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Article: An miRNA with a major impact on stress.

Simmons, Sarah Cooper / Robison, A J

2023 Volume 39, Issue 9, Page(s) 642–643

Abstract: miRNAs regulate mRNAs, including those important for synapse function in the brain. Mucha and colleagues recently identified a novel miRNA-mRNA interaction in the basolateral amygdala that acts as a homeostatic counter to stress-induced anxiety and ... ...

Abstract	miRNAs regulate mRNAs, including those important for synapse function in the brain. Mucha and colleagues recently identified a novel miRNA-mRNA interaction in the basolateral amygdala that acts as a homeostatic counter to stress-induced anxiety and synaptic changes, suggesting miRNAs as potential avenues for therapeutic intervention in anxiety disorders.
MeSH term(s)	MicroRNAs/genetics ; Brain
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	619240-3
ISSN	1362-4555 ; 0168-9525 ; 0168-9479
ISSN (online)	1362-4555
ISSN	0168-9525 ; 0168-9479
DOI	10.1016/j.tig.2023.06.005
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Article ; Online: Slowly Expanding Lesions: A New Target for Progressive Multiple Sclerosis Trials?

Simmons, Sarah B / Ontaneda, Daniel

Neurology

2022 Volume 98, Issue 17, Page(s) 699–700

MeSH term(s)	Brain ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Chronic Progressive/drug therapy
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000200230
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Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: MRI findings in blinded trials should be available to treating physicians - No.

Simmons, Sarah B / Cohen, Jeffrey A

Multiple sclerosis (Houndmills, Basingstoke, England)

2021 Volume 27, Issue 6, Page(s) 814–815

MeSH term(s)	Humans ; Magnetic Resonance Imaging ; Physicians ; Research Design ; Research Personnel
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/1352458520986959
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Article ; Online: Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development.

Simmons, Sarah C / Grecco, Greg G / Atwood, Brady K / Nugent, Fereshteh S

Neuropharmacology

2022 Volume 222, Page(s) 109312

Abstract: In this review, we focus on prenatal opioid exposure (POE) given the significant concern for the mental health outcomes of children with parents affected by opioid use disorder (OUD) in the view of the current opioid crisis. We highlight some of the less ...

Abstract	In this review, we focus on prenatal opioid exposure (POE) given the significant concern for the mental health outcomes of children with parents affected by opioid use disorder (OUD) in the view of the current opioid crisis. We highlight some of the less explored interactions between developmental age and sex on synaptic plasticity and associated behavioral outcomes in preclinical POE research. We begin with an overview of the rich literature on hippocampal related behaviors and plasticity across POE exposure paradigms. We then discuss recent work on reward circuit dysregulation following POE. Additional risk factors such as early life stress (ELS) could further influence synaptic and behavioral outcomes of POE. Therefore, we include an overview on the use of preclinical ELS models where ELS exposure during key critical developmental periods confers considerable vulnerability to addiction and stress psychopathology. Here, we hope to highlight the similarity between POE and ELS on development and maintenance of opioid-induced plasticity and altered opioid-related behaviors where similar enduring plasticity in reward circuits may occur. We conclude the review with some of the limitations that should be considered in future investigations. This article is part of the Special Issue on 'Opioid-induced addiction'.
MeSH term(s)	Humans ; Child ; Female ; Pregnancy ; Analgesics, Opioid/adverse effects ; Opioid-Related Disorders ; Opioid Epidemic ; Adverse Childhood Experiences ; Behavior, Addictive
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2022.109312
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Article ; Online: The effects of cannabis and alcohol on driving performance and driver behaviour: a systematic review and meta-analysis.

Simmons, Sarah M / Caird, Jeff K / Sterzer, Frances / Asbridge, Mark

Addiction (Abingdon, England)

2022 Volume 117, Issue 7, Page(s) 1843–1856

Abstract: Background and aims: Cannabis and alcohol are frequently detected in fatal and injury motor vehicle crashes. While epidemiological meta-analyses of cannabis and alcohol have found associations with an increase in crash risk, convergent evidence from ... ...

