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Article ; Online: Skull base lymphoma with panhypopituitarism.

Rios, Marvin / Wahl, Matthew P / Simmons, Debra L / Schlegel, Amnon

2020 Volume 21, Issue 8, Page(s) e405

MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Hypopituitarism/etiology ; Lymphoma/complications ; Lymphoma/drug therapy ; Lymphoma/pathology ; Male ; Skull Base Neoplasms/complications ; Skull Base Neoplasms/drug therapy ; Skull Base Neoplasms/pathology
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(20)30221-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Insulin use in chronic kidney disease and the risk of hypoglycemic events.

Grube, Daulton / Wei, Guo / Boucher, Robert / Abraham, Nikita / Zhou, Na / Gonce, Victoria / Carle, Judy / Simmons, Debra L / Beddhu, Srinivasan

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 73

Abstract: Background: We examined in persons with type 2 diabetes (T2D) whether the use of insulin and the risk of serious hypoglycemic events with insulin is higher in persons with more advanced CKD.: Methods: In a national cohort of 855,133 veterans with T2D ...

Abstract	Background: We examined in persons with type 2 diabetes (T2D) whether the use of insulin and the risk of serious hypoglycemic events with insulin is higher in persons with more advanced CKD. Methods: In a national cohort of 855,133 veterans with T2D seen at Veteran Affairs clinics between Jan 1, 2008 and December 31, 2010 with at least two serum creatinine measurements, we defined insulin use from pharmacy records and serious hypoglycemic events by ICD-9/10 codes from emergency room visits or hospitalizations that occurred until December 31, 2016. Results: Mean age was 66 ± 11 years and 97% were men. Mean baseline eGFR was 73 ± 22 ml/min/1.73 m Conclusions and relevance: In T2D, more advanced CKD was associated with greater insulin use. Both insulin use and advanced CKD were risk factors for serious hypoglycemic events. The safety of insulin compared to newer glycemic agents in more advanced CKD needs further study.
MeSH term(s)	Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Glomerular Filtration Rate ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Insulin/adverse effects ; Male ; Middle Aged ; Propensity Score ; Proportional Hazards Models ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Risk Factors ; Severity of Illness Index
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-02687-w
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Article: Combined Medicine-Pediatrics Fellowships: A Guide for Fellowship Directors and Residents.

Shen, Burton H / Vakharia, Janaki / Topor, Lisa S / Robbins, Brett / Diamond-Falk, Kathryn / Brown, Stefanie / Mason, Katherine / Barron, Christine / Simmons, Debra L / McKown, Kevin M / McLaughlin, Suzanne

Cureus

2021 Volume 13, Issue 6, Page(s) e15688

Abstract: Dual training in Internal Medicine-Pediatrics (MedPeds) was recognized by the American Board of Medical Specialties in 1967. Residents complete 24 months each in Internal Medicine and Pediatrics and are board-eligible for both at the conclusion of ... ...

Abstract	Dual training in Internal Medicine-Pediatrics (MedPeds) was recognized by the American Board of Medical Specialties in 1967. Residents complete 24 months each in Internal Medicine and Pediatrics and are board-eligible for both at the conclusion of training. Graduates are eligible for fellowships in either or both fields. Many graduates pursue fellowship training. A small absolute number of graduates apply for dual training in adult and pediatric subspecialties, but those that do bring direct, in-depth clinical experience across the lifespan, and familiarity with care in both pediatric and adult settings. As such, they contribute unique perspectives and capabilities to their fellowship and future practice. This includes the ability to provide subspecialty care in settings with limited resources, where they are able to address needs without age restrictions, and in the transition of subspecialty care for emerging adults with childhood-onset conditions. Due to the small number of applicants pursuing joint adult and pediatric fellowships, many fellowship directors may have limited experience with dual fellowships but may want to create opportunities for these unique trainees. This summary was developed jointly by residents, fellows, MedPeds program directors, and fellowship directors in Pediatrics and Internal Medicine subspecialties, and approved by their respective leadership councils to offer some key points on common questions, suggest additional resources, and share best practices, with a goal of facilitating this process for fellowship programs and residents alike.
Language	English
Publishing date	2021-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.15688
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Article ; Online: Couple-based lifestyle intervention to prevent type 2 diabetes: protocol for a randomised pilot trial.

BMJ open

2023 Volume 13, Issue 2, Page(s) e068623

Abstract: Introduction: Type 2 diabetes is prevalent among US adults. Lifestyle interventions that modify health behaviours prevent or delay progression to diabetes among individuals at high risk. Despite the well-documented influence of individuals' social ... ...

