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  1. Article ; Online: WHO global strategy to eliminate cervical cancer as a public health problem: An opportunity to make it a disease of the past.

    Simelela, Princess Nothemba

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2020  Volume 152, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  2. Article ; Online: How should we listen to ECHO?

    Noguchi, Lisa Miyako / Simelela, Princess Nothemba

    Lancet (London, England)

    2019  Volume 394, Issue 10195, Page(s) 275–276

    MeSH term(s) Clinical Decision-Making ; Clinical Trials as Topic ; Contraception/adverse effects ; Contraception/instrumentation ; Contraception/methods ; Copper ; Female ; HIV Infections/epidemiology ; Humans ; Intention to Treat Analysis ; Intrauterine Devices/adverse effects ; Kenya/epidemiology ; Levonorgestrel/administration & dosage ; Levonorgestrel/adverse effects ; Observational Studies as Topic ; Practice Guidelines as Topic ; South Africa/epidemiology ; Zambia/epidemiology
    Chemical Substances Levonorgestrel (5W7SIA7YZW) ; Copper (789U1901C5)
    Language English
    Publishing date 2019-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31387-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 94: Show issues

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  3. Article ; Online: Improving access to human papillomavirus vaccines: A case study in the IA2030 core principle of partnership.

    Cernuschi, Tania / Hall, Shanelle / Malvolti, Stefano / Bloem, Paul / Kampo, Aboubacar / Debruyne, Luc / Hwang, Angela / Simelela, Princess Nothemba

    Vaccine

    2022  

    Abstract: Partnerships are fundamental to progress in immunization, and this is especially true for human papillomavirus (HPV) vaccination, which must be delivered in the context of a broader immunization, sexual and reproductive health, and cervical cancer ... ...

    Abstract Partnerships are fundamental to progress in immunization, and this is especially true for human papillomavirus (HPV) vaccination, which must be delivered in the context of a broader immunization, sexual and reproductive health, and cervical cancer prevention programs. Starting from the discovery and development of HPV vaccines, through to implementation and improvement of the program's resilience, partnerships have played a critical role. In May 2018, the Global Strategy to Accelerate the Elimination of Cervical Cancer set a target for 90 % of girls to be fully vaccinated with HPV vaccine by age 15 years. This will require effective partnership and multisectoral collaboration among current and future partners to ensure alignment of interests, efficient execution, and the establishment of mechanisms to resolve emerging challenges and pre-empt foreseeable risks. In ramping up this partnering approach, HPV can provide a template for other health and immunization programs.
    Language English
    Publishing date 2022-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.11.040
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    Zs.MO 458: Show issues

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  4. Article ; Online: Gender mainstreaming within WHO: not without equity and human rights.

    Magar, Veronica / Heidari, Shirin / Zamora, Gerardo / Coates, Anna / Simelela, Princess Nothemba / Swaminathan, Soumya

    Lancet (London, England)

    2019  Volume 393, Issue 10182, Page(s) 1678–1679

    MeSH term(s) Gender Identity ; Human Rights ; Humans ; Women's Rights ; World Health Organization/organization & administration
    Language English
    Publishing date 2019-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)30763-9
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  5. Article ; Online: Community-integrated self-collected HPV-based cervix screening in a low-resource rural setting: a pragmatic, cluster-randomized trial.

    Gottschlich, Anna / Payne, Beth A / Trawin, Jessica / Albert, Arianne / Jeronimo, Jose / Mitchell-Foster, Sheona / Mithani, Nadia / Namugosa, Ruth / Naguti, Priscilla / Pedersen, Heather / Rawat, Angeli / Simelela, Princess Nothemba / Singer, Joel / Smith, Laurie W / van Niekerk, Dirk / Orem, Jackson / Nakisige, Carolyn / Ogilvie, Gina

    Nature medicine

    2023  Volume 29, Issue 4, Page(s) 927–935

    Abstract: Effective approaches to improve coverage of self-collected human papillomavirus (HPV)-based cervix screening (SCS) as well as attendance at treatment for HPV-positive participants are needed to inform policy on optimal integration of cervical cancer ... ...

