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  1. Article ; Online: Smartphone-based device for point-of-care diagnostics of pulmonary inflammation using convolutional neural networks (CNNs).

    Ghaderinia, Mohammadreza / Abadijoo, Hamed / Mahdavian, Ashkan / Kousha, Ebrahim / Shakibi, Reyhaneh / Taheri, Seyed Mohammad Reza / Simaee, Hossein / Khatibi, Ali / Moosavi-Movahedi, Ali Akbar / Khayamian, Mohammad Ali

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6912

    Abstract: In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. ... ...

    Abstract In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a chest CT scan. However, the lack of accessibility to the CT machines in many poor medical centers as well as its expensive service, demands more accessible methods for fast and cheap detection of lung inflammation. Here, we have introduced a novel method for tracing the inflammation and lung involvement in patients with pulmonary inflammation, such as COVID-19, by a simple electrolyte detection in their sputum samples. The presence of the electrolyte in the sputum sample results in the fern-like structures after air-drying. These fern patterns are different in the CT positive and negative cases that are detected by an AI application on a smartphone and using a low-cost and portable mini-microscope. Evaluating 160 patient-derived sputum sample images, this method demonstrated an interesting accuracy of 95%, as confirmed by CT-scan results. This finding suggests that the method has the potential to serve as a promising and reliable approach for recognizing lung inflammatory diseases, such as COVID-19.
    MeSH term(s) Humans ; Smartphone ; Neural Networks, Computer ; COVID-19/diagnosis ; Inflammation ; Point-of-Care Testing ; Electrolytes ; COVID-19 Testing
    Chemical Substances Electrolytes
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54939-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients.

    Abadijoo, Hamed / Khayamian, Mohammad Ali / Faramarzpour, Mahsa / Ghaderinia, Mohammadreza / Simaee, Hossein / Shalileh, Shahriar / Yazdanparast, Seyed Mojtaba / Ghabraie, Bahman / Makarem, Jalil / Sarrami-Forooshani, Ramin / Abdolahad, Mohammad

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 850571

    Abstract: In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. ... ...

    Abstract In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. All of the scientists believe that the major challenge toward the mortality of the COVID-19 patients is the out-of-control immune system activation and the subsequent cytokine production. During this process, the adaptive immune system is highly activated, and many of the lymphocytes start to clonally expand; hence many cytokines are also released. So, any attempt to harness this cytokine storm and calm down the immune outrage is appreciated. While the battleground for the immune hyperactivation is the lung ambient of the infected patients, the only medical treatment for suppressing the hypercytokinemia is based on the immunosuppressor drugs that systemically dampen the immunity with many unavoidable side effects. Here, we applied the alternating electric field to suppress the expansion of the highly activated lymphocytes, and by reducing the number of the renewed cells, the produced cytokines were also decreased. Applying this method to the blood of the COVID-19 patients
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.850571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients.

    Khayamian, Mohammad Ali / Parizi, Mohammad Salemizadeh / Ghaderinia, Mohammadreza / Abadijoo, Hamed / Vanaei, Shohreh / Simaee, Hossein / Abdolhosseini, Saeed / Shalileh, Shahriar / Faramarzpour, Mahsa / Naeini, Vahid Fadaei / Hoseinpour, Parisa / Shojaeian, Fatemeh / Abbasvandi, Fereshteh / Abdolahad, Mohammad

    RSC advances

    2021  Volume 11, Issue 55, Page(s) 34503–34515

    Abstract: Concurrent with the pandemic announcement of SARS-CoV-2 infection by the WHO, a variety of reports were published confirming the cytokine storm as the most mortal effect of the virus on the infected patients. Hence, cytokine storm as an evidenced ... ...

    Abstract Concurrent with the pandemic announcement of SARS-CoV-2 infection by the WHO, a variety of reports were published confirming the cytokine storm as the most mortal effect of the virus on the infected patients. Hence, cytokine storm as an evidenced consequence in most of the COVID-19 patients could offer a promising opportunity to use blood as a disease progression marker. Here, we have developed a rapid electrochemical impedance spectroscopy (EIS) sensor for quantifying the overall immune activity of the patients. Since during the cytokine storm many types of cytokines are elevated in the blood, there is no need for specific detection of a single type of cytokine and the collective behavior is just measured without any electrode functionalization. The sensor includes a monolayer graphene on a copper substrate as the working electrode (WE) which is able to distinguish between the early and severe stage of the infected patients. The charge transfer resistance (
    Language English
    Publishing date 2021-10-25
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra04298j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Necroptosis triggered by ROS accumulation and Ca

    Barati, Mojdeh / Javidi, Mohammad Amin / Darvishi, Behrad / Shariatpanahi, Seyed Peyman / Mesbah Moosavi, Zahra S / Ghadirian, Reyhane / Khani, Tahereh / Sanati, Hassan / Simaee, Hossein / Shokrollahi Barough, Mahdieh / Farahmand, Leila / Madjid Ansari, Alireza

    Free radical biology & medicine

    2021  Volume 169, Page(s) 84–98

    Abstract: Whereas the anti-neoplastic activity of extremely low frequency magnetic fields (ELF-EMF) is well-documented in literature, little is known about its underlying anti-cancer mechanisms and induced types of cell death. Here, for the first time, we reported ...

