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  1. Article ; Online: Estimation of volatile organic compound exposure concentrations and time to reach a specific dermal absorption using physiologically based pharmacokinetic modeling.

    Simon, Laurent

    Journal of occupational and environmental hygiene

    2023  Volume 21, Issue 1, Page(s) 1–12

    Abstract: A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for ... ...

    Abstract A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for bromochloromethane. These concentrations were reconstructed based on chemical blood levels measured in 4 hr, with errors varying from 0.0% to 52.0%. The PBPK approach adequately predicted the blood concentrations and helped simulate contaminant transport through the stratum corneum and distribution in the body compartments. The proposed technique made it possible to estimate the skin absorption time (SAT) obtained from acute inhalation toxicity data. An inverse relationship exists between the SAT and exposure concentration. The method can be helpful in toxicology and risk assessment of hazardous volatile organic compounds.
    MeSH term(s) Rats ; Animals ; Volatile Organic Compounds ; Models, Biological ; Risk Assessment
    Chemical Substances Volatile Organic Compounds
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131820-7
    ISSN 1545-9632 ; 1545-9624
    ISSN (online) 1545-9632
    ISSN 1545-9624
    DOI 10.1080/15459624.2023.2257774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5821: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fast Track Treatment of Hypothyroidism with Levothyroxine: Reaching Homeostasis within Four Weeks.

    Goede, Simon L

    Acta biotheoretica

    2023  Volume 71, Issue 2, Page(s) 10

    Abstract: With the current clinical method for the treatment of hypothyroidism the target for the optimum individual values for free thyroxine concentrations [FT4] and thyrotropine concentrations [TSH] of the specific patient are unknown. This situation leads to ... ...

    Abstract With the current clinical method for the treatment of hypothyroidism the target for the optimum individual values for free thyroxine concentrations [FT4] and thyrotropine concentrations [TSH] of the specific patient are unknown. This situation leads to unnecessary long experimental medication administration that can take a period of sometimes one year. In this article a method will be described where hypothyroid patients are characterized with weekly measured FT4 and TSH concentrations during the first three weeks of synthetic thyroxine or levothyroxine (L-T4) treatment to predict their optimum [FT4] and belonging [TSH] endpoint for a euthyroid homeostatic state. The treatment with levothyroxine will start for all patients with a reference dose of 100 µg, which can be adjusted by the treating physician to a more safe and appropriate dose for the individual which is monitored with weekly thyroid function tests to observe the progress. After three weeks all characteristics of the patient can be inferred from the measured data. The final titration target together with the individual thyroxine half life can be calculated. With the known characteristics and the L-T4 titration target the clinician or treating physician has an instrument to reduce the experimental treatment burden for the patient from one year to a maximum of four weeks.
    MeSH term(s) Animals ; Thyroxine/therapeutic use ; Hypothyroidism/drug therapy ; Therapies, Investigational ; Homeostasis ; Thyrotropin
    Chemical Substances Thyroxine (Q51BO43MG4) ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 63-2
    ISSN 1572-8358 ; 0001-5342
    ISSN (online) 1572-8358
    ISSN 0001-5342
    DOI 10.1007/s10441-023-09461-x
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    In stock of ZB MED Bonn / Germany

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    72/15359: Show issues

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  3. Article ; Online: Analysis of the absorption kinetics following dermal exposure to large doses of volatile organic compounds.

    Simon, Laurent

    Mathematical biosciences

    2022  Volume 351, Page(s) 108889

    Abstract: A mathematical method was developed to study the skin penetration of volatile organic compounds (VOCs) after exposure to a high dose of the substance. While closed-form solutions exist to describe the diffusion and evaporation from small amounts, ... ...

    Abstract A mathematical method was developed to study the skin penetration of volatile organic compounds (VOCs) after exposure to a high dose of the substance. While closed-form solutions exist to describe the diffusion and evaporation from small amounts, numerical approaches are often implemented to predict dermal transport involving large doses. This work offers a Laplace transform-based method to estimate the time constant and dynamic and steady-state behaviors. First, the process was divided into two stages, separated by the time it took for excess chemicals to be depleted from the skin surface. Series solutions were written for the percutaneous VOC concentration, absorption and evaporation in the first stage. Application of Laplace transform methods yielded transient profiles after the compound dissipated from the surface of the stratum corneum. In addition, the procedure facilitated the calculation of the time constant and steady-state values. The method was validated using benchtop and fume hood experiments conducted with N,N-diethyl-3-methylbenzamide (DEET) and air velocities of 0.165 m/s and 0.72 m/s, respectively. The increase in the flow rate decreased the total amount of VOC absorbed and reduced the period required for the surface fluid to disappear.
    MeSH term(s) Diffusion ; Kinetics ; Skin/metabolism ; Skin Absorption ; Volatile Organic Compounds/metabolism
    Chemical Substances Volatile Organic Compounds
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1126-5
    ISSN 1879-3134 ; 0025-5564
    ISSN (online) 1879-3134
    ISSN 0025-5564
    DOI 10.1016/j.mbs.2022.108889
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1534: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Realizing the potential of restoration science.

