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  1. Article ; Online: Intrathecal baclofen for the management of hereditary spastic paraparesis: a systematic review.

    Viana Pinto, Luisa / Romeiro, Isabel / Gouveia, Filipa / Ramalho, Joana / Ribeiro Silva, Sara / Táboas Simões, Maria Inês / Rodrigues Leal, Joana

    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation

    2024  Volume 47, Issue 1, Page(s) 3–9

    Abstract: This systematic review aims to evaluate the use of intrathecal baclofen (ITB) for hereditary spastic paraparesis (HSP) treatment. An extensive search in two electronical databases was performed. We identified articles published between 1990 and 2022 ( ... ...

    Abstract This systematic review aims to evaluate the use of intrathecal baclofen (ITB) for hereditary spastic paraparesis (HSP) treatment. An extensive search in two electronical databases was performed. We identified articles published between 1990 and 2022 (PubMed, Scopus), and applied the following inclusion criteria: diagnosis of HSP at the time of the intervention, either familial or sporadic; report on the effect of ITB in patients with HSP; test trial via either bolus injections or continuous infusion tests; and ITB pump implantation. A data extraction sheet based on the Cochrane Consumers and Communication Review Group's data extraction template was created and adapted to collect relevant data. A qualitative analysis was performed to present the results in narrative summary fashion. A total of 6 studies met our inclusion criteria. 51 patients with HSP had a pre-implantation ITB trial. The time since the diagnosis until the pump implantation ranged from 5 to 30 years. The initial bolus ranged from 20 to 50 μg and the mean doses used at steady state ranged from 65 to 705 μg. An improvement in spasticity was observed on the modified Ashworth Scale in patients treated with ITB. Although all studies reported a subjective gait improvement, not all found an objective improvement in gait. The most common side effect reported was catheter-related problems. The findings of this review support the use of ITB as an effective and a viable option for the treatment of spasticity in HSP refractory to conservative therapies.
    MeSH term(s) Humans ; Baclofen/adverse effects ; Paraparesis, Spastic/chemically induced ; Paraparesis, Spastic/drug therapy ; Infusion Pumps, Implantable ; Injections, Spinal ; Muscle Spasticity/drug therapy
    Chemical Substances Baclofen (H789N3FKE8)
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 533323-4
    ISSN 1473-5660 ; 0342-5282
    ISSN (online) 1473-5660
    ISSN 0342-5282
    DOI 10.1097/MRR.0000000000000607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1326: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: First ecotoxicological characterization of paraffin microparticles: a biomarker approach in a marine suspension-feeder, Mytilus sp.

    Nunes, Bruno / Simões, Maria Inês / Navarro, Juan Carlos / Castro, Bruno Branco

    Environmental science and pollution research international

    2020  Volume 27, Issue 33, Page(s) 41946–41960

    Abstract: Microplastics are one of the main environmental pollutants in marine ecosystems, and their presence in seawater is a consequence of the widespread use of plastic materials in modern commodities. This wide usage of plastics includes the employment of ... ...

