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Book ; Thesis: Die Knochendichte der Wirbelsäule gemessen anhand von Hounsfieldeinheiten einer Computertomographie

Simion, George / Schwarz, Falko / Reuken, Philipp Alexander / Setzer, Matthias

2023

Institution	Friedrich-Schiller-Universität Jena
Author's details	von George Simion
Keywords	Wirbelkörper ; Knochendichte
Subject	Corpus vertebrae
Language	German
Size	52 Blätter, Illustrationen, Diagramme, 29,5 cm
Publishing place	Jena
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Friedrich-Schiller-Universität Jena, 2023
Note	Tag der Verteidigung: 07.02.2023
HBZ-ID	HT030013843
Database	Catalogue ZB MED Medicine, Health

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2023 E 797	order for loan	Magazin

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Article ; Online: Bone density of the axis (C2) measured using Hounsfield units of computed tomography.

Simion, George / Eckardt, Niklas / Senft, Christian / Schwarz, Falko

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 93

Abstract: Introduction: The assessment of bone density is of great importance nowadays due to the increasing age of patients. Especially in regard to the surgical stabilization of the spine, the assessment of bone density is important for therapeutic decision ... ...

Abstract	Introduction: The assessment of bone density is of great importance nowadays due to the increasing age of patients. Especially in regard to the surgical stabilization of the spine, the assessment of bone density is important for therapeutic decision making. The aim of this work was to record trabecular bone density values using Hounsfield units of the second cervical vertebra. Material and methods: The study is a monocentric retrospective data analysis of 198 patients who received contrast-enhanced polytrauma computed tomography in a period of two years at a maximum care hospital. Hounsfield units were measured in three different regions within the C2: dens, transition area between dens and vertebral body and vertebral body. The measured Hounsfield units were converted into bone density values using a validated formula. Results: A total of 198 patients were included. The median bone density varied in different regions of all measured C2 vertebrae: in the dens axis, C2 transition area between dens and vertebral body, and in the vertebral body bone densities were 302.79 mg/cm Conclusions: The transitional area from dens axis to corpus showed statistically significant lower bone density values compared to the adjacent regions (p < 0.001). This area seems to be a predilection site for fractures of the 2nd cervical vertebra, which is why special attention should be paid here in radiological diagnostics after a trauma.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Bone Density ; Retrospective Studies ; Spine ; Tomography, X-Ray Computed ; Radiography ; Spinal Fractures/surgery
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-03560-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone density of the cervical, thoracic and lumbar spine measured using Hounsfield units of computed tomography - results of 4350 vertebras.

Simion, George / Eckardt, Niklas / Ullrich, Bernhard W / Senft, Christian / Schwarz, Falko

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 200

Abstract: Introduction: The assessment of bone density has gained significance in recent years due to the aging population. Accurate assessment of bone density is crucial when deciding on the appropriate treatment plan for spinal stabilization surgery. The ... ...

Abstract	Introduction: The assessment of bone density has gained significance in recent years due to the aging population. Accurate assessment of bone density is crucial when deciding on the appropriate treatment plan for spinal stabilization surgery. The objective of this work was to determine the trabecular bone density values of the subaxial cervical, thoracic and lumbar spine using Hounsfield units. Material and methods: Data from 200 patients who underwent contrast-enhanced polytrauma computed tomography at a maximum care hospital over a two-year period were retrospectively analyzed. HUs were measured with an elliptical measurement field in three different locations within the vertebral body: below the upper plate, in the middle of the vertebral body, and above the base plate. The measured Hounsfield units were converted into bone density values using a validated formula. Results: The mean age of the patient collective was 47.05 years. Mean spinal bone density values decreased from cranial to caudal (C3: 231.79 mg/cm Conclusions: In our study, bone density decreased from cranial to caudal with higher values in the cervical spine. These data from the individual spinal segments may be helpful to comprehensively evaluate the status of the spine and to design a better preoperative plan before instrumentation.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Bone Density ; Retrospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07324-1
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Article: Study on the Weldability of Copper-304L Stainless Steel Dissimilar Joint Performed by Robotic Gas Tungsten Arc Welding.

