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  1. Article ; Online: ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8

    Sin, Jun Hyung / Kashyap, Sujit / Acenas, Dante / Cortez, Jessica T / Lee, James / Marson, Alexander / Matloubian, Mehrdad / Waterfield, Michael R

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 208, Issue 5, Page(s) 1155–1169

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Chromatin Immunoprecipitation ; DNA Transposable Elements/genetics ; Gene Deletion ; Gene Silencing ; Histones/genetics ; Humans ; Immunologic Memory/immunology ; Interleukin-2/biosynthesis ; Interleukin-2/metabolism ; Listeria monocytogenes/immunology ; Listeriosis/immunology ; Listeriosis/microbiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Interleukin-7/biosynthesis ; Receptors, Interleukin-7/genetics ; Receptors, Interleukin-7/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism
    Chemical Substances Atf7ip protein, mouse ; DNA Transposable Elements ; Histones ; Interleukin-2 ; Receptors, Interleukin-7 ; Repressor Proteins
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  2. Article ; Online: Ikaros is a principal regulator of Aire

    Sin, Jun Hyung / Sucharov, Juliana / Kashyap, Sujit / Wang, Yi / Proekt, Irina / Liu, Xian / Parent, Audrey V / Gupta, Alexander / Kastner, Philippe / Chan, Susan / Gardner, James M / Ntranos, Vasilis / Miller, Corey N / Anderson, Mark S / Schjerven, Hilde / Waterfield, Michael R

    Science immunology

    2023  Volume 8, Issue 88, Page(s) eabq3109

    Abstract: Mutations in the gene encoding the zinc-finger transcription factor Ikaros ( ...

    Abstract Mutations in the gene encoding the zinc-finger transcription factor Ikaros (
    MeSH term(s) Humans ; Mice ; Animals ; Central Tolerance ; Cell Differentiation ; Thymus Gland ; Transcription Factors ; Gene Expression Regulation
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abq3109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The epigenetic regulator ATF7ip inhibits

    Sin, Jun Hyung / Zuckerman, Cassandra / Cortez, Jessica T / Eckalbar, Walter L / Erle, David J / Anderson, Mark S / Waterfield, Michael R

    The Journal of experimental medicine

    2019  Volume 216, Issue 9, Page(s) 2024–2037

    Abstract: T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically. Due to the role of Th17 cells ... ...

    Abstract T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically. Due to the role of Th17 cells in autoimmune pathogenesis, it is important to understand the factors that control Th17 development. Here we identify the activating transcription factor 7 interacting protein (ATF7ip) as a critical regulator of Th17 differentiation. Mice with T cell-specific deletion of
    MeSH term(s) Animals ; Cell Differentiation ; Colitis/immunology ; Colitis/pathology ; DNA, Intergenic/genetics ; Epigenesis, Genetic ; Histones/metabolism ; Interleukin-2/metabolism ; Lysine/metabolism ; Methylation ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell/metabolism ; Repressor Proteins/deficiency ; Repressor Proteins/metabolism ; Th17 Cells/cytology ; Th17 Cells/immunology
    Chemical Substances Atf7ip protein, mouse ; DNA, Intergenic ; Histones ; Interleukin-2 ; Receptors, Antigen, T-Cell ; Repressor Proteins ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20182316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.107: Show issues Location:
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    Zs.MG 45: Show issues

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  4. Article ; Online: Dietary DHA amplifies LXA

    Gao, Yuan / Su, John / Zhang, Yibing / Chan, Allison / Sin, Jun Hyung / Wu, Di / Min, Kyungi / Gronert, Karsten

    Mucosal immunology

    2018  Volume 11, Issue 6, Page(s) 1674–1683

    Abstract: Recently identified regulatory PMN control immune-driven dry eye disease (DED) in females by producing the arachidonic acid (ω-6)-derived specialized pro-resolving mediator (SPM), ... ...

    Abstract Recently identified regulatory PMN control immune-driven dry eye disease (DED) in females by producing the arachidonic acid (ω-6)-derived specialized pro-resolving mediator (SPM), LXA
    MeSH term(s) Animals ; Cells, Cultured ; Diet ; Docosahexaenoic Acids/deficiency ; Docosahexaenoic Acids/metabolism ; Dry Eye Syndromes/immunology ; Eye/immunology ; Female ; Humans ; Lipoxins/metabolism ; Lymph Nodes/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophils/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Lipoxins ; lipoxin A4 ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2018-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-018-0070-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6796: Show issues Location:
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