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Article ; Online: Incontinence urinaire de l’enfant.

Simonnet, Hina / Lallemant-Dudek, Pauline

2024 Volume 74, Issue 2, Page(s) 179–184

Abstract: URINARY INCONTINENCE IN CHILDREN. Urinary incontinence in children and adolescents is most often of functional origin. Questioning and clinical examination with a bladder diary should look for underlying urological or neurological causes. The type of ... ...

Title translation	Urinary incontinence in children.
Abstract	URINARY INCONTINENCE IN CHILDREN. Urinary incontinence in children and adolescents is most often of functional origin. Questioning and clinical examination with a bladder diary should look for underlying urological or neurological causes. The type of incontinence, daytime or nocturnal, must be specified to adapt treatments. Renal and bladder ultrasound is recommended, and urodynamic studies are not routinely used. Lifestyle advice and bowel management are prerequisites for treatment. Depending on the type of symptoms, drug treatment, pelvic floor treatment, behavioral measures or stimulation of the posterior tibial nerve can be proposed. The evolution can sometimes be slow with a significant impact on quality of life, and neurocognitive aspects need to be considered.
MeSH term(s)	Child ; Adolescent ; Humans ; Quality of Life ; Urinary Incontinence/diagnosis ; Urinary Incontinence/etiology ; Urinary Incontinence/therapy ; Pelvic Floor ; Physical Examination ; Life Style
Language	French
Publishing date	2024-02-28
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article: Neurologic Outcomes and Quality of Life in Children After Extracorporeal Membrane Oxygenation.

Michel, Alizée / Vedrenne-Cloquet, Meryl / Kossorotoff, Manoëlle / Thy, Michaël / Levy, Raphaël / Pouletty, Marie / De Marcellus, Charles / Grimaud, Marion / Moulin, Florence / Hully, Marie / Simonnet, Hina / Desguerre, Isabelle / Renolleau, Sylvain / Oualha, Mehdi / Chareyre, Judith

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 25, Issue 3, Page(s) e158–e167

Abstract: Rationale: Use of life support with extracorporeal membrane oxygenation (ECMO) is associated with brain injury. However, the consequences of these injuries on subsequent neurologic development and health-related quality of life (HRQoL) are poorly ... ...

Abstract	Rationale: Use of life support with extracorporeal membrane oxygenation (ECMO) is associated with brain injury. However, the consequences of these injuries on subsequent neurologic development and health-related quality of life (HRQoL) are poorly described in children. Objectives: The aim of this preliminary study was to describe short- and long-term neurologic outcomes in survivors of ECMO, as well as their HRQoL. Design: Retrospective identified cohort with contemporary evaluations. Setting: Necker Children's Hospital academic PICU. Patients: Forty survivors who underwent ECMO (October 2014 to January 2020) were included in follow-up assessments in May 2021. Interventions: None. Measurement and main results: We first reviewed the outcomes of ECMO at the time of PICU discharge, which included a summary of neurology, radiology, and Pediatric Overall/Cerebral Performance Category (POPC/PCPC) scores. Then, in May 2021, we interviewed parents and patients to assess HRQoL (Pediatric Quality of Life Inventory [PedsQL]) and POPC/PCPC for children 3 years old or older, and Denver II test (DTII) for younger children. An evaluation of DTII in the youngest patients 1 year after ECMO decannulation was also added. Median age at ECMO was 1.4 years (interquartile range [IQR], 0.4-6 yr). Thirty-five children (88%) underwent a venoarterial ECMO. At PICU discharge, 15 of 40 patients (38%) had neurologic impairment. Assessment of HRQoL was carried out at median of 1.6 years (IQR, 0.7-3.3 yr) after PICU discharge. PedsQL scores were over 70 of 100 for all patients (healthy peers mean results: 80/100), and scores were like those published in patients suffering with chronic diseases. In May 2021, seven of 15 patients had a normal DTII, and 36 of 40 patients had a POPC/PCPC score less than or equal to 3. Conclusions: None of our patients presented severe disability at long term, and HRQoL evaluation was reassuring. Considering the risk of neurologic impairment after ECMO support, a systematic follow-up of these high-risk survivor patients would be advisable.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Quality of Life ; Extracorporeal Membrane Oxygenation/adverse effects ; Retrospective Studies ; Health Status ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003419
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Unilateral predominance of abnormal movements: A characteristic feature of the pediatric anti-NMDA receptor encephalitis?

