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Article ; Online: N-Acetylcysteine: The Next Best Thing for Cardiovascular Interventions and Surgery?

Simeone, Beatrice / Rocco, Erica / Biondi-Zoccai, Giuseppe / Versaci, Francesco

2024

Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001558
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Zs.A 1471: Show issues

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Article ; Online: ABC as aortic valve, Body Mass Index, COVID, and more: a welcome yet challenging update for cardiovascular practitioners.

Rocco, Erica / Simeone, Beatrice / Biondi-Zoccai, Giuseppe / Spadafora, Luigi

Minerva cardiology and angiology

2024 Volume 72, Issue 2, Page(s) 99–101

MeSH term(s)	Humans ; Aortic Valve ; Body Mass Index ; COVID-19 ; Aortic Valve Stenosis ; Cardiovascular System
Language	English
Publishing date	2024-04-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.24.06554-2
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Zs.A 14: Show issues

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Article ; Online: Mitophagy modulation for the treatment of cardiovascular diseases.

Forte, Maurizio / D'Ambrosio, Luca / Schiattarella, Gabriele G / Salerno, Nadia / Perrone, Marco Alfonso / Loffredo, Francesco S / Bertero, Edoardo / Pilichou, Kalliopi / Manno, Girolamo / Valenti, Valentina / Spadafora, Luigi / Bernardi, Marco / Simeone, Beatrice / Sarto, Gianmarco / Frati, Giacomo / Perrino, Cinzia / Sciarretta, Sebastiano

European journal of clinical investigation

2024 , Page(s) e14199

Abstract: Background: Defects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged as a novel and ...

Abstract	Background: Defects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged as a novel and potential therapeutic target. Methods: In this review, we discuss current evidence about the biological significance of mitophagy in relevant preclinical models of cardiac and vascular diseases, such as heart failure, ischemia/reperfusion injury, metabolic cardiomyopathy and atherosclerosis. Results: Multiple studies have shown that cardiac and vascular mitophagy is an adaptive mechanism in response to stress, contributing to cardiovascular homeostasis. Mitophagy defects lead to cell death, ultimately impairing cardiac and vascular function, whereas restoration of mitophagy by specific compounds delays disease progression. Conclusions: Despite previous efforts, the molecular mechanisms underlying mitophagy activation in response to stress are not fully characterized. A comprehensive understanding of different forms of mitophagy active in the cardiovascular system is extremely important for the development of new drugs targeting this process. Human studies evaluating mitophagy abnormalities in patients at high cardiovascular risk also represent a future challenge.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.14199
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Zs.A 677: Show issues

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Article ; Online: Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study.

Tocci, Giuliano / Biondi-Zoccai, Giuseppe / Forte, Maurizio / Gallo, Giovanna / Nardoianni, Giulia / Fiori, Emiliano / D'Ambrosio, Luca / Di Pietro, Riccardo / Stefanini, Giulio / Cannata, Francesco / Rocco, Erica / Simeone, Beatrice / Sarto, Gianmarco / Schirone, Leonardo / D'Amico, Alessandra / Peruzzi, Mariangela / Nocella, Cristina / Volpe, Massimo / Rubattu, Speranza

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 33, Issue 11, Page(s) 2287–2293

Abstract: Background and aims: Trehalose, spermidine, nicotinamide, and polyphenols are natural substances that exert pro-autophagic and antioxidant properties. Their role in blood pressure (BP) regulation and preservation of vascular function in essential ... ...

