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Article ; Online: Molecular typing of community-acquired methicillin-resistant Staphylococcus aureus isolated from 2- to 6-year old children by staphylococcal protein A and agr typing in Isfahan, Iran

Sina Mobasherizadeh / Hasan Shojaei / Davood Azadi / Seyed Asghar Havaei / Behrooz Ataei / Farzin Khorvash

Advanced Biomedical Research, Vol 10, Iss 1, Pp 3-

2021 Volume 3

Abstract: Background: Methicillin - resistant Staphylococcus aureus (MRSA) has become a considerable public health concern in the entire world due to the rapid spread of this bacterium in human community; also the epidemiology of MRSA has changed, as the isolation ...

Abstract	Background: Methicillin - resistant Staphylococcus aureus (MRSA) has become a considerable public health concern in the entire world due to the rapid spread of this bacterium in human community; also the epidemiology of MRSA has changed, as the isolation of MRSA strains from healthy and non-healthy patients. Therefore, the objective of this study is to determine the genetic diversity and antibiotic resistance profile of community-acquired (CA)-MRSA nasal carriage in the Iranian samples. Materials and Methods: A total of 25 CA-MRSA were isolated from the anterior nares of 410 healthy preschool children. All MRSA isolates were characterized by the detection of the toxic shock syndrome toxin-1 (TSST-1) and typed by γ-hemolysin genes, agr groups, and staphylococcal protein A (spa) typing. Kirby-Buyer antibiotic susceptibility testing was performed and interpreted as per the standard guidelines. Results: A total of 25 (6.1%) MRSA isolates were recovered from the anterior nares of 410 preschool children. Sixteen isolates (64%) were positive for the TSST-1 gene. Three agr specificity groups were determined, as follows: eight (32%) isolates belonged to agr Group I, five (20%) isolates belonged to agr Group II, and 12 (48%) isolates belonged to agr Group III. The repeated profiles of these spa types of 25 isolates were organized into eight different lineages groups. Five of lineages contained a single strain, three of lineages contained two strains, and three of lineages consisted of more than three strains. Conclusions: The results of our study show that the rate of MRSA in our region is significantly high. Additionally, spa type t037 was the predominant type among CA S. aureus.
Keywords	agr protein ; methicillin-resistant staphylococcus aureus ; staphylococcal protein a ; toxic shock syndrome toxin 1 ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biofilm Formation in Nonmultidrug-resistant Escherichia coli Isolated from Patients with Urinary Tract Infection in Isfahan, Iran

Farkhondeh Poursina / Shima Sepehrpour / Sina Mobasherizadeh

Advanced Biomedical Research, Vol 7, Iss 1, Pp 40-

2018 Volume 40

Abstract: Background: Escherichia coli is a Gram-negative, opportunistic human pathogen in which increasing antibiotic resistance is a great concern for continued human survival. Although biofilm formation is a mechanism that helps E. coli to survive in ... ...

Abstract	Background: Escherichia coli is a Gram-negative, opportunistic human pathogen in which increasing antibiotic resistance is a great concern for continued human survival. Although biofilm formation is a mechanism that helps E. coli to survive in unfavorable conditions, according to the importance of biofilm formation in developing the antibiotic resistance here, we studied the relation between antibiotic resistance and in vitro qualitative rating method biofilm formation in E. coli isolated from patients with urinary tract infection (UTI). Materials and Methods: The clinical isolates of E. coli (n = 100) were collected from urine of patients with UTI attending Isfahan Alzahra hospital. The strains were confirmed as E. coli using biochemical tests and molecular method. The Kirby-Bauer disk diffusion tests were done according to the Clinical and Laboratory Standards Institute protocol, and the biofilm synthesis was performed by microplate method. The binary logistic test was applied and P < 0.05 was considered statistically significant. Results: Our results showed a high outbreak of multidrug-resistant (MDR) E. coli strains (73%) and the highest resistance was observed toward ampicillin. The prevalence of biofilm producer isolates was 80% that 29% produced strong biofilm. The distribution of non-MDR isolates was high among strong biofilm producers, which shows a significant negative correlation between biofilm production and MDR pattern (P < 0.001). Conclusions: We found a negative correlation between MDR phenotype and biofilm formation capacity. This transmits the concept that more antibiotic susceptibility of strong biofilm producers may be due to the reduced exposure to multiple antibiotics.
Keywords	Antibiotic resistance ; biofilm formation ; Escherichia coli ; urinary tract infections ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of the Prevalence of Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) among Staphylococcus aureus Isolates in a Burn Unit with Non-Burning Units

