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  1. Article ; Online: Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.

    Liu, Elise G / Zhang, Biyan / Martin, Victoria / Anthonypillai, John / Kraft, Magdalena / Grishin, Alexander / Grishina, Galina / Catanzaro, Jason R / Chinthrajah, Sharon / Sindher, Tina / Manohar, Monali / Quake, Antonia Zoe / Nadeau, Kari / Burks, A Wesley / Kim, Edwin H / Kulis, Michael D / Henning, Alice K / Jones, Stacie M / Leung, Donald Y M /
    Sicherer, Scott H / Wood, Robert A / Yuan, Qian / Shreffler, Wayne / Sampson, Hugh / Shabanova, Veronika / Eisenbarth, Stephanie C

    Science translational medicine

    2022  Volume 14, Issue 671, Page(s) eabq0599

    Abstract: ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food allergy. ... ...

    Abstract ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food allergy. Specifically, it has been hypothesized that food-specific IgA binds ingested allergens and promotes tolerance by immune exclusion; however, the evidence to support this hypothesis is indirect and mixed. Although it is known that healthy adults have peanut-specific IgA in the gut, it is unclear whether children also have gut peanut-specific IgA. We found in a cohort of non-food-allergic infants (
    MeSH term(s) Child ; Infant ; Adult ; Humans ; Arachis ; Allergens ; Peanut Hypersensitivity ; Food Hypersensitivity ; Immunoglobulin A ; Epitopes
    Chemical Substances Allergens ; Immunoglobulin A ; Epitopes
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abq0599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  2. Article ; Online: The SunBEAm birth cohort: Protocol design.

    Keet, Corinne / Sicherer, Scott H / Bunyavanich, Supinda / Visness, Cynthia / Fulkerson, Patricia C / Togias, Alkis / Davidson, Wendy / Perry, Susan / Hamrah, Sanaz / Calatroni, Agustin / Robinson, Katina / Dunaway, Lars / Davis, Carla M / Anvari, Sara / Leong-Kee, Susan M / Hershey, Gurjit Khurana / DeFranco, Emily / Devonshire, Ashley / Kim, Haejin /
    Joseph, Christine / Davidson, Brent / Strong, Noel K / Tsuang, Angela J / Groetch, Marion / Wang, Julie / Dantzer, Jennifer / Mudd, Kim / Aina, Abimbola / Shreffler, Wayne / Yuan, Qian / Simmons, Virginia / Leung, Donald Y M / Hui-Beckman, Jessica / Ramos, Jania Arcia / Chinthrajah, Sharon / Winn, Virginia / Sindher, Tina / Jones, Stacie M / Manning, Nirvana A / Scurlock, Amy M / Kim, Edwin / Stuebe, Alison / Gern, James E / Singh, Anne Marie / Krupp, Jennifer / Wood, Robert A

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 3

    Abstract: Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement ... ...

    Abstract Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort.
    Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes.
    Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs.
    Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Systems biological assessment of human immunity to BNT162b2 mRNA vaccination.

    Arunachalam, Prabhu S / Scott, Madeleine K D / Hagan, Thomas / Li, Chunfeng / Feng, Yupeng / Wimmers, Florian / Grigoryan, Lilit / Trisal, Meera / Edara, Venkata Viswanadh / Lai, Lilin / Chang, Sarah Esther / Feng, Allan / Dhingra, Shaurya / Shah, Mihir / Lee, Allie Skye / Chinthrajah, Sharon / Sindher, Tina / Mallajosyula, Vamsee / Gao, Fei /
    Sigal, Natalia / Kowli, Sangeeta / Gupta, Sheena / Pellegrini, Kathryn / Tharp, Gregory / Maysel-Auslender, Sofia / Bosinger, Steven / Maecker, Holden T / Boyd, Scott D / Davis, Mark M / Utz, Paul J / Suthar, Mehul S / Khatri, Purvesh / Nadeau, Kari C / Pulendran, Bali

    Research square

    2021  

    Abstract: The emergency use authorization of two COVID-19 mRNA vaccines in less than a year since the emergence of SARS-CoV-2, represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is ... ...

    Abstract The emergency use authorization of two COVID-19 mRNA vaccines in less than a year since the emergence of SARS-CoV-2, represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown. Here we used a systems biological approach to comprehensively profile the innate and adaptive immune responses in 56 healthy volunteers vaccinated with the Pfizer-BioNTech mRNA vaccine. Vaccination resulted in robust production of neutralizing antibodies (nAbs) against the parent strain and the variant of concern, B.1.351, but no induction of autoantibodies, and significant increases in antigen-specific polyfunctional CD4 and CD8 T cells after the second dose. The innate response induced within the first 2 days of booster vaccination was profoundly increased, relative to the response at corresponding times after priming. Thus, there was a striking increase in the: (i) frequency of CD14+CD16+ inflammatory monocytes; (ii) concentration of IFN-
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-438662/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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