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  1. AU="Singer, Christian F"
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  1. Article: Genetic Testing in Breast Cancer: New Standards of Care.

    Singer, Christian F

    Breast care (Basel, Switzerland)

    2021  Volume 16, Issue 3, Page(s) 193–195

    Language English
    Publishing date 2021-06-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000516788
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6620: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes.

    Singer, Christian F

    Hormone molecular biology and clinical investigation

    2020  Volume 41, Issue 3

    Abstract: Objectives To review non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes. Content Women with a gBRCA1 or 2 mutations face a high cumulative breast and ovarian cancer risk. While bilateral mastectomy (PBM) and ... ...

    Abstract Objectives To review non-surgical prevention strategies in women with hereditary breast and ovarian cancer syndromes. Content Women with a gBRCA1 or 2 mutations face a high cumulative breast and ovarian cancer risk. While bilateral mastectomy (PBM) and bilateral salpingo-oophrectomy (PBSO) profoundly reduce the respective cancer risks, they are also associated with considerable side effects. There is therefore an urgent need for alternative and non-surgical risk reduction options. Tamoxifen and aromatase inhibitors have both been evaluated in secondary prevention, but their benefit in primary prevention is currently unknown in BRCA mutation carriers. In addition, their use is compromised by their side effect profile which makes them less appealing for a use in chemoprevention. Summary and outlook Denosumab is a well-tolerated osteoprotective drug, which has been demonstrated to have a potential preventive effect particularly in BRCA1-deficient models in vitro. The prospectively randomized double-blind BRCA-P trial is currently investigating the preventative effect of denosumab in healthy BRCA1 germ line mutation carriers.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Chemoprevention/adverse effects ; Chemoprevention/methods ; Female ; Hereditary Breast and Ovarian Cancer Syndrome/drug therapy ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; Hereditary Breast and Ovarian Cancer Syndrome/prevention & control ; Humans
    Chemical Substances Antineoplastic Agents ; BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
    Language English
    Publishing date 2020-05-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2536635-X
    ISSN 1868-1891 ; 1868-1883
    ISSN (online) 1868-1891
    ISSN 1868-1883
    DOI 10.1515/hmbci-2019-0057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nonsurgical Prevention Strategies in

    Singer, Christian F

    Breast care (Basel, Switzerland)

    2020  Volume 16, Issue 2, Page(s) 144–148

    Abstract: Background: Female carriers of a : Summary: While endocrine treatments with tamoxifen and aromatase inhibitors (AI) have been shown to be effective in secondary prevention, their benefit in primary prevention has never been prospectively evaluated. ... ...

    Abstract Background: Female carriers of a
    Summary: While endocrine treatments with tamoxifen and aromatase inhibitors (AI) have been shown to be effective in secondary prevention, their benefit in primary prevention has never been prospectively evaluated. Moreover, their side effect profile makes them inappropriate candidates for chemoprevention in healthy premenopausal women. Recently, denosumab, a well-tolerated osteoprotective drug, has been shown to have an antitumoral effect on RANK+,
    Key message: The prospectively randomized, double-blind BRCA-P trial is currently investigating the preventative effect of denosumab in healthy
    Language English
    Publishing date 2020-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000507503
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  4. Article: Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.

    Kenn, Michael / Karch, Rudolf / Singer, Christian F / Dorffner, Georg / Schreiner, Wolfgang

    Journal of personalized medicine

    2023  Volume 13, Issue 1

    Abstract: Evidence theory by Dempster-Shafer for determination of hormone receptor status in breast cancer samples was introduced in our previous paper. One major topic pointed out here is the link between pieces of evidence found from different origins. In this ... ...

    Abstract Evidence theory by Dempster-Shafer for determination of hormone receptor status in breast cancer samples was introduced in our previous paper. One major topic pointed out here is the link between pieces of evidence found from different origins. In this paper the challenge of selecting appropriate ways of fusing evidence, depending on the type and quality of data involved is addressed. A parameterized family of evidence combination rules, covering the full range of potential needs, from emphasizing discrepancies in the measurements to aspiring accordance, is covered. The consequences for real patient samples are shown by modeling different decision strategies.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010119
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  5. Article ; Online: Deep learning for predicting future lesion emergence in high-risk breast MRI screening: a feasibility study.

    Burger, Bianca / Bernathova, Maria / Seeböck, Philipp / Singer, Christian F / Helbich, Thomas H / Langs, Georg

    European radiology experimental

    2023  Volume 7, Issue 1, Page(s) 32

    Abstract: Background: International societies have issued guidelines for high-risk breast cancer (BC) screening, recommending contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast as a supplemental diagnostic tool. In our study, we tested the ... ...

