	Book
HBZ-ID	HT006800204
ISBN	92-5-102602-5 ; 978-92-5-102602-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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894/372	order for loan	Geschlossenes Magazin (U2)

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Book ; Online: Machine Learning-Enabled Precision Position Control and Thermal Regulation in Advanced Thermal Actuators

Mirvakili, Seyed Mo / Haghighat, Ehsan / Sim, Douglas

2023

Abstract: With their unique combination of characteristics - an energy density almost 100 times that of human muscle, and a power density of 5.3 kW/kg, similar to a jet engine's output - Nylon artificial muscles stand out as particularly apt for robotics ... ...

Abstract	With their unique combination of characteristics - an energy density almost 100 times that of human muscle, and a power density of 5.3 kW/kg, similar to a jet engine's output - Nylon artificial muscles stand out as particularly apt for robotics applications. However, the necessity of integrating sensors and controllers poses a limitation to their practical usage. Here we report a constant power open-loop controller based on machine learning. We show that we can control the position of a nylon artificial muscle without external sensors. To this end, we construct a mapping from a desired displacement trajectory to a required power using an ensemble encoder-style feed-forward neural network. The neural controller is carefully trained on a physics-based denoised dataset and can be fine-tuned to accommodate various types of thermal artificial muscles, irrespective of the presence or absence of hysteresis.
Keywords	Computer Science - Robotics ; Computer Science - Machine Learning ; J.2
Subject code	629
Publishing date	2023-10-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: "Zur Umsetzung des Human Scale bedarf es viel mehr gebietsübergreifende Planungsarbeit"

Sim, David

Collage : Zeitschrift für Raumentwicklung = périodique du développement territorial = periodico di sviluppo territoriale ; 1309648-5 ; 2673-6381 ; - ; 2016 ; 4

2016

Publisher	Bund Schweizer Planer
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Association Between COVID-19 and Febrile Seizure: A Retrospective Case-Control Study.

Hanlon, Sean M / Sim, Don / Schneider, Jack G / Yang, Ziyi / Thompson, Sean M

Pediatric emergency care

2023 Volume 39, Issue 5, Page(s) 360–363

Abstract: Background/objective: Throughout the pandemic, febrile seizures have resulted from infection secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The objective of this study is to determine if there is an increased association ... ...

Abstract	Background/objective: Throughout the pandemic, febrile seizures have resulted from infection secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The objective of this study is to determine if there is an increased association between COVID-19 and febrile seizures as compared with other causes of febrile seizures. Methods: This was a retrospective case control study. Data were collected from the National Institute of Health (NIH) supported National COVID Cohort Collaborative (N3C). Patients from 6 to 60 months who were tested for COVID-19 were included; cases were defined as COVID-19-positive patients whereas controls were defined as COVID-19-negative patients. Febrile seizures diagnosed within 48 hours of the COVID-19 test were considered to be associated with the test result. Patients were subjected to a stratified gender and date matching design followed by a logistic regression controlling for age and race. Results: During the study period, 27,692 patients were included. Of those, 6923 patients were COVID-19-positive, among which 189 had febrile seizures (2.7%). After logistic regression, the likelihood of having febrile seizures concurrently with COVID-19 as compared with other causes was 0.96 ( P = 0.949; confidence interval, 0.81, 1.14). Conclusions: There were 2.7% of the patients with COVID-19 that were diagnosed with a febrile seizure. However, when subjected to a matched case control design with logistic regression controlling for confounding variables, there does not appear to be an increased risk of febrile seizures secondary to COVID-19 as compared with other causes.
MeSH term(s)	Humans ; Seizures, Febrile/epidemiology ; Seizures, Febrile/etiology ; Seizures, Febrile/diagnosis ; COVID-19/complications ; COVID-19/epidemiology ; Case-Control Studies ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002935
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Article ; Online: Cost-Effectiveness of Empagliflozin on Top of Standard of Care for Heart Failure With Reduced Ejection Fraction in Singapore.

Varghese, Lijoy / Lin, Weiqin / Linden, Stephan / Lum, Ai Ling / Sim, David

Value in health regional issues

2023 Volume 34, Page(s) 108–117

Abstract: Objectives: The prevalence of heart failure (HF) and its risk factors are high in Singapore. The EMPEROR-Reduced trial demonstrated that add-on empagliflozin resulted in a reduction in the risk of cardiovascular death or hospitalization for HF compared ... ...

Abstract	Objectives: The prevalence of heart failure (HF) and its risk factors are high in Singapore. The EMPEROR-Reduced trial demonstrated that add-on empagliflozin resulted in a reduction in the risk of cardiovascular death or hospitalization for HF compared with standard of care (SoC). This study aimed to estimate the cost-effectiveness of empagliflozin+SoC versus SoC in patients with HF with reduced ejection fraction from a Singaporean healthcare perspective. Methods: A Markov cohort model simulated progression through health states based on New York Heart Association classes over a lifetime horizon using a cycle length of 1 month. Transition probabilities, and the risk of transient events (hospitalization for HF and cardiovascular/all-cause death) were modeled based on the EMPEROR-Reduced trial. Costs for HF-related events, adverse events, and for monitoring were estimated from a combination of published literature and publicly available fees for public hospitals/polyclinics. Results: Empagliflozin+SoC was estimated to be very cost-effective versus SoC alone with an incremental cost-effectiveness ratio of<8000 Singapore Dollars/quality-adjusted life-year gained. The base-case results were robust as evidenced from the consistency of various scenario and sensitivity analyses performed. When using Kansas City Cardiomyopathy Questionnaire - Clinical Summary Score quartiles as the health states, the incremental cost-effectiveness ratio reduced significantly to 4625 Singapore Dollars/quality-adjusted life-year. Conclusion: The use of empagliflozin on top of SoC represents a highly cost-effective solution for the treatment of patients with HF with reduced ejection fraction in Singapore when considering its efficacy, relative affordability, and the growing economic burden of HF in Singapore.
MeSH term(s)	Humans ; Cost-Benefit Analysis ; Stroke Volume ; Singapore ; Standard of Care ; Heart Failure
Chemical Substances	empagliflozin (HDC1R2M35U)
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2679127-4
ISSN	2212-1102 ; 2212-1099
ISSN (online)	2212-1102
ISSN	2212-1099
DOI	10.1016/j.vhri.2022.12.003
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