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Book: Analysis of membrane lipids

Prasad, Rajendra / Singh, Ashutosh

(Springer protocols)

2020

Author's details	edited by Rajendra Prasad, Ashutosh Singh
Series title	Springer protocols
Language	English
Size	x, 222 Seiten, Illustrationen
Publisher	Humana Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book
HBZ-ID	HT020487939
ISBN	978-1-0716-0630-8 ; 9781071606315 ; 1-0716-0630-1 ; 107160631X
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2020 A 884	available for loan (reading room)	Lesesaal EG

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Book: Eco-friendly agro-biological techniques for enhancing crop productivity

Sengar, Rakesh S. / Singh, Ashutosh

2018

Author's details	Rakesh Singh Sengar, Ashu Singh, editors
Keywords	Chlorophyll fluorescence ; Climate ready crop ; Food Security ; PGPR ; PGPR in Management ; Sustainable Management ; Volatile Antibiotics
Subject code	630
Language	English
Size	viii, 282 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm
Publisher	Springer
Publishing place	Singapore
Publishing country	Singapore
Document type	Book
HBZ-ID	HT019514772
ISBN	978-981-10-6933-8 ; 981-10-6933-6 ; 9789811069345 ; 9811069344
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
188/97	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Heterologous Expression of Candida Antifungal Target Genes in the Model Organism Saccharomyces cerevisiae.

Healey, Kelley R / Singh, Ashutosh

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2658, Page(s) 181–190

Abstract: Understanding how a gene variant may influence antifungal resistance, or other phenotypic characteristics, is an important step in determining or dissecting resistance mechanisms. The influence of specific genes or gene alleles on a phenotype can ... ...

Abstract	Understanding how a gene variant may influence antifungal resistance, or other phenotypic characteristics, is an important step in determining or dissecting resistance mechanisms. The influence of specific genes or gene alleles on a phenotype can initially be assessed within the model organism, Saccharomyces cerevisiae. S. cerevisiae exhibits efficient rates of homologous recombination making it amendable for heterologous expression and represents a susceptible organism that can be used to determine changes in antifungal susceptibilities. Many groups have developed different methodologies for the cloning, expression, and screening processes. In this chapter, we present straightforward methodology that utilizes gap-repair cloning to express a plasmid-borne copy of Candida auris ERG11 within S. cerevisiae. Multiple alleles can be compared in order to determine how specific alterations influence triazole susceptibility. Primer design, gap-repair co-transformation, and colony PCR screening are detailed.
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/metabolism ; Candida/genetics ; Saccharomyces cerevisiae/metabolism ; Microbial Sensitivity Tests ; Drug Resistance, Fungal/genetics
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3155-3_12
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: OFP-TM: an online VM failure prediction and tolerance model towards high availability of cloud computing environments.

Saxena, Deepika / Singh, Ashutosh Kumar

The Journal of supercomputing

2022 Volume 78, Issue 6, Page(s) 8003–8024

Abstract: The indispensable collaboration of cloud computing in every digital service has raised its resource usage exponentially. The ever-growing demand of cloud resources evades service availability leading to critical challenges such as cloud outages, SLA ... ...

Abstract	The indispensable collaboration of cloud computing in every digital service has raised its resource usage exponentially. The ever-growing demand of cloud resources evades service availability leading to critical challenges such as cloud outages, SLA violation, and excessive power consumption. Previous approaches have addressed this problem by utilizing multiple cloud platforms or running multiple replicas of a Virtual Machine (VM) resulting into high operational cost. This paper has addressed this alarming problem from a different perspective by proposing a novel
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1479917-0
ISSN	1573-0484 ; 0920-8542
ISSN (online)	1573-0484
ISSN	0920-8542
DOI	10.1007/s11227-021-04235-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is There a Weekend Effect in the Management of Maxillofacial Trauma Patients?

