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  1. Article ; Online: Eosinophilic granulomatosis with polyangiitis associated with abducens nerve palsy.

    Toma, Chiara / Sindaco, Daniele / Musolino, Maria / Traverso, Carlo Enrico / Iester, Michele / Vagge, Aldo

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2022  

    Abstract: We present the case of a 61-year-old man who reported diplopia due to a right abducens nerve palsy. The patient complained of fever every night (37.5° C), paresthesia of the second and third hand fingers, and he showed an increased C-reactive protein, ... ...

    Abstract We present the case of a 61-year-old man who reported diplopia due to a right abducens nerve palsy. The patient complained of fever every night (37.5° C), paresthesia of the second and third hand fingers, and he showed an increased C-reactive protein, high erythrocyte sedimentation rate, and high eosinophilia. He had a history of allergic asthma, chronic rhinosinusitis, and surgically treated nasal polyps. His past medical history and labs led us to identify the eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome. EGPA is a potentially life-threatening condition, and a proper diagnosis was critical to managing this patient's abducens nerve palsy.
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2022.08.266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Trabeculectomy versus Xen gel implant for the treatment of open-angle glaucoma: a 3-year retrospective analysis.

    Cappelli, Francesca / Cutolo, Carlo Alberto / Olivari, Sara / Testa, Valeria / Sindaco, Daniele / Pizzorno, Chiara / Ciccione, Sara / Traaverso, Carlo Enrico / Iester, Michele

    BMJ open ophthalmology

    2022  Volume 7, Issue 1, Page(s) e000830

    Abstract: Objective: To compare the two surgical techniques in terms of efficacy, safety, and postoperative management over 36 months of follow-up.: Methods: This retrospective clinical cohort study compared the outcome of trabeculectomy surgery and Xen gel ... ...

    Abstract Objective: To compare the two surgical techniques in terms of efficacy, safety, and postoperative management over 36 months of follow-up.
    Methods: This retrospective clinical cohort study compared the outcome of trabeculectomy surgery and Xen gel implant in patients having uncontrolled glaucoma. Patients were recruited using the following inclusion criteria: uncontrolled intraocular pressure (IOP) on maximally tolerated medical therapy, healthy conjunctiva freely mobile in the superior sector, open-angle, glaucomatous visual field damage, full follow upfollow-up of at least 36 months. Thirty-four patients were submitted to trabeculectomy and 34 to Xen gel implant. We set the lower limit at 6mmHg mm Hg and the upper limit ≤12 mm Hg for criteria A, upper limit to ≤15 mm Hg for criteria B and upper limit ≤18 mm Hg for criteria C. Criteria for success have been characterizedcharacterised according to whether or not this has been achieved without (complete success) or with IOP -lowering medications (qualified success).
    Results: For all survival curves, trabeculectomy was superior to Xen gel implant. When considering complete success, the log-rank test for criteria A was statistically significant (pp=0.006), marginally significant for criteria B (pp=0.065) and not significant for criteria C (pp=0.23). When qualified success was considered, trabeculectomy was superior to Xen gel for criteria A, B, and C (pp=0.012, pp=0.033 and pp=0.025, respectively). Higher number of post-operative flat chamber and bleb leakage was observed in the trabeculectomy group.
    Conclusion: Xen gel implant techniques offer a better safety profile but a lower IOP reduction compared to compared with the gold -standard technique.
    MeSH term(s) Cohort Studies ; Glaucoma/surgery ; Glaucoma, Open-Angle/surgery ; Humans ; Retrospective Studies ; Trabeculectomy/methods ; Treatment Outcome
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2397-3269
    ISSN (online) 2397-3269
    DOI 10.1136/bmjophth-2021-000830
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  3. Article: Recombinant Human Nerve Growth Factor (Cenegermin)-Driven Corneal Wound Healing Process: An Evidence-Based Analysis.

    Bonzano, Chiara / Olivari, Sara / Cutolo, Carlo Alberto / Macrì, Angelo / Sindaco, Daniele / Borroni, Davide / Bonzano, Elisabetta / Traverso, Carlo Enrico

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 760507

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.760507
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  4. Article ; Online: Ophthalmologic evaluation in vitamin-E deficiency: A case report.

    Sindaco, Daniele / Cappelli, Francesca / Vagge, Aldo / Traverso, Carlo E / Iester, Michele

    European journal of ophthalmology

    2020  Volume 32, Issue 1, Page(s) NP254–NP257

    Abstract: A 41-year-old woman has come to our attention complaining of decreased visual acuity and monocular diplopia associated with upper and lower limb hypoesthesia. Malabsorption syndrome with vitamin A and E deficiency developed after a bariatric ... ...

