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Article ; Online: Assessing the Efficacy of Oral Immunotherapy for the Desensitisation of Peanut Allergy in Children (STOP II): A Phase 2 Randomised Controlled Trial.

Simons, Elinor

2014 Volume 134 Suppl 3, Page(s) S155–6

Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2014-1817NN
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Article ; Online: Social well-being among children with vs without food allergy before and during coronavirus disease 2019.

Merrill, Kaitlyn A / Abrams, Elissa M / Simons, Elinor / Protudjer, Jennifer Lisa Penner

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2022 Volume 129, Issue 4, Page(s) 519–521

MeSH term(s)	COVID-19 ; Child ; Food Hypersensitivity/epidemiology ; Humans ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2022.02.022
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Article ; Online: Epinephrine in the Management of Anaphylaxis.

Brown, Julie C / Simons, Elinor / Rudders, Susan A

The journal of allergy and clinical immunology. In practice

2020 Volume 8, Issue 4, Page(s) 1186–1195

Abstract: Epinephrine is life-saving and the only first-line medication in the management of anaphylaxis. At therapeutic doses, it acts rapidly to reverse nearly all symptoms of anaphylaxis, and stabilize mast cells. The standard approved doses administered ... ...

Abstract	Epinephrine is life-saving and the only first-line medication in the management of anaphylaxis. At therapeutic doses, it acts rapidly to reverse nearly all symptoms of anaphylaxis, and stabilize mast cells. The standard approved doses administered intramuscularly in the lateral thigh have a long track record for safe and effective use, but more information is needed on epinephrine pharmacokinetics and pharmacodynamics to ensure that current dosing strategies are optimal. Epinephrine should be administered promptly once anaphylaxis is suspected, to minimize morbidity and mortality. Providers on the front-line for managing patients with life-threatening allergic reactions need clear parameters and tools to guide the appropriate use of epinephrine, which take into account the potential evolution of symptoms and signs over time. All patients at risk for anaphylaxis should carry 2 epinephrine autoinjectors and be taught and able to demonstrate how to use them. Epinephrine autoinjectors need to be affordable, readily available, and easy for patients with allergies to carry and use. Furthermore, these devices should be available to meet the needs of all patients, from small infants through large or obese adults. The ideal means for storing and delivering epinephrine in prehospital and hospital environments warrants further study, to determine how to best balance efficiency, safety, and costs.
MeSH term(s)	Adult ; Anaphylaxis/drug therapy ; Epinephrine/therapeutic use ; Humans ; Infant ; Injections ; Injections, Intramuscular ; Mast Cells
Chemical Substances	Epinephrine (YKH834O4BH)
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2019.12.015
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Article ; Online: Prehospital epinephrine administration for treating anaphylaxis among those with comorbid asthma: A scoping review.

Hong, Billy / Merrill, Kaitlyn A / Golding, Michael A / Simons, Elinor / Ben-Shoshan, Moshe / Protudjer, Jennifer L P

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2023 Volume 131, Issue 1, Page(s) 69–74.e1

Abstract: Background: Prompt and correct use of epinephrine for treating anaphylaxis is considered essential in reducing the risk of fatal outcomes from anaphylaxis. Nevertheless, prehospital use of epinephrine remains low. Although asthma is a common comorbidity ...

Abstract	Background: Prompt and correct use of epinephrine for treating anaphylaxis is considered essential in reducing the risk of fatal outcomes from anaphylaxis. Nevertheless, prehospital use of epinephrine remains low. Although asthma is a common comorbidity in individuals experiencing severe allergic reactions, little attention has been given to whether asthma functions as a predictor of prehospital epinephrine administration. Objective: To perform a scoping review of the extant literature on using epinephrine to manage anaphylaxis in patients with comorbid asthma before presenting to the emergency department. Methods: Per Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review guidelines, peer-reviewed articles published in English or French were searched for within the Medline, Cumulative Index to Nursing and Allied Health Literature, and Embase databases between June 11 and June 18, 2021. We excluded studies that did not contain primary data. Results: The literature search yielded 1022 articles that were screened at the title and abstract level by 2 independent reviewers. Of these, 90 (8.8%) advanced to full-text review, and ultimately, 8 studies (0.8% of all articles; 8.9% of full-text articles) were included in the analysis. Overall, the association between comorbid asthma and epinephrine use in the prehospital setting for managing anaphylaxis was inconsistently reported in the literature. Three studies reported a positive association, whereas 2 others suggested a link, but their results were no longer significant when controlling for other study variables. Three studies described no significant association. Conclusion: Although asthma is frequently comorbid in individuals experiencing anaphylaxis, the association between comorbid asthma and prehospital epinephrine treatment rates remains an understudied area of patient care.
MeSH term(s)	Humans ; Anaphylaxis/drug therapy ; Anaphylaxis/epidemiology ; Asthma/drug therapy ; Asthma/epidemiology ; Comorbidity ; Emergency Medical Services ; Epinephrine/therapeutic use
Chemical Substances	Epinephrine (YKH834O4BH)
Language	English
Publishing date	2023-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2023.04.010
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Article ; Online: Association between gas stove use and childhood asthma in the Canadian CHILD Cohort Study.

