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  1. Article ; Online: Significance of thiol-disulfide balance in SARS-CoV-2 infection

    Simić Tatjana

    Medicinski Podmladak, Vol 72, Iss 3, Pp 30-

    2021  Volume 36

    Abstract: Studies of the molecular mechanisms regarding interaction of different viruses with receptors on the host cell surface have shown that the viral entry depends on the specific relationship between free thiol (SH) groups and disulfides on the virus surface, ...

    Abstract Studies of the molecular mechanisms regarding interaction of different viruses with receptors on the host cell surface have shown that the viral entry depends on the specific relationship between free thiol (SH) groups and disulfides on the virus surface, as well as the thiol disulfide balance on the host cell surface. The presence of oxidizing compounds or alkylating agents, which disturb the thiol-disulfide balance on the surface of the virus, can also affect its infectious potential. Disturbed thiol-disulfide balance may also influence protein-protein interactions between SARS-CoV-2 protein S and ACE2 receptors of the host cell. This review presents the basic mechanisms of maintaining intracellular and extracellular thiol disulfide balance and previous experimental and clinical evidence in favor of impaired balance in SARS-CoV-2 infection. Besides, the results of the clinical application or experimental analysis of compounds that induce changes in the thiol disulfide balance towards reduction of disulfide bridges in proteins of interest in COVID-19 infection are presented.
    Keywords thiol-disulfide balance ; covid-19 ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher University of Belgrade, Medical Faculty
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Role of Glutathione Transferase Omega-Class Variant Alleles in Individual Susceptibility to Ovarian Cancer.

    Simic, Petar / Coric, Vesna / Pljesa, Igor / Savic-Radojevic, Ana / Zecevic, Nebojsa / Kocic, Jovana / Simic, Tatjana / Pazin, Vladimir / Pljesa-Ercegovac, Marija

    International journal of molecular sciences

    2024  Volume 25, Issue 9

    Abstract: The tumor microenvironment is affected by reactive oxygen species and has been suggested to have an important role in ovarian cancer (OC) tumorigenesis. The role of glutathione transferases (GSTs) in the maintenance of redox balance is considered as an ... ...

    Abstract The tumor microenvironment is affected by reactive oxygen species and has been suggested to have an important role in ovarian cancer (OC) tumorigenesis. The role of glutathione transferases (GSTs) in the maintenance of redox balance is considered as an important contributing factor in cancer, including OC. Furthermore, GSTs are mostly encoded by highly polymorphic genes, which further highlights their potential role in OC, known to originate from accumulated genetic changes. Since the potential relevance of genetic variations in omega-class GSTs (
    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/genetics ; Glutathione Transferase/genetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Middle Aged ; Alleles ; Genotype ; Adult ; Aged ; Case-Control Studies ; Gene Frequency
    Chemical Substances Glutathione Transferase (EC 2.5.1.18) ; GSTO1 protein, human (EC 2.5.1.18) ; GSTO2 protein, human (EC 2.5.1.18)
    Language English
    Publishing date 2024-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anti-inflammatory and anti-atherogenic role of BMP receptor II in atherosclerosis.

    Simic, Tatjana

    Future cardiology

    2013  Volume 9, Issue 5, Page(s) 619–622

    Abstract: Evaluation of: Kim CW, Song H, Kumar S et al. Anti-inflammatory and anti-atherogenic role of BMP receptor II in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33, 1350-1359 (2013). Increased expression of BMPs in atherosclerosis suggested that the ... ...

    Abstract Evaluation of: Kim CW, Song H, Kumar S et al. Anti-inflammatory and anti-atherogenic role of BMP receptor II in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33, 1350-1359 (2013). Increased expression of BMPs in atherosclerosis suggested that the knockdown of the receptor mediating BMP action would prevent endothelial inflammation and atherosclerosis. Based on this hypothesis, Kim et al. performed a series of experiments in which the effect of BMP receptor type II (BMPRII) knockout was tested in in vitro and in vivo models of atherogenesis. Unexpectedly, they found that the loss of BMPRII induces endothelial inflammation and atherosclerosis. Knockdown of BMPRII in endothelial cells induced monocyte adhesion through the expression of ICAM-1 and VCAM-1. The loss of BMPRII induced endothelial inflammation and atherosclerosis in apoE-deficient mice. Besides, BMPRII expression was gradually lost over the course of atherosclerosis progression in human coronary arteries.
    MeSH term(s) Animals ; Atherosclerosis/metabolism ; Bone Morphogenetic Protein Receptors/metabolism ; Humans ; NF-kappa B/metabolism
    Chemical Substances NF-kappa B ; Bone Morphogenetic Protein Receptors (EC 2.7.11.30)
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca.13.61
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: GSTM1