    Abstract Microplastics are one of the main environmental pollutants in marine ecosystems, and their presence in seawater is a consequence of the widespread use of plastic materials in modern commodities. This wide usage of plastics includes the employment of microspheres in common personal care products, which end up being ultimately released into the aquatic compartment. Known ecotoxicological effects of microplastics favoured the search for technologically viable and environmentally safer alternatives, such as paraffin wax microparticles, whose ecotoxicological risks have not been entirely characterized. To address this gap, the present study exposed mussels (Mytilus sp.) for 96 h to three densities (5 mg/L, 20 mg/L and 80 mg/L) of four size ranges (100-300 μm, 300-500 μm, 400-850 μm, and 800-1200 μm) of paraffin wax particles. Toxicological endpoints were the activities of four enzymes involved in key cellular processes, including antioxidant defence (catalase (CAT), glutathione reductase (GRed) and glutathione peroxidase (GPx)) and phase II metabolism (glutathione S-transferases (GSTs)), as well as lipid content and fatty acid profiles of the digestive gland. Significant interactions between the presence/absence of food and paraffin particle density were found, as food sometimes worked as a confounding factor in the analysed biomarkers. Despite this uncertainty, some overall patterns emerged. In general, smaller paraffin wax particles (100-300 μm) caused little effects on the activity of the four enzymes tested, whereas larger particles (800-1200 μm) caused significant effects on almost all biomarkers. CAT activity was enhanced in animals exposed to larger paraffin particles, whilst GPx activity was depressed; GRed activity was not affected by the exposure to paraffin particles. The activity of GSTs was enhanced, but only in one tested condition. No effects were observed in terms of the total lipid content and fatty acids of exposed animals. Overall, data obtained in this work suggest that, at densities of paraffin wax particles comparable to the levels found in the environment for microplastic beads, no toxicity is expected to occur in the tested mussel species, by measuring the here-assessed toxicological endpoints.
    MeSH term(s) Animals ; Biomarkers ; Ecosystem ; Mytilus ; Paraffin ; Plastics ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
    Chemical Substances Biomarkers ; Plastics ; Water Pollutants, Chemical ; Paraffin (8002-74-2)
    Language English
    Publishing date 2020-07-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-020-10055-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  3. Article ; Online: Hidradenocarcinoma do Escroto com Metastização Ganglionar.

    Simões, Maria Inês / Marcão, Isabel / Toscano, Mário / Borges, Luís

    Acta medica portuguesa

    2018  Volume 31, Issue 3, Page(s) 176–179

    Abstract: Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, ... ...

    Title translation Hidradenocarcinoma of the Scrotum with Lymph Node Metastasis.
    Abstract Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, axillary and nuchal regions. It has an aggressive behavior, with high rate of local recurrence and distance metastasis, associated with a poor prognosis. We present a case of hidradenocarcinoma of the scrotum manifested by lymph node metastasis through an exercise of clinical and histological differential diagnosis of an inguinal adenopathy in a young adult.
    MeSH term(s) Acrospiroma/pathology ; Acrospiroma/surgery ; Adult ; Genital Neoplasms, Male/pathology ; Genital Neoplasms, Male/surgery ; Humans ; Lymphatic Metastasis ; Male ; Scrotum ; Sweat Gland Neoplasms/pathology ; Sweat Gland Neoplasms/surgery
    Language Portuguese
    Publishing date 2018-03-29
    Publishing country Portugal
    Document type Case Reports ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.9017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2343: Show issues Location:
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  4. Article ; Online: Miocardiopatia de Takotsubo: Na Origem do Choque Cardiogénico.

    Fevereiro, Maria do Carmo / Simões, Maria Inês / Lampreia, Fátima / Marcão, Isabel / Godinho, António / Lopes, Vitor

    Acta medica portuguesa

    2015  Volume 28, Issue 5, Page(s) 670–673

    Abstract: Takotsubo cardiomyopathy, of unknown etiology, is characterized by sudden and transient systolic dysfunction of the mid-apical segments of the left ventricle without significant coronary disease, and full normalization of segmental changes. More common ... ...

    Title translation Takotsubo Cardiomyopathy: Cause of a Cardiogenic Shock.
    Abstract Takotsubo cardiomyopathy, of unknown etiology, is characterized by sudden and transient systolic dysfunction of the mid-apical segments of the left ventricle without significant coronary disease, and full normalization of segmental changes. More common in middle-aged women, it is cause of differential diagnosis with acute coronary syndrome. We present the case of a 59 year old woman admitted to the emergency room with sudden chest pain and dyspnea. At presentation: acute hypotensive pulmonary edema requiring aminergic support and invasive ventilation. Blood tests showed elevated necrosis myocardial enzymes. Serial electrocardiograms: sinus rhythm with progressive inversion of the T wave through the precordial leads (v2 - v6). Control echocardiograms: overall decreased systolic function with apical akinesia, and full reversal of the changes in 2 weeks. Cardiogenic shock of unknown etiology was admitted and a coronary computed tomography angiography was performed excluding coronary heart disease, supporting the diagnosis of Takotsubo cardiomyopathy.
    Language Portuguese
    Publishing date 2015-09
    Publishing country Portugal
    Document type English Abstract ; Journal Article
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2343: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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