Abstract	Background and aims: Cannabis and alcohol are frequently detected in fatal and injury motor vehicle crashes. While epidemiological meta-analyses of cannabis and alcohol have found associations with an increase in crash risk, convergent evidence from driving performance measures is insufficiently quantitatively characterized. Our objectives were to quantify the magnitude of the effect of cannabis and alcohol-alone and in combination-on driving performance and behaviour. Methods: Systematic review and meta-analysis. We systematically searched Academic Search Complete, CINAHL, Embase, Scopus, Google Scholar, MEDLINE, PsycINFO, SPORTDiscus and TRID. Of the 616 studies that underwent full-text review, this meta-analysis represents 57 studies and 1725 participants. We extracted data for hazard response time, lateral position variability, lane deviations or excursions, time out of lane, driving speed, driving speed variability, speed violations, time speeding, headway, headway variability and crashes from experimental driving studies (i.e. driving simulator, closed-course, on-road) involving cannabis and/or alcohol administration. We reported meta-analyses of effect sizes using Hedges' g and r. Results: Cannabis alone was associated with impaired lateral control [e.g. g = 0.331, 95% confidence interval (CI) = 0.212-0.451 for lateral position variability; g = 0.198, 95% CI = 0.001-0.395 for lane excursions) and decreased driving speed (g = -0.176, 95% CI = -0.298 to -0.053]. The combination of cannabis and alcohol was associated with greater driving performance decrements than either drug in isolation [e.g. g = 0.480, 95% CI = 0.096-0.865 for lateral position variability (combination versus alcohol); g = 0.525, 95% CI = 0.049-1.002 for time out of lane (versus alcohol); g = 0.336, 95% CI = 0.036-0.636 for lateral position variability (combination versus cannabis; g = 0.475, 95% CI = 0.002-0.949 for time out of lane (combination versus cannabis)]. Subgroup analyses indicated that the effects of cannabis on driving performance measures were similar to low blood alcohol concentrations. A scarcity of data and study heterogeneity limited the interpretation of some measures. Conclusions: This meta-analysis indicates that cannabis, like alcohol, impairs driving, and the combination of the two drugs is more detrimental to driving performance than either in isolation.
MeSH term(s)	Accidents, Traffic ; Automobile Driving ; Blood Alcohol Content ; Cannabinoid Receptor Agonists ; Cannabis ; Driving Under the Influence ; Ethanol ; Hallucinogens ; Humans ; Psychomotor Performance
Chemical Substances	Blood Alcohol Content ; Cannabinoid Receptor Agonists ; Hallucinogens ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.15770
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Article ; Online: Impact of a pulsed xenon disinfection system on hospital onset Clostridioides difficile infections in 48 hospitals over a 5-year period.

Simmons, Sarah / Wier, Grady / Pedraza, Antonio / Stibich, Mark

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 1084

Abstract: Background: The role of the environment in hospital acquired infections is well established. We examined the impact on the infection rate for hospital onset Clostridioides difficile (HO-CDI) of an environmental hygiene intervention in 48 hospitals over ... ...

Abstract	Background: The role of the environment in hospital acquired infections is well established. We examined the impact on the infection rate for hospital onset Clostridioides difficile (HO-CDI) of an environmental hygiene intervention in 48 hospitals over a 5 year period using a pulsed xenon ultraviolet (PX-UV) disinfection system. Methods: Utilization data was collected directly from the automated PX-UV system and uploaded in real time to a database. HO-CDI data was provided by each facility. Data was analyzed at the unit level to determine compliance to disinfection protocols. Final data set included 5 years of data aggregated to the facility level, resulting in a dataset of 48 hospitals and a date range of January 2015-December 2019. Negative binomial regression was used with an offset on patient days to convert infection count data and assess HO-CDI rates vs. intervention compliance rate, total successful disinfection cycles, and total rooms disinfected. The K-Nearest Neighbor (KNN) machine learning algorithm was used to compare intervention compliance and total intervention cycles to presence of infection. Results: All regression models depict a statistically significant inverse association between the intervention and HO-CDI rates. The KNN model predicts the presence of infection (or whether an infection will be present or not) with greater than 98% accuracy when considering both intervention compliance and total intervention cycles. Conclusions: The findings of this study indicate a strong inverse relationship between the utilization of the pulsed xenon intervention and HO-CDI rates.
MeSH term(s)	Clostridioides ; Disinfection ; Hospitals ; Humans ; Ultraviolet Rays ; Xenon
Chemical Substances	Xenon (3H3U766W84)
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06789-y
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Article ; Online: Effects of selective patient screening for MRSA on overall MRSA hospital-acquired infection rates.