Mitru, Andrei / Semenescu, Augustin / Simion, George / Scutelnicu, Elena / Voiculescu, Ionelia

Materials (Basel, Switzerland)

2022 Volume 15, Issue 16

Abstract: The welding process of dissimilar metals, with distinct chemical, physical, thermal, and structural properties, needs to be studied and treated with special attention. The main objectives of this research were to investigate the weldability of the ... ...

Abstract	The welding process of dissimilar metals, with distinct chemical, physical, thermal, and structural properties, needs to be studied and treated with special attention. The main objectives of this research were to investigate the weldability of the dissimilar joint made between the 99.95% Cu pipe and the 304L stainless steel plate by robotic Gas Tungsten Arc Welding (GTAW), without filler metal and without preheating of materials, and to find the optimum welding regime. Based on repeated adjustments of the main process parameters-welding speed, oscillation frequency, pulse frequency, main welding current, pulse current, and decrease time of welding current at the process end-it was determined the optimum process and, further, it was possible to carry out joints free of cracks and porosity, with full penetration, proper compactness, and sealing properties, that ensure safety in operating conditions. The microstructure analysis revealed the fusion zone as a multi-element alloy with preponderant participation of Cu that has resulted from mixing the non-ferrous elements and iron. Globular Cu- or Fe-rich compounds were developed during welding, being detected by Scanning Electron Microscope (SEM). Moreover, the Energy Dispersive X-ray Analysis (EDAX) recorded the existence of a narrow double mixing zone formed at the interface between the fusion zone and the 304L stainless steel that contains about 66 wt.% Fe, 18 wt.% Cr, 8 wt.% Cu, and 4 wt.% Ni. Due to the formation of Fe-, Cr-, and Ni-rich compounds, a hardness increase up to 127 HV
Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15165535
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Article: Critical Review on Magnetically Impelled Arc Butt Welding: Challenges, Perspectives and Industrial Applications.

Chaturvedi, Mukti / Vendan Subbiah, Arungalai / Simion, George / Rusu, Carmen Catalina / Scutelnicu, Elena

Materials (Basel, Switzerland)

2023 Volume 16, Issue 21

Abstract: Magnetically Impelled Arc Butt (MIAB) welding is a cutting-edge joining method that replaces the conventional welding procedures such as resistance, friction, flash and butt welding. It is a solid-state process that uses a rotating arc to heat up the ... ...

Abstract	Magnetically Impelled Arc Butt (MIAB) welding is a cutting-edge joining method that replaces the conventional welding procedures such as resistance, friction, flash and butt welding. It is a solid-state process that uses a rotating arc to heat up the butt ends of tubes, being followed by a forging process that completes the joining of the workpieces The magnetic flux density and the current interact to develop the Lorentz force that impels the arc along the faying surfaces. This process is found to produce high tensile strength and defect-free welds in ferrous materials and for this reason, it is predominantly employed in automobile applications for joining metallic tubes. Also, this joining procedure can be applied in the fabrication of boilers, heat exchangers, furnace piping in petrochemical industry and other safety-critical high-pressure machinery parts. The MIAB method has several advantages such as a shorter welding cycle, lower input energy requirement and lower loss of material. Compared to other solid-state welding processes, the MIAB welding has an important advantage in terms of cost-efficient welds with better control and reliability. Moreover, there are researchers who have investigated the joining of non-ferrous dissimilar materials using this welding procedure. The studies have been focused on process parametric analysis that involves optimizing and forecasting the magnetic field and thermal profile distribution. This review article provides competitive insights into various design features, computational methods, tests and material characterization, technical issues and workarounds, as well as automation aspects related to the MIAB-welding process. This work will prove to be a quick reference for researchers, useful to identify the research gaps and conflicting ideas that can be further explored for advancements in joining the similar and dissimilar materials.
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16217054
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Conference proceedings: Risk and extent of intracranial haemorrhage in patients with COVID-19 infection admitted to intensive care unit

Simion, George / Kamp, Marcel A. / Senft, Christian A. / Dinc, Nazife

2022 , Page(s) V311

Title translation	Risiko und Ausmaß intracranialer Blutungen bei Patienten mit einer COVID-19-Infektion auf der Intensivstation
Event/congress	73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
Keywords	Medizin, Gesundheit
Publishing date	2022-05-25
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22dgnc299
Database	German Medical Science

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Article ; Online: Lung cancer mimickers - a case series of seven patients and review of the literature.