Abstract	Background and aims: Trehalose, spermidine, nicotinamide, and polyphenols are natural substances that exert pro-autophagic and antioxidant properties. Their role in blood pressure (BP) regulation and preservation of vascular function in essential hypertension is unknown. The aim of this study was to evaluate the effect of a mixture of these agents on BP level, markers of oxidative stress, autophagy, endothelial function, and vascular stiffness in outpatients with grade 1 uncomplicated essential hypertension. Methods and results: A single-centre, open-label, case-control, pilot study was conducted in adult outpatients (aged ≥18 years) receiving or not the mixture for two months along with the standard therapies. Both at baseline and at the end of the treatment the following clinical parameters were evaluated: brachial seated office BP level, central aortic pressure, pulse wave velocity, augmentation index (AI@75). Both at baseline and at the end of the treatment, a blood sample was drawn for the measurement of: H Conclusions: The supplementation of the trehalose, spermidine, nicotinamide, and polyphenols mixture counteracted hypertension-related arterial stiffness through mechanisms likely dependent on oxidative stress downregulation and autophagy stimulation. These natural activators of autophagy may represent favourable adjuvants for prevention of the hypertensive cardiovascular damage.
Language	English
Publishing date	2023-07-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.07.026
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Zs.A 3149: Show issues

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Article: Stress Echocardiography in Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.

Ciampi, Quirino / Pepi, Mauro / Antonini-Canterin, Francesco / Barbieri, Andrea / Barchitta, Agata / Faganello, Giorgio / Miceli, Sofia / Parato, Vito Maurizio / Tota, Antonio / Trocino, Giuseppe / Abbate, Massimiliana / Accadia, Maria / Alemanni, Rossella / Angelini, Andrea / Anglano, Francesco / Anselmi, Maurizio / Aquila, Iolanda / Aramu, Simona / Avogadri, Enrico /

