LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 12

Search options

  1. Article ; Online: Research progress on the mechanism of Plantaginis semen in reducing uric acid

    Deng Yu, Yu Siming, Chen Ruiyan

    Xin yixue, Vol 53, Iss 9, Pp 635-

    2022  Volume 638

    Abstract: With social progress and diversified development of dietary structure, a high level of uric acid has been caused in human body, leading to an increase in the prevalence of hyperuricemia, gout and metabolic syndrome year by year. At present, the efficacy ... ...

    Abstract With social progress and diversified development of dietary structure, a high level of uric acid has been caused in human body, leading to an increase in the prevalence of hyperuricemia, gout and metabolic syndrome year by year. At present, the efficacy of western medicine in lowering uric acid is remarkable, but certain adverse reactions may be induced. Hence, the development of natural products of uric acid reduction has gradually become a research hotspot. As a clearing damp and promoting diuresis traditional Chinese medicine, Plantaginis semen is one of the commonly used Chinese medicines for the clinical treatment of hyperuricemia and gout. Modern pharmacological studies have confirmed the main chemical components can reduce uric acid level by inhibiting the activity of xanthine oxidase and suppressing uric acid transporter. In this article, the chemical components and uric acid-lowering effect of Plantaginis semen were reviewed.
    Keywords |plantaginis semen|uric acid|hyperuricemia|mechanism|research progress ; Medicine ; R
    Subject code 540
    Language Chinese
    Publishing date 2022-09-01T00:00:00Z
    Publisher Editorial Office of Journal of New Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Adherence to and persistence with lacosamide, perampanel, lamotrigine, and levetiracetam in adult patients with focal epilepsy in Japan

    Siming Chen / Toshiki Fukasawa / Akio Ikeda / Masato Takeuchi / Akihiro Shimotake / Satomi Yoshida / Koji Kawakami

    Heliyon, Vol 9, Iss 4, Pp e15017- (2023)

    A descriptive cohort study using a claims database

    2023  

    Abstract: Objective: We evaluated adherence to and 1-year persistence of two third-generation anti-seizure medications (ASMs), lacosamide and perampanel, in adult patients with focal epilepsy, compared with lamotrigine and levetiracetam. Methods: A cohort study ... ...

    Abstract Objective: We evaluated adherence to and 1-year persistence of two third-generation anti-seizure medications (ASMs), lacosamide and perampanel, in adult patients with focal epilepsy, compared with lamotrigine and levetiracetam. Methods: A cohort study was conducted using a Japanese health insurance claims database (JMDC Inc.). We identified patients with adult-onset focal epilepsy who initiated any of the four ASMs between August 31, 2016, and October 31, 2019. Patients were further classified into ASM-naïve patients initiating any of the four ASMs as first-line treatment, and ASM-experienced patients initiating any of the four ASMs as second- or later-line treatment. Outcomes included adherence (proportion of days covered [PDC], defined as the total number of days covered by ASMs divided by the total number of days in the follow-up period) and 1-year persistence for the four ASMs. Results: We identified 141 lacosamide, 75 perampanel, 80 lamotrigine, and 530 levetiracetam initiators. Among these, the proportion of ASM-naïve patients was highest in the levetiracetam group (60.8%), followed by the lamotrigine (25.0%), lacosamide (20.6%), and perampanel groups (1.3%). Mean PDC (standard deviation) was similar across the four groups, at 0.95 (0.08) for lacosamide, 0.93 (0.12) for perampanel, 0.92 (0.10) for lamotrigine and 0.94 (0.11) for levetiracetam. The proportion of patients persisting with treatment for 1 year was highest in the lacosamide group (73.0%), followed by the levetiracetam (58.3%), lamotrigine (57.5%), and perampanel groups (54.7%). In ASM-naïve patients, adherence and 1-year persistence were almost identical in the lacosamide, lamotrigine, and levetiracetam groups. Results for ASM-experienced patients did not significantly differ from those of all patients. Significance: With regard to adherence and 1-year persistence, lacosamide may be equal to or better than lamotrigine and levetiracetam, especially in patients with experienced ASM, while perampanel may be comparable to lamotrigine and ...
    Keywords Pharmacoepidemiology ; Proportion of days covered ; Real-world evidence ; Third-generation anti-seizure medication ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 616
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Encoded C4 homologue enzymes genes function under abiotic stresses in C3 plant

    Siming Chen / Wangmenghan Peng / Ebenezer Ottopah Ansah / Fei Xiong / Yunfei Wu

    Plant Signaling & Behavior, Vol 17, Iss

    2022  Volume 1

    Abstract: Plant organisms assimilate CO2 through the photosynthetic pathway, which facilitates in the synthesis of sugar for plant development. As environmental elements including water level, CO2 concentration, temperature and soil characteristics change, the ... ...