    Stojkovic Lalosevic, Milica / Coric, Vesna / Pekmezovic, Tatjana / Simic, Tatjana / Pavlovic Markovic, Aleksandra / Pljesa Ercegovac, Marija

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Glutathione S-Transferase pi/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/drug therapy ; Glutathione Transferase/genetics ; Female ; Male ; Middle Aged ; Aged ; Prospective Studies ; Serbia ; Adenocarcinoma/genetics ; Adenocarcinoma/mortality ; Adenocarcinoma/drug therapy ; Polymorphism, Genetic ; Fluorouracil/therapeutic use ; Genotype ; Prognosis ; Kaplan-Meier Estimate ; Organoplatinum Compounds/therapeutic use ; Leucovorin/therapeutic use ; Oxaliplatin/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Proportional Hazards Models ; Adult
    Chemical Substances Glutathione S-Transferase pi (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18) ; GSTP1 protein, human (EC 2.5.1.18) ; Fluorouracil (U3P01618RT) ; Organoplatinum Compounds ; Leucovorin (Q573I9DVLP) ; Oxaliplatin (04ZR38536J)
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60040553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  5. Article ; Online: Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness.

    Nikic, Predrag / Dragicevic, Dejan / Jerotic, Djurdja / Savic, Slaviša / Djukic, Tatjana / Stankovic, Branko / Kovacevic, Luka / Simic, Tatjana / Matic, Marija

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 1

    Abstract: Background and Objectives: Oxidative stress induced by increased reactive oxygen species (ROS) production plays an important role in carcinogenesis. The entire urinary tract is continuously exposed to numerous potentially mutagenic environmental agents ... ...

    Abstract Background and Objectives: Oxidative stress induced by increased reactive oxygen species (ROS) production plays an important role in carcinogenesis. The entire urinary tract is continuously exposed to numerous potentially mutagenic environmental agents which generate ROS during their biotransformation. In first line defense against free radicals, antioxidant enzymes superoxide dismutase (SOD2) and glutathione peroxidase (GPX1) both have essential roles. Altered enzyme activity and decreased ability of neutralizing free oxygen radicals as a consequence of genetic polymorphisms in genes encoding these two enzymes are well described so far. This study aimed to investigate the association of GPX1 (rs1050450) and SOD2 (rs4880) genetic variants with the urothelial bladder cancer (UBC) risk independently and in combination with smoking. Furthermore, we aimed to determine whether the UBC stage and pathological grade were influenced by GPX1 and SOD2 polymorphisms. Material and Methods: The study population included 330 patients with UBC (mean age 65 ± 10.3 years) and 227 respective controls (mean age 63.4 ± 7.9 years). Single nucleotide polymorphism (SNP) of GPX1 (rs1050450) was analyzed using the PCR-RFLP, while SOD2 (rs4880) SNP was analyzed using the q-PCR method. Results: Our results showed that UBC risk was significantly increased among carriers of at least one variant SOD2 Val allele compared to the SOD2 Ala16Ala homozygotes (OR = 1.55, p = 0.03). Moreover, this risk was even more pronounced in smokers with at least one variant SOD2 Val allele, since they have even 7.5 fold higher UBC risk (OR = 7.5, p < 0.001). Considering GPX1 polymorphism, we have not found an association with UBC risk. However, GPX1 genotypes distribution differed significantly according to the tumor stage (p ˂ 0.049) and pathohistological grade (p ˂ 0.018). Conclusion: We found that SOD2 genetic polymorphism is associated with the risk of UBC development independently and in combination with cigarette smoking. Furthermore, we showed that GPX1 genetic polymorphism is associated with the aggressiveness of the disease.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism ; Antioxidants ; Glutathione Peroxidase GPX1 ; Reactive Oxygen Species ; Polymorphism, Single Nucleotide/genetics ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Genotype ; Urinary Bladder Neoplasms/genetics ; Free Radicals ; Genetic Predisposition to Disease ; Case-Control Studies
    Chemical Substances Glutathione Peroxidase (EC 1.11.1.9) ; Antioxidants ; Glutathione Peroxidase GPX1 (EC 1.11.1.9) ; Reactive Oxygen Species ; Superoxide Dismutase (EC 1.15.1.1) ; Free Radicals
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59010131
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    Zs.A 6270: Show issues Location:
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  6. Article: Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy.