Hossein SEDAGHAT / Tahmineh NARIMANI / Bahram NASR ESFAHANI / Sina MOBASHERIZADEH / Seyed Asghar HAVAEI

Iranian Journal of Public Health, Vol 50, Iss

2020 Volume 1

Abstract: Background: Staphylococcus aureus (S. aureus) is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections. Methods: Overall, 85 S. aureus isolates were isolated from clinical and nasal hospitalized ... ...

Abstract	Background: Staphylococcus aureus (S. aureus) is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections. Methods: Overall, 85 S. aureus isolates were isolated from clinical and nasal hospitalized patients and health care workers (HCWs) in a burn unit and non-burn units in Isfahan from June 2016 and September 2016. Genes encoding penicillin-binding protein 2a (mecA) and adhesive surface proteins, including fibronectin-binding proteins (fnbA, fnbB), fibrinogen binding protein (fib), laminin-binding protein(eno), collagen binding protein (cna), elastin binding protein (ebps), intracellular adhesion operon (icaA and icaD) were detected using PCR method. Results: The rate of methicillin-resistant S. aureus (MRSA) among burn and non-burn isolates were 62% (18/29) and 25% (14/56), respectively. The most prevalent MSCRAMMs genes in burn units were eno (86%) and fib (66%). The most common gene pattern in burn center was icaA+fib+eno. The frequency of icaD, fib and ebpS was higher in clinical samples than nasal samples. No relation was found between the MSCRAMMs genes in the burn unit and non-burn units. Conclusion: The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of icaD, fib and ebpS in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of S. aureus.
Keywords	Staphylococcus aureus ; Methicillin-resistant S. aureus ; Surface proteins ; Proteins ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: بررسی شیوع ژن CTX-M در سویه‌های Escherichia coli جدا شده از عفونت ادراری در دو گروه از بیماران سرپایی و بستری شهر اصفهان

Mehdi Mobasherizadeh / Seyed Kazem Bidoki / Sina Mobasherizadeh

مجله دانشکده پزشکی اصفهان, Vol 33, Iss 360, Pp 2019-

2016 Volume 2025

Abstract: مقدمه: افزایش شیوع بتا لاکتامازهای گروه CTX-M در جهان در برخی از پاتوژن‌های گرم منفی باعث نگرانی جامعه‌ی پزشکی شده است. هدف از این مطالعه، بررسی فراوانی نسبی باکتری‌های Escherichia coli تولید کننده‌ی بتا لاکتاماز وسیع‌الطیف (ESBL یا Extended-spectrum ... ...