    Abstract Plant organisms assimilate CO2 through the photosynthetic pathway, which facilitates in the synthesis of sugar for plant development. As environmental elements including water level, CO2 concentration, temperature and soil characteristics change, the plants may recruit series of genes to help adapt the hostile environments and challenges. C4 photosynthesis plants are an excellent example of plant evolutionary adaptation to diverse condition. Compared with C3 photosynthesis plants, C4 photosynthesis plants have altered leaf anatomy and new metabolism for CO2 capture, with multiple related enzymes such as phosphoenolpyruvate carboxylase (PEPCase), pyruvate orthophosphate dikinase (PPDK), NAD(P)-malic enzyme (NAD(P)-ME), NAD(P) – malate dehydrogenase (NAD(P)-MDH) and carbonic anhydrases (CA), identified to participate in the carbon concentrating mechanism (CCM) pathway. Recently, great achievements about C4 CCM-related genes have been made in the dissection of C3 plant development processes involving various stresses. In this review, we describe the functions of C4 CCM-related homologous genes in carbon and nitrogen metabolism in C3 plants. We further summarize C4 CCM-related homologous genes’ functions in response to stresses in C3 plants. The understanding of C4 CCM-related genes’ function in response to abiotic stress in plant is important to modify the crop plants for climate diversification.
    Keywords c4 ; c3 ; abiotic stress ; photosynthesis ; plant ; Plant ecology ; QK900-989 ; Biology (General) ; QH301-705.5
    Subject code 580
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Comparison of Stomatal Structure and Distribution between Ovules and Leaves in Ginkgo biloba

    Siming Chen / Di Wang / Xi Sheng / Chengyu Zhang / Wei Li / Nan Xiao / Li Wang / Zhaogeng Lu

    Forests, Vol 13, Iss 1801, p

    2022  Volume 1801

    Abstract: Stomata are plant epidermal structures that play essential roles in photosynthesis, respiration, and transpiration. Although stomata on plant leaves have been extensively studied, their structure and distribution on other organs remain poorly understood. ...

    Abstract Stomata are plant epidermal structures that play essential roles in photosynthesis, respiration, and transpiration. Although stomata on plant leaves have been extensively studied, their structure and distribution on other organs remain poorly understood. The “living fossil “, Ginkgo biloba , has naked ovules that are thought to be primitive reproductive structures in ancient seed plants. Therefore, we hypothesized that there are some distinct stoma features in G. biloba ovules that have not been reported. In this study, we investigated the morphological development of stomata on ovules and leaves of Ginkgo biloba using scanning electron microscopy, then examined the anatomical characteristics of the general stalk and petiole using semi-thin sectioning. We found that stomata were distributed on the epidermis of the whole ovule, except near the micropyle; these stomata persisted until harvest, indicating that ovules perform gross photosynthesis to an extent similar to the photosynthesis observed in leaves, which is beneficial to ovule development. Ovule and leaf stomata share similar orientation, composition, and development; however, their distribution and subsidiary cell morphology significantly differ. The morphology of the general stalk was similar to the morphology of the petiole, but xylem cell development was minimal, and no sclerenchyma cells were present beneath the epidermis; these findings suggested that the general stalk is biomechanically weaker than the petiole. Overall, these results suggest that despite their differences, G. biloba ovules and leaves share many morphological and anatomical similarities in terms of stomatal architecture and stalk anatomy. These findings will help to elucidate the leaf origins of “flowers” in ancient plants.
    Keywords Ginkgo biloba ; leaf ; ovule ; stalk ; stomata ; development ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Loading neural stem cells on hydrogel scaffold improves cell retention rate and promotes functional recovery in traumatic brain injury

    Tiange Chen / Yuguo Xia / Liyang Zhang / Tao Xu / Yan Yi / Jianwei Chen / Ziyuan Liu / Liting Yang / Siming Chen / Xiaoxi Zhou / Xin Chen / Haiyu Wu / Jinfang Liu

    Materials Today Bio, Vol 19, Iss , Pp 100606- (2023)

    2023  

    Abstract: Neural stem cell (NSC) has gained considerable attention in traumatic brain injury (TBI) treatment because of their ability to replenish dysfunctional neurons and stimulate endogenous neurorestorative processes. However, their therapeutic effects are ... ...

