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  1. Article ; Online: Is an abdominal cerclage indicated with a cervical myomectomy? A case report.

    Simon, Vanille / Bergeron, Marie-Ève / Lamarre, André / Laberge, Philippe / Maheux-Lacroix, Sarah

    Case reports in women's health

    2021  Volume 32, Page(s) e00345

    Abstract: Introduction: Cervical myomectomy can compromise cervical integrity and the risk of subsequent cervical incompetence is unclear. In this case report, the literature on cervical myomectomies is reviewed as well as that on the potential benefits of ... ...

    Abstract Introduction: Cervical myomectomy can compromise cervical integrity and the risk of subsequent cervical incompetence is unclear. In this case report, the literature on cervical myomectomies is reviewed as well as that on the potential benefits of cervical cerclage.
    Case presentation: A 30-year-old woman, nulligravida, with a 12 cm cervical leiomyoma consulted for heavy menstrual bleeding and pelvic pain. After failure of multiple medical therapies, a laparoscopic cervical myomectomy was successfully performed after pre-operative uterine artery embolization using absorbable gelatin sponges to reduce surgical blood loss.
    Discussion: A concomitant laparoscopic cerclage was achieved in order to prevent cervical incompetence, given that the full thickness of the anterior cervix was penetrated during the myomectomy.
    Language English
    Publishing date 2021-07-21
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2021.e00345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical use of Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer in France in 2021.

    Benoit, Louise / de Thorey, Axelle Gillet / David, Manuel Gomes / Azais, Henri / Bentivegna, Enrica / Nguyen-Xuan, Huyen-Thu / Simon, Vanille / Achen, Guillaume / Bats, Anne-Sophie / Koual, Meriem

    Journal of gynecology obstetrics and human reproduction

    2023  Volume 53, Issue 1, Page(s) 102703

    Abstract: Introduction: Indocyanine green (ICG) for axillary sentinel lymph node (SLN) detection in early breast cancer is at least equivalent to radioisotopic and/or colorimetric techniques. This procedure has not yet been recommended by learned societies in ... ...

    Abstract Introduction: Indocyanine green (ICG) for axillary sentinel lymph node (SLN) detection in early breast cancer is at least equivalent to radioisotopic and/or colorimetric techniques. This procedure has not yet been recommended by learned societies in France. Following the recent drug approval of Infracyanin ® in this indication, we wished to study the use of ICG in France.
    Methods: We conducted a web-based survey among members of multiple French breast cancer societies throughout November 2021. The survey assessed the profile of the respondent, the use or not of ICG for the detection of SLN in breast cancer, the technique used and the opinion of non-users and their expectations on the subject.
    Results: Seventy-five surgeons participated. More than a third (37 %) have been using ICG for the detection of SLN in breast cancer for 2 to 3 years. Technique was highly variable. According to 82.1 % of the respondents, less than 20 procedures are necessary to master the use of ICG. The main advantage reported for this method is the reduction of organizational constraints. The obstacles to the use of the ICG are the near infra-red camera equipment, but also the lack of validation by the French guidelines. Among non-users, 83 % would like to develop this technique in their center and 72.3 % are interested in training on this subject.
    Conclusion: This work highlights the need for French learned societies to take a stand on this issue but also the need to carry out studies on the technical aspects in order to standardise practices.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy ; Indocyanine Green ; Breast Neoplasms/pathology ; Coloring Agents ; France
    Chemical Substances Indocyanine Green (IX6J1063HV) ; Coloring Agents
    Language English
    Publishing date 2023-11-29
    Publishing country France
    Document type Journal Article
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2023.102703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: No Impact of Smoking Status on Breast Cancer Tumor Infiltrating Lymphocytes, Response to Neoadjuvant Chemotherapy and Prognosis.

