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Article ; Online: Multisystem inflammatory syndrome in adults (MIS-A) following COVID-19 requiring venoarterial extracorporeal membrane oxygenation.

Newman, Seth / Zou, Fengwei / Madan, Shivank / Sims, Daniel

BMJ case reports

2022 Volume 15, Issue 3

Abstract: The SARS-CoV-2 virus has caused a global pandemic with serious impact around the world. Patients most commonly present with severe lung involvement and acute respiratory failure; however, multisystem inflammatory syndrome in adults (MIS-A) is a known- ... ...

Abstract	The SARS-CoV-2 virus has caused a global pandemic with serious impact around the world. Patients most commonly present with severe lung involvement and acute respiratory failure; however, multisystem inflammatory syndrome in adults (MIS-A) is a known-although rare-complication. We present a case of a 49-year-old patient who presented with combined cardiogenic and vasodilatory shock and was diagnosed with MIS-A. He initially required venoarterial extracorporeal membrane oxygenation and Impella for haemodynamic support but was able to be weaned off these devices with complete recovery of left ventricular systolic function. This case demonstrates that MIS-A may present as haemodynamic collapse in adults, but complete recovery is possible with proper haemodynamic support.
MeSH term(s)	Adult ; COVID-19 ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/therapy
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-247427
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Article: What We Have Learned About Combining a Ketogenic Diet and Chemoimmunotherapy: a Case Report and Review of Literature.

Sims, Daniel / Liman, Agnes K / Leung, Victoria / Hwang, Andrew / Means, Jeffrey / Liman, Andrew D

Federal practitioner : for the health care professionals of the VA, DoD, and PHS

2023 Volume 40, Issue Suppl 3, Page(s) S98–S104

Abstract: Background: A high-fat, moderate-protein, low-carbohydrate ketogenic diet has been reported in the literature as a treatment option for patients with cancer.: Case presentation: A 69-year-old veteran was initially diagnosed with stage III colorectal ... ...

Abstract	Background: A high-fat, moderate-protein, low-carbohydrate ketogenic diet has been reported in the literature as a treatment option for patients with cancer. Case presentation: A 69-year-old veteran was initially diagnosed with stage III colorectal cancer and progressed to having liver, pancreatic, and omental lymph node involvement despite completing adjuvant FOLFOX (fluorouracil, leucovorin calcium, and oxaliplatin) after surgery. The patient was treated with FOLFIRI (fluorouracil, leucovorin calcium, and irinotecan hydrochloride) and bevacizumab, followed by encorafenib and cetuximab on progression. Subsequently, he received pembrolizumab but continued to progress. The patient was later placed on trifluridine/tipiracil and bevacizumab concurrent with a ketogenic diet. Positron emission tomography and carcinoembryonic antigen levels indicated disease stabilization for 10 months. On progression, the patient was transitioned to ipilumimab and nivolumab and continued to adhere to the ketogenic diet. The patient's disease has continued to remain stable for the past 1 year. His degree of ketosis was determined using the glucose ketone index. The patient continues to have a good quality of life during concurrent ketogenic diet and therapy. Conclusions: This case supports the tolerability of the ketogenic diet along with chemotherapy and immunotherapy and should be considered as an adjunct to standard cancer treatment. In this report, we reviewed the latest literature about cellular mechanism of the ketogenic diet and the efficacy and relationship with chemotherapy and immunotherapy. We are about to open a ketogenic diet protocol at the Veterans Affairs Central California Health Care System in Fresno.
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article
ISSN	1078-4497
ISSN	1078-4497
DOI	10.12788/fp.0399
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Article ; Online: Exophiala dermatitidis

Seo, Jiyoung / Mangeshkar, Shaunak / Farooq, Muhammad U / Clark, Rachel Marie / Forest, Stephen J / Sims, Daniel B / Tauras, James / Murthy, Sandhya

BMJ case reports

2023 Volume 16, Issue 12

Abstract: Fungal infective endocarditis, although rare, carries a high mortality risk. We present a case of successful multidisciplinary management ... ...

Abstract	Fungal infective endocarditis, although rare, carries a high mortality risk. We present a case of successful multidisciplinary management of
MeSH term(s)	Humans ; Male ; Mitral Valve/surgery ; Endocarditis, Bacterial/surgery ; Endocarditis/diagnosis ; Endocarditis/drug therapy ; Endocarditis/microbiology ; Exophiala ; Heart Valve Diseases/surgery ; Mycoses ; Heart Valve Prosthesis/adverse effects
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-257224
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Article ; Online: Outcomes of Non-ST-Segment Myocardial Infarction During Chronic Heart Failure and End-Stage Renal Disease.

