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  1. Article ; Online: Beware of simple explanations.

    Simon, Tabassome / Danchin, Nicolas

    Heart (British Cardiac Society)

    2020  Volume 107, Issue 5, Page(s) 348–349

    MeSH term(s) Coronary Artery Disease ; Humans ; Hypertension
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-317605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  2. Article ; Online: Effect of Restrictive or Liberal Blood Transfusion on Major Cardiovascular Events in Patients With Acute Myocardial Infarction and Anemia-Reply.

    Ducrocq, Gregory / Simon, Tabassome / Steg, P Gabriel

    JAMA

    2021  Volume 325, Issue 24, Page(s) 2506–2507

    MeSH term(s) Anemia/etiology ; Anemia/therapy ; Blood Transfusion ; Humans ; Myocardial Infarction/therapy
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.6039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-intensity lipid-lowering regimens in patients with stable coronary artery disease: the intriguing question of all-cause mortality.

    Danchin, Nicolas / Simon, Tabassome

    European heart journal. Cardiovascular pharmacotherapy

    2019  Volume 6, Issue 5, Page(s) 328–330

    MeSH term(s) Biomarkers/blood ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cause of Death ; Clinical Trials as Topic ; Down-Regulation ; Dyslipidemias/blood ; Dyslipidemias/drug therapy ; Dyslipidemias/mortality ; Humans ; Hypolipidemic Agents/adverse effects ; Hypolipidemic Agents/therapeutic use ; Lipids/blood ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances Biomarkers ; Hypolipidemic Agents ; Lipids
    Language English
    Publishing date 2019-09-19
    Publishing country England
    Document type Letter ; Meta-Analysis
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvz049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Duration of antiplatelet therapy after DES implantation: can we trust non-inferiority open-label trials?

    Steg, Philippe Gabriel / Simon, Tabassome

    European heart journal

    2017  Volume 38, Issue 14, Page(s) 1044–1047

    Language English
    Publishing date 2017-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx110
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    Zs.MO 640: Show issues

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  5. Article ; Online: Coronary artery bypass surgery: The starting point of a long medical journey.

    Danchin, Nicolas / Puymirat, Etienne / Latremouille, Christian / Simon, Tabassome

    European journal of preventive cardiology

    2019  Volume 26, Issue 4, Page(s) 398–400

    MeSH term(s) Coronary Artery Bypass ; Coronary Artery Disease ; Humans
    Language English
    Publishing date 2019-01-03
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487318822097
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    Zs.A 4686: Show issues Location:
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  6. Article ; Online: Association of Use and Dose of Lipid-Lowering Therapy Post Acute Myocardial Infarction With 5-Year Survival in Older Adults.

    Fayol, Antoine / Schiele, François / Ferrières, Jean / Puymirat, Etienne / Bataille, Vincent / Tea, Victoria / Chamandi, Chekrallah / Albert, Franck / Lemesle, Gilles / Cayla, Guillaume / Weizman, Orianne / Simon, Tabassome / Danchin, Nicolas

    Circulation. Cardiovascular quality and outcomes

    2024  , Page(s) e010685

    Abstract: Background: Older people are underrepresented in randomized trials. The association between lipid-lowering therapy (LLT) and its intensity after acute myocardial infarction and long-term mortality in this population deserves to be assessed.: Methods: ...

    Abstract Background: Older people are underrepresented in randomized trials. The association between lipid-lowering therapy (LLT) and its intensity after acute myocardial infarction and long-term mortality in this population deserves to be assessed.
    Methods: The FAST-MI (French Registry of Acute ST-Elevation or Non-ST-Elevation Myocardial Infarction) program consists of nationwide French surveys including all patients admitted for acute myocardial infarction ≤48 hours from onset over a 1- to 2-month period in 2005, 2010, and 2015, with long-term follow-up. Numerous data were collected and a centralized 10-year follow-up was organized. The present analysis focused on the association between prescription of LLT (atorvastatin ≥40 mg or equivalent, or any combination of statin and ezetimibe) and 5-year mortality in patients aged ≥80 years discharged alive. Cox multivariable analysis and propensity score matching were used to adjust for baseline differences.
    Results: Among the 2258 patients aged ≥80 years (mean age, 85±4 years; 51% women; 39% ST-segment elevation myocardial infarction; 58% with percutaneous coronary intervention), 415 were discharged without LLT (18%), 866 with conventional doses (38%), and 977 with high-dose LLT (43%). Five-year survival was 36%, 47.5%, and 58%, respectively. Compared with patients without LLT, high-dose LLT was significantly associated with lower 5-year mortality (adjusted hazard ratio, 0.78 [95% CI, 0.66-0.92]), whereas conventional-intensity LLT was not (adjusted hazard ratio, 0.93 [95% CI, 0.80-1.09]). In propensity score-matched cohorts (n=278 receiving high-intensity LLT and n=278 receiving no statins), 5-year survival was 52% with high-intensity LLT at discharge and 42% without statins (hazard ratio, 0.78 [95% CI, 0.62-0.98]).
    Conclusions: In these observational cohorts, high-intensity LLT at discharge after acute myocardial infarction was associated with reduced all-cause mortality at 5 years in an older adult population. These results suggest that high-intensity LLT should not be denied to patients on the basis of old age.
    Registration: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT00673036, NCT01237418, and NCT02566200.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010685
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    Zs.A 6744: Show issues Location:
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  7. Article: Participation des infirmiers aux projets de recherche clinique : une étude transversale dans cinq hôpitaux.