Benjumea-Cuartas, Vanessa / Eisermann, Monika / Simonnet, Hina / Hully, Marie / Nabbout, Rima / Desguerre, Isabelle / Kaminska, Anna

Epilepsy & behavior case reports

2017 Volume 7, Page(s) 42–44

Abstract: Anti-NMDA receptor encephalitis is a treatable autoimmune disease characterized by cognitive, motor and psychiatric features that primarily affects young adults and children. We present a case of a 7-year-old boy with asymmetrical (mainly right hemibody) ...

Abstract	Anti-NMDA receptor encephalitis is a treatable autoimmune disease characterized by cognitive, motor and psychiatric features that primarily affects young adults and children. We present a case of a 7-year-old boy with asymmetrical (mainly right hemibody) and abnormal polymorphic movements without concomitant scalpictal EEG changes but had background slowing predominating over the left hemisphere. This report illustrates previous descriptions of asymmetric presentation of abnormal movements in pediatric anti-NMDA receptor encephalitis and emphasizes the importance of video-EEG interpreted within the overall clinical context, to differentiate epileptic from non-epileptic abnormal movements in patients with autoimmune encephalitis.
Language	English
Publishing date	2017-01-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2708718-9
ISSN	2213-3232
ISSN	2213-3232
DOI	10.1016/j.ebcr.2016.12.002
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Article ; Online: Acute axonal neuropathy subtype of Guillain Barré syndrome in a French pediatric series: Adequate follow-up may require repetitive electrophysiological studies.

Chareyre, Judith / Hully, Marie / Simonnet, Hina / Musset, Lucile / Barnerias, Christine / Kossorotoff, Manoelle / Quijano-Roy, Susana / Desguerre, Isabelle / Gitiaux, Cyril

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2017 Volume 21, Issue 6, Page(s) 891–897

Abstract: Different subtypes of Guillain Barré Syndromes (GBSs) are defined by their electrophysiological characteristics, acute inflammatory demyelinating neuropathy (AIDP), and acute motor/motor-sensory axonal forms (AMAN/AMSAN) with either reversible nerve ... ...

Abstract	Different subtypes of Guillain Barré Syndromes (GBSs) are defined by their electrophysiological characteristics, acute inflammatory demyelinating neuropathy (AIDP), and acute motor/motor-sensory axonal forms (AMAN/AMSAN) with either reversible nerve conduction failure (RCF) or axonal degeneration. Our aim was to describe initial clinical and electrophysiological characteristics of axonal forms of GBS in a pediatric population and their short- and long-term evolution. Electroneuromyogram (ENMG) results were collected at diagnosis and at two months of evolution and interpreted using the recently proposed pattern of RCF vs axonal degeneration. Clinical evaluation was standardized using the GBS disability scale ("GBSds") at diagnosis, and then at 3, 6, and 12 months of evolution. Outcome was compared to those of patients with AIDP diagnosed within the same period. Eleven patients were included, among whom eight patients presenting with AMAN and three with AMSAN. Two subgroups were identified according to severity. Three patients had a severe form (GBSds ≥2 at 12 months), two of them presenting an axonal degeneration on ENMG studies. Seven patients had a less severe form (GBSds ≤1 at 12 months), five of them with RCF on ENMG studies. Axonal forms had a more severe evolution than demyelinating forms (n = 17) at 3 months (median GBSds 3 and 2, respectively), 6 months (2 and 0), and 12 months (1 and 0), (p < 0,05). Axonal forms of GBS in children have a more severe global outcome than demyelinating forms. Axonal degeneration in two successive early ENMGs may be a prognostic factor of poor outcome.
Language	English
Publishing date	2017-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2017.07.005
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 641: Show issues

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Article ; Online: Exploring the Early Organization and Maturation of Linguistic Pathways in the Human Infant Brain.

Dubois, Jessica / Poupon, Cyril / Thirion, Bertrand / Simonnet, Hina / Kulikova, Sofya / Leroy, François / Hertz-Pannier, Lucie / Dehaene-Lambertz, Ghislaine

Cerebral cortex (New York, N.Y. : 1991)

2016 Volume 26, Issue 5, Page(s) 2283–2298

Abstract: Linguistic processing is based on a close collaboration between temporal and frontal regions connected by two pathways: the "dorsal" and "ventral pathways" (assumed to support phonological and semantic processing, respectively, in adults). We ... ...