Neacşu, Florina / Vârban, Angela Ştefania / Simion, George / Şurghie, Raluca / Pătraşcu, Oana Maria / Sajin, Maria / Dumitru, Mihai / Vrînceanu, Daniela

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2022 Volume 62, Issue 3, Page(s) 697–704

Abstract: Background: Lung is the third most frequent identified site of malignancy and lung cancer is the most lethal type of cancer in the world. Several benign lung diseases or proliferations may mimic lung carcinoma in its clinical, pathological, and ... ...

Abstract	Background: Lung is the third most frequent identified site of malignancy and lung cancer is the most lethal type of cancer in the world. Several benign lung diseases or proliferations may mimic lung carcinoma in its clinical, pathological, and radiological presentation, which makes the differential diagnosis life changing. This case series was designed to describe the main diagnosis encountered in a multidisciplinary emergency hospital during the last years in Romania. Results: The most challenging cases encountered during the recent years were those of lung hamartoma associated with eosinophilic pneumonia because of the multicentricity of the disease and the suspicion for metastasis in the clinical setting, pulmonary aspergillosis that presented as a cystic lesion with a 9 mm mural nodule, actinomycosis discovered as firm nodule showing aspects of false pleural invasion, cryptococcosis - a hilar mass for which a pneumectomy was prepared, pulmonary parasitosis that presented as a nodule with irregular borders, causing pleural retraction, one case of inflammatory myofibroblastic tumor of the lung, one case of tumorlet type neuroendocrine lesion in a patient with history of melanoma and renal oncocytoma, admitted under the suspicion of lung metastasis. Conclusions: These are some of the main mimickers of primary or secondary lung cancers and one must be aware of these similitudes to avoid higher cost procedures, psychological stress for the patient and higher mortality.
MeSH term(s)	Diagnosis, Differential ; Humans ; Lung/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Melanoma/diagnosis ; Romania
Language	English
Publishing date	2022-03-09
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.62.3.06
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Article: A rare case of signet-ring cell carcinoma associated with poorly differentiated adenocarcinoma of the non-ampullary duodenum.

Caraşca, Cosmin / Simion, George / Nechifor-Boilă, Adela Corina / Boeriu, Alina Mioara / Dobru, Ecaterina Daniela

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2018 Volume 59, Issue 1, Page(s) 311–315

Abstract: Primary duodenal cancer is a rare entity accounting for only 0.3% of all gastrointestinal cancers. Histopathologically, most duodenal cancers are mucin-producing adenocarcinomas, 34% being poorly differentiated. Signet-ring cell (SRC) carcinoma is ... ...