Alhuarrat, Majd Al Deen / Alhuarrat, Mohammed Rasoul / Varrias, Dimitrios / Patel, Snehal R / Sims, Daniel B / Latib, Azeem / Jorde, Ulrich P / Saeed, Omar

The American journal of cardiology

2023 Volume 200, Page(s) 1–7

Abstract: Non-ST-segment myocardial infarction (NSTEMI) occurs frequently in a growing population of patients with chronic heart failure (HF) and end-stage renal disease (ESRD) but outcomes with invasive management approaches are unknown. We sought to determine in- ...

Abstract	Non-ST-segment myocardial infarction (NSTEMI) occurs frequently in a growing population of patients with chronic heart failure (HF) and end-stage renal disease (ESRD) but outcomes with invasive management approaches are unknown. We sought to determine in-hospital outcomes with percutaneous coronary intervention (PCI) in comparison with medical management only. The National Inpatient Sample was used to capture hospitalizations in the United States from 2006 to 2019. Admissions for NSTEMI in patients with chronic HF and ESRD were identified by International Classification of Diseases codes. The cohort was divided into those that received PCI or medical management only. In-hospital outcomes were compared by multivariable logistic regression and propensity matching. In 27,433 hospitalizations, 8,004 patients (29%) underwent PCI, and 19,429 (71%) were managed with medications only. PCI was associated with lower adjusted odds of death during hospitalization (adjusted odds ratio 0.59, 95% confidence interval 0.52 to 0.66, p <0.01). This association remained consistent after propensity matching (adjusted odds ratio 0.56, 95% confidence interval 0.49 to 0.64, p <0.01) and was apparent across all subtypes of HF. Patients with PCI had greater duration (5, 3, to 9 vs, 5, 3 to 8 days, p <0.01) and cost of hospitalization ($107,942, 70,230 to $173,182 vs, $44,156, 24,409 to $80,810, p <0.01). In conclusion, patients with HF and ESRD admitted for NSTEMI experienced lower in-hospital mortality with PCI in comparison with medical therapy only. Invasive percutaneous revascularization may be reasonable for appropriately selected patients with HF and ESRD but randomized controlled trials are needed to determine its safety and efficacy in this high-risk population.
MeSH term(s)	Humans ; United States/epidemiology ; Non-ST Elevated Myocardial Infarction/complications ; Non-ST Elevated Myocardial Infarction/epidemiology ; Non-ST Elevated Myocardial Infarction/therapy ; Percutaneous Coronary Intervention ; Treatment Outcome ; Myocardial Infarction/complications ; Myocardial Infarction/epidemiology ; Myocardial Infarction/therapy ; Heart Failure/complications ; Heart Failure/epidemiology ; Heart Failure/therapy ; Chronic Disease ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Risk Factors
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.05.007
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Article ; Online: Himalayan P Waves, Alpine A Waves.

Vlismas, Peter P / Jorde, Ulrich P / Sims, Daniel B

Circulation. Heart failure

2019 Volume 12, Issue 10, Page(s) e006235

MeSH term(s)	Action Potentials ; Adult ; Atrial Function, Right ; Atrial Pressure ; Cardiomyopathy, Restrictive/complications ; Cardiomyopathy, Restrictive/diagnosis ; Cardiomyopathy, Restrictive/physiopathology ; Cardiomyopathy, Restrictive/surgery ; Electrocardiography ; Heart Atria/physiopathology ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/physiopathology ; Heart Failure/surgery ; Heart Rate ; Heart Transplantation ; Humans ; Male ; Predictive Value of Tests
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.119.006235
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Article: Systems of Care in Cardiogenic Shock.

Alvarez Villela, Miguel / Clark, Rachel / William, Preethi / Sims, Daniel B / Jorde, Ulrich P

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 712594

Abstract: Outcomes for cardiogenic shock (CS) patients remain relatively poor despite significant advancements in primary percutaneous coronary interventions (PCI) and temporary circulatory support (TCS) technologies. Mortality from CS shows great disparities that ...

Abstract	Outcomes for cardiogenic shock (CS) patients remain relatively poor despite significant advancements in primary percutaneous coronary interventions (PCI) and temporary circulatory support (TCS) technologies. Mortality from CS shows great disparities that seem to reflect large variations in access to care and physician practice patterns. Recent reports of different models to standardize care in CS have shown considerable potential at improving outcomes. The creation of regional, integrated, 3-tiered systems, would facilitate standardized interventions and equitable access to care. Multidisciplinary CS teams at Level I centers would direct care in a hub-and-spoke model through jointly developed protocols and real-time shared decision making. Levels II and III centers would provide early access to life-saving therapies and safe transfer to designated hub centers. In regions with large geographical distances, the implementation of telemedicine-cardiac intensive care unit (CICU) care can be an important resource for the creation of effective systems of care.
Language	English
Publishing date	2021-09-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.712594
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Article ; Online: Case Report: My lung broke my heart! Takotsubo cardiomyopathy due to pneumonia.

