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  1. Article: Music Therapy Selection.

    Simpson, Fraser

    Child and adolescent mental health

    2020  Volume 8, Issue 3, Page(s) 148

    Language English
    Publishing date 2020-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073663-0
    ISSN 1475-3588 ; 1475-357X
    ISSN (online) 1475-3588
    ISSN 1475-357X
    DOI 10.1111/1475-3588.00062_5
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  2. Article ; Online: Steroid Premedication and Monoclonal Antibody Therapy: Should We Reconsider?

    Karlsen, Emma-Anne / Walpole, Euan / Simpson, Fiona

    Current treatment options in oncology

    2024  Volume 25, Issue 3, Page(s) 275–283

    Abstract: Opinion statement: Monoclonal antibody (mAb) therapy is now considered a main component of cancer therapy in Australia. Although traditionally thought of as pure signalling inhibitors, a large proponent of these medications function through antibody- ... ...

    Abstract Opinion statement: Monoclonal antibody (mAb) therapy is now considered a main component of cancer therapy in Australia. Although traditionally thought of as pure signalling inhibitors, a large proponent of these medications function through antibody-dependent cell-mediated cytotoxicity (ADCC). Currently, most protocols and institutional guidelines for ADCC-mediated mAbs promote the use of corticosteroids as premedication: this is implemented to reduce infusion-related reactions (IRRs) and antiemesis prophylaxis and combat concurrently administered chemotherapy-related syndromes. Concerningly, the inhibitory effects of ADCC by corticosteroids are well documented; henceforth, it is possible the current standard of care is misaligned to the literature surrounding ADCC. Subsequently, clinicians' decisions to act in contrast to this literature may be reducing the efficacy of mAbs. The literature suggests that the redundant use of corticosteroids should be cautioned against when used in conjunction with ADCC-mediated mAbs-this is due to the consequent reduction in anti-tumour activity. Owing to the fact IRRs typically occur upon initial infusion, the authors advocate for individual clinicians and institutional protocols to considering augmenting their practice to corticosteroid premedication at the first dose only, unless clinically indicated. Additionally, product information (PI) and consumer medicine information (CMI) documents distributed by Australian and international regulatory agencies should consider disclosing the risk of concurrent steroids with these medications. Moreover, the authors suggest considering alternative medications for the management of side effects.
    MeSH term(s) Humans ; Cell Line, Tumor ; Australia ; Antibodies, Monoclonal/adverse effects ; Steroids ; Premedication ; Adrenal Cortex Hormones
    Chemical Substances Antibodies, Monoclonal ; Steroids ; Adrenal Cortex Hormones
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-023-01170-4
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  3. Article ; Online: Overlapping Machinery in Lysosome-Related Organelle Trafficking: A Lesson from Rare Multisystem Disorders.

    Banushi, Blerida / Simpson, Fiona

    Cells

    2022  Volume 11, Issue 22

    Abstract: Lysosome-related organelles (LROs) are a group of functionally diverse, cell type-specific compartments. LROs include melanosomes, alpha and dense granules, lytic granules, lamellar bodies and other compartments with distinct morphologies and functions ... ...

    Abstract Lysosome-related organelles (LROs) are a group of functionally diverse, cell type-specific compartments. LROs include melanosomes, alpha and dense granules, lytic granules, lamellar bodies and other compartments with distinct morphologies and functions allowing specialised and unique functions of their host cells. The formation, maturation and secretion of specific LROs are compromised in a number of hereditary rare multisystem disorders, including Hermansky-Pudlak syndromes, Griscelli syndrome and the Arthrogryposis, Renal dysfunction and Cholestasis syndrome. Each of these disorders impacts the function of several LROs, resulting in a variety of clinical features affecting systems such as immunity, neurophysiology and pigmentation. This has demonstrated the close relationship between LROs and led to the identification of conserved components required for LRO biogenesis and function. Here, we discuss aspects of this conserved machinery among LROs in relation to the heritable multisystem disorders they associate with, and present our current understanding of how dysfunctions in the proteins affected in the disease impact the formation, motility and ultimate secretion of LROs. Moreover, we have analysed the expression of the members of the CHEVI complex affected in Arthrogryposis, Renal dysfunction and Cholestasis syndrome, in different cell types, by collecting single cell RNA expression data from the human protein atlas. We propose a hypothesis describing how transcriptional regulation could constitute a mechanism that regulates the pleiotropic functions of proteins and their interacting partners in different LROs.
    MeSH term(s) Humans ; Arthrogryposis ; Lysosomes/metabolism ; Melanosomes/metabolism ; Rare Diseases/metabolism ; Cholestasis/metabolism ; Kidney Diseases/metabolism
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11223702
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  4. Article ; Online: A PEGylated liposomal formulation of prochlorperazine that limits brain exposure but retains dynamin II activity: A potential adjuvant therapy for cancer patients receiving chemotherapeutic mAbs.