Azzaro, Giuseppe / Badano, Luigi / Balducci, Anna / Ballocca, Flavia / Barbarossa, Alessandro / Barbati, Giovanni / Barletta, Valentina / Barone, Daniele / Becherini, Francesco / Benfari, Giovanni / Beraldi, Monica / Bergandi, Gianluigi / Bilardo, Giuseppe / Binno, Simone Maurizio / Bolognesi, Massimo / Bongiovi, Stefano / Bragato, Renato Maria / Braggion, Gabriele / Brancaleoni, Rossella / Bursi, Francesca / Dessalvi, Christian Cadeddu / Cameli, Matteo / Canu, Antonella / Capitelli, Mariano / Capra, Anna Clara Maria / Carbonara, Rosa / Carbone, Maria / Carbonella, Marco / Carrabba, Nazario / Casavecchia, Grazia / Casula, Margherita / Chesi, Elena / Cicco, Sebastiano / Citro, Rodolfo / Cocchia, Rosangela / Colombo, Barbara Maria / Colonna, Paolo / Conte, Maddalena / Corrado, Giovanni / Cortesi, Pietro / Cortigiani, Lauro / Costantino, Marco Fabio / Cozza, Fabiana / Cucchini, Umberto / D'Angelo, Myriam / Da Ros, Santina / D'Andrea, Fabrizio / D'Andrea, Antonello / D'Auria, Francesca / De Caridi, Giovanni / De Feo, Stefania / De Matteis, Giovanni Maria / De Vecchi, Simona / Del Giudice, Carmen / Dell'Angela, Luca / Paoli, Lucrezia Delli / Dentamaro, Ilaria / Destefanis, Paola / Di Bella, Gianluca / Di Fulvio, Maria / Di Gaetano, Renato / Di Giannuario, Giovanna / Di Gioia, Angelo / Di Martino, Luigi Flavio Massimiliano / Di Muro, Carmine / Di Nora, Concetta / Di Salvo, Giovanni / Dodi, Claudio / Dogliani, Sarah / Donati, Federica / Dottori, Melissa / Epifani, Giuseppe / Fabiani, Iacopo / Ferrara, Francesca / Ferrara, Luigi / Ferrua, Stefania / Filice, Gemma / Fiorino, Maria / Forno, Davide / Garini, Alberto / Giarratana, Gioachino Agostino / Gigantino, Giuseppe / Giorgi, Mauro / Giubertoni, Elisa / Greco, Cosimo Angelo / Grigolato, Michele / Marra, Walter Grosso / Holzl, Anna / Iaiza, Alessandra / Iannaccone, Andrea / Ilardi, Federica / Imbalzano, Egidio / Inciardi, Riccardo M / Inserra, Corinna Antonia / Iori, Emilio / Izzo, Annibale / La Rosa, Giuseppe / Labanti, Graziana / Lanzone, Alberto Maria / Lanzoni, Laura / Lapetina, Ornella / Leiballi, Elisa / Librera, Mariateresa / Conte, Carmenita Lo / Monaco, Maria Lo / Lombardo, Antonella / Luciani, Michelangelo / Lusardi, Paola / Magnante, Antonio / Malagoli, Alessandro / Malatesta, Gelsomina / Mancusi, Costantino / Manes, Maria Teresa / Manganelli, Fiore / Mantovani, Francesca / Manuppelli, Vincenzo / Marchese, Valeria / Marinacci, Lina / Mattioli, Roberto / Maurizio, Civelli / Mazza, Giuseppe Antonio / Mazza, Stefano / Melis, Marco / Meloni, Giulia / Merli, Elisa / Milan, Alberto / Minardi, Giovanni / Monaco, Antonella / Monte, Ines / Montresor, Graziano / Moreo, Antonella / Mori, Fabio / Morini, Sofia / Moro, Claudio / Morrone, Doralisa / Negri, Francesco / Nipote, Carmelo / Nisi, Fulvio / Nocco, Silvio / Novello, Luigi / Nunziata, Luigi / Perini, Alessandro Paoletti / Parodi, Antonello / Pasanisi, Emilio Maria / Pastorini, Guido / Pavasini, Rita / Pavoni, Daisy / Pedone, Chiara / Pelliccia, Francesco / Pelliciari, Giovanni / Pelloni, Elisa / Pergola, Valeria / Perillo, Giovanni / Petruccelli, Enrica / Pezzullo, Chiara / Piacentini, Gerardo / Picardi, Elisa / Pinna, Giovanni / Pizzarelli, Massimiliano / Pizzuti, Alfredo / Poggi, Matteo Maria / Posteraro, Alfredo / Privitera, Carmen / Rampazzo, Debora / Ratti, Carlo / Rettegno, Sara / Ricci, Fabrizio / Ricci, Caterina / Rolando, Cristina / Rossi, Stefania / Rovera, Chiara / Ruggieri, Roberta / Russo, Maria Giovanna / Sacchi, Nicola / Saladino, Antonino / Sani, Francesca / Sartori, Chiara / Scarabeo, Virginia / Sciacqua, Angela / Scillone, Antonio / Scopelliti, Pasquale Antonio / Scorza, Alfredo / Scozzafava, Angela / Serafini, Francesco / Serra, Walter / Severino, Sergio / Simeone, Beatrice / Sirico, Domenico / Solari, Marco / Spadaro, Gian Luca / Stefani, Laura / Strangio, Antonio / Surace, Francesca Chiara / Tamborini, Gloria / Tarquinio, Nicola / Tassone, Eliezer Joseph / Tavarozzi, Isabella / Tchana, Bertrand / Tedesco, Giuseppe / Tinto, Monica / Torzillo, Daniela / Totaro, Antonio / Triolo, Oreste Fabio / Troisi, Federica / Tusa, Maurizio / Vancheri, Federico / Varasano, Vincenzo / Venezia, Amedeo / Vermi, Anna Chiara / Villari, Bruno / Zampi, Giordano / Zannoni, Jessica / Zito, Concetta / Zugaro, Antonello / Picano, Eugenio / Carerj, Scipione

Journal of cardiovascular echography

2023 Volume 33, Issue 3, Page(s) 125–132

Abstract: Background: The Italian Society of Echography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand the volumes of activity, modalities and stressors used during stress echocardiography (SE) in Italy.: Methods: We analyzed ... ...