    Abstract A 41-year-old woman has come to our attention complaining of decreased visual acuity and monocular diplopia associated with upper and lower limb hypoesthesia. Malabsorption syndrome with vitamin A and E deficiency developed after a bariatric biliopancreatic diversion. The clinical ophthalmological signs and symptoms improved after oral vitamin supplementation therapy. The past medical history is essential in the case of a patient complaining of visual symptoms compatible with vitamin deficiency in order to detect the cause and to start a prompt therapy to avoid irreversible neurological and visual sequelae. The clinical features of our case closely resemble other cases described in the literature of patients affected by vitamin A and E deficiency secondary to malabsorption syndrome.
    MeSH term(s) Adult ; Biliopancreatic Diversion ; Female ; Humans ; Malabsorption Syndromes/diagnosis ; Malabsorption Syndromes/etiology ; Vitamins/therapeutic use
    Chemical Substances Vitamins
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120970112
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    Zs.A 3342: Show issues Location:
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  5. Article ; Online: Blue light filtering ophthalmic lenses: A systematic review.

    Vagge, Aldo / Ferro Desideri, Lorenzo / Del Noce, Chiara / Di Mola, Ilaria / Sindaco, Daniele / Traverso, Carlo E

    Seminars in ophthalmology

    2021  Volume 36, Issue 7, Page(s) 541–548

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Animals ; Cataract Extraction ; Humans ; Lens, Crystalline ; Lenses, Intraocular ; Light ; Macular Degeneration
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.1080/08820538.2021.1900283
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    Zs.A 2153: Show issues Location:
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  6. Article: Evaluating the Correlation between Alzheimer's Amyloid-β Peptides and Glaucoma in Human Aqueous Humor.

    Cappelli, Francesca / Caudano, Francesca / Marenco, Maria / Testa, Valeria / Masala, Alessandro / Sindaco, Daniele / Macrì, Angelo / Traverso, Carlo E / Iester, Michele / Ricciarelli, Roberta

    Translational vision science & technology

    2020  Volume 9, Issue 5, Page(s) 21

    Abstract: Purpose: Recent studies suggest that glaucoma may share common pathogenic mechanisms with Alzheimer's disease. To test this hypothesis, we investigated the correlation between glaucoma and amyloid-β: Methods: Eighty-one candidates for cataract or ... ...

    Abstract Purpose: Recent studies suggest that glaucoma may share common pathogenic mechanisms with Alzheimer's disease. To test this hypothesis, we investigated the correlation between glaucoma and amyloid-β
    Methods: Eighty-one candidates for cataract or glaucoma surgery were consecutively enrolled, with a median age of 77 years; of these, 32 subjects were affected by glaucoma and 49 were controls. Before surgery, each patient received an ophthalmological examination including biometry, intraocular pressure (IOP) measurement, fundus photography, and determination of the mean thickness of the ganglion cell complex (GCC) and/or retinal nerve fiber layer. During the surgical procedure, an AH sample was collected and immediately processed for total protein (TP) and Aβ
    Results: Aβ
    Conclusions: Our results indicate that an increased protein concentration in the AH could play a role in the pathogenesis of glaucomatous disease.
    Translational relevance: This study strongly supports the hypothesis that increased TP in the AH may have a pathogenic role in glaucoma. Further investigations are needed to clarify whether the protein enhancement represents a causative factor and whether it can be used as a marker of disease or as a novel therapeutic target.
    MeSH term(s) Aged ; Alzheimer Disease ; Amyloid beta-Peptides ; Aqueous Humor ; Glaucoma ; Glaucoma, Open-Angle ; Humans
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2020-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2674602-5
    ISSN 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.9.5.21
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  7. Article ; Online: Early Postoperative Intraocular Pressure is Associated With Better Pressure Control After XEN Implantation.

    Cutolo, Carlo A / Iester, Michele / Bagnis, Alessandro / Bonzano, Chiara / Negri, Letizia / Olivari, Sara / Cappelli, Francesca / Testa, Valeria / Sindaco, Daniele / Pizzorno, Chiara / Scotto, Riccardo / Saccheggiani, Michela / Traverso, Carlo E

    Journal of glaucoma

    2020  Volume 29, Issue 6, Page(s) 456–460

    Abstract: PRéCIS:: Gel stent implantation is a bleb-forming surgery designed to achieve predictable pressure drop. An early low intraocular pressure (IOP) is associated with the long-term success of the procedure.: Purpose: To identify the variables associated ... ...