    Abstract Effective approaches to improve coverage of self-collected human papillomavirus (HPV)-based cervix screening (SCS) as well as attendance at treatment for HPV-positive participants are needed to inform policy on optimal integration of cervical cancer screening programs within existing infrastructure in low-resource settings. ASPIRE Mayuge was a pragmatic cluster-randomized trial in rural Mayuge district, Uganda, comparing the superiority of two recruitment implementation strategies for SCS: Door-to-Door versus Community Health Day. Villages were randomized (unblinded) to a strategy, and participants aged 25-49 years with no previous history of hysterectomy or treatment for cervical cancer or pre-cancer were eligible. Participants completed a survey and participated in SCS. The primary outcome was rate of attendance at treatment after a positive SCS. The trial randomized 31 villages and 2,019 participants included in these analyses (Door-to-Door: 16 clusters, 1,055 participants; Community Health Day: 15 clusters, 964 participants). Among HPV-positive participants, attendance at treatment rates were 75% (Door-to-Door) and 67% (Community Health Day) (P = 0.049). Participants in the Community Health Day intervention were less likely to attend treatment compared to Door-to-Door (risk ratio = 0.78, 95% confidence interval: 0.64-0.96). No adverse events were reported. Policymakers in low-resource settings can use these results to guide implementation of SCS programs. ISRCTN registration: 12767014 . ClinicalTrials.gov registration: NCT04000503 .
    MeSH term(s) Female ; Humans ; Cervix Uteri ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/therapy ; Early Detection of Cancer/methods ; Papillomavirus Infections/diagnosis ; Mass Screening/methods ; Papillomaviridae
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02288-6
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  6. Article ; Online: Experiences with thermal ablation for cervical precancer treatment after self-collection HPV-based screening in the ASPIRE Mayuge randomized trial.

    Gottschlich, Anna / Payne, Beth A / Trawin, Jessica / Albert, Arianne / Jeronimo, Jose / Mitchell-Foster, Sheona / Mithani, Nadia / Namugosa, Ruth / Naguti, Priscilla / Orem, Jackson / Rawat, Angeli / Simelela, Princess Nothemba / Singer, Joel / Smith, Laurie W / van Niekerk, Dirk / Nakisige, Carolyn / Ogilvie, Gina

    International journal of cancer

    2022  Volume 152, Issue 8, Page(s) 1630–1639

    Abstract: Cervical cancer remains a significant public health burden in low-resourced countries. Thus, the WHO prioritized cervix screening, and recently recommended thermal ablation treatment for cervical precancer. However, there is limited information on side ... ...

    Abstract Cervical cancer remains a significant public health burden in low-resourced countries. Thus, the WHO prioritized cervix screening, and recently recommended thermal ablation treatment for cervical precancer. However, there is limited information on side effects during treatment and recovery, and acceptability among those treated. The ASPIRE Mayuge trial recruited women to participate in self-collection cervix screening between 2019 and 2020 (N = 2019). Screen-positive women (N = 531, 26.3%) were referred for visual inspection with acetic acid and thermal ablation treatment, per Uganda Ministry of Health recommendations; 71.2% of those referred attended follow-up. Six months post-screening, a subset of trial participants were recontacted. Those who received thermal ablation completed a survey assessing side effects during and after the procedure, and willingness to recommend the treatment to others. We summarized the results to describe the side effects and acceptability of thermal ablation treatment. Of 2019 participants, 349 (17%) received thermal ablation. A subset of 135 completed the follow-up survey, where 90% reported pain during treatment; however, intensity and duration were low. Over a third of women reported problems with recovery for reasons including pain, discharge and bleeding. Regardless, 98% reported they would recommend the treatment to others. The use of thermal ablation to treat cervical precancer appears to be highly acceptable in this population. While many women reported side effects during the procedure and recovery, the majority said they would recommend the treatment to others. However, given the substantial proportion who reported problems with recovery, efforts should be made to provide additional resources to women after receiving thermal ablation treatment for cervical precancer.
    MeSH term(s) Female ; Humans ; Papillomavirus Infections/diagnosis ; Uterine Cervical Dysplasia ; Uterine Cervical Neoplasms/diagnosis ; Hyperthermia, Induced ; Cervix Uteri ; Mass Screening/methods ; Early Detection of Cancer/methods ; Papillomaviridae
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.34369
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