Abstract	Introduction: Type 2 diabetes is prevalent among US adults. Lifestyle interventions that modify health behaviours prevent or delay progression to diabetes among individuals at high risk. Despite the well-documented influence of individuals' social context on their health, evidence-based type 2 diabetes prevention interventions do not systematically incorporate participants' romantic partners. Involving partners of individuals at high risk for type 2 diabetes in primary prevention may improve engagement and outcomes of programmes. The randomised pilot trial protocol described in this manuscript will evaluate a couple-based lifestyle intervention to prevent type 2 diabetes. The objective of the trial is to describe the feasibility of the couple-based intervention and the study protocol to guide planning of a definitive randomised clinical trial (RCT). Methods and analysis: We used community-based participatory research principles to adapt an individual diabetes prevention curriculum for delivery to couples. This parallel two-arm pilot study will include 12 romantic couples in which at least one partner (ie, 'target individual') is at risk for type 2 diabetes. Couples will be randomised to either the 2021 version of the CDC's PreventT2 curriculum designed for delivery to individuals (six couples), or PreventT2 Together, the adapted couple-based curriculum (six couples). Participants and interventionists will be unblinded, but research nurses collecting data will be blinded to treatment allocation. Feasibility of the couple-based intervention and the study protocol will be assessed using both quantitative and qualitative measures. Ethics and dissemination: This study has been approved by the University of Utah IRB (#143079). Findings will be shared with researchers through publications and presentations. We will collaborate with community partners to determine the optimal strategy for communicating findings to community members. Results will inform a subsequent definitive RCT. Trial registration number: NCT05695170.
MeSH term(s)	Adult ; Humans ; Pilot Projects ; Life Style ; Diabetes Mellitus, Type 2/prevention & control ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-068623
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Article ; Online: Parental Leave in Graduate Medical Education: Recommendations for Reform.

Vassallo, Patricia / Jeremiah, Jennifer / Forman, Leanne / Dubois, Lauralee / Simmons, Debra L / Chretien, Katherine / Amin, Alpesh / Coleman, David / Collichio, Frances

The American journal of medicine

2018 Volume 132, Issue 3, Page(s) 385–389

MeSH term(s)	Clinical Competence ; Education, Medical, Graduate ; Fellowships and Scholarships ; Health Workforce ; Humans ; Internship and Residency ; Organizational Policy ; Parental Leave ; Salaries and Fringe Benefits ; Training Support ; United States ; Workload
Language	English
Publishing date	2018-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2018.11.006
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Article: Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial .

Nowak, Kristen L / Chonchol, Michel / Jovanovich, Anna / You, Zhiying / Ambrosius, Walter T / Cho, Monique E / Glasser, Stephen / Lash, James / Simmons, Debra L / Taylor, Addison / Weiner, Daniel / Rastogi, Anjay / Oparil, Suzanne / Supiano, Mark A

Clinical nephrology

2020 Volume 94, Issue 1, Page(s) 26–35

Abstract: Aims: Arterial stiffness increases with both advancing age and chronic kidney disease (CKD) and may contribute to kidney function decline, but evidence is inconsistent. We hypothesized that greater baseline arterial stiffness (assessed as pulse pressure ...

Abstract	Aims: Arterial stiffness increases with both advancing age and chronic kidney disease (CKD) and may contribute to kidney function decline, but evidence is inconsistent. We hypothesized that greater baseline arterial stiffness (assessed as pulse pressure (PP) and carotid-femoral pulse-wave velocity CFPWV)) was independently associated with kidney disease progression over the follow-up period (3.8 years) in the Systolic Blood Pressure Intervention Trial (SPRINT). Materials and methods: 8,815 SPRINT participants were included in the analysis of PP. 592 adults who participated in a SPRINT ancillary study that measured CFPWV were included in subgroup analyses. Cox proportional hazards analysis was used to examine the association between PP and time to kidney disease progression endpoints: (A) incident estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m Results and conclusion: Mean ± SD age was 68 ± 10 years, baseline PP was 62 ± 14 mmHg, and CFPWV was 10.8 ± 2.7 m/s. In the fully adjusted model, PP ≥ median was associated with an increased hazard of kidney disease progression endpoints (HR: 1.93 (1.43 - 2.61)). The association remained significant in individuals without (2.05 (1.47 - 2.87)) but not with baseline CKD (1.28 (0.55 - 2.65)). In fully adjusted models, higher baseline PP associated with eGFR decline (p < 0.0001 (all, CKD, non-CKD)), but baseline CFPWV did not. Among older adults at high risk for cardiovascular events, baseline PP was associated with kidney disease progression.
MeSH term(s)	Aged ; Blood Pressure/physiology ; Disease Progression ; Humans ; Middle Aged ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/physiopathology ; Vascular Stiffness/physiology
Language	English
Publishing date	2020-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN109982
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Zs.A 873: Show issues

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Article: The Role of Advocacy in Adapting the Diabetes Prevention Program for Couple-Based Delivery That Reaches Marginalized Groups.

