Article ; Online: Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories.
mSphere
2020 Volume 5, Issue 3
Abstract: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has motivated an intensive analysis of its molecular epidemiology following its worldwide spread. To understand the early evolutionary events following its emergence, a data set ...
Abstract | The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has motivated an intensive analysis of its molecular epidemiology following its worldwide spread. To understand the early evolutionary events following its emergence, a data set of 985 complete SARS-CoV-2 sequences was assembled. Variants showed a mean of 5.5 to 9.5 nucleotide differences from each other, consistent with a midrange coronavirus substitution rate of 3 × 10 |
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MeSH term(s) | APOBEC Deaminases ; Base Composition/genetics ; Base Sequence/genetics ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/pathology ; Cytidine Deaminase/genetics ; Cytosine/analysis ; Genome, Viral/genetics ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Pandemics ; Pneumonia, Viral/pathology ; Polymorphism, Single Nucleotide/genetics ; Severe acute respiratory syndrome-related coronavirus/genetics ; SARS-CoV-2 ; Uracil/analysis |
Chemical Substances | Uracil (56HH86ZVCT) ; Cytosine (8J337D1HZY) ; APOBEC Deaminases (EC 3.5.4.5) ; APOBEC3 proteins, human (EC 3.5.4.5) ; Cytidine Deaminase (EC 3.5.4.5) |
Keywords | covid19 |
Language | English |
Publishing date | 2020-06-24 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 2379-5042 |
ISSN (online) | 2379-5042 |
DOI | 10.1128/mSphere.00408-20 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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