Abstract	Primary duodenal cancer is a rare entity accounting for only 0.3% of all gastrointestinal cancers. Histopathologically, most duodenal cancers are mucin-producing adenocarcinomas, 34% being poorly differentiated. Signet-ring cell (SRC) carcinoma is extremely uncommon in the duodenum. Herein, we report a rare case of SRC carcinoma associated with poorly differentiated adenocarcinoma of the non-ampullary duodenum in a 74-year-old woman. The patient was admitted to the hospital for persistent epigastric pain, significant weight loss and hypochromic microcytic anemia. Esophago-gastro-duodenoscopy revealed a protruded lesion, with ulceration in the second portion of the duodenum, above the papilla. The patient was referred to surgery and pancreatico-duodenectomy with lymph node dissection was performed. The tumor consisted predominately of SRCs, Periodic Acid Schiff (PAS)-Alcian blue positive. The tumor cells were CDX2, cytokeratin (CK) 7 and CK 18/8 positive, which suggested a primary upper gastrointestinal tract site of origin. Immunostaining for mucin (MUC) 2 and MUC5AC was also positive demonstrating the duodenal goblet cells differentiation with a mixed gastric-foveolar and intestinal phenotype. Based on the morphological features and the immunohistochemical profile, a diagnosis of SRC carcinoma associated with poorly differentiated adenocarcinoma of the non-ampullary duodenum was set.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Aged ; Carcinoma, Signet Ring Cell/diagnosis ; Carcinoma, Signet Ring Cell/pathology ; Duodenum/pathology ; Female ; Humans ; Immunohistochemistry ; Rare Diseases
Language	English
Publishing date	2018-06-25
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
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Article: Duodenal gastrointestinal stromal tumor presenting as pancreatic head mass - a case report.

Vasile, DănuŢ / Iancu, George / Iancu, Raluca Claudia / Simion, George / Ciuluvică, Radu Constantin

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2017 Volume 58, Issue 1, Page(s) 255–259

Abstract: Duodenal gastrointestinal stromal tumors (GISTs) are uncommon. Tumors arising from the first and the second part of the duodenum (DI and DII, respectively) can be wrongly diagnosed as pancreatic mass. We present a case of a 59-year-old woman who came ... ...

Abstract	Duodenal gastrointestinal stromal tumors (GISTs) are uncommon. Tumors arising from the first and the second part of the duodenum (DI and DII, respectively) can be wrongly diagnosed as pancreatic mass. We present a case of a 59-year-old woman who came with abdominal pain and severe upper gastrointestinal bleeding (hemoglobin 3.5 g÷dL). A solid, heterogeneously enhancing neoplasm in the head of the pancreas was revealed preoperatively by an abdominal computed tomography scan. A diagnosis of GIST was suggested. On exploratory laparotomy, there was a large mass which appeared to be originating from duodenum or from head of pancreas. Intraoperative histopathological diagnosis was GIST. Histopathology showed spindle cell tumor with cytoplasmic eosinophilia and foci of necrosis. The mitotic count was less than 5÷50 high power fields (HPFs). Tumor was involving duodenal muscularis propria, with no infiltration in the duodenal epithelial layer and the pancreas. Immunohistochemical study revealed positive staining for CD117. The tumor was finally diagnosed as GIST arising from the duodenal wall, growing exophytically and attached to the common bile duct and pancreas, without infiltrating the pancreas. Duodenal gastrointestinal stromal tumors can grow exophytically into a large mass and involve the pancreas without infiltrating microscopically and present as pancreatic head mass.
Language	English
Publishing date	2017
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
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ab Jg. 2022: Lesesaal (EG)

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Article: A rare case of uterine myxoid leiomyosarcoma: a case report.

Mitrache, Luminita Elena / Dumitru, Vasile Adrian / Simion, George / Cirstoiu, Monica / Sajin, Maria

Maedica

2015 Volume 9, Issue 3, Page(s) 269–271

Abstract: We present the rare case of a 61-year-old female patient who was submitted in the hospital with metrorrhagia and pelvi-abdominal pain. Echographic examination revealed an heterogeneous uterine mass measuring 190/130/110 mm. Therefore, total hysterectomy ... ...

Abstract	We present the rare case of a 61-year-old female patient who was submitted in the hospital with metrorrhagia and pelvi-abdominal pain. Echographic examination revealed an heterogeneous uterine mass measuring 190/130/110 mm. Therefore, total hysterectomy with bilateral ooforectomy was performed. Grossly, the uterus presented a tumoral mass with areas of hemorrhage, necrosis and abundant mucoid degeneration. On light microscopic examination a malignant neoplastic proliferation with features of myxoid leiomyosarcoma was noted. In this paper, we presented this rare form of leiomyosarcoma with an emphasis on its particularities that have not been mentioned in the literature.
Language	English
Publishing date	2015-02-13
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
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