Bédard, Marc-Antoine / Reyna, Myrtha E / Moraes, Theo J / Simons, Elinor / Turvey, Stuart E / Mandhane, Piush / Brook, Jeffrey R / Subbarao, Padmaja

Canadian journal of public health = Revue canadienne de sante publique

2023 Volume 114, Issue 4, Page(s) 705–708

MeSH term(s)	Child ; Humans ; Cohort Studies ; Canada/epidemiology ; Asthma/epidemiology ; Asthma/therapy ; Air Pollution, Indoor
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	417262-0
ISSN	1920-7476 ; 0008-4263
ISSN (online)	1920-7476
ISSN	0008-4263
DOI	10.17269/s41997-023-00779-0
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Article: Winnipeg-based elementary school teachers' perspectives on food allergy management: a qualitative analysis.

Santos, Mae Jhelene L / Merrill, Kaitlyn / Riediger, Natalie / Abrams, Elissa M / Piquemal, Nathalie / Simons, Elinor / Protudjer, Jennifer L P

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2023 Volume 19, Issue 1, Page(s) 62

Abstract: Background: Food allergy affects 7-8% of children worldwide. Teachers supervise children in school, where most children spend their day. Yet, teachers have variable food allergy-related knowledge.: Objective: We aimed to identify how Winnipeg-based ... ...

Abstract	Background: Food allergy affects 7-8% of children worldwide. Teachers supervise children in school, where most children spend their day. Yet, teachers have variable food allergy-related knowledge. Objective: We aimed to identify how Winnipeg-based elementary school teachers manage food allergy and prevent food-triggered allergic reactions in their classrooms and schools. Methods: Kindergarten-Grade 6 public and private school teachers, from Winnipeg, Canada, were interviewed virtually upon providing written informed consent. Interviews were recorded and transcribed verbatim. The study followed a pragmatic framework. Data were analysed via thematic analysis by multiple researchers. Results: We interviewed 16 teachers, who primarily identified as female (87.5%). Most teachers worked in public schools (87.5%) and, on average, had 5.8 years of teaching experience. We identified four themes within the data. Most teachers (68.9%) had direct or indirect experience with food allergy. Theme 1 described the minimal standardization and inconsistent enforcement of food allergy policies between and within schools. Teachers also had varied food allergy knowledge. Theme 2 reflected teachers' variable confidence/perceived knowledge towards food allergy management, including feeling of stress and anxiety. Theme 3 captured the lack of standardized food allergy education for teachers, and concerns about the adequacy of the current provincial program. Theme 4 described how teachers spoke of relying on other school staff, families and students to have effective communication. Conclusion: Teachers' food allergy management was informed by their knowledge and lived experience, guided by their school policies and individualized students' needs. Teachers identified gaps in knowledge and communication, and desired more training and resources.
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-023-00798-z
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Article ; Online: Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort.

Turner, Sarah E / Roos, Leslie / Nickel, Nathan / Pei, Jacqueline / Mandhane, Piushkumar J / Moraes, Theo J / Turvey, Stuart E / Simons, Elinor / Subbarao, Padmaja / Azad, Meghan B

BMC public health

2024 Volume 24, Issue 1, Page(s) 675

Abstract: Objective: Breastfeeding is associated with reduced postpartum depression, stronger parent-child relationships, and fewer behavioral disorders in early childhood. We tested the mediating roles of postpartum depression and parent-child relationship in ... ...

