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  1. Article ; Online: Bivalent COVID-19 booster vaccines and the absence of BA.5-specific antibodies.

    Carreño, Juan Manuel / Singh, Gagandeep / Simon, Viviana / Krammer, Florian

    The Lancet. Microbe

    2023  Volume 4, Issue 8, Page(s) e569

    MeSH term(s) Humans ; COVID-19/prevention & control ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00118-0
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  2. Article ; Online: Serology assays to manage COVID-19.

    Krammer, Florian / Simon, Viviana

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6495, Page(s) 1060–1061

    MeSH term(s) Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Enzyme-Linked Immunosorbent Assay ; Humans ; Neutralization Tests ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc1227
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    Zs.A 27: Show issues Location:
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  3. Article ; Online: Positive, again! What to make of "re-positive" SARS-CoV-2 molecular test results.

    Simon, Viviana / van Bakel, Harm / Sordillo, Emilia Mia

    EBioMedicine

    2020  Volume 60, Page(s) 103011

    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Humans ; Nucleic Acid Amplification Techniques ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; RNA, Viral/genetics ; RNA, Viral/metabolism ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103011
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  5. Article ; Online: Serology assays to manage COVID-19

    Krammer, Florian / Simon, Viviana

    Science

    2020  Volume 368, Issue 6495, Page(s) 1060–1061

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc1227
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Development of an HIV reporter virus that identifies latently infected CD4

    Kim, Eun Hye / Manganaro, Lara / Schotsaert, Michael / Brown, Brian D / Mulder, Lubbertus C F / Simon, Viviana

    Cell reports methods

    2022  Volume 2, Issue 6, Page(s) 100238

    Abstract: There is no cure for HIV infection, as the virus establishes a latent reservoir, which escapes highly active antiretroviral treatments. One major obstacle is the difficulty identifying cells that harbor latent proviruses. We devised a single-round viral ... ...

    Abstract There is no cure for HIV infection, as the virus establishes a latent reservoir, which escapes highly active antiretroviral treatments. One major obstacle is the difficulty identifying cells that harbor latent proviruses. We devised a single-round viral vector that carries a series of versatile reporter molecules that are expressed in an LTR-dependent or LTR-independent manner and make it possible to accurately distinguish productive from latent infection. Using primary human CD4
    MeSH term(s) Humans ; HIV Infections ; CD4-Positive T-Lymphocytes ; Virus Latency ; HIV-1/genetics ; Proviruses/genetics ; Latent Infection
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2022.100238
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  7. Article ; Online: Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines.

    Ju, Yi / Carreño, Juan Manuel / Simon, Viviana / Dawson, Kenneth / Krammer, Florian / Kent, Stephen J

    Nature reviews. Immunology

    2022  Volume 23, Issue 3, Page(s) 135–136

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Vaccines ; SARS-CoV-2 ; Vaccines, Synthetic ; Antibodies, Neutralizing
    Chemical Substances COVID-19 Vaccines ; Vaccines, Synthetic ; Antibodies, Neutralizing
    Language English
    Publishing date 2022-12-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00825-x
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  8. Article ; Online: Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection.

    Bhavsar, Disha / Singh, Gagandeep / Sano, Kaori / Gleason, Charles / Srivastava, Komal / Carreno, Juan Manuel / Simon, Viviana / Krammer, Florian

    mBio

    2023  , Page(s) e0228023

    Abstract: Importance: Antibodies on mucosal surfaces of the upper respiratory tract have been shown to be important for protection from infection with SARS-CoV-2. Here we investigate the induction of serum IgG, saliva IgG, and saliva sIgA after COVID-19 mRNA ... ...

    Abstract Importance: Antibodies on mucosal surfaces of the upper respiratory tract have been shown to be important for protection from infection with SARS-CoV-2. Here we investigate the induction of serum IgG, saliva IgG, and saliva sIgA after COVID-19 mRNA booster vaccination or breakthrough infections.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02280-23
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  9. Article ; Online: The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all

    Singh, Gagandeep / Abbad, Anass / Kleiner, Giulio / Srivastava, Komal / Gleason, Charles / Carreño, Juan Manuel / Simon, Viviana / Krammer, Florian

    mBio

    2023  Volume 15, Issue 1, Page(s) e0225023

    Abstract: Importance: As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies ... ...

    Abstract Importance: As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies against diverse coronavirus spike proteins. While these antibodies are binding antibodies that likely have little neutralization capacity and while their contribution to cross-protection is unclear, it is possible that they may play a role in protection from progression to severe disease with novel coronaviruses.
    MeSH term(s) Humans ; COVID-19 ; Prevalence ; SARS-CoV-2/genetics ; Cross Reactions ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02250-23
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  10. Article ; Online: SARS-CoV-2 BA.1 and BA.2 breakthrough infections boost antibody responses to early Omicron subvariants but not BQ.1.1 or XBB.1.5.

    Abbad, Anass / Yellin, Temima / Singh, Gagandeep / Fried, Miriam / Raskin, Ariel / Tcheou, Johnstone / Monahan, Brian / Gleason, Charles / Simon, Viviana / Carreño, Juan Manuel / Krammer, Florian

    Cell reports. Medicine

    2024  Volume 5, Issue 3, Page(s) 101474

    Abstract: Subvariants of the Omicron lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently escape neutralizing antibody responses induced by both vaccination and infection with antigenically distinct variants. Here, we describe the ... ...

    Abstract Subvariants of the Omicron lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently escape neutralizing antibody responses induced by both vaccination and infection with antigenically distinct variants. Here, we describe the potency and breadth of neutralizing and binding antibody responses against a large panel of variants following an Omicron BA.1 or BA.2 breakthrough infection in a heterogeneous cohort of individuals with diverse exposure histories. Both BA.1 and BA.2 breakthrough infections significantly boost antibody levels and broaden antibody reactivity. However, this broader immunity induced by BA.1 and BA.2 breakthrough infections does not neutralize Omicron BQ and XBB subvariants efficiently. While these subvariants are not neutralized well by post-breakthrough sera, suggesting escape, binding non-neutralizing antibody responses are sustained. In summary, our data suggest that while BA.1 and BA.2 breakthrough infections broaden the immune response to SARS-CoV-2 spike, the induced neutralizing antibody response is still outpaced by viral evolution.
    MeSH term(s) Humans ; Antibody Formation ; Breakthrough Infections ; COVID-19 ; SARS-CoV-2 ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Neutralizing
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101474
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