Simmons, Sarah

Critical care nursing quarterly

2011 Volume 34, Issue 1, Page(s) 18–24

Abstract: Purpose: Determine if implementing a methicillin-resistant Staphylococcus aureus (MRSA) active surveillance program in the intensive care unit (ICU) only would affect hospitalwide transmission of MRSA.: Methods: Hospital-acquired MRSA rates were ... ...

Abstract	Purpose: Determine if implementing a methicillin-resistant Staphylococcus aureus (MRSA) active surveillance program in the intensive care unit (ICU) only would affect hospitalwide transmission of MRSA. Methods: Hospital-acquired MRSA rates were collected from January 2007 to December 2009. In July 2008, an active surveillance program was implemented in all ICU areas. The hospital-acquired MRSA rates were compared before and after the implementation of the screening program. Results: The ICU rate of hospital-acquired MRSA reduced from 3.19/1000 patient-days to 1.66/1000 patient-days (P .005). The facility's hospital-acquired MRSA rate was reduced from 0.80/1000 patient-days to 0.38/1000 patient-days (P .0003). Conclusion: Implementing an ICU-only active surveillance program is an effective method of controlling MRSA transmission on a hospitalwide level. Additional high-risk areas to consider include long-term acute care facilities, rehabilitation units, and patients with long-term indwelling medical devices.
MeSH term(s)	Cohort Studies ; Cross Infection/diagnosis ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Humans ; Infection Control/organization & administration ; Mass Screening ; Methicillin-Resistant Staphylococcus aureus ; Patient Selection ; Retrospective Studies ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/prevention & control
Language	English
Publishing date	2011-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639095-x
ISSN	1550-5111 ; 0887-9303
ISSN (online)	1550-5111
ISSN	0887-9303
DOI	10.1097/CNQ.0b013e31820480bf
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Article ; Online: Predicting disability worsening in relapsing and progressive multiple sclerosis.

Simmons, Sarah B / Schippling, Sven / Giovannoni, Gavin / Ontaneda, Daniel

Current opinion in neurology

2021 Volume 34, Issue 3, Page(s) 312–321

Abstract: Purpose of review: Multiple sclerosis (MS) is a clinically heterogeneous disease, which complicates expectant management as well as treatment decisions. This review provides an overview of both well established and emerging predictors of disability ... ...

Abstract	Purpose of review: Multiple sclerosis (MS) is a clinically heterogeneous disease, which complicates expectant management as well as treatment decisions. This review provides an overview of both well established and emerging predictors of disability worsening, including clinical factors, imaging factors, biomarkers and treatment strategies. Recent findings: In addition to well known clinical predictors (age, male sex, clinical presentation, relapse behaviour), smoking, obesity, vascular and psychiatric comorbidities are associated with subsequent disability worsening in persons with MS. A number of imaging features are predictive of disability worsening and are present to varying degrees in relapsing and progressive forms of MS. These include brain volumes, spinal cord atrophy, lesion volumes and optical coherence tomography features. Cerebrospinal and more recently blood biomarkers including neurofilament light show promise as more easily attainable biomarkers of future disability accumulation. Importantly, recent observational studies suggest that initiation of early-intensive therapy, as opposed to escalation based on breakthrough disease, is associated with decreased accumulation of disability overall, although randomized controlled trials investigating this question are underway. Summary: Understanding risk factors associated with disability progression can help to both counsel patients and enhance the clinician's availability to provide evidence-based treatment recommendations.
MeSH term(s)	Atrophy ; Disability Evaluation ; Disease Progression ; Humans ; Magnetic Resonance Imaging ; Multiple Sclerosis, Chronic Progressive ; Multiple Sclerosis, Relapsing-Remitting ; Nervous System Malformations ; Recurrence
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000000928
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Article ; Online: Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons.