Abstract	مقدمه: افزایش شیوع بتا لاکتامازهای گروه CTX-M در جهان در برخی از پاتوژن‌های گرم منفی باعث نگرانی جامعه‌ی پزشکی شده است. هدف از این مطالعه، بررسی فراوانی نسبی باکتری‌های Escherichia coli تولید کننده‌ی بتا لاکتاماز وسیع‌الطیف (ESBL یا Extended-spectrum beta-lactamase)، فراوانی ژن CTX-M و الگوی مقاومت آنتی‌بیوتیکی در بیماران مبتلا به عفونت‌های ادراری ناشی از باکتری Escherichia coli در دو گروه بیمارستانی و سرپایی در شهر اصفهان در سال 1392 بود. روش‌ها: این مطالعه بر روی 120 نمونه‌ی باكتری Escherichia coli جدا شده از بیماران سرپایی و بستری مبتلا به عفونت ادراری انجام شد. جهت تعیین حساسیت آنتی‌بیوتیکی، از روش Disc diffusion استفاده شد. سویه‌های تولید کننده‌ی ESBL با استفاده از روش Combined disc تأیید شد و با روش PCR (Polymerase chain reaction) از نظر ژن CTX-M مورد بررسی قرار گرفتند. از نرم‌افزار WHONET 5.6 و آزمون Excel جهت واکاوی داده‌ها استفاده شد. یافته‌ها: از مجموع 120 سویه‌ی Escherichia coli، به ترتیب در گروه‌های سرپایی و بستری، 12 مورد (0/20 درصد) و 33 مورد (0/55 درصد) ESBL مثبت بودند. مقاومت به آمپی‌سیلین و کوتریماکسازول در گروه سرپایی به ترتیب 4/84 و 1/60 درصد و در گروه بستری 9/94 و 8/84 درصد گزارش شد. با استفاده از روش PCR، مشخص شد که 30 سویه، واجد ژن CTX-M بودند. نتیجه‌گیری: تولید ESBL در ایزوله‌های بیمارستانی، تهدید بزرگی برای مصرف آنتی‌بیوتیک‌های وسیع‌الطیف است. با توجه به حضور ژن CTX-M در درصد بالایی از این سویه‌ها، مطالعات بیشتر ملکولی و اپیدمیولوژیک در محیط‌های درمانی ضروری می‌باشد.
Keywords	Urinary tract infection ; Escherichia coli ; CTX-M ; ESBL ; Medicine ; R ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2016-01-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High Prevalence of Multiple Drug Resistance among ESBLs-Producing Klebsiella pneumoniae Isolated from Hospitalized Patients in Isfahan, Iran

Zahra Tahanasab / Sina Mobasherizadeh / Mehdi Moghadampour / Aliakbar Rezaei / Nafiseh Maleki / Jamshid Faghri

Journal of Medical Bacteriology, Vol 5, Iss 5-

2017 Volume 6

Abstract: Background: This study was to evaluate the prevalence of CTX-Mand TEM type ESBLs-producing K. pneumoniae and determination of MDR, XDR, and PDR phenotypes of these isolates as well as find out the genetic relationship and molecular typing of these ... ...

Abstract	Background: This study was to evaluate the prevalence of CTX-Mand TEM type ESBLs-producing K. pneumoniae and determination of MDR, XDR, and PDR phenotypes of these isolates as well as find out the genetic relationship and molecular typing of these isolates using phenotypic and genotypic methods. Methods: Non-repetitive 96 K. pneumonia isolates were isolated from hospitalized patients in Al-Zahra hospital of Isfahan, Iran. The antibiotic susceptibility test was assessed for 20 antibiotics using Kirby-Bauer disk diffusion method. The frequency of ESBL-producing isolates was determined by phenotypic confirmatory test. All ESBLs-producing isolates were assessed for blaTEM and blaCTX-M genes using PCR method. Molecular typing was performed by enterobacterial repetitive intergenic consensus sequence-based PCR (ERIC-PCR). Results: Among 96 isolates, 58 isolates (60.4%) were ESBL-producers. In this study, 85.7% and 30.3% of ESBL-producing isolates showed MDR and XDR phenotypes, respectively. No PDR isolate was found. PCR amplification on ESBL-producing isolates showed that 47 (81%) isolates were carried blaTEM gene, while blaCTX-M was detected in all isolates (100%). ERIC-PCR typing was characterized the high genetic similarity among ESBL-producing K. pneumonia isolates and revealed 32 band pattern for the isolates. Conclusion: This study showed high prevalence of important ESBL genes (blaCTX-M and blaTEM genes) among the K. pneumoniae isolated from in-patients. Constant following of ESBLs, also identification of their types, in bacteria isolated from hospitalized patients has an important clinical impact. It can provide valuable information for the choice of appropriate antibacterial therapy and decrease of antibiotic resistance.
Keywords	Klebsiella pneumoniae ; MDR ; ESBLs ; TEM ; CTX-M ; ERIC-PCR ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation and Identification of Carbapenemase KPC Producing Strains of Enterobacteriaceae and Determination of Their Antibiotic Susceptibility Patterns