Singh, Ashutosh Kumar / Khanal, Nikita

Journal of Nepal Health Research Council

2022 Volume 19, Issue 4, Page(s) 700–704

Abstract: Background: Many previous studies have shown that patients admitted to the hospital at weekends have a longer delay than those on weekdays. It has been proposed that the equality of specialist services throughout the week could mitigate the 'weekend ... ...

Abstract	Background: Many previous studies have shown that patients admitted to the hospital at weekends have a longer delay than those on weekdays. It has been proposed that the equality of specialist services throughout the week could mitigate the 'weekend effect.' This study aimed to determine whether or not a weekend effect is observed in Oral and Maxillofacial surgery patients at a medical college and teaching hospital. Methods: Our primary predictor variable was the day of admission. Our primary outcome of interest was the length of hospital stay from admission to operation. Descriptive analysis, correlation analysis, One way ANOVA, and post hoc comparison were performed for statistical analysis. Results: Out of 1185, 1005 (84.8%) were male and 180 (15.2%) female, with a mean age of 30.3 (SD=14.1) years. There was a significantly higher admission on weekends, Friday, and Saturday, and the weekend admissions were associated with a longer delay from admission to operation. The night shift was also associated with a longer delay from admission to operation. The diagnosis based procedure had the most significant effect on delay from admission to operation. The patient's age and gender had no association with the primary outcome. Conclusions: There is a delay in the definitive treatment of maxillofacial surgery patients admitted on weekends. These findings have implications for adequate staffing and resource allocation on the weekends based on admission volume.
MeSH term(s)	Adult ; Female ; Hospital Mortality ; Hospitals, Teaching ; Humans ; Length of Stay ; Male ; Maxillofacial Injuries/surgery ; Nepal ; Retrospective Studies ; Time Factors
Language	English
Publishing date	2022-03-13
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2551251-1
ISSN	1999-6217 ; 1999-6217
ISSN (online)	1999-6217
ISSN	1999-6217
DOI	10.33314/jnhrc.v19i04.3665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Drug Screening Assays on Medulloblastoma Stem Cells Using Compound Libraries.

Singh, Ashutosh / Garg, Neha

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2423, Page(s) 95–101

Abstract: Conventional chemotherapies for medulloblastoma are restricted to only proliferative population leaving the cancer stem cells unscathed. This shortcoming of the traditional therapies is attributed to the relapse and metastasis of the cancer. The current ... ...

Abstract	Conventional chemotherapies for medulloblastoma are restricted to only proliferative population leaving the cancer stem cells unscathed. This shortcoming of the traditional therapies is attributed to the relapse and metastasis of the cancer. The current research is entirely focused on the screening of therapeutic agents that can restrict and target the self-renewal potential of the cancer stem cells. The advances in drug screening strategies have led to high-throughput screening which provide a robust and expeditious platform to screen potential compounds against cancer stem cells. In this book chapter, we describe two in vitro assays that are routinely used to measure the cell killing and anti-self-renewal activity of the compounds against the cancer stem cells. Combining these assays with high-throughput screening offers a rapid, reliable, and inexpensive approach to screen potential compounds against cancer stem cells and to overcome the limitation of conventional chemotherapeutic agents.
MeSH term(s)	Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/pathology ; Drug Evaluation, Preclinical ; High-Throughput Screening Assays ; Humans ; Medulloblastoma/pathology ; Neoplasm Recurrence, Local/pathology ; Neoplastic Stem Cells/pathology ; Small Molecule Libraries/pharmacology
Chemical Substances	Small Molecule Libraries
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1952-0_9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fungal pathogens and COVID-19.

Singh, Ashutosh / Kaur, Amtoj / Chowdhary, Anuradha

Current opinion in microbiology

2023 Volume 75, Page(s) 102365

Abstract: COVID-19 pandemic highlighted the complications of secondary fungal infections that occurred globally in severe cases of coronavirus disease managed in the intensive care units. Furthermore, varied underlying host factors, such as preexisting ... ...