    Lewis, Simon L

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2022  Volume 378, Issue 1867, Page(s) 20210174

    Abstract: Restoration science is growing fast. The restoration of habitats is increasingly part of the discussion over how to tackle the challenges of climate change, biodiversity loss and rural development. With this increasing role and attendant visibility, ... ...

    Abstract Restoration science is growing fast. The restoration of habitats is increasingly part of the discussion over how to tackle the challenges of climate change, biodiversity loss and rural development. With this increasing role and attendant visibility, restoration science has seen increasing controversy. Here I describe six aspects of robust restoration science that should be kept in mind to help realize its potential: do data-driven studies; focus on robust results; improve reproducibility; contextualize the results; give attention to economics; consider the wider goals of restoration. Realizing the potential of restoration science, via robust scientific studies, will provide society with the knowledge and tools to make better choices about which habitats to restore and where. This article is part of the theme issue 'Understanding forest landscape restoration: reinforcing scientific foundations for the UN Decade on Ecosystem Restoration'.
    MeSH term(s) Ecosystem ; Reproducibility of Results ; Biodiversity ; Forests ; Climate Change ; Conservation of Natural Resources
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2021.0174
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    In stock of ZB MED Cologne/Königswinter

    Einzelsignatur: Show issues

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  5. Article ; Online: Dental Use and Spending in Medicare Advantage and Traditional Medicare, 2010-2021.

    Simon, Lisa / Cai, Christopher

    JAMA network open

    2024  Volume 7, Issue 2, Page(s) e240401

    MeSH term(s) Aged ; Humans ; Medicare Part C ; United States ; Dentistry ; Economics, Dental
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.0401
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  6. Article: Personality Risk Factors for Vape Use amongst Young Adults and Its Consequences for Sleep and Mental Health.

    Evans, Simon L / Alkan, Erkan

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 4

    Abstract: 1) Background: The surge in vape (e-cigarette) use among young adults is concerning, as there is limited knowledge about risk factors and health consequences. This study explores the personality traits linked to vape use, and associations between vaping ...

    Abstract (1) Background: The surge in vape (e-cigarette) use among young adults is concerning, as there is limited knowledge about risk factors and health consequences. This study explores the personality traits linked to vape use, and associations between vaping and chronotype, sleep quality, and mental health, among young adults. (2) Methods: 316 participants, aged 18-25, completed measurements of mindfulness, rumination, self-compassion, anxiety/depression, chronotype, and sleep quality. (3) Results: the vape user group scored significantly lower on mindfulness, higher on rumination, and lower on self-compassion. Vape users were more likely to be evening types and had significantly lower sleep quality and higher anxiety symptoms, as well as higher alcohol use and loneliness (at trend) (4) Conclusions: These novel findings enhance our understanding of what might predispose young adults to vaping and the potential impact on their mental health and sleep quality. Findings point to specific cognitive/personality traits as vaping risk factors, which could inform intervention strategies.
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12040423
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  7. Article ; Online: Stretching the Scope of Behavioral Interventions: Proceedings of the 4th International Behavioural Trials Network Hybrid Meeting.

    Bacon, Simon L / Lavoie, Kim L

    Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

    2024  Volume 58, Issue 5, Page(s) 375–400

    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632630-4
    ISSN 1532-4796 ; 0883-6612
    ISSN (online) 1532-4796
    ISSN 0883-6612
    DOI 10.1093/abm/kaad059
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: From Exceptionalism to Essentialism in Dentistry.

    Simon, Lisa

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2021  Volume 49, Issue 1, Page(s) 89–91

    MeSH term(s) Dentistry ; Health Policy ; Health Services Accessibility ; Humans
    Language English
    Publishing date 2021-05-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1017/jme.2021.14
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2075: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Building a cm

    Malesys, V / Andrieux-Ledier, A / Lavenus, P / Simon, L

    Nanotechnology

    2024  Volume 35, Issue 28

    Abstract: In this article, we aim to develop and study a highly sensitive and selective ... ...

    Abstract In this article, we aim to develop and study a highly sensitive and selective cm
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad3b02
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  10. Article ; Online: How Will Dentistry Respond to the Coronavirus Disease 2019 (COVID-19) Pandemic?

    Simon, Lisa

    JAMA health forum

    2020  Volume 1, Issue 5, Page(s) e200625

    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2020.0625
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