    Martin, Maria / Bérard, Laurence / Simon, Tabassome / Leblanc, Judith

    Soins; la revue de reference infirmiere

    2019  Volume 64, Issue 838, Page(s) 13–19

    Abstract: The number of hospital-based clinical trials is resulting in the growing involvement of nurses. A cross-sectional study in five hospitals involving 60 nurses assessed the clinical research activities, the time allocated and the training level. The ... ...

    Title translation Nurses' participation in clinical research projects: a cross-sectional study in five hospitals.
    Abstract The number of hospital-based clinical trials is resulting in the growing involvement of nurses. A cross-sectional study in five hospitals involving 60 nurses assessed the clinical research activities, the time allocated and the training level. The results suggest that identifying specific nursing time devoted to clinical research may influence the activities carried out. Improving the definition of these activities could facilitate their integration into nursing practice.
    MeSH term(s) Clinical Trials as Topic/statistics & numerical data ; Cross-Sectional Studies ; Hospitals ; Humans ; Nursing Staff, Hospital/psychology
    Language French
    Publishing date 2019-09-18
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
    DOI 10.1016/j.soin.2019.07.003
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    Zs.B 2545: Show issues Location:
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  8. Article ; Online: Clinical Impact of Pharmacogenomics of Clopidogrel in Stroke.

    Simon, Tabassome / Danchin, Nicolas

    Circulation

    2016  Volume 135, Issue 1, Page(s) 34–37

    MeSH term(s) Cytochrome P-450 CYP2C19/genetics ; Genotype ; Humans ; Pharmacogenetics ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors ; Stroke ; Ticlopidine/analogs & derivatives ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; clopidogrel (A74586SNO7) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Ticlopidine (OM90ZUW7M1)
    Language English
    Publishing date 2016-12-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.116.025198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Response by Puymirat et al to Letter Regarding Article, "Acute Myocardial Infarction Changes in Patient Characteristics, Management, and 6-Month Outcomes Over a Period of 20 Years in the FAST-MI Program (French Registry of Acute ST Elevation or Non-ST-Elevation Myocardial Infarction) 1995 to 2015".

    Puymirat, Etienne / Simon, Tabassome / Danchin, Nicolas

    Circulation

    2018  Volume 137, Issue 21, Page(s) 2307–2308

    MeSH term(s) Humans ; Myocardial Infarction ; Non-ST Elevated Myocardial Infarction ; Registries ; ST Elevation Myocardial Infarction
    Language English
    Publishing date 2018-05-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.033969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments.

    Mega, Jessica L / Simon, Tabassome

    Lancet (London, England)

    2015  Volume 386, Issue 9990, Page(s) 281–291

    Abstract: Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, prevent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed drugs worldwide. The first drugs designed to inhibit platelets or ... ...

    Abstract Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, prevent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed drugs worldwide. The first drugs designed to inhibit platelets or coagulation factors, such as the antiplatelet clopidogrel and the anticoagulant warfarin, significantly reduced the risk of thrombotic events at the cost of increased bleeding in patients. However, both clopidogrel and warfarin have some pharmacological limitations including interpatient variability in antithrombotic effects in part due to the metabolism, interactions (eg, drug, environment, and genetic), or targets of the drugs. Increased knowledge of the pharmacology of antithrombotic drugs and the mechanisms underlying thrombosis has led to the development of newer drugs with faster onset of action, fewer interactions, and less interpatient variability in their antithrombotic effects than previous antithrombotic drugs. Treatment options now include the next-generation antiplatelet drugs prasugrel and ticagrelor, and, in terms of anticoagulants, inhibitors that directly target factor IIa (dabigatran) or Xa (rivaroxaban, apixaban, edoxaban) are available. In this Series paper we review the pharmacological properties of these most commonly used oral antithrombotic drugs, and explore the development of antiplatelet and anticoagulant therapies.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacology ; Blood Coagulation/drug effects ; Blood Platelets/drug effects ; Cytochrome P-450 Enzyme System/drug effects ; Humans ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/pharmacology ; Purinergic P2Y Receptor Antagonists/administration & dosage
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2015-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(15)60243-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 94: Show issues

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