Abstract	COVID-19 pandemic highlighted the complications of secondary fungal infections that occurred globally in severe cases of coronavirus disease managed in the intensive care units. Furthermore, varied underlying host factors, such as preexisting immunosuppression, the use of immunomodulatory agents, and invasive procedures predisposing lung tissues to fungal colonization and proliferation, caused increased susceptibility to fungal infections in COVID-19 patient populations. These invasive fungal infections directly impact the overall length of hospitalization and mortality. The most commonly reported fungal infections in patients with COVID-19 include aspergillosis, invasive candidiasis, and mucormycosis. An overall worldwide increase in the prevalence of candidiasis and aspergillosis was observed in COVID-19 patients , whereas outbreaks of mucormycosis were mainly recorded from India. Diagnostic challenges and limited antifungal treatment options make secondary fungal infections among COVID-19 patients more burdensome, which results in improper management and increased mortality.
MeSH term(s)	Humans ; COVID-19 ; Mucormycosis/drug therapy ; Pandemics ; Aspergillosis ; Candidiasis ; Coinfection
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1418474-6
ISSN	1879-0364 ; 1369-5274
ISSN (online)	1879-0364
ISSN	1369-5274
DOI	10.1016/j.mib.2023.102365
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Zs.A 5514: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 51: Show issues

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Article ; Online: [No title information]

Lokhande, Kiran Bharat / Shrivastava, Ashish / Singh, Ashutosh

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 23, Page(s) 14259–14274

Abstract: Monkeypox virus (MPXV) outbreak in non-endemic countries is a worldwide public health emergency. An enveloped double-stranded DNA virus belongs to the genus Orth poxvirus. A viral zoonotic infection known as monkeypox has been a serious risk to public ... ...

Abstract	Monkeypox virus (MPXV) outbreak in non-endemic countries is a worldwide public health emergency. An enveloped double-stranded DNA virus belongs to the genus Orth poxvirus. A viral zoonotic infection known as monkeypox has been a serious risk to public health, especially in Africa. However, it has recently spread to other continents, so it might soon become a worldwide problem. There is an increased risk of transmission of the virus because there is a lack of effective treatment that cures the disease. To stop the multi-country outbreak from spreading, it is important to discover effective medications urgently. The objective of the current study is to swiftly find new treatments for the monkeypox virus using advanced computational approaches. By investigating five potential MPXV targets (DNA ligase, Palmytilated Extracellular Enveloped Virus (EEV) membrane protein, Scaffold protein D13, Thymidylate Kinase, and Viral core cysteine proteinase), this research was carried out using cutting-edge computational techniques against human monkeypox virus infection. Here we present the accurate 3D structures and their binding cavities of the selected targets with higher confidence using AlphaFold 2 and SiteMap analysis. Molecular docking and MD simulation analysis revealed the top five potential lead compounds with higher binding affinity and stability toward selected targets. Binding free energy calculations and other essential dynamics analysis supports the finding. The selected lead compounds utilizing virtual screening and drug repurposing approach reported in this study are beneficial for medical scientists and experimental biologists in drug development for the treatment of human MPXV.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Humans ; Mpox (monkeypox)/drug therapy ; Molecular Docking Simulation ; Membrane Proteins ; Computer Simulation ; DNA Ligases
Chemical Substances	Membrane Proteins ; DNA Ligases (EC 6.5.1.-)
Language	English
Publishing date	2023-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2183342
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Molecular Insights into the Effect of Crystal Planes on Droplet Wetting.

Chatterjee, Samyabrata / Singh, Ashutosh / Chakraborty, Monojit

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 13, Page(s) 4789–4798

Abstract: Dynamic wetting by liquids on solid surfaces depends on several aspects such as surface energy, roughness, and interfacial tension, among many others. Copper (Cu), gold (Au), aluminum (Al), and silicon (Si) are a few of the most important metals that are ...