    Abstract Whereas the anti-neoplastic activity of extremely low frequency magnetic fields (ELF-EMF) is well-documented in literature, little is known about its underlying anti-cancer mechanisms and induced types of cell death. Here, for the first time, we reported induction of necroptosis, a specific type of programed necrotic cell death, in MC4-L2 breast cancer cell lines following a 2 h/day exposure to a 100 Hz, 1 mT ELF-EMF for five days. For in vivo assessment, inbred BALB/c mice bearing established MC-4L2 tumors were exposed to 100 mT, 1 Hz ELF-EMF 2 h daily for a period of 28-day, following which tumors were dissected and fixed for evaluation of tumor biomarkers expression and types of cell death induced using TUNEL assay, Immunohistochemistry and H&E staining. Peripheral blood samples were also collected for assessing pro-inflammatory cytokine profile following exposure. An exaggerated proinflammatory response evident form enhancement of IFN-γ (4.8 ± 0.24 folds) and TNF-α (3.1 ± 0.19 folds) and number of tumors infiltrating lymphocytes (TILs), specially CD8
    MeSH term(s) Animals ; Electromagnetic Fields ; Mice ; Mice, Inbred BALB C ; Necroptosis ; Neoplasms ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2021-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A label-free graphene-based impedimetric biosensor for real-time tracing of the cytokine storm in blood serum; suitable for screening COVID-19 patients

    Khayamian, Mohammad Ali / Parizi, Mohammad Salemizadeh / Ghaderinia, Mohammadreza / Abadijoo, Hamed / Vanaei, Shohreh / Simaee, Hossein / Abdolhosseini, Saeed / Shalileh, Shahriar / Faramarzpour, Mahsa / Naeini, Vahid Fadaei / Hoseinpour, Parisa / Shojaeian, Fatemeh / Abbasvandi, Fereshteh / Abdolahad, Mohammad

    RSC advances. 2021 Oct. 25, v. 11, no. 55

    2021  

    Abstract: Concurrent with the pandemic announcement of SARS-CoV-2 infection by the WHO, a variety of reports were published confirming the cytokine storm as the most mortal effect of the virus on the infected patients. Hence, cytokine storm as an evidenced ... ...

    Abstract Concurrent with the pandemic announcement of SARS-CoV-2 infection by the WHO, a variety of reports were published confirming the cytokine storm as the most mortal effect of the virus on the infected patients. Hence, cytokine storm as an evidenced consequence in most of the COVID-19 patients could offer a promising opportunity to use blood as a disease progression marker. Here, we have developed a rapid electrochemical impedance spectroscopy (EIS) sensor for quantifying the overall immune activity of the patients. Since during the cytokine storm many types of cytokines are elevated in the blood, there is no need for specific detection of a single type of cytokine and the collective behavior is just measured without any electrode functionalization. The sensor includes a monolayer graphene on a copper substrate as the working electrode (WE) which is able to distinguish between the early and severe stage of the infected patients. The charge transfer resistance (RCT) in the moderate and severe cases varies about 65% and 138% compared to the normal groups, respectively and a specificity of 77% and sensitivity of 100% based on ELISA results were achieved. The outcomes demonstrate a significant correlation between the total mass of the three main hypercytokinemia associated cytokines including IL-6, TNF-α and IFN-γ in patients and the RCT values. As an extra application, the biosensor's capability for diagnosis of COVID-19 patients was tested and a sensitivity of 92% and specificity of 50% were obtained compared to the RT-PCR results.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; biosensors ; blood serum ; dielectric spectroscopy ; disease progression ; electrodes ; graphene ; group behavior ; interleukin-6 ; pandemic ; viruses
    Language English
    Dates of publication 2021-1025
    Size p. 34503-34515.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d1ra04298j
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Capture-free deactivation of CTCs in the bloodstream; a metastasis suppression method by electrostatic stimulation of the peripheral blood.

    Ghaderinia, Mohammadreza / Khayamian, Mohammad Ali / Abadijoo, Hamed / Shalileh, Shahriar / Faramarzpour, Mahsa / Zandi, Ashkan / Simaee, Hossein / Abbasvandi, Fereshteh / Esmailinejad, Mohammad Reza / Rafizadeh-Tafti, Saeed / Jahangiri, Mojtaba / Kordehlachin, Yasin / Ghaffari, Hadi / Ansari, Ehsan / Dabbagh, Najmeh / Akbari, Mohammad Esmaeil / Hoseinpour, Parisa / Abdolahad, Mohammad

    Biosensors & bioelectronics

    2021  Volume 183, Page(s) 113194

    Abstract: While limited investigations have been reported on CTC elimination and its profits, recently, some new works were reported on detection followed by the destruction of CTCs. Limitations and complications of CTC capturing procedures have highly reduced the ...

    Abstract While limited investigations have been reported on CTC elimination and its profits, recently, some new works were reported on detection followed by the destruction of CTCs. Limitations and complications of CTC capturing procedures have highly reduced the chance of selective destruction of CTCs in the bloodstream in the therapeutic guidelines of the patients. Here, we selectively deactivated the invasive function of CTCs during their circulation in the bloodstream by exposing the whole blood to pure positive electrostatic charge stimulation (PPECS). Our treatment suppressed pulmonary metastasis and extended the survival of the mice had been intravenously injected by electrostatically deactivated 4T1 breast cancer CTCs. Moreover, the number of cancerous lung nodules was drastically reduced in the mice injected by treated CTCs in comparison with the non-treated cohort. Evaluating the side effect of the PPECS on the blood components revealed no major effect on the functional properties of the white blood cells, and just a negligible fraction (∼10%) was damaged during this process. This approach does not need any capturing or targeting of CTCs from the blood as it is focused on perturbing the electrical function of negatively-charged tumor cells after being exposed to positive electrostatic charges. Taken together, continuous in-vivo deactivation of CTCs by PPECS with no requirement to complicated capturing protocols may improve the survival of cancer patients.
    MeSH term(s) Animals ; Biosensing Techniques ; Breast Neoplasms ; Cell Line, Tumor ; Humans ; Mice ; Neoplasm Metastasis ; Neoplastic Cells, Circulating/pathology ; Static Electricity
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2021.113194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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