    Abstract Neural stem cell (NSC) has gained considerable attention in traumatic brain injury (TBI) treatment because of their ability to replenish dysfunctional neurons and stimulate endogenous neurorestorative processes. However, their therapeutic effects are hindered by the low cell retention rate after transplantation into the dynamic brain. In this study, we found cerebrospinal fluid (CSF) flow after TBI is an important factor associated with cell loss following NSC transplantation. Recently, several studies have shown that hydrogels could serve as a beneficial carrier for stem cell transplantation, which provides a solution to prevent CSF flow-induced cell loss after TBI. For this purpose, we evaluated three different hydrogel scaffolds and found the gelatin methacrylate (GelMA)/sodium alginate (Alg) (GelMA/Alg) hydrogel scaffold showed the best capabilities for NSC adherence, growth, and differentiation. Additionally, we detected that pre-differentiated NSCs, which were loaded on the GelMA/Alg hydrogel and cultured for 7 days in neuronal differentiation medium (NSC [7d]), had the highest cell retention rate after CSF impact. Next, the neuroprotective effects of the NSC-loaded GelMA/Alg hydrogel scaffold were evaluated in a rat model of TBI. NSC [7d]-loaded GelMA/Alg markedly decreased microglial activation and neuronal death in the acute phase, reduced tissue loss, alleviated astrogliosis, promoted neurogenesis, and improved neurological recovery in the chronic phase. In summary, we demonstrated that the integration with the GelMA/Alg and modification of NSC differentiation could inhibit the influence of CSF flow on transplanted NSCs, leading to increased number of retained NSCs and improved neuroprotective effects, providing a promising alternative for TBI treatment.
    Keywords Cerebrospinal fluid flow ; Neural stem cells ; Hydrogel scaffold ; Traumatic brain injury ; Neuroprotection ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 610 ; 571
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability

    Siming Chen / Zhiwen He / Tianchen Peng / Fenfang Zhou / Gang Wang / Kaiyu Qian / Lingao Ju / Yu Xiao / Xinghuan Wang

    JCI Insight, Vol 6, Iss

    2021  Volume 19

    Abstract: Proline rich 11 (PRR11), a novel tumor-related gene, has been identified in different tumors. However, the relevant biological functions of PRR11 in human clear cell renal cell carcinoma (ccRCC) have not been studied. In this study, we first identified ... ...

    Abstract Proline rich 11 (PRR11), a novel tumor-related gene, has been identified in different tumors. However, the relevant biological functions of PRR11 in human clear cell renal cell carcinoma (ccRCC) have not been studied. In this study, we first identified PRR11 as a biomarker of ccRCC and predictor of poor prognosis by bioinformatics. Then, we showed that PRR11 silencing substantially reduced ccRCC cell proliferation and migration in vitro and in vivo. Importantly, we found that PRR11 induced the degradation of the E2F1 protein through its interaction with E2F1, and PRR11 reduced the stability of the E2F1 protein in ccRCC cells, thereby affecting cell cycle progression. Further results indicated that the downregulation of E2F1 expression partially reversed the changes in ccRCC cell biology caused by PRR11 deletion. In addition, we showed that PRR11 was a target gene of c-Myc. The transcription factor c-Myc may have promoted the expression of PRR11 in ccRCC cells by binding to the PRR11 promoter region, thereby accelerating the progression of ccRCC. In summary, we found that PRR11 served as an oncogene in ccRCC, and PRR11 reduced the protein stability of E2F1 and could be activated by c-Myc.
    Keywords Cell biology ; Nephrology ; Medicine ; R
    Subject code 500
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: RF Magnetron Sputtering Aluminum Oxide Film for Surface Passivation on Crystalline Silicon Wafers

    Siming Chen / Luping Tao / Libin Zeng / Ruijiang Hong

    International Journal of Photoenergy, Vol

    2013  Volume 2013

    Keywords Physical and theoretical chemistry ; QD450-801 ; Chemistry ; QD1-999 ; Science ; Q ; DOAJ:Chemistry (General) ; DOAJ:Chemistry
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Investigating the Impact of Shading Effect on the Characteristics of a Large-Scale Grid-Connected PV Power Plant in Northwest China

    Yunlin Sun / Siming Chen / Liying Xie / Ruijiang Hong / Hui Shen

    International Journal of Photoenergy, Vol

    2014  Volume 2014

    Keywords Physical and theoretical chemistry ; QD450-801 ; Chemistry ; QD1-999 ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Continuous-wave quantum dot photonic crystal lasers grown on on-axis Si (001)

    Taojie Zhou / Mingchu Tang / Guohong Xiang / Boyuan Xiang / Suikong Hark / Mickael Martin / Thierry Baron / Shujie Pan / Jae-Seong Park / Zizhuo Liu / Siming Chen / Zhaoyu Zhang / Huiyun Liu

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 7

    Abstract: Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon ... ...

    Abstract Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon substrate.
    Keywords Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Continuous-wave quantum dot photonic crystal lasers grown on on-axis Si (001)

    Taojie Zhou / Mingchu Tang / Guohong Xiang / Boyuan Xiang / Suikong Hark / Mickael Martin / Thierry Baron / Shujie Pan / Jae-Seong Park / Zizhuo Liu / Siming Chen / Zhaoyu Zhang / Huiyun Liu

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 7

    Abstract: Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon ... ...

    Abstract Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon substrate.
    Keywords Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top