Abstract	Linguistic processing is based on a close collaboration between temporal and frontal regions connected by two pathways: the "dorsal" and "ventral pathways" (assumed to support phonological and semantic processing, respectively, in adults). We investigated here the development of these pathways at the onset of language acquisition, during the first post-natal weeks, using cross-sectional diffusion imaging in 21 healthy infants (6-22 weeks of age) and 17 young adults. We compared the bundle organization and microstructure at these two ages using tractography and original clustering analyses of diffusion tensor imaging parameters. We observed structural similarities between both groups, especially concerning the dorsal/ventral pathway segregation and the arcuate fasciculus asymmetry. We further highlighted the developmental tempos of the linguistic bundles: The ventral pathway maturation was more advanced than the dorsal pathway maturation, but the latter catches up during the first post-natal months. Its fast development during this period might relate to the learning of speech cross-modal representations and to the first combinatorial analyses of the speech input.
MeSH term(s)	Brain/anatomy & histology ; Brain/growth & development ; Cross-Sectional Studies ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; Female ; Frontal Lobe/anatomy & histology ; Frontal Lobe/embryology ; Humans ; Infant ; Language Development ; Linguistics ; Male ; Neural Pathways/anatomy & histology ; Neural Pathways/growth & development ; Temporal Lobe/anatomy & histology ; Temporal Lobe/embryology ; White Matter/anatomy & histology ; White Matter/embryology
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhv082
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Zs.A 3235: Show issues

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Article ; Online: Extracranial vertebral artery dissection in children: natural history and management.

Simonnet, Hina / Deiva, Kumaran / Bellesme, Céline / Cabasson, Sébastien / Husson, Béatrice / Toulgoat, Frédérique / Théaudin, Marie / Ducreux, Denis / Tardieu, Marc / Saliou, Guillaume

Neuroradiology

2015 Volume 57, Issue 7, Page(s) 729–738

Abstract: Introduction: The objective of this study is to describe clinical and imaging presentation and outcome in extracranial vertebral artery dissection.: Methods: Single-centre retrospective study over a 14-year period included 20 consecutive patients ... ...

Abstract	Introduction: The objective of this study is to describe clinical and imaging presentation and outcome in extracranial vertebral artery dissection. Methods: Single-centre retrospective study over a 14-year period included 20 consecutive patients under the age of 16 years with extracranial vertebral artery dissection. The diagnosis was based on vascular imaging performed at the acute phase and clinical symptoms. Results: A male predominance was observed (sex ratio 9/1). The first symptoms consisted of headache (45%), neck pain (15%), nausea (30%) and vertigo (30%). Clinical signs leading to admission to hospital were hemiparesis (60%), visual disorders with oculomotor disorders (20%) or visual field defects (20%) and cerebellar syndrome (35%). Eight patients (40%) reported repeated transient episodes of neurological deficits, prior to the diagnosis. The segment most commonly affected was V2-V3 (50%), followed by V3 (15%) and V2 (15%), V3-V4 (10%) and proximal V4 (10%). All patients but one presented cerebral infarction. Eleven patients received first-line treatment with low molecular weight heparin (LMWH), and nine patients received aspirin. Three patients experienced a recurrence of symptoms, one under vitamin K antagonist (VKA) and 2 under aspirin. All three were switched to LMWH with success. Fifty-eight percent of the dissected arteries were occluded at long-term follow-up, although 73% of them were patent at the acute phase. Conclusion: Initial imaging must include posterior fossa vessels and the craniocervical region with V2-V3 segments. Conventional angiography may be indicated in the absence of a definitive diagnosis on noninvasive imaging. Healing of the dissected vertebral artery predominantly resulted in occlusion, which does not constitute a pejorative factor but indicates good quality healing.
MeSH term(s)	Adolescent ; Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Cerebral Angiography ; Child ; Child, Preschool ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Infant ; Magnetic Resonance Angiography ; Male ; Platelet Aggregation Inhibitors/therapeutic use ; Retrospective Studies ; Treatment Outcome ; Vertebral Artery Dissection/complications ; Vertebral Artery Dissection/diagnosis ; Vertebral Artery Dissection/therapy ; Vitamin K/antagonists & inhibitors ; Vitamin K/therapeutic use
Chemical Substances	Anticoagulants ; Heparin, Low-Molecular-Weight ; Platelet Aggregation Inhibitors ; Vitamin K (12001-79-5) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2015-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-015-1520-x
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Article ; Online: Parents' behavior in response to infant crying: abusive head trauma education.