Dariush Shokri / Sina Mobasherizadeh / Masoumeh Norouzi Baruq / Majid Yaran

مجله دانشکده پزشکی اصفهان, Vol 31, Iss 248, Pp 1247-

2013 Volume 1256

Abstract: Background: The aim of this study was to isolate and identify KPC (Klebsiella pneumonia carbapenemase) enzyme producing strains of Enterobacteriaceae, and determine their antibiotic susceptibility pattern in three hospitals of Isfahan, Iran. This subject ...

Abstract	Background: The aim of this study was to isolate and identify KPC (Klebsiella pneumonia carbapenemase) enzyme producing strains of Enterobacteriaceae, and determine their antibiotic susceptibility pattern in three hospitals of Isfahan, Iran. This subject has not previously been investigated comprehensively. Methods: KPC detection was done by Modified Hodge Test (MHT) and their antibiotic susceptibility patterns were determined by disc diffusion method. Findings: The total of 475 strains were isolated and detected as Enterobacteriaceae during the period of 9 months (July 2012-March 2013) in three hospitals in Isfahan province, Iran. These isolates contained Escherichia coli: 285 strains (60%), Klebsiella: 128 strains (27%), Enterobacter aerogenes: 16 strains (3.4%), Enterobacter cloacae: 9 strains (1.9%), Proteus vulgaris: 12 strains (2.5%), Proteus mirabilis: 4 strains (0.84%), Citrobacter freundii: 8 strains (1.7%), Citrobacter diversus: 3 strains (0.6%), Serratia marcescens: 3 strains (0.6%), Shigella sonnei: 4 strains (0.84%), Salmonella paratyphi A: 2 strains (0.42%), and Providencia stuartii: 1 strain (0.2%). Percentage resistant to ceftazidime and cefotaxime and non-susceptibility to imipenem and meropenem for above isolates were, respectively, as follows: for Escherichia coli isolates 60, 63, 6, and 9; for Klebsiella isolates 70, 75, 55, and 58; for Klebsiella pneumoniae 100, 100, 95, and 94; and for other Enterobacteriaceae isolates 20, 17, 5, and 3. Our results showed that KPC test was positive for 2 isolates (0.7%) among Escherichia coli strains, 65 (87%) isolates among Klebsiella pneumoniae, and 1 isolate (6%) among Proteus strains . This was approved by Etest based MIC method. Conclusion: In general, our results showed that among Enterobacteriaceae isolates, Klebsiella pneumoniae isolates had higher KPC enzyme production, and most strains had multidrug resistant.
Keywords	Enterobacteriaceae ; Klebsiella pneumoniae ; Klebsiella pneumoniae carbapenemase (KPC) ; Etest method ; Modified Hodge Test (MHT) ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	570
Language	Persian
Publishing date	2013-10-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation and Purification of an Ultraviolet-Stable Bacteriocin Produced by Enterococcus Faecium Strain DSH20 against Listeria monocytogenes

Dariush Shokri / Saeideh Zaghian / Hossein Fazeli / Sina Mobasherizadeh / Behrooz Ataei

مجله دانشکده پزشکی اصفهان, Vol 31, Iss 236, Pp 649-

2013 Volume 660

Abstract: Background: Furthermore application of bacteriocins as alternates for antibiotics, they are fermented as food preservation currently. The aim of this study was isolation and purification of ultraviolet-resistant bacteriocins from enterococci strains ... ...