    Simon, Vanille / Laot, Lucie / Laas, Enora / Rozette, Sonia / Guerin, Julien / Balezeau, Thomas / Nicolas, Marion / Pierga, Jean-Yves / Coussy, Florence / Laé, Marick / De Croze, Diane / Grandal, Beatriz / Abecassis, Judith / Dumas, Elise / Lerebours, Florence / Reyal, Fabien / Hamy, Anne-Sophie

    Cancers

    2020  Volume 12, Issue 10

    Abstract: Tobacco use is associated with an increase in breast cancer (BC) mortality. Pathologic complete response (pCR) rate to neoadjuvant chemotherapy (NAC) is influenced by tumor-infiltrating lymphocyte (TIL) levels and is associated with a better long-term ... ...

    Abstract Tobacco use is associated with an increase in breast cancer (BC) mortality. Pathologic complete response (pCR) rate to neoadjuvant chemotherapy (NAC) is influenced by tumor-infiltrating lymphocyte (TIL) levels and is associated with a better long-term survival outcome. The aim of our study is to evaluate the impact of smoking status on TIL levels, response to NAC and prognosis for BC patients. We retrospectively evaluated pre- and post-NAC stromal and intra tumoral TIL levels and pCR rates on a cohort of T1-T3NxM0 BC patients treated with NAC between 2002 and 2012 at Institut Curie. Smoking status (current, ever, never smokers) was collected in clinical records. We analyzed the association between smoking status, TIL levels, pCR rates and survival outcomes among the whole population, and according to BC subtype. Nine hundred and fifty-six BC patients with available smoking status information were included in our analysis (current smokers,
    Language English
    Publishing date 2020-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12102943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Therapeutic value of surgical paraaortic staging in locally advanced cervical cancer: a multicenter cohort analysis from the FRANCOGYN study group.

    Dabi, Yohann / Simon, Vanille / Carcopino, Xavier / Bendifallah, Sofiane / Ouldamer, Lobna / Lavoue, Vincent / Canlorbe, Geoffroy / Raimond, Emilie / Coutant, Charles / Graesslin, Olivier / Collinet, Pierre / Bricou, Alexandre / Daraï, Emile / Huchon, Cyrille / Ballester, Marcos / Haddad, Bassam / Touboul, Cyril

    Journal of translational medicine

    2018  Volume 16, Issue 1, Page(s) 326

    Abstract: Background: The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the survival impact of surgical staging in patients with LACC and no ... ...

    Abstract Background: The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the survival impact of surgical staging in patients with LACC and no evidence of paraaortic lymph node (PALN) metastasis on pre-operative imaging work-up.
    Methods: Data of 1447 patients with cervical cancer treated between 1996 and 2016 were extracted from maintained databases of 10 French University hospitals. Patients with locally advanced disease (IB2 or more) treated by concurrent chemoradiation therapy (CRT) and no evidence of paraaortic metastasis on pre-operative imaging work-up were selected for further analysis. The Kaplan-Meier method was used to estimate the survival distribution. A Cox proportional hazards model was used to account for the influence of multiple variables.
    Results: Six hundred and forty-seven patients were included, 377 (58.3%) with surgical staging and 270 (41.7%) without, with a mean follow up of 38.1 months (QI 13.0-56.0). Pathologic analysis revealed positive lymph nodes in 47 patients (12.5%). In multivariate model analysis, surgical staging remained an independent prognostic factor for DFS (OR 0.64, CI 95% 0.46-0.89, p = 0.008) and OS (OR 0.43, CI 95% 0.27-0.68, p < 0.001). The other significant parameter in multivariate analysis for both DFS and OS was treatment by intracavitary brachytherapy (OR respectively of 0.7 (0.5-1.0) and 0.6 (0.4-0.9), p < 0.05).
    Conclusion: Nodal surgical staging had an independent positive impact on survival in patients with LACC treated with CRT with no evidence of metastatic PALN on imaging.
    MeSH term(s) Adult ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Proportional Hazards Models ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
    Language English
    Publishing date 2018-11-26
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-018-1703-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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