Abstract	Dynamic wetting by liquids on solid surfaces depends on several aspects such as surface energy, roughness, and interfacial tension, among many others. Copper (Cu), gold (Au), aluminum (Al), and silicon (Si) are a few of the most important metals that are used extensively as substrates in various industrial and biomedical applications. Metals are etched frequently on different crystal planes for fabrication purposes. Etching exposes distinct crystal planes that may come in contact with the liquids when used for different applications. The interaction of the crystal planes with the liquid that comes in contact with the solid dictates the wetting behavior of the surface. This necessitates the importance of understanding how various crystal planes of the same metals behave under similar conditions. Herein, three specific crystal planes, namely, (1 0 0), (1 1 0), and (1 1 1), are investigated at a molecular scale for the above-mentioned metals. The dynamic contact angle and contact diameter trends revealed that the relatively hydrophobic surfaces (Cu, Si) tend to reach their equilibrium contact angle faster compared to the hydrophilic substrates (Al, Au). Molecular kinetic theory is used to estimate the three-phase contact line friction which is found to be higher for (1 1 1) planes. Further, a consistent potential energy distribution variation is observed for the crystal lattice of (1 0 0), (1 1 0), and (1 1 1). These findings can be used as a guideline to determine the factors needed to completely describe a dynamic wetting phenomenon of the droplet over the different crystal planes. The understanding will be of great use in deciding experimental strategies where fabricated different crystal planes would be required to have a liquid contact.
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c00167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanocellulose from agro-waste: a comprehensive review of extraction methods and applications

Padhi, Subhanki / Singh, Ashutosh / Routray, Winny

Rev Environ Sci Biotechnol. 2023 Mar., v. 22, no. 1 p.1-27

2023

Abstract: Agro-based wastes contain significant quantities of cellulosic materials from which nanocellulose can be extracted using various physical, biological, and chemical methods. These agro-wastes are termed lignocellulosic biomass as they contain cellulose, ... ...

Abstract	Agro-based wastes contain significant quantities of cellulosic materials from which nanocellulose can be extracted using various physical, biological, and chemical methods. These agro-wastes are termed lignocellulosic biomass as they contain cellulose, lignin and hemicellulose in abundance. Nanocellulose has its dimensions in nanoscale with excellent and distinctive attributes that attract researchers. Nanocellulose matrices are broadly categorised as nanocellulose crystals, nanocellulose fibrils and bacterial nanocellulose. Nanocellulose possesses some extremely significant properties, including biodegradability and biocompatibility, high aspect ratio, better mechanical attributes, easy surface modification, crystallinity, non-toxic nature, and water absorption capacity, making it a perfect material for a wide range of applications. The presence of hydroxyl groups on the surface of nanocellulose helps in its easier surface modification by various processes like carboxylation, silylation, esterification, amidation and etherification, which further allows its application as functional material. This review encompasses a brief discussion of the pre-treatments of lignocellulosic biomass, the different isolation processes of nanocellulose and the surface modification done to improve dispersibility in the polymer matrix. In this review, the different applications of nanocellulose in food industries, in biomedical and pharmaceutical fields, and their safety issues and toxicity to humans and the environment have also been briefly discussed.
Keywords	agricultural wastes ; biocompatibility ; biodegradability ; biomass ; carboxylation ; cellulose ; crystal structure ; dispersibility ; esterification ; hemicellulose ; lignin ; lignocellulose ; silylation ; toxicity ; water binding capacity
Language	English
Dates of publication	2023-03
Size	p. 1-27.
Publishing place	Springer Netherlands
Document type	Article ; Online
Note	Review
ZDB-ID	2076953-2
ISSN	1572-9826 ; 1569-1705
ISSN (online)	1572-9826
ISSN	1569-1705
DOI	10.1007/s11157-023-09643-6
Database	NAL-Catalogue (AGRICOLA)

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