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  1. Book ; Online ; E-Book: Inflammation

    Cavaillon, Jean-Marc / Singer, Mervyn

    from molecular and cellular mechanisms to the clinic

    2018  

    Author's details edited by Jean-Marc Cavaillon and Mervyn Singer
    Language English
    Size 1 Online-Ressource (2085 Seiten), Illustrationen
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019614893
    ISBN 978-3-527-69216-3 ; 9783527338993 ; 9783527692187 ; 9783527692170 ; 9783527692156 ; 3-527-69216-9 ; 3527338993 ; 3527692185 ; 3527692177 ; 3527692150
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Less Haste, More Speed, More Science: Lessons to be Learned from COVID-19 Studies.

    Singer, Mervyn

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 11, Page(s) 1258–1260

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19 ; Double-Blind Method ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; gimsilumab (8961SFA7R3)
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202203-0617ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Back to Basics…and Translating to Success-A Call to Arms.

    Singer, Mervyn

    Critical care medicine

    2020  Volume 48, Issue 8, Page(s) 1245–1246

    MeSH term(s) Humans ; Research ; Sepsis ; Translating
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcomes for patients with COVID-19: known knowns, known unknowns, and unknown unknowns.

    Singer, Mervyn

    The Medical journal of Australia

    2020  Volume 214, Issue 1, Page(s) 20–21

    MeSH term(s) Australia ; COVID-19 ; Humans ; Intensive Care Units ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2020-12-09
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50890
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  5. Book: Mechanisms of sepsis induced organ dysfunction and recovery

    Abraham, Edward / Singer, Mervyn

    (Update in intensive care and emergency medicine ; 44)

    2007  

    Title variant sepsis-induced
    Author's details E. Abraham ; M. Singer
    Series title Update in intensive care and emergency medicine ; 44
    Collection
    Keywords Sepsis / complications ; Multiple Organ Failure / etiology ; Critical Care / methods ; Sepsis ; Multiorganversagen
    Subject Multi organ failure ; MOF ; MOV ; Blutvergiftung ; Septikämie
    Language English
    Size XIII, 453 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014872255
    ISBN 978-3-540-30157-8 ; 3-540-30157-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2566 order for loan Magazin

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  6. Article ; Online: Sepsis: personalization v protocolization?

    Singer, Mervyn

    Critical care (London, England)

    2019  Volume 23, Issue Suppl 1, Page(s) 127

    Abstract: The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined 'Without clinical expertise, practice risks becoming tyrannised by evidence'. Rigid protocols and mandates, based on an ... ...

    Abstract The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined 'Without clinical expertise, practice risks becoming tyrannised by evidence'. Rigid protocols and mandates, based on an inconclusive and low-level evidence base, cannot suit the physiological, biochemical and biological heterogeneity displayed by the individual septic patient. Indeed, clear proof of outcome benefit through adoption of an inflexible management approach is lacking and will certainly be detrimental to some. Therapy thus needs to be tailored to meet the individual patient's needs. The same principle should be applied to clinical trials; the continued disappointments of multiple investigational strategies trialled over three decades, despite (often) a sound biological rationale, suggest a repeated methodological failure that does not account for the marked heterogeneity within the septic patient's biological phenotype and thus marked variation in their host response. The increasing availability of rapid point-of-care diagnostics and theranostics should facilitate better patient selection and titrated optimization of the therapeutic intervention.
    MeSH term(s) Biomarkers/analysis ; Biomarkers/blood ; Evidence-Based Medicine/methods ; Guideline Adherence/standards ; Humans ; Precision Medicine/trends ; Sepsis/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-06-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2398-5
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  7. Article ; Online: Why the Sequential Organ Failure Assessment score needs updating?

    Moreno, Rui / Singer, Mervyn / Rhodes, Andrew

    Critical care science

    2024  Volume 36, Page(s) e20240296en

    MeSH term(s) Humans ; Organ Dysfunction Scores ; Multiple Organ Failure/diagnosis ; Sepsis
    Language Portuguese
    Publishing date 2024-04-08
    Publishing country Brazil
    Document type Editorial
    ISSN 2965-2774
    ISSN (online) 2965-2774
    DOI 10.62675/2965-2774.20240296-en
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Personalizing Sepsis Care.

    Singer, Mervyn

    Critical care clinics

    2018  Volume 34, Issue 1, Page(s) 153–160

    Abstract: Sepsis describes a broad-based syndrome covering many infectious agents, affecting various sites in patients of differing age, gender, and comorbidity and resulting in varying degrees and combinations of organ dysfunction. Protocolized care with rigid ... ...

    Abstract Sepsis describes a broad-based syndrome covering many infectious agents, affecting various sites in patients of differing age, gender, and comorbidity and resulting in varying degrees and combinations of organ dysfunction. Protocolized care with rigid goals may suit populations, assuming the evidence-lite recommendations are beneficial, but not necessarily individual patients. A personalized approach to management is rational and preferable. Other than clinical heterogeneity, a range of biological signatures exist in sepsis, and these fluctuate over the disease course. Subsets of septic patients can display distinct biological signatures that may potentially be used to identify suitability for different treatments and titration to optimal effect.
    MeSH term(s) Critical Care/standards ; Humans ; Patient-Centered Care/standards ; Practice Guidelines as Topic ; Sepsis/therapy
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2017.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 990: Show issues Location:
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  9. Book: Oxford handbook of critical care

    Singer, Mervyn / Webb, Andrew R.

    (Oxford handbooks ; Oxford medical publications)

    2009  

    Author's details Mervyn Singer ; Andrew R. Webb
    Series title Oxford handbooks
    Oxford medical publications
    Keywords Critical Care ; Critical care medicine
    Subject code 616.028
    Language English
    Size XXX, 669 S. : Ill., graph. Darst., 18cm
    Edition 3. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Previous ed.: 2005
    HBZ-ID HT015899578
    ISBN 978-0-19-923533-9 ; 0-19-923533-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
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  10. Article ; Online: The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply.

    Hofmaenner, Daniel A / Singer, Mervyn

    Intensive care medicine

    2022  Volume 48, Issue 8, Page(s) 1118–1119

    MeSH term(s) Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Factor Xa Inhibitors/therapeutic use ; Humans ; Intensive Care Units ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06768-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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