Ahmed, Navid / Gandhi, Himali / Sims, Daniel B

F1000Research

2018 Volume 7, Page(s) 518

Abstract: Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a cardiac syndrome that often mimics acute myocardial infarction. TTC is commonly triggered by physical or emotional stress; however, acute infection is a rarer etiology. ... ...

Abstract	Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a cardiac syndrome that often mimics acute myocardial infarction. TTC is commonly triggered by physical or emotional stress; however, acute infection is a rarer etiology. This report concerns the case of an 82-year-old female who presented with non-positional and non-pleuritic chest pain, with an associated fever and cough and chest x-ray findings consistent with pneumonia. Cardiac enzymes and ECG findings were consistent with acute coronary syndrome (ACS); however, during coronary angiography, no coronary artery disease could explain the patient's ACS. A post-catheterization echocardiogram revealed an ejection fraction of 25%, with apical akinesis. A repeat echocardiogram 4 weeks after presentation showed a normal EF and normal wall motion, confirming a diagnosis of TTC.
Language	English
Publishing date	2018-04-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.14546.1
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Article ; Online: Effect of pulmonary artery pressure-guided therapy on heart failure readmission in a nationally representative cohort.

Kishino, Yoshikazu / Kuno, Toshiki / Malik, Aaqib H / Lanier, Gregg M / Sims, Daniel B / Ruiz Duque, Ernesto / Briasoulis, Alexandros

ESC heart failure

2022 Volume 9, Issue 4, Page(s) 2511–2517

Abstract: Aims: Pulmonary artery pressure (PAP)-guided therapy in patients with heart failure (HF) using the CardioMEMS (CMM) device, an implantable PAP sensor, has been shown to reduce HF hospitalizations in previous studies. We sought to evaluate the clinical ... ...

Abstract	Aims: Pulmonary artery pressure (PAP)-guided therapy in patients with heart failure (HF) using the CardioMEMS (CMM) device, an implantable PAP sensor, has been shown to reduce HF hospitalizations in previous studies. We sought to evaluate the clinical benefit of the CMM device in regard to 30, 90, and 180 day readmission rates in real-world usage. Methods and results: We queried the Nationwide Readmissions Database (NRD) to identify patients who underwent CMM implantation (International Classification of Diseases 9 and 10 codes) between the years 2014 and 2019 and studied their HF readmissions. Moreover, we compared CMM patients and their readmissions with a matched cohort of patients with HF but without CMM. Multivariable Cox regression analysis was performed to adjust for other predictors of readmissions. Prior to matching, we identified 5 326 530 weighted HF patients without CMM and 1842 patients with CMM. After propensity score matching for several patients and hospital-related characteristics, the cohort consisted of 1839 patients with CMM and 1924 with HF without CMM. Before matching, CMM patients were younger (67.0 ± 13.5 years vs. 72.3 ± 14.1 years, P < 0.001), more frequently male (62.7% vs. 51.5%, P < 0.001), with higher rates of prior percutaneous coronary intervention (16.9% vs. 13.2%, P = 0.002), peripheral vascular disease (29.6% vs. 17.8%, P < 0.001), pulmonary circulatory disorder (38.7% vs. 23.2%, P < 0.001), atrial fibrillation (51.2% vs. 45.3%, P = 0.002), prior left ventricular assist device (1.8% vs. 0.2%, P < 0.001), high income (32.2% vs. 16.4%, P < 0.001), and acute kidney disease (43.8% vs. 29.9%, P < 0.001). Readmission rates at 30 days were 17.3% vs. 20.9% for patients with vs. without CMM, respectively, and remained statistically significant after matching (17.3% vs. 21.5%, P = 0.002). The rates of 90 day (29.6% vs. 36.5%, P = 0.002) and 180 day (39.6% vs. 46.6%, P = 0.009) readmissions were lower in the CMM group. In a multivariable regression model, CMM was associated with lower risk of readmissions (hazard ratio 0.75, 95% confidence interval 0.63-0.89, P = 0.001). Conclusions: The CMM device was associated with reduced HF rehospitalization rates in a nationally representative cohort of HF patients, validating the clinical trial that led to the approval of this device and its utilization in the treatment of HF.
MeSH term(s)	Cardiac Resynchronization Therapy/methods ; Cardiac Resynchronization Therapy Devices ; Heart Failure/epidemiology ; Heart Failure/therapy ; Humans ; Male ; Patient Readmission ; Pulmonary Artery ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13956
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Article ; Online: Characteristics and Outcomes of COVID-19 Patients Supported by Venoarterial or Veno-Arterial-Venous Extracorporeal Membrane Oxygenation.