Simonnet, Hina / Laurent-Vannier, Anne / Yuan, Wenlun / Hully, Marie / Valimahomed, Sakil / Bourennane, Malek / Chevignard, Mathilde

Child abuse & neglect

2014 Volume 38, Issue 12, Page(s) 1914–1922

Abstract: Abusive head trauma (AHT) is still too common, and probably underestimated. It is the leading cause of death from child abuse. Crying is thought to contribute to the act of shaking. Objectives of this study were to (a) assess parents' knowledge about ... ...

Abstract	Abusive head trauma (AHT) is still too common, and probably underestimated. It is the leading cause of death from child abuse. Crying is thought to contribute to the act of shaking. Objectives of this study were to (a) assess parents' knowledge about infant crying, their ability to manage crying, and their knowledge about AHT; and (b) assess the feasibility and the impact of a simple educational intervention about crying and AHT with parents shortly after their child's birth. A short questionnaire was completed orally by the parents of 190 consecutive newborns in a maternity hospital at day 2 of life. Then, during the routine examination of the child, the pediatrician gave parents a short talk about infant crying and AHT, and a pamphlet. Finally, parents were contacted by phone at 6 weeks for the post-intervention questionnaire assessing their knowledge about crying and AHT. Among 202 consecutive births, parents of 190 children were included (266 parents; 70% mothers) over a 1-month period and answered the pre-intervention questionnaire. The intervention was feasible and easy to provide. Twenty-seven percent of mothers and 36% of fathers had never heard of AHT. At 6 weeks, 183 parents (68% of the sample; 80% mothers) answered the post-intervention questionnaire. Parents' knowledge improved significantly post-intervention. Parents found the intervention acceptable and useful. Health care professionals such as pediatricians or nurses could easily provide this brief talk to all parents during systematic newborn examination.
MeSH term(s)	Adolescent ; Adult ; Child Abuse/prevention & control ; Craniocerebral Trauma/epidemiology ; Craniocerebral Trauma/prevention & control ; Crying ; Female ; France ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Parents/education ; Shaken Baby Syndrome/prevention & control ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2014-12
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2014.06.002
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Article ; Online: Early electro-clinical features may contribute to diagnosis of the anti-NMDA receptor encephalitis in children.

Gitiaux, Cyril / Simonnet, Hina / Eisermann, Monika / Leunen, Dorothee / Dulac, Olivier / Nabbout, Rima / Chevignard, Mathilde / Honnorat, Jerôme / Gataullina, Svetlana / Musset, Lucile / Scalais, Emmanuel / Gauthier, Agnès / Hully, Marie / Boddaert, Nathalie / Kuchenbuch, Mathieu / Desguerre, Isabelle / Kaminska, Anna

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2013 Volume 124, Issue 12, Page(s) 2354–2361

Abstract: Objective: To describe initial and follow-up electroencephalographic (EEG) characteristics in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.: Methods: Consecutive polygraphic video-EEG recordings were analyzed in nine pediatric ... ...

Abstract	Objective: To describe initial and follow-up electroencephalographic (EEG) characteristics in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Methods: Consecutive polygraphic video-EEG recordings were analyzed in nine pediatric patients with anti-NMDAR encephalitis at the initial stage of the disease and during the intermediate period until motor recovery. EEG characteristics in waking and sleep stages as well as EEG correlates of abnormal movements are described. Results: In six patients, [corrected] the waking EEG showed preserved background activity and either focal or unilateral hemispheric slowing. These children had more favorable outcome than the three children with diffuse slowing. Unilateral [corrected] abnormal movements contra-lateral to hemispheric or focal slowing were also indicative of milder severity when compared to generalized abnormal movements and diffuse slowing. During non-rapid eye movement (NREM) sleep, a decrease in the expected slow waves and unilateral or diffuse theta-alpha band rhythms were observed in six children, not correlated with the outcome, representing a suggestive EEG pattern of anti-NMDAR encephalitis. [corrected]. Conclusions: In pediatric patients presenting behavioral disorders and abnormal movements, early EEG patterns may be suggestive of anti-NMDAR encephalitis. Moreover early electro-clinical presentation contributes to outcome prediction. Significance: This case series demonstrates that early EEG patterns may be suggestive of anti-NMDAR encephalitis in pediatric patients with behavioral disorders and abnormal movements.
MeSH term(s)	Adolescent ; Alpha Rhythm ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Child ; Child, Preschool ; Dyskinesias/diagnosis ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Reproducibility of Results ; Research Design ; Sleep Stages ; Theta Rhythm ; Wavelet Analysis
Language	English
Publishing date	2013-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2013.05.023
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