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  1. Book: Das Ende des Alterns

    Sinclair, David A. / LaPlante, Matthew D. / Vogel, Sebastian / Delphia, Catherine L.

    die revolutionäre Medizin von morgen

    2019  

    Title translation Lifespan
    Author's details Prof. Dr. David A. Sinclair mit Prof. Matthew D. LaPlante ; aus dem Englischen von Dr. Sebastian Vogel ; mit Illustrationen von Catherine L. Delphia
    Keywords Evolution ; Essay & ; Sachbuch ; Gene ; Genetik ; Biologie ; Sirtuine ; Hundertfünfzig werden ; Altern ; ewige jugend ; unsterblichkeit ; Menschheitstraum ; pop science ; harvard medical school ; Epigenetik ; Medizin der Zukunft ; krebs ; diabetes ; alzheimer ; epigenom
    Subject Alterungsprozess ; Altwerden ; Seneszenz ; Alterung
    Subject code 500
    Language German
    Size 511 Seiten, Illustrationen, 20.8 cm x 13.4 cm
    Edition Erste Auflage
    Publisher DuMont
    Publishing place Köln
    Publishing country Germany
    Document type Book
    HBZ-ID HT020235224
    ISBN 978-3-8321-8104-8 ; 3-8321-8104-0 ; 9783832184797 ; 3832184791
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 1375 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Restricting mealtime ameliorates neurodegeneration.

    Tian, Xiao / Sinclair, David A

    Cell metabolism

    2023  Volume 35, Issue 10, Page(s) 1673–1674

    Abstract: Alzheimer's disease is often accompanied by disruptions in circadian rhythms, which may exacerbate the disease's progression. In this issue, Whittaker and colleagues demonstrate that the modulation of circadian rhythms by time-restricted feeding can ... ...

    Abstract Alzheimer's disease is often accompanied by disruptions in circadian rhythms, which may exacerbate the disease's progression. In this issue, Whittaker and colleagues demonstrate that the modulation of circadian rhythms by time-restricted feeding can alter the disease trajectory in Alzheimer's mouse models.
    MeSH term(s) Animals ; Mice ; Circadian Rhythm ; Alzheimer Disease ; Disease Models, Animal ; Meals
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human trials exploring anti-aging medicines.

    Guarente, Leonard / Sinclair, David A / Kroemer, Guido

    Cell metabolism

    2024  Volume 36, Issue 2, Page(s) 354–376

    Abstract: Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, ... ...

    Abstract Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD
    MeSH term(s) Humans ; NAD ; Aging ; Metformin/pharmacology ; Metformin/therapeutic use ; Cardiovascular Diseases ; Neoplasms
    Chemical Substances NAD (0U46U6E8UK) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.12.007
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  4. Article ; Online: Sirtuin Evolution at the Dawn of Animal Life.

    Gold, David A / Sinclair, David A

    Molecular biology and evolution

    2022  Volume 39, Issue 9

    Abstract: Sirtuins are a family of proteins that protect against cellular injury and aging; understanding their evolution should reveal fundamental mechanisms governing longevity. "Early-branching" animals such as sea sponges and jellyfish have been understudied ... ...

    Abstract Sirtuins are a family of proteins that protect against cellular injury and aging; understanding their evolution should reveal fundamental mechanisms governing longevity. "Early-branching" animals such as sea sponges and jellyfish have been understudied in previous analyses of sirtuin diversity. These organisms not only hold important positions at the base of the evolutionary tree, but also have unique aging dynamics that defy convention, such as quasi-immortality and high regenerative capacity. In this study, we survey the evolution of sirtuin proteins in animals, with a focus on the oldest living lineages. We describe previously unrecognized expansions of "Class IV" and "Class I" sirtuins around the origin of animals, raising the number of sirtuin families in the last common ancestor to at least nine. Most of these undescribed sirtuins have been lost in vertebrates and other bilaterian animals. Our work also clarifies the evolution of PNC1 and NAMPT enzymes that carry out the rate-limiting step in sirtuin-related NAD+ biosynthesis. The genes for PNC1 and NAMPT enzymes were both present in the first animals, with the genes being lost a minimum of 11 and 13 times, respectively, over the course of animal evolution. We propose that species with these ancestral gene repertoires are ideal model organisms for studying the genetic regulation of animal longevity and will provide clues to increasing longevity in humans.
    MeSH term(s) Aging ; Animals ; Humans ; Longevity/genetics ; NAD ; Sirtuins/genetics ; Sirtuins/metabolism ; Vertebrates/metabolism
    Chemical Substances NAD (0U46U6E8UK) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msac192
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  5. Article ; Online: Response to: The information theory of aging has not been tested.

    Yang, Jae-Hyun / Hayano, Motoshi / Rajman, Luis A / Sinclair, David A

    Cell

    2024  Volume 187, Issue 5, Page(s) 1103–1105

    MeSH term(s) Aging ; Information Theory ; Humans ; Animals
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Letter
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.014
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  6. Article ; Online: The Information Theory of Aging.