Haroun, Magued W / Patel, Snehal R / Sims, Daniel B / Jorde, Ulrich P / Goldstein, Daniel J / Saeed, Omar

Journal of cardiothoracic and vascular anesthesia

2022 Volume 36, Issue 8 Pt B, Page(s) 2935–2941

Abstract: Objectives: Cardiac injury has been reported in up to 20%-to-30% of patients with COVID-19, and severe disease can lead to cardiopulmonary failure. The role of mechanical circulatory support in these patients remains undetermined. The authors here aimed ...

Abstract	Objectives: Cardiac injury has been reported in up to 20%-to-30% of patients with COVID-19, and severe disease can lead to cardiopulmonary failure. The role of mechanical circulatory support in these patients remains undetermined. The authors here aimed to determine the characteristics and outcomes of patients with COVID-19 requiring venoarterial extracorporeal membrane oxygenation (VA ECMO) or veno-arterial-venous (VAV) ECMO support. Design and setting: A multicenter, retrospective case series. Participants: The cohort consisted of adult patients (18 years of age and older) with confirmed COVID-19 requiring VA ECMO or VAV ECMO support in the period from March 1, 2020, to April 30, 2021. Outcomes were recorded until July 31, 2021. Measurements and main results: To show factors related to death during hospitalization, patients were grouped as survivors and nonsurvivors. Kaplan-Meier analysis was used to estimate 90-day in-hospital mortality. Overall, 37 patients from 12 centers comprised the study cohort. The median patient age was 44 years old (interquartile range [IQR], 35-52), and 12 (32%) were female patients. The duration of ECMO support ranged from 2-to-132 days. At the end of the follow-up period, 13 patients (35%) were discharged or transferred alive, and 24 patients (65%) died during the hospitalization. The cumulative in-hospital mortality at 90 days was 64% (95% confidence interval: 47-81). During the time from intubation to VA ECMO or VAV ECMO initiation (1 day [IQR 0-7.5] v 6 days [IQR 2.5-14], p = 0.0383), body mass index (32 [IQR 26-36] v 37 [IQR 33-40], p = 0.009), and baseline C-reactive protein (7.15 v 38.9 mg/dL, p = 0.009) were higher in those who expired. Conclusion: Only one-third of the patients with COVID-19 requiring VA ECMO or VAV ECMO survived to discharge. Close monitoring of at-risk patients with early initiation of ECMO with circulatory support may further improve outcomes.
MeSH term(s)	Adolescent ; Adult ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation ; Female ; Hospital Mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Retrospective Studies
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.01.049
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Seroreversion of positive anti-hepatitis C virus antibodies in left ventricular assist device recipients: Now you see them, now you don't.

Sims, Daniel B / Kataria, Rachna / Rangasamy, Sabarivinoth / Jorde, Ulrich P

Artificial organs

2019 Volume 43, Issue 8, Page(s) 791–795

Abstract: The clinical significance of positive anti-hepatitis C virus (anti-HCV) antibody tests in recipients of left ventricular assist devices remains unclear. In light of emerging evidence suggesting the possibility of persistent low-level HCV infection in ... ...

Abstract	The clinical significance of positive anti-hepatitis C virus (anti-HCV) antibody tests in recipients of left ventricular assist devices remains unclear. In light of emerging evidence suggesting the possibility of persistent low-level HCV infection in patients with positive anti-HCV antibody test but negative HCV ribonucleic acid, it is very important to distinguish the truly false positive HCV antibodies, in recipients of continuous flow left ventricular assist devices, from those suggestive of a prior clinically resolved infection or one where a low-level viremia may have persisted. We conducted a retrospective analysis of left ventricular assist device recipients at our institution. While the total incidence of positive HCV antibody with concomitantly negative HCV ribonucleic acid test (19.2%) was in keeping with the incidences reported in prior cross-sectional studies, we longitudinally followed our patients and observed a 100% seroreversion. Seroreversion, which has not been reported in other studies, occurred either during continued left ventricular assist device support (10 out of 26) or after heart transplant (7 out of 26). Hundred percent seroreversion strongly suggested that the anti-HCV antibodies were truly false positive.
MeSH term(s)	Adult ; Aged ; False Positive Reactions ; Female ; Heart-Assist Devices ; Hepatitis C/blood ; Hepatitis C/diagnosis ; Hepatitis C Antibodies/blood ; Humans ; Longitudinal Studies ; Male ; Middle Aged
Chemical Substances	Hepatitis C Antibodies
Language	English
Publishing date	2019-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13433
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