Langlois, Ludovic D / Selvaraj, Prabhuanand / Simmons, Sarah C / Gouty, Shawn / Zhang, Yumin / Nugent, Fereshteh S

IBRO neuroscience reports

2022 Volume 12, Page(s) 157–162

Abstract: Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory deficits in affected individuals [1]. Although most studies have investigated the role of hippocampal ... ...

Abstract	Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory deficits in affected individuals [1]. Although most studies have investigated the role of hippocampal synaptic dysfunction in earlier time points following a single injury, the long-lasting effects of mTBI on hippocampal synaptic transmission following multiple brain concussions have not been well-elucidated. Using a repetitive closed head injury (3XCHI) mouse model of mTBI, we examined the alteration of spontaneous synaptic transmission onto hippocampal CA1 pyramidal neurons by recording spontaneous excitatory AMPA receptor (AMPAR)- and inhibitory GABA
Language	English
Publishing date	2022-02-09
Publishing country	Netherlands
Document type	Journal Article
ISSN	2667-2421
ISSN (online)	2667-2421
DOI	10.1016/j.ibneur.2022.02.002
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Article: Blast-Induced Mild Traumatic Brain Injury Alterations of Corticotropin-Releasing Factor Neuronal Activity in the Mouse Hypothalamic Paraventricular Nucleus.

Simmons, Sarah / Langlois, Ludovic D / Oyola, Mario G / Gouty, Shawn / Wu, T John / Nugent, Fereshteh S

Frontiers in synaptic neuroscience

2022 Volume 13, Page(s) 804898

Abstract: Blast-induced mild traumatic brain injury (mbTBI) is the most common cause of TBI in US service members and veterans. Those exposed to TBI are at greater risk of developing neuropsychiatric disorders such as posttraumatic stress disorder, anxiety and ... ...

Abstract	Blast-induced mild traumatic brain injury (mbTBI) is the most common cause of TBI in US service members and veterans. Those exposed to TBI are at greater risk of developing neuropsychiatric disorders such as posttraumatic stress disorder, anxiety and depressive disorders, and substance use disorders following TBI. Previously, we have demonstrated that mbTBI increases anxiety-like behaviors in mice and dysregulates stress at the level of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN). To expand on how mTBI may dysregulate the stress axis centrally, here PVN CRF neuronal activity was evaluated using whole cell-patch clamp recordings in hypothalamic slices from sham and mbTBI adult male CRF:tdTomato mice 7 days post-injury. We found that mbTBI generally did not affect the neuronal excitability and intrinsic membrane properties of PVN CRF neurons; this injury selectively increased the frequency of spontaneous neuronal firing of PVN CRF neurons localized to the dorsal PVN (dPVN) but not ventral PVN (vPVN). Consistently, mbTBI-induced dPVN CRF hyperactivity was associated with pre- and post-synaptic depression of spontaneous GABAergic transmission onto dPVN CRF neurons suggesting that mbTBI-induced GABAergic synaptic dysfunction may underlie dPVN CRF neuronal hyperactivity and increases in dPVN CRF signaling. The present results provide the first evidence for mbTBI-induced alterations in PVN CRF neuronal activity and GABAergic synaptic function that could mediate hypothalamic CRF dysregulation following mbTBI contributing to stress psychopathology associated with blast injury.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592086-8
ISSN	1663-3563
ISSN	1663-3563
DOI	10.3389/fnsyn.2021.804898
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