    Subasic, Christopher N / Simpson, Fiona / Minchin, Rodney F / Kaminskas, Lisa M

    Nanomedicine : nanotechnology, biology, and medicine

    2024  Volume 56, Page(s) 102733

    Abstract: Anti-cancer monoclonal antibodies often fail to provide therapeutic benefit in receptor-positive patients due to rapid endocytosis of antibody-bound cell surface receptors. High dose co-administration of prochlorperazine (PCZ) inhibits endocytosis and ... ...

    Abstract Anti-cancer monoclonal antibodies often fail to provide therapeutic benefit in receptor-positive patients due to rapid endocytosis of antibody-bound cell surface receptors. High dose co-administration of prochlorperazine (PCZ) inhibits endocytosis and sensitises tumours to mAbs by inhibiting dynamin II but can also introduce neurological side effects. We examined the potential to use PEGylated liposomal formulations of PCZ (LPCZ) to retain the anti-cancer effects of PCZ, but limit brain uptake. Uncharged liposomes showed complete drug encapsulation and pH-dependent drug release, but cationic liposomes showed limited drug encapsulation and lacked pH-dependent drug release. Uncharged LPCZ showed comparable inhibition of EGFR internalisation to free PCZ in KJD cells. After IV administration to rats, LPCZ reduced the plasma clearance and brain uptake of PCZ compared to IV PCZ. The results suggest that LPCZ may offer some benefit over PCZ as an adjunct therapy in cancer patients receiving mAb treatment.
    MeSH term(s) Humans ; Rats ; Animals ; Prochlorperazine/adverse effects ; Dynamin II/metabolism ; Liposomes/therapeutic use ; Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/metabolism ; Brain/metabolism ; Polyethylene Glycols/therapeutic use
    Chemical Substances Prochlorperazine (YHP6YLT61T) ; Dynamin II (EC 3.6.5.5) ; Liposomes ; Antineoplastic Agents ; Antibodies, Monoclonal ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2024.102733
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  5. Article: METHODS OF PLAGUE CONTROL.

    Simpson, F

    American journal of public health (New York, N.Y. : 1912)

    2007  Volume 10, Issue 11, Page(s) 845–850

    Abstract: If we are economically and efficiently to ward off plague we must rid ourselves of the rat. This demands coördination of effort, management, organization and funds. Rat destruction and rat-proofing are preventive measures that fortunately do not involve ... ...

    Abstract If we are economically and efficiently to ward off plague we must rid ourselves of the rat. This demands coördination of effort, management, organization and funds. Rat destruction and rat-proofing are preventive measures that fortunately do not involve financial loss, while they will eliminate the dangerous rodent from the homes and environment of men.
    Language English
    Publishing date 2007-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 0271-4353
    ISSN 0271-4353
    DOI 10.2105/ajph.10.11.845
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  6. Article ; Online: Redesigning a More Actionable, Service Line Specific, Surgical Performance Dashboard for an Academic Referral Hospital by Adding Severity of Post-Operative Complications.

    Simpson, Francis / Sweeney, John F / Shaffer, Virginia / Sharma, Jyotirmay

    The American surgeon

    2022  Volume 88, Issue 4, Page(s) 571–577

    MeSH term(s) Hospitals ; Humans ; Postoperative Complications ; Quality Improvement ; Referral and Consultation
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348211061694
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  7. Article ; Online: Evaluation of Viscosity Dependence of the Critical Meniscus Height with Optical Fiber Sensors.

    Binetti, Leonardo / Simpson, Fraser / Alwis, Lourdes S M

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 23

    Abstract: Conventional means of data extraction using optical fiber interrogators are not adequate for fast-paced detection of a target parameter. In this instance, the relationship between the critical meniscus heights (CMH) of several liquids to the extraction ... ...

    Abstract Conventional means of data extraction using optical fiber interrogators are not adequate for fast-paced detection of a target parameter. In this instance, the relationship between the critical meniscus heights (CMH) of several liquids to the extraction speed of a rod submerged in them, have been analyzed. A limitation of a previous interrogator used for the purpose had been light absorption by the liquid due to the used bandwidth of the readily-available light source, i.e., C-band. The newly proposed technique addresses this limitation by utilizing a broadband light source instead, with a Si-photodetector and an Arduino. In addition, the Arduino is capable of extracting data at a relatively faster rate with respect to the conventional optical interrogator. The use of a different operational wavelength (850 nm instead of 1550 nm) increased the r
    Language English
    Publishing date 2021-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21238130
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  8. Article ; Online: Long COVID in children: the perspectives of parents and children need to be heard.