Abstract	Background: The Italian Society of Echography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand the volumes of activity, modalities and stressors used during stress echocardiography (SE) in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved through an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories, and SE examinations were performed in 179 centers (80.6%): 87 centers (47.5%) were in the northern regions of Italy, 33 centers (18.4%) were in the central regions, and 61 (34.1%) in the southern regions. We annotated a total of 4057 SE. We divided the SE centers into three groups, according to the numbers of SE performed: <10 SE (low-volume activity, 40 centers), between 10 and 39 SE (moderate volume activity, 102 centers) and ≥40 SE (high volume activity, 37 centers). Dipyridamole was used in 139 centers (77.6%); exercise in 120 centers (67.0%); dobutamine in 153 centers (85.4%); pacing in 37 centers (21.1%); and adenosine in 7 centers (4.0%). We found a significant difference between the stressors used and volume of activity of the centers, with a progressive increase in the prevalence of number of stressors from low to high volume activity ( Conclusions: This nationwide survey demonstrated that SE was significantly widespread and practiced throughout Italy. In addition to the traditional indication to coronary artery disease based on regional wall motion analysis, other indications are emerging with an increase in the use of LUS and CFVR, especially in high-volume centers.
Language	English
Publishing date	2023-11-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_48_23
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Article: Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.

Azzaro, Giuseppe / Badano, Luigi / Balducci, Anna / Ballocca, Flavia / Barbarossa, Alessandro / Barbati, Giovanni / Barletta, Valentina / Barone, Daniele / Becherini, Francesco / Benfari, Giovanni / Beraldi, Monica / Bergandi, Gianluigi / Bilardo, Giuseppe / Binno, Simone Maurizio / Bolognesi, Massimo / Bongiovi, Stefano / Bragato, Renato Maria / Braggion, Gabriele / Brancaleoni, Rossella / Bursi, Francesca / Dessalvi, Christian Cadeddu / Cameli, Matteo / Canu, Antonella / Capitelli, Mariano / Capra, Anna Clara Maria / Carbonara, Rosa / Carbone, Maria / Carbonella, Marco / Carrabba, Nazario / Casavecchia, Grazia / Casula, Margherita / Chesi, Elena / Cicco, Sebastiano / Citro, Rodolfo / Cocchia, Rosangela / Colombo, Barbara Maria / Colonna, Paolo / Conte, Maddalena / Corrado, Giovanni / Cortesi, Pietro / Cortigiani, Lauro / Costantino, Marco Fabio / Cozza, Fabiana / Cucchini, Umberto / D'Angelo, Myriam / Ros, Santina Da / D'Andrea, Fabrizio / D'Andrea, Antonello / D'Auria, Francesca / De Caridi, Giovanni / De Feo, Stefania / De Matteis, Giovanni Maria / De Vecchi, Simona / Giudice, Carmen Del / Dell'Angela, Luca / Paoli, Lucrezia Delli / Dentamaro, Ilaria / Destefanis, Paola / Di Fulvio, Maria / Di Gaetano, Renato / Di Giannuario, Giovanna / Di Gioia, Angelo / Di Martino, Luigi Flavio Massimiliano / Di Muro, Carmine / Di Nora, Concetta / Di Salvo, Giovanni / Dodi, Claudio / Dogliani, Sarah / Donati, Federica / Dottori, Melissa / Epifani, Giuseppe / Fabiani, Iacopo / Ferrara, Francesca / Ferrara, Luigi / Ferrua, Stefania / Filice, Gemma / Fiorino, Maria / Forno, Davide / Garini, Alberto / Giarratana, Gioachino Agostino / Gigantino, Giuseppe / Giorgi, Mauro / Giubertoni, Elisa / Greco, Cosimo Angelo / Grigolato, Michele / Marra, Walter Grosso / Holzl, Anna / Iaiza, Alessandra / Iannaccone, Andrea / Ilardi, Federica / Imbalzano, Egidio / Inciardi, Riccardo / Inserra, Corinna Antonia / Iori, Emilio / Izzo, Annibale / Rosa, Giuseppe La / Labanti, Graziana / Lanzone, Alberto Maria / Lanzoni, Laura / Lapetina, Ornella / Leiballi, Elisa / Librera, Mariateresa / Conte, Carmenita Lo / Monaco, Maria Lo / Lombardo, Antonella / Luciani, Michelangelo / Lusardi, Paola / Magnante, Antonio / Malagoli, Alessandro / Malatesta, Gelsomina / Mancusi, Costantino / Manes, Maria Teresa / Manganelli, Fiore / Mantovani, Francesca / Manuppelli, Vincenzo / Marchese, Valeria / Marinacci, Lina / Mattioli, Roberto / Maurizio, Civelli / Mazza, Giuseppe Antonio / Mazza, Stefano / Melis, Marco / Meloni, Giulia / Merli, Elisa / Milan, Alberto / Minardi, Giovanni / Monaco, Antonella / Monte, Ines / Montresor, Graziano / Moreo, Antonella / Mori, Fabio / Morini, Sofia / Moro, Claudio / Morrone, Doralisa / Negri, Francesco / Nipote, Carmelo / Nisi, Fulvio / Nocco, Silvio / Novello, Luigi / Nunziata, Luigi / Perini, Alessandro Paoletti / Parodi, Antonello / Pasanisi, Emilio Maria / Pastorini, Guido / Pavasini, Rita / Pavoni, Daisy / Pedone, Chiara / Pelliccia, Francesco / Pelliciari, Giovanni / Pelloni, Elisa / Pergola, Valeria / Perillo, Giovanni / Petruccelli, Enrica / Pezzullo, Chiara / Piacentini, Gerardo / Picardi, Elisa / Pinna, Giovanni / Pizzarelli, Massimiliano / Pizzuti, Alfredo / Poggi, Matteo Maria / Posteraro, Alfredo / Privitera, Carmen / Rampazzo, Debora / Ratti, Carlo / Rettegno, Sara / Ricci, Fabrizio / Ricci, Caterina / Rolando, Cristina / Rossi, Stefania / Rovera, Chiara / Ruggieri, Roberta / Russo, Maria Giovanna / Sacchi, Nicola / Saladino, Antonino / Sani, Francesca / Sartori, Chiara / Scarabeo, Virginia / Sciacqua, Angela / Scillone, Antonio / Scopelliti, Pasquale Antonio / Scorza, Alfredo / Scozzafava, Angela / Serafini, Francesco / Serra, Walter / Severino, Sergio / Simeone, Beatrice / Sirico, Domenico / Solari, Marco / Spadaro, Gian Luca / Stefani, Laura / Strangio, Antonio / Surace, Francesca Chiara / Tamborini, Gloria / Tarquinio, Nicola / Tassone, Eliezer Joseph / Tavarozzi, Isabella / Tchana, Bertrand / Tedesco, Giuseppe / Tinto, Monica / Torzillo, Daniela / Totaro, Antonio / Triolo, Oreste Fabio / Troisi, Federica / Tusa, Maurizio / Vancheri, Federico / Varasano, Vincenzo / Venezia, Amedeo / Vermi, Anna Chiara / Villari, Bruno / Zampi, Giordano / Zannoni, Jessica / Zito, Concetta / Zugaro, Antonello / Di Bella, Gianluca / Carerj, Scipione

Journal of cardiovascular echography

2023 Volume 33, Issue 1, Page(s) 1–9

Abstract: Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy.: Methods: We analyzed echocardiography ...

Abstract	Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers ( Conclusions: This nationwide survey demonstrated that digital infrastructures and advanced echocardiography modalities, such as 3D and STE, are widely available in Italy with a notable diffuse uptake of LUS in the core TTE examination, a suboptimal diffusion of PACS recording, and conservative use of UCA, 3D, and strain. There are significant differences between northern and central-southern regions and echocardiographic laboratories that pertain to the cardiac unit. This inhomogeneous distribution of technology represents one of the main issues that must be solved to standardize the practice of echocardiography.
Language	English
Publishing date	2023-05-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_16_23
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Article ; Online: N-Acetylcysteine: The Next Best Thing for Cardiovascular Interventions and Surgery?

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Article ; Online: ABC as aortic valve, Body Mass Index, COVID, and more: a welcome yet challenging update for cardiovascular practitioners.

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Article ; Online: Mitophagy modulation for the treatment of cardiovascular diseases.

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Article ; Online: Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study.

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Article: Stress Echocardiography in Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.

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Article: Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging.

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