Abstract	Objective: Breastfeeding is associated with reduced postpartum depression, stronger parent-child relationships, and fewer behavioral disorders in early childhood. We tested the mediating roles of postpartum depression and parent-child relationship in the association between breastfeeding practices and child behavior. Study design: We used standardized questionnaire data from a subset of the CHILD Cohort Study (n = 1,573) to measure postpartum depression at 6 months, 1 year and 2 years, parent-child relationship 1 year and 2 years, and child behavior at 5 years using the Child Behavior Checklist (range 0-100). Breastfeeding practices were measured at 3 months (none, partial, some expressed, all direct at the breast), 6 months (none, partial, exclusive), 12 months, and 24 months (no, yes). Confounders included birth factors, maternal characteristics, and socioeconomic status. Results: Breast milk feeding at 3 or 6 months was associated with - 1.13 (95% CI: -2.19-0.07) to -2.14 (95% CI: -3.46, -0.81) lower (better) child behavior scores. Reduced postpartum depression at 6 months mediated between 11.5% and 16.6% of the relationship between exclusive breast milk feeding at 3 months and better child behavior scores. Together, reduced postpartum depression at 1 year and reduced parent-child dysfunction at 2 years mediated between 21.9% and 32.1% of the relationship between breastfeeding at 12 months and better child behavior scores. Conclusion: Postpartum depression and parent-child relationship quality partially mediate the relationship between breastfeeding practices and child behavior. Breastfeeding, as well as efforts to support parental mental health and parent-child relationships, may help to improve child behavior.
MeSH term(s)	Child, Preschool ; Female ; Child ; Humans ; Breast Feeding ; Cohort Studies ; Depression, Postpartum/epidemiology ; Milk, Human ; Child Behavior ; Parent-Child Relations
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17994-0
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Article ; Online: Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study.

Wiedeman, Alejandra M / Miliku, Kozeta / Moraes, Theo J / Mandhane, Piushkumar J / Simons, Elinor / Subbarao, Padmaja / Turvey, Stuart E / Zwicker, Jill G / Devlin, Angela M

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2024

Abstract: There is concern that during a low-risk pregnancy, women are consuming more than recommended (400 µg/day) supplemental folic acid and may not meet recommendations for other nutrients. The objective of this study was to determine folic acid supplement use ...

Abstract	There is concern that during a low-risk pregnancy, women are consuming more than recommended (400 µg/day) supplemental folic acid and may not meet recommendations for other nutrients. The objective of this study was to determine folic acid supplement use and dietary folate intakes in the second trimester (week 18) of pregnancy in women (
Language	English
Publishing date	2024-02-06
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2023-0258
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Article ; Online: Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study.

Scime, Natalie V / Turner, Sarah / Miliku, Kozeta / Simons, Elinor / Moraes, Theo J / Field, Catherine J / Turvey, Stuart E / Subbarao, Padmaja / Mandhane, Piushkumar J / Azad, Meghan B

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234680-6
ISSN	1556-8342 ; 1556-8253
ISSN (online)	1556-8342
ISSN	1556-8253
DOI	10.1089/bfm.2024.0019
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Article ; Online: Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk.

Hoskinson, Courtney / Medeleanu, Maria V / Reyna, Myrtha E / Dai, Darlene Ly / Chowdhury, Biswajit / Moraes, Theo J / Mandhane, Piushkumar J / Simons, Elinor / Kozyrskyj, Anita L / Azad, Meghan B / Petersen, Charisse / Turvey, Stuart E / Subbarao, Padmaja

The Journal of allergy and clinical immunology

2024

Abstract: Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in both pediatric and adult populations. The development of AD has been linked to antibiotic usage, which causes perturbation of the microbiome and has been ... ...

Abstract	Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in both pediatric and adult populations. The development of AD has been linked to antibiotic usage, which causes perturbation of the microbiome and has been associated with abnormal immune system function. However, imbalances in the gut microbiome itself associated with antibiotic usage have been inconsistently linked to AD. Objective: This study aimed to elucidate the timing and specific factors mediating the relationship between systemic (oral or intravenous) antibiotic usage and AD. Methods: We used statistical modelling and differential analysis to link CHILD participants' history of antibiotic usage and early-life gut microbiome alterations to atopic dermatitis. Results: Here we report that systemic antibiotics during the first year of life, as compared to later, are associated with AD risk (adjusted odds ratio (aOR) = 1.81 [95% CI = 1.28 - 2.57], p < 0.001), with an increased number of antibiotic courses corresponding to a dose-response-like increased risk of AD risk (1 course: aOR = 1.67 [95% CI = 1.17 - 2.38]; 2 or more courses: aOR = 2.16 [95% CI = 1.30 - 3.59]). Further, we demonstrate that microbiome alterations associated with both AD and systemic antibiotic usage fully mediate the effect of antibiotic usage on the development of AD (β Conclusion: Our findings indicate that early-life antibiotic usage, especially in the first year of life, modulates key gut microbiome components that may be used as markers to predict and possibly prevent the development of AD.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2024.03.025
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