    Abstract PRéCIS:: Gel stent implantation is a bleb-forming surgery designed to achieve predictable pressure drop. An early low intraocular pressure (IOP) is associated with the long-term success of the procedure.
    Purpose: To identify the variables associated with the success of the XEN procedure.
    Patients and methods: This was part of a prospective, uncontrolled, consecutive case series study. Patients with primary open-angle glaucoma or pseudo-exfoliative glaucoma were included. All the patients underwent surgical XEN implant procedure with mitomycin-C subconjunctival injection 20 minutes before surgery. Success criteria were an off-medication IOP of 6 to 16 mm Hg 12 months after surgery; no additional glaucoma surgery; no visual threatening complications, no visual acuity loss >1 Snellen line. One eye per patient was considered for statistical analysis. A univariate Cox proportional hazard regression analysis was performed to identify potential risk factors for surgical failure. Then, a multivariate Cox model was built.
    Results: One hundred twenty-three patients were recruited in this study: 93 patients underwent XEN implantation alone whereas 30 the combined procedure with phacoemulsification and intraocular lens implantation. Univariate Cox regression showed that the day after surgery intraocular lens>9 mm Hg was associated with surgical failure (P=0.02) and a postoperative number of needlings ≥2 in the follow-up was also predictive of surgical failure (P<0.01). These data were confirmed by a multivariate model too. At 1 year the surgical success criteria were 76% in the group with 24-hour IOP≤9 mm Hg, whereas it was 43% when above 9 mm Hg (P=0.026).
    Conclusions: Our study shows that an early IOP≤9 mm Hg is predictive of the efficacy of the procedure during 1-year follow-up, whereas more than 2 needlings are predictive of failure.
    MeSH term(s) Adult ; Aged ; Exfoliation Syndrome/complications ; Exfoliation Syndrome/physiopathology ; Exfoliation Syndrome/surgery ; Female ; Glaucoma Drainage Implants/adverse effects ; Glaucoma, Open-Angle/complications ; Glaucoma, Open-Angle/physiopathology ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure/physiology ; Lenses, Intraocular ; Male ; Middle Aged ; Mitomycin/administration & dosage ; Phacoemulsification/methods ; Postoperative Period ; Prospective Studies ; Tonometry, Ocular ; Treatment Outcome ; Visual Acuity
    Chemical Substances Mitomycin (50SG953SK6)
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000001501
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    Zs.A 3795: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Bilateral morphometric analysis of corneal sub-basal nerve plexus in patients undergoing unilateral cataract surgery: a preliminary in vivo confocal microscopy study.

    Giannaccare, Giuseppe / Bernabei, Federico / Pellegrini, Marco / Guaraldi, Fabio / Turchi, Federica / Torrazza, Carlo / Senni, Carlotta / Scotto, Riccardo / Sindaco, Daniele / Di Cello, Luca / Versura, Piera / Scorcia, Vincenzo / Traverso, Carlo E / Vagge, Aldo

    The British journal of ophthalmology

    2020  Volume 105, Issue 2, Page(s) 174–179

    Abstract: Aims: To evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.: Methods: IVCM was performed before ( ... ...

    Abstract Aims: To evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.
    Methods: IVCM was performed before (V0) and 1 month after surgery (V1) in both operated eyes (OEs) and unoperated eyes (UEs) of 30 patients. Thirty age and sex-matched subjects acted as controls. Corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD), corneal nerve fibre length (CNFL), corneal nerve total branch density (CTBD), corneal nerve fibre area (CNFA), corneal nerve fibre width, corneal nerve fractal dimension (CNFrD) and dendritic cells density were calculated.
    Results: Mean CNFD, CNBD, CNFL, CTBD, CNFA and CNFrD significantly decreased at V1 versus V0 in both eyes (respectively, 15.35±7.00 vs 21.21±6.56 n/mm
    Conclusion: Patients undergoing cataract surgery exhibit bilateral alterations of CSNP. This finding could have broad implications in the setting of sequential cataract surgery.
    MeSH term(s) Aged ; Aged, 80 and over ; Autonomic Nervous System Diseases/diagnosis ; Autonomic Nervous System Diseases/etiology ; Cornea/innervation ; Female ; Humans ; Lens Implantation, Intraocular ; Male ; Microscopy, Confocal ; Nerve Fibers/pathology ; Ophthalmic Nerve/diagnostic imaging ; Ophthalmic Nerve/pathology ; Phacoemulsification/adverse effects ; Prospective Studies
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2019-315449
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