    Simpson, Frances / Chew-Graham, Carolyn / Lokugamage, Amali

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2021  Volume 71, Issue 706, Page(s) 216

    MeSH term(s) COVID-19/complications ; Child ; Humans ; Parents ; SARS-CoV-2
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp21X715769
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  9. Article: Percutaneous thrombolysis via cholecystostomy catheter to dissolve biliary clots causing obstructive jaundice.

    Smith, Sonya A / Simpson, Fraser / Bell-Allen, Nicholas / Brown, Nicholas / Mudaliar, Sanjivan / Aftab, Khurram / Tam, Diana / Chandrasegaram, Manju D

    Journal of surgical case reports

    2024  Volume 2024, Issue 2, Page(s) rjae055

    Abstract: Haemobilia, or bleeding within the biliary tree, is rare. It can cause biliary obstruction secondary to blood clots. A comorbid 87-year-old was admitted to hospital with acute cholecystitis, choledocholithiasis, and ... ...

    Abstract Haemobilia, or bleeding within the biliary tree, is rare. It can cause biliary obstruction secondary to blood clots. A comorbid 87-year-old was admitted to hospital with acute cholecystitis, choledocholithiasis, and an
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjae055
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  10. Article ; Online: Dose-Dependent Effect of Phenothiazines as Dynamin II Inhibitors on the Uptake of PEGylated Liposomes by Endocytic Cells and In Vivo Pharmacokinetics of PEGylated Liposomal Doxorubicin in Rats.

    Subasic, Christopher N / Butcher, Neville J / Simpson, Fiona / Minchin, Rodney F / Kaminskas, Lisa M

    Molecular pharmaceutics

    2023  Volume 20, Issue 9, Page(s) 4468–4477

    Abstract: Dynamin II (dynII) plays a significant role in the internalization pathways of endocytic cells, by allowing membrane invaginations to "bud off". An important class of dynII inhibitors that are used clinically are phenothiazines, such as prochlorperazine ( ...

    Abstract Dynamin II (dynII) plays a significant role in the internalization pathways of endocytic cells, by allowing membrane invaginations to "bud off". An important class of dynII inhibitors that are used clinically are phenothiazines, such as prochlorperazine (PCZ). PCZ is an antipsychotic drug but is also currently in clinical trials at higher concentrations as an adjuvant in cancer patients that increases the efficacy of monoclonal antibodies at high intravenous doses. It is unknown, however, whether high-dose dynII inhibitors have the potential to alter the pharmacokinetics of co-administered chemotherapeutic nanomedicines that are largely cleared via the mononuclear phagocyte system. This work therefore sought to investigate the impact of clinically relevant concentrations of phenothiazines, PCZ and thioridazine, on in vitro liposome endocytosis and in vivo liposome pharmacokinetics after PCZ infusion in rats. The uptake of fluorescently labeled PEGylated liposomes into differentiated and undifferentiated THP-1 and RAW246.7 cells, and primary human peripheral white blood cells, was investigated via flow cytometry after co-incubation with dynII inhibitors. The IV pharmacokinetics of PEGylated liposomes were also investigated in rats after a 20 min infusion with PCZ. Phenothiazines and dyngo4a reduced the uptake of PEGylated liposomes by THP-1 and RAW264.7 cells in a concentration-dependent manner in vitro. However, dynII inhibitors did not alter the mean uptake of liposomes by human peripheral white blood cells, but endocytic white cells from some donors exhibited sensitivity to phenothiazine exposure. When a clinically relevant dose of PCZ was co-administered with PEGylated liposomal doxorubicin (Caelyx/Doxil) in rats, the pharmacokinetics and biodistribution of liposomes were unaltered. These data suggest that while clinically relevant doses of dynII inhibitors can inhibit the uptake of liposomes by endocytic cells in vitro, they are unlikely to significantly affect the pharmacokinetics of long-circulating, co-administered liposomes.
    MeSH term(s) Rats ; Humans ; Animals ; Liposomes ; Dynamin II ; Tissue Distribution ; Doxorubicin ; Polyethylene Glycols ; Phenothiazines ; Prochlorperazine
    Chemical Substances liposomal doxorubicin ; Liposomes ; Dynamin II (EC 3.6.5.5) ; Doxorubicin (80168379AG) ; Polyethylene Glycols (3WJQ0SDW1A) ; Phenothiazines ; Prochlorperazine (YHP6YLT61T)
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00102
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