Abstract	Background: Furthermore application of bacteriocins as alternates for antibiotics, they are fermented as food preservation currently. The aim of this study was isolation and purification of ultraviolet-resistant bacteriocins from enterococci strains active against Listeria monocytogenes. Methods: Different strains of enterococci bacteria were isolated and identified from various clinical specimens and bacteriocin production were evaluated against strains of Listeria monocytogenes. An isolate of enterococcus bacteria that produce significant bacteriocin against all studied strains of Listeria monocytogenes was identified based on its phenotypical and biochemical properties as well as its 16SrRNA gene sequencing. In the next stage, this bacteriocin was purified and the effects of proteolytic enzymes, pH, temperature and ultraviolet radiation (UV) on its activity were tested and its molecular weight was determined by SDS-PAGE (Sodium dodecyl sulfate polyacrylamide gel electrophoresis) method. Findings: 17 strains of enterococci were isolated and five isolates exhibited an inhibitory effect against Listeria monocytogenes strains and among them, one enterococcus had inhibitory effect against all four strains of Listeria monocytogenes. This enterococcus was identified as Enterococcus faecium strain DSH20 (access number: JX567733.1). Using proteolytic enzymes led to the loss of antimicrobial activity; so, protein nature of it was confirmed. Bacteriocin production was resistant to UV, high temperature and pH changes. The molecular weight of the bacteriocin was at approximately 35 kilodaltons. Conclusion: Biochemical properties of this bacteriocin, such as thermal stability, resistance to UV radiation and pH, were significant. These properties present it as an alternative of antimicrobial agents against Listeria monocytogenes and preserving of fermented foods.
Keywords	Bacteriocin ; Vancomycin-resistant enterococcus ; Listeria monocytogenes ; Listeriosis ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	570
Language	Persian
Publishing date	2013-07-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Relative Frequency of Clostridium Difficile in Fecal Samples of Hospitalized Patients with Diarrhea by ELISA Method

Mohammad Reza Nasri / Farzin Khorvash / Mohammad Reza Zolfaghari / Sina Mobasherizadeh

مجله دانشکده پزشکی اصفهان, Vol 29, Iss 167, Pp 2376-

2012 Volume 2382

Abstract: Background: The present study was conducted to evaluate the relative frequency of Clostridium difficile (C. difficile) in patients at a university hospital, Isfahan, Iran. Methods: This descriptive, analytic study was conducted on 162 patients ... ...

Abstract	Background: The present study was conducted to evaluate the relative frequency of Clostridium difficile (C. difficile) in patients at a university hospital, Isfahan, Iran. Methods: This descriptive, analytic study was conducted on 162 patients hospitalized in various wards of Alzahra Hospital (an 800-bed teaching hospital) of Isfahan during October 2009 to March 2010. Fecal samples of patients who suffered from diarrhea after receiving antibiotics were collected. Microbial analysis was performed to determine the existence of C. difficile. C. difficile toxins (A and B) were detected by ELISA method. The obtained data was statistically analyzed using chi-square test in SPSS at a significance level of P < 0.05. Findings: C. difficile toxins were detected in 36 (22.2%) patients. The frequency of toxins occurrence was significantly higher in men (P ≤ 0.005). In addition, a large number of individuals infected by C. difficile toxins were children under 4 years of age. Ceftriaxone caused many cases of diarrhea in our studied population. Conclusion: In general, based on our results, wrong prescription and antibiotics abuse can cause infection with C. difficile in patients receiving antibiotics. Therefore, the physicians must pay more attention to the recovery of patients with antibiotics.
Keywords	Clostridium difficile ; Antibiotic-associated diarrhea ; Toxin A and B ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2012-02-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antibacterial effect of triantibiotic mixture, chlorhexidine gel, and two natural materials Propolis and Aloe vera against Enterococcus faecalis

Leila Bazvand / Mohammad Ghasem Aminozarbian / Alireza Farhad / Hamid Noormohammadi / Seyed Mohsen Hasheminia / Sina Mobasherizadeh

Dental Research Journal, Vol 11, Iss 4, Pp 469-

An ex vivo study

2014 Volume 474

Abstract: Background: The aim of this ex vivo study was to compare the antimicrobial effect of triantibiotic paste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin. Materials and Methods: Ninety fresh extracted single-rooted ... ...