    Abstract Background: International societies have issued guidelines for high-risk breast cancer (BC) screening, recommending contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast as a supplemental diagnostic tool. In our study, we tested the applicability of deep learning-based anomaly detection to identify anomalous changes in negative breast CE-MRI screens associated with future lesion emergence.
    Methods: In this prospective study, we trained a generative adversarial network on dynamic CE-MRI of 33 high-risk women who participated in a screening program but did not develop BC. We defined an anomaly score as the deviation of an observed CE-MRI scan from the model of normal breast tissue variability. We evaluated the anomaly score's association with future lesion emergence on the level of local image patches (104,531 normal patches, 455 patches of future lesion location) and entire CE-MRI exams (21 normal, 20 with future lesion). Associations were analyzed by receiver operating characteristic (ROC) curves on the patch level and logistic regression on the examination level.
    Results: The local anomaly score on image patches was a good predictor for future lesion emergence (area under the ROC curve 0.804). An exam-level summary score was significantly associated with the emergence of lesions at any location at a later time point (p = 0.045).
    Conclusions: Breast cancer lesions are associated with anomalous appearance changes in breast CE-MRI occurring before the lesion emerges in high-risk women. These early image signatures are detectable and may be a basis for adjusting individual BC risk and personalized screening.
    Relevance statement: Anomalies in screening MRI preceding lesion emergence in women at high-risk of breast cancer may inform individualized screening and intervention strategies.
    Key points: • Breast lesions are associated with preceding anomalies in CE-MRI of high-risk women. • Deep learning-based anomaly detection can help to adjust risk assessment for future lesions. • An appearance anomaly score may be used for adjusting screening interval times.
    MeSH term(s) Female ; Humans ; Prospective Studies ; Deep Learning ; Feasibility Studies ; Contrast Media ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Magnetic Resonance Imaging/methods
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2509-9280
    ISSN (online) 2509-9280
    DOI 10.1186/s41747-023-00343-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neoadjuvant Therapy and Axillary Lymph Node Status in HER2-Positive Breast Cancer.

    Danzinger, Sabine / Pfeifer, Christian / Wimmer, Sophia / Tendl-Schulz, Kristina / Singer, Christian F

    Cancer investigation

    2023  Volume 41, Issue 6, Page(s) 593–600

    Abstract: Based on an estimating model, the aim of our study was to evaluate the axillary lymph node involvement of patients with primary invasive early human epidermal growth factor receptor 2 (HER2)-positive breast cancer before receiving neoadjuvant therapy ( ... ...

    Abstract Based on an estimating model, the aim of our study was to evaluate the axillary lymph node involvement of patients with primary invasive early human epidermal growth factor receptor 2 (HER2)-positive breast cancer before receiving neoadjuvant therapy (NAT). Patients with primary surgery (
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Neoadjuvant Therapy/methods ; Lymph Nodes/pathology ; Receptor, ErbB-2/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2238312
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    Zs.A 1862: Show issues Location:
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  7. Article: Therapeutic Strategies in Triple-Negative Breast Cancer.

    Paradiso, Angelo / Singer, Christian F

    Breast care (Basel, Switzerland)

    2017  Volume 12, Issue 1, Page(s) 6–7

    Language English
    Publishing date 2017-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2202236-3
    ISSN 1661-3805 ; 1661-3791
    ISSN (online) 1661-3805
    ISSN 1661-3791
    DOI 10.1159/000460238
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  8. Article ; Online: ESR1-Amplification-Associated Estrogen Receptor α Activity in Breast Cancer.

    Holst, Frederik / Singer, Christian F

    Trends in endocrinology and metabolism: TEM

    2016  Volume 27, Issue 11, Page(s) 751–752

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Letter
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2016.08.002
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    Zs.A 2999: Show issues Location:
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  9. Article: Extraosseous osteoblastoma: A rare cause of breast mass in a prepubertal girl.

    Danzinger, Sabine / Kager, Leo / Bernathova, Maria / Lang, Susanna / Haslik, Werner / Singer, Christian F

    Clinical case reports

    2021  Volume 9, Issue 5, Page(s) e04094

    Abstract: Extraosseous osteoblastoma of the breast, a rare disease, was diagnosed in a prepubertal girl. After tumor excision, the patient recovered well and an optimal cosmetic result was achieved. Interdisciplinary discussions about the case are essential. ...

    Abstract Extraosseous osteoblastoma of the breast, a rare disease, was diagnosed in a prepubertal girl. After tumor excision, the patient recovered well and an optimal cosmetic result was achieved. Interdisciplinary discussions about the case are essential.
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4094
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  10. Article ; Online: Grundlagen und Wirkungsweise von zielgerichteten Therapien.

    Singer, Christian F

    Wiener medizinische Wochenschrift (1946)

    2010  

    Abstract: Conventional cytotoxic therapy is usually characterized by low specificity and considerable side effects. Targeted therapy, by contrast, allows for a specific inhibition with an acceptable side effect profile. A prerequisite for the development of such a ...

    Title translation Principles and method of action of targeted therapies.
    Abstract Conventional cytotoxic therapy is usually characterized by low specificity and considerable side effects. Targeted therapy, by contrast, allows for a specific inhibition with an acceptable side effect profile. A prerequisite for the development of such a therapy, however, is the identification and characterization of the molecular mechanisms that lead to tumor growth. Antibody-based targeted therapies usually attack cell membrane-bound or extracellular proteins, while tyrosin kinase inhibitors usually act at intracellular domains of transmembranous proteins. Both strategies ultimately lead to an inhibition of the signal transduction cascade and thereby block increased cell proliferation, metastasis, or the production of new blood or lymph vessels.
    Language German
    Publishing date 2010-08-24
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-010-0817-y
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