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  1. Article ; Online: Stent or Convert: Management of Failing Endografts.

    Singh, Aminder A / Ambler, Graeme K

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2023  Volume 67, Issue 3, Page(s) 406–407

    MeSH term(s) Humans ; Stents ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Prosthesis Design ; Treatment Outcome ; Aortic Aneurysm, Abdominal/surgery
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2023.10.020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2283: Show issues Location:
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  2. Article: Asking the tuberculosis community to demand for more.

    Singh, Alka Aggarwal

    The Indian journal of tuberculosis

    2020  Volume 67, Issue 4, Page(s) 453–455

    MeSH term(s) Community Health Services ; Global Health ; Health Services Needs and Demand ; Humans ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/prevention & control ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/prevention & control
    Language English
    Publishing date 2020-07-16
    Publishing country India
    Document type Editorial
    ZDB-ID 603129-8
    ISSN 0019-5707 ; 0019-5705
    ISSN 0019-5707 ; 0019-5705
    DOI 10.1016/j.ijtb.2020.07.008
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  3. Article ; Online: Small Aneurysm Surveillance Over 80: Is it Worthwhile?

    Singh, Aminder A / Boyle, Jonathan R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2021  Volume 62, Issue 1, Page(s) 54

    MeSH term(s) Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/epidemiology ; Aortic Aneurysm, Abdominal/surgery ; Aortic Rupture ; Humans
    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2021.03.018
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells.

    Singh, Aminder A / Shetty, Deeti K / Jacob, Aishwarya G / Bayraktar, Semih / Sinha, Sanjay

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1349548

    Abstract: Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs. However, genetic information can inform both identification and treatment at an early stage. Indeed, a diagnosis is important for personalised surveillance and ... ...

    Abstract Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs. However, genetic information can inform both identification and treatment at an early stage. Indeed, a diagnosis is important for personalised surveillance and intervention plans, as well as cascade screening of family members. Currently, only 20% of heritable TAD patients have a causative mutation identified and, consequently, further advances in genetic coverage are required to define the remaining molecular landscape. The rapid expansion of next generation sequencing technologies is providing a huge resource of genetic data, but a critical issue remains in functionally validating these findings. Induced pluripotent stem cells (iPSCs) are patient-derived, reprogrammed cell lines which allow mechanistic insights, complex modelling of genetic disease and a platform to study aortic genetic variants. This review will address the need for iPSCs as a frontline diagnostic tool to evaluate variants identified by genomic discovery studies and explore their evolving role in biological insight through to drug discovery.
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1349548
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  5. Article ; Online: BM-MSC-Loaded Graphene-Collagen Cryogels Ameliorate Neuroinflammation in a Rat Spinal Cord Injury Model.

    Agarwal, Gopal / Roy, Abhishek / Singh, Abhishek A / Kumar, Hemant / Mandoli, Amit / Srivastava, Akshay

    ACS applied bio materials

    2024  Volume 7, Issue 3, Page(s) 1478–1489

    Abstract: A major obstacle to axonal regeneration following spinal cord injury (SCI) is neuroinflammation mediated by astrocytes and microglial cells. We previously demonstrated that graphene-based collagen hydrogels alone can decrease neuroinflammation in SCI. ... ...

    Abstract A major obstacle to axonal regeneration following spinal cord injury (SCI) is neuroinflammation mediated by astrocytes and microglial cells. We previously demonstrated that graphene-based collagen hydrogels alone can decrease neuroinflammation in SCI. Their regenerative potential, however, is poorly understood and incomplete. Furthermore, stem cells have demonstrated both neuroprotective and regenerative properties in spinal cord regeneration, although there are constraints connected with the application of stem cell-based therapy. In this study, we have analyzed the regeneration capability of human bone marrow mesenchymal stem cell (BM-MSC)-loaded graphene-cross-linked collagen cryogels (Gr-Col) in a thoracic (T10-T11) hemisection model of SCI. Our study found that BM-MSC-loaded Gr-Col improves axonal regeneration, reduces neuroinflammation by decreasing astrocyte reactivity, and promotes M2 macrophage polarization. BM-MSC-loaded-Gr-Col demonstrated enhanced regenerative potential compared to Gr-Col and the injury group control. Next-generation sequencing (NGS) analysis revealed that BM-MSC-loaded-Gr-Col modulates the JAK2-STAT3 pathway, thus decreasing the reactive and scar-forming astrocyte phenotype. The decrease in neuroinflammation in the BM-MSC-loaded-Gr-Col group is attributed to the modulation of Notch/Rock and STAT5a/b and STAT6 signaling. Overall, Gene Set Enrichment Analysis suggests the promising role of BM-MSC-loaded-Gr-Col in promoting axonal regeneration after SCI by modulating molecular pathways such as the PI3/Akt pathway, focal adhesion kinase, and various inflammatory pathways.
    MeSH term(s) Rats ; Animals ; Humans ; Cryogels/metabolism ; Graphite ; Neuroinflammatory Diseases ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/therapy ; Collagen ; Mesenchymal Stem Cells/metabolism
    Chemical Substances Cryogels ; Graphite (7782-42-5) ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00876
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  6. Article ; Online: Understanding the current acute aortic syndrome (AAS) pathways-The Collaborative Acute Aortic Syndrome Project (CAASP) protocol.

