Article ; Online: Crystalline Antibody-Laden Alginate Particles: A Platform for Enabling High Concentration Subcutaneous Delivery of Antibodies.
2023 Volume 12, Issue 15, Page(s) e2202370
Abstract: Subcutaneous (SC) administration is a desired route for monoclonal antibodies (mAbs). However, formulating mAbs for small injection volumes at high concentrations with suitable stability and injectability is a significant challenge. Here, this work ... ...
| Abstract | Subcutaneous (SC) administration is a desired route for monoclonal antibodies (mAbs). However, formulating mAbs for small injection volumes at high concentrations with suitable stability and injectability is a significant challenge. Here, this work presents a platform technology that combines the stability of crystalline antibodies with injectability and tunability of soft hydrogel particles. Composite alginate hydrogel particles are generated via a gentle centrifugal encapsulation process which avoids use of chemical reactions or an external organic phase. Crystalline suspension of anti-programmed cell death protein 1 (PD-1) antibody (pembrolizumab) is utilized as a model therapeutic antibody. Crystalline forms of the mAb encapsuled in the hydrogel particles lead to stable, high concentration, and injectable formulations. Formulation concentrations as high as 315 mg mL |
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| MeSH term(s) | Rats ; Animals ; Humans ; Alginates/chemistry ; Rats, Wistar ; Antibodies, Monoclonal/pharmacokinetics ; Subcutaneous Tissue/metabolism ; Hydrogels/chemistry |
| Chemical Substances | Alginates ; Antibodies, Monoclonal ; Hydrogels |
| Language | English |
| Publishing date | 2023-02-22 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2649576-4 |
| ISSN | 2192-2659 ; 2192-2640 |
| ISSN (online) | 2192-2659 |
| ISSN | 2192-2640 |
| DOI | 10.1002/adhm.202202370 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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