Abstract	Background: The aim of this ex vivo study was to compare the antimicrobial effect of triantibiotic paste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin. Materials and Methods: Ninety fresh extracted single-rooted teeth were used in a dentin block model. Seventy-five teeth were infected with E. faecalis and divided into four experimental groups (n = 15). Experimental groups were treated with triantibiotic mixture with distilled water, 0.2% chlorhexidine gel, 70% ethanol + Propolis and Aloe vera. Fifteen teeth treated with distilled water as the positive control and 15 samples, free of bacterial contamination, were considered as the negative control. Gates-Glidden drill #4 was used for removal of surface dentin and Gates-Glidden drill #5 was used to collect samples of deep dentin. The samples were prepared and colony-forming units were counted. Data were analyzed by one-way ANOVA and post hoc Tukey tests. Statistical significance was defined at P < 0.05. Results: Triantibiotic mixture group exhibited the least bacterial growth. However, the rate of bacterial growth showed no significant differences between chlorhexidine and Propolis groups (P > 0.05). Aloe vera had antibacterial effects on E. faecalis, but in comparison with other medicaments, it was less effective (P < 0.05). Conclusion: This experimental study showed that triantibiotic mixture, 0.2% chlorhexidine gel, Propolis and Aleo vera were relatively effective against E. faecalis. All the intracanal medicements had similar effects on E. faecalis in deep dentin except for Aloe vera.
Keywords	Aloe vera ; chlorhexidine gel ; Enterococcus faecalis ; intracanal medicaments ; propolis ; triantibiotic mixture ; Medicine ; R ; Dentistry ; RK1-715
Subject code	630
Publishing date	2014-01-01T00:00:00Z
Publisher	Isfahan University of Medical Sciences
Document type	Article ; Online
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Article ; Online: A Comparison of Antibiotic Susceptibility Patterns of Klebsiella Associated Urinary Tract Infection in Spinal Cord Injured Patients with Nosocomial Infection

Farzin Khorvash / Kamyar Mostafavizadeh / Sina Mobasherizadeh / Mohaddeseh Behjati

Acta Medica Iranica, Vol 47, Iss

2009 Volume 6

Abstract: Just regarding different risk factors for antibiotic resistant uropathogenes, it seems justice to improve diagnostic power for drug resistant uropathogenes and well appropriate empirical therapy. 300 and 145 cases of clinicopathologically diagnosed ... ...

Abstract	Just regarding different risk factors for antibiotic resistant uropathogenes, it seems justice to improve diagnostic power for drug resistant uropathogenes and well appropriate empirical therapy. 300 and 145 cases of clinicopathologically diagnosed nosocomial and spinal cord injured (SCI) associated urinary tract infection (UTI), respectively, were considered as our samples included in our 24 months study (2005 and 2006). 50 (16.6%) and 26 (17.9%) correctly diagnosed Klebsiella, respectively, were cultured from our specimens . MIC pattern of this uropathogenes for 8 antibiotics was determined by gradient concentration method. The prevalence of antibiotic resistant Klebsiella was more among nosocomial associated UTI rather than SCI UTI (P<0.05). According to susceptibility cut-off point criteria of CLSI M7-A6 (Clinical and Laboratory Standard Institute), Klebsiella resistance rate of nosocomial and SCI were 40% and 0 in amikacin (P <0.0001), 86.2% and 16.7% in ceftazidime (P<0.001), 69% and 25% in ceftriaxon (P<0.005), 5.1% and 0 in imipenem (P<0.0001), 50% and 25% in ciprofloxacin (P< 0.05), 81% and 22.2% in gentamicin 100%and 62.5% (P<0.001) in trimethoprim/sulfamethoxazole (P<0.05 ) respectively. Only resistance to nalidixic acid was mildly higher in SCI Klebsiella (68.8%, 66.7%). MIC 50 of all antibiotics except nalidixic acid and trimethoprim/sulfamethoxazole were higher in nosocomial Klebsiella (P<0.05). In conclusion although the whole risk factors for UTI in the cases of SCI associated UTI are more than for nosocomial UTI. Interestingly, the prevalence of Klebsiella resistant UTI was more in the second group.
Keywords	Klebsiella ; urinary tract infection ; spinal cord injuries ; anti-bacterial agents ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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