    Zhong, Jim / Vigneswaran, Ganesh / Safdar, Nawaz Z / Mandal, Indrajeet / Singh, Aminder A / Nandhra, Sandip

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297782

    Abstract: Background: Acute aortic syndrome (AAS) is an emergency associated with high peri-hospital mortality rates. Variable clinical presentation makes timely diagnosis challenging and such delays in diagnosis directly impact patient outcomes.: Aims and ... ...

    Abstract Background: Acute aortic syndrome (AAS) is an emergency associated with high peri-hospital mortality rates. Variable clinical presentation makes timely diagnosis challenging and such delays in diagnosis directly impact patient outcomes.
    Aims and objectives: The aims of the Collaborative Acute Aortic Syndrome Project (CAASP) are to characterise and evaluate the current AAS pathways of a cohort of hospitals in the UK, USA and New Zealand to determine if patient outcomes are influenced by the AAS pathway (time to hospital admission, diagnosis and management plan) and demographic, social, geographic and patient-specific factors (clinical presentation and comorbidities). The objectives are to describe different AAS pathways and time duration between hospital admission to diagnosis and management plan instigation, and to compare patient outcomes between pathways.
    Methods: The study is a multicentre, retrospective service evaluation project of adult patients diagnosed on imaging with AAS. It will be coordinated by the UK National Interventional Radiology Trainee Research (UNITE) network and Vascular and Endovascular Research Network (VERN) in conjunction with The Aortic Dissection Charitable Trust (TADCT). All AAS cases diagnosed on imaging between 1st January 2018 to 1st June 2021 will be included and followed-up for 6 months. Eligibility criteria include aortic dissection (AD) Type A, Type B, non A/B, penetrating aortic ulcer, and intramural haematoma. Exclusion criteria are non-AAS pathology, acute on chronic AAS, and age<18. This project will evaluate patient demographics, timing of presentation, patient symptoms, risk factors for AD, physical examination findings, timing to imaging and treatment, hospital stay, and mortality. Univariate and multivariate analysis will be used to identify predictors associated with prolonged time to diagnosis or treatment and mortality at 30 days.
    MeSH term(s) Adult ; Humans ; Adolescent ; Aortic Aneurysm/complications ; Retrospective Studies ; Acute Disease ; Aortic Dissection/diagnosis ; Risk Factors
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297782
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  7. Article ; Online: Secondary metabolites responses of plants exposed to ozone: an update.

    Singh, Aditya Abha / Ghosh, Annesha / Agrawal, Madhoolika / Agrawal, Shashi Bhushan

    Environmental science and pollution research international

    2023  Volume 30, Issue 38, Page(s) 88281–88312

    Abstract: Tropospheric ozone ( ... ...

    Abstract Tropospheric ozone (O
    MeSH term(s) Ozone/pharmacology ; Reactive Oxygen Species/metabolism ; Plants/metabolism ; Antioxidants/metabolism ; Soil ; Plant Leaves/metabolism
    Chemical Substances Ozone (66H7ZZK23N) ; Reactive Oxygen Species ; Antioxidants ; Soil
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28634-2
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    Z 5915: Show issues

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  8. Article ; Online: Re: Protamine in Carotid Surgery: The Advantages Outweigh the Disadvantages.

    Falter, Florian / Singh, Aminder A / Boyle, Jonathan R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2022  Volume 64, Issue 1, Page(s) 136–137

    MeSH term(s) Endarterectomy, Carotid ; Heparin ; Heparin Antagonists ; Humans ; Protamines
    Chemical Substances Heparin Antagonists ; Protamines ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2022.05.023
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Diabetes and Aneurysm Rupture: New Evidence Muddies the Water.

    Singh, Aminder A / Boyle, Jonathan R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2020  Volume 60, Issue 1, Page(s) 43

    MeSH term(s) Aneurysm, Ruptured ; Aortic Aneurysm, Abdominal ; Case-Control Studies ; Denmark ; Diabetes Mellitus ; Humans ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2020-03-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2020.02.029
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  10. Article ; Online: Readmission and Re-intervention are Better Measures of EVAR Quality.

    Singh, Aminder A / Boyle, Jonathan R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2020  Volume 60, Issue 4, Page(s) 518

    MeSH term(s) Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Humans ; Patient Readmission ; United Kingdom
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2020.08.011
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