    Lu, Yuancheng Ryan / Tian, Xiao / Sinclair, David A

    Nature aging

    2023  Volume 3, Issue 12, Page(s) 1486–1499

    Abstract: Information storage and retrieval is essential for all life. In biology, information is primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a foundational blueprint and the epigenome, consisting of chemical modifications ... ...

    Abstract Information storage and retrieval is essential for all life. In biology, information is primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a foundational blueprint and the epigenome, consisting of chemical modifications to DNA and histone proteins, regulates gene expression patterns and endows cells with specific identities and functions. Unlike the stable, digital nature of genetic information, epigenetic information is stored in a digital-analog format, susceptible to alterations induced by diverse environmental signals and cellular damage. The Information Theory of Aging (ITOA) states that the aging process is driven by the progressive loss of youthful epigenetic information, the retrieval of which via epigenetic reprogramming can improve the function of damaged and aged tissues by catalyzing age reversal.
    MeSH term(s) Epigenesis, Genetic ; DNA Methylation ; Information Theory ; Histones/genetics
    Chemical Substances Histones
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-023-00527-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes.

    Amorim, João A / Sinclair, David A

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2310, Page(s) 301–309

    Abstract: Metabolic flexibility is vital for organisms to respond to and survive changes in energy availability. A critical metabolic flexibility regulator is peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), which regulates various ... ...

    Abstract Metabolic flexibility is vital for organisms to respond to and survive changes in energy availability. A critical metabolic flexibility regulator is peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), which regulates various transcription factors and nuclear receptors that, in turn, regulate mitochondrial homeostasis and fatty acid oxidation. PGC-1α is itself regulated, with one of the significant modes of regulation being acetylation. Thus, measuring the acetylation status of PGC-1α is a critical indicator of cells' metabolic flexibility. In this chapter, we describe a method of evaluating PGC-1α acetylation in primary mouse myotubes. This method can also be used with other cell types and tissues.
    MeSH term(s) Acetylation ; Animals ; Biomarkers/metabolism ; Cell Separation ; Cells, Cultured ; Energy Metabolism ; Mice ; Mitochondria, Muscle/metabolism ; Muscle Fibers, Skeletal/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Primary Cell Culture ; Protein Processing, Post-Translational ; Transfection
    Chemical Substances Biomarkers ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Ppargc1a protein, mouse
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1433-4_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: NAD

    Zheng, Minyan / Schultz, Michael B / Sinclair, David A

    Trends in immunology

    2022  Volume 43, Issue 4, Page(s) 283–295

    Abstract: ... ...

    Abstract NAD
    MeSH term(s) COVID-19 ; Humans ; Inflammasomes/metabolism ; NAD/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Virus Diseases
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NAD (0U46U6E8UK)
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.02.001
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  9. Article ; Online: Epigenetic changes during aging and their reprogramming potential.

    Kane, Alice E / Sinclair, David A

    Critical reviews in biochemistry and molecular biology

    2019  Volume 54, Issue 1, Page(s) 61–83

    Abstract: The aging process results in significant epigenetic changes at all levels of chromatin and DNA organization. These include reduced global heterochromatin, nucleosome remodeling and loss, changes in histone marks, global DNA hypomethylation with CpG ... ...

    Abstract The aging process results in significant epigenetic changes at all levels of chromatin and DNA organization. These include reduced global heterochromatin, nucleosome remodeling and loss, changes in histone marks, global DNA hypomethylation with CpG island hypermethylation, and the relocalization of chromatin modifying factors. Exactly how and why these changes occur is not fully understood, but evidence that these epigenetic changes affect longevity and may cause aging, is growing. Excitingly, new studies show that age-related epigenetic changes can be reversed with interventions such as cyclic expression of the Yamanaka reprogramming factors. This review presents a summary of epigenetic changes that occur in aging, highlights studies indicating that epigenetic changes may contribute to the aging process and outlines the current state of research into interventions to reprogram age-related epigenetic changes.
    MeSH term(s) Aging ; Animals ; Cellular Reprogramming ; Chromatin/genetics ; CpG Islands ; DNA Methylation ; Epigenesis, Genetic ; Humans
    Chemical Substances Chromatin
    Language English
    Publishing date 2019-03-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1000977-2
    ISSN 1549-7798 ; 1381-3455 ; 1040-9238
    ISSN (online) 1549-7798
    ISSN 1381-3455 ; 1040-9238
    DOI 10.1080/10409238.2019.1570075
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  10. Article ; Online: Frailty biomarkers in humans and rodents: Current approaches and future advances.

    Kane, Alice E / Sinclair, David A

    Mechanisms of ageing and development

    2019  Volume 180, Page(s) 117–128

    Abstract: Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, ... ...

    Abstract Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty.
    MeSH term(s) Aging/metabolism ; Aging/pathology ; Animals ; Biomarkers/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Female ; Frailty/metabolism ; Frailty/pathology ; Humans ; Inflammation Mediators/metabolism ; Interleukin-6/metabolism ; Male ; Mice ; Rats
    Chemical Substances Biomarkers ; Brain-Derived Neurotrophic Factor ; IL6 protein, human ; Inflammation Mediators ; Interleukin-6 ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2019-04-17
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2019.03.007
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