Aguirre, Monique C / Brown, Heather / Gershenoff, Dana / Hinton, Kristie L / Huntzinger, Olivia M / Klein, Natalie / Ramos, Carmen / Tavake-Pasi, O Fahina / Witte, Brieanne / Wolfsfeld, Marc / Sher, Tamara / Simmons, Debra L / Smith, Timothy W / Clark, Lauren / Baucom, Katherine J W

The Behavior therapist

2021 Volume 43, Issue 7, Page(s) 261–265

Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747035-0
ISSN	0278-8403
ISSN	0278-8403
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Article: Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naïve patients: response to Rosenstock et al.

Hamid, Zulekha / Simmons, Debra L

Diabetes care

2006 Volume 29, Issue 10, Page(s) 2331; author reply 2332

MeSH term(s)	Cholesterol, LDL/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Drug Therapy, Combination ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Insulin/analogs & derivatives ; Insulin/economics ; Insulin/therapeutic use ; Insulin Glargine ; Insulin, Long-Acting ; Metformin/administration & dosage ; Metformin/therapeutic use ; Sulfonylurea Compounds/administration & dosage ; Sulfonylurea Compounds/therapeutic use ; Thiazolidinediones/therapeutic use
Chemical Substances	Cholesterol, LDL ; Hypoglycemic Agents ; Insulin ; Insulin, Long-Acting ; Sulfonylurea Compounds ; Thiazolidinediones ; rosiglitazone (05V02F2KDG) ; Insulin Glargine (2ZM8CX04RZ) ; Metformin (9100L32L2N)
Language	English
Publishing date	2006-10
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc06-0909
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: AAIM Guidelines for Interview and Post-Interview Communication for Graduate Medical Education Recruitment.

Alweis, Richard L / Williams, Christopher M / Luther, Vera P / Simmons, Debra L / Kopelman, Richard / Angus, Steven V / Liao, Solomon / Nagalla, Sri / Muchmore, Elaine A

The American journal of medicine

2019 Volume 132, Issue 9, Page(s) 1106–1111

MeSH term(s)	Communication ; Education, Medical, Graduate ; Guidelines as Topic ; Humans ; Internship and Residency ; Interviews as Topic/standards ; Personnel Selection/standards ; United States
Language	English
Publishing date	2019-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2019.05.023
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Article ; Online: Primary pituitary diffuse large B-cell lymphoma with somatotroph hyperplasia and acromegaly: case report.

Ravindra, Vijay M / Raheja, Amol / Corn, Heather / Driscoll, Meghan / Welt, Corrine / Simmons, Debra L / Couldwell, William T

Journal of neurosurgery

2016 Volume 126, Issue 5, Page(s) 1725–1730

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and comprises approximately 30% of all lymphomas. Patients typically present with a nonpainful mass in the neck, groin, or abdomen associated with constitutional ... ...

Abstract	Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and comprises approximately 30% of all lymphomas. Patients typically present with a nonpainful mass in the neck, groin, or abdomen associated with constitutional symptoms. In this report, however, the authors describe a rare case of a 61-year-old woman with hyperprolactinemia, hypothyroidism, and acromegaly (elevation of insulin-like growth factor-1 [IGF-1]) with elevated growth hormone-releasing hormone (GHRH) in whom an MRI demonstrated diffuse enlargement of the pituitary gland. Despite medical treatment, the patient had persistent elevation of IGF-1. She underwent a transsphenoidal biopsy, which yielded a diagnosis of DLBCL with an activated B-cell immunophenotype with somatotroph hyperplasia. After stereo-tactic radiation therapy in combination with chemotherapy, she is currently in remission from her lymphoma and has normalized IGF-1 levels without medical therapy, 8 months after her histopathological diagnosis. This is the only reported case of its kind and displays the importance of a broad differential diagnosis, multidisciplinary evaluation, and critical intraoperative decision-making when treating atypical sellar lesions.
MeSH term(s)	Acromegaly/etiology ; Acromegaly/pathology ; Female ; Humans ; Hyperplasia ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/surgery ; Middle Aged ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/surgery ; Somatotrophs/pathology
Language	English
Publishing date	2016-08-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2016.5.JNS16828
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