    Avramović, Nataša / Mandić, Boris / Savić-Radojević, Ana / Simić, Tatjana

    Pharmaceutics

    2020  Volume 12, Issue 4

    Abstract: Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both ... ...

    Abstract Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues,producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency,specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
    Language English
    Publishing date 2020-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics12040298
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  7. Article ; Online: Glutathione transferase gene polymorphism in end stage renal disease

    Šuvakov Sonja / Simić Tatjana / Damjanovic Tatjana

    Medicinski Podmladak, Vol 67, Iss 3, Pp 36-

    2016  Volume 41

    Abstract: Chronic kidney disease is described as a progressive and irreversible deterioration in kidney function. When there is less than 10% of nephron function pertained, patients face end-stage renal disease, where renal replacement therapy is needed. Data show ...

    Abstract Chronic kidney disease is described as a progressive and irreversible deterioration in kidney function. When there is less than 10% of nephron function pertained, patients face end-stage renal disease, where renal replacement therapy is needed. Data show that the most common method used to treat advanced and permanent kidney failure is hemodialysis. . Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. The role of genetic polymorphism of antioxidant enzymes GSTA1, GSTM1, GSTP1 and GSTT1 in susceptibility towards end-stage renal disease development has become prominent recently. Furthermore, GST gene polymorphism may modulate the degree of oxidative stress byproducts in end-stage renal disease patients and, therefore, influence their overall and cause-specific cardiovascular mortality.
    Keywords glutathione S-transferases ; haemodialysis ; oxidative stress ; polymorphism ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher University of Belgrade, Medical Faculty
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Airport traffic complexity and environment efficiency metrics for evaluation of ATM measures

    Simić, Tatjana Krstić / Babić, Obrad

    Journal of air transport management Vol. 42 , p. 260-271

    2015  Volume 42, Page(s) 260–271

    Author's details Tatjana Krstić Simić; Obrad Babić
    Keywords Air traffic management ; Airport ; Traffic complexity ; Environment ; Efficiency
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 1208154-1 ; 2027741-6
    ISSN 0969-6997
    ISSN 0969-6997
    Database ECONomics Information System

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  9. Article: The Polymorphisms in

    Petrovic, Milos / Simic, Tatjana / Djukic, Tatjana / Radic, Tanja / Savic-Radojevic, Ana / Zekovic, Milica / Durutovic, Otas / Janicic, Aleksandar / Milojevic, Bogomir / Kajmakovic, Boris / Zivkovic, Marko / Bojanic, Nebojsa / Bumbasirevic, Uros / Coric, Vesna

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant altered redox ... ...

    Abstract Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant altered redox profile have already been associated with the increased risk for testicular germ cell cancer (GCT) development. The aim of this pilot study was to assess the individual, combined, haplotype, and cumulative effect of
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13061269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GPX3

    Markovic, Marko / Ranin, Jovan / Bukumiric, Zoran / Jerotic, Djurdja / Savic-Radojevic, Ana / Pljesa-Ercegovac, Marija / Djukic, Tatjana / Ercegovac, Marko / Asanin, Milika / Milosevic, Ivana / Stevanovic, Goran / Simic, Tatjana / Coric, Vesna / Matic, Marija

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: In SARS-CoV-2 infection, excessive activation of the immune system intensively increases reactive oxygen species levels, causing harmful hyperinflammatory and oxidative state cumulative effects which may contribute to COVID-19 severity. Therefore, we ... ...

    Abstract In SARS-CoV-2 infection, excessive activation of the immune system intensively increases reactive oxygen species levels, causing harmful hyperinflammatory and oxidative state cumulative effects which may contribute to COVID-19 severity. Therefore, we assumed that antioxidant genetic profile, independently and complemented with laboratory markers, modulates COVID-19 severity. The study included 265 COVID-19 patients. Polymorphism of G
    MeSH term(s) Humans ; COVID-19/genetics ; SARS-CoV-2 ; Genotype ; Polymorphism, Genetic ; Fibrinogen/genetics ; Glutathione Peroxidase/genetics ; Glutathione Transferase/genetics
    Chemical Substances Fibrinogen (9001-32-5) ; GPX3 protein, human (EC 1.11.1.-) ; Glutathione Peroxidase (EC 1.11.1.9) ; GSTO1 protein, human (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18)
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216151
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