Article ; Online: Association between lipoprotein (a) and risk of heart failure: A systematic review and meta-analysis of Mendelian randomization studies.
Current problems in cardiology
2024 Volume 49, Issue 4, Page(s) 102439
Abstract: Background: Rising incidence of heart failure (HF) in the Western world despite advanced clinical care necessitate exploration of further preventive tools and strategies. Lipoprotein(a) [Lp(a)], recognized as one of the major cardiovascular risk factors ...
| Abstract | Background: Rising incidence of heart failure (HF) in the Western world despite advanced clinical care necessitate exploration of further preventive tools and strategies. Lipoprotein(a) [Lp(a)], recognized as one of the major cardiovascular risk factors has also been implicated as a risk factor for HF. However, existing evidence remains inconclusive and that has led us to perform this meta-analysis. Methods: PubMed/Medline, EMBASE and Scopus were systematically searched for studies evaluating an association of Lp(a) with occurrence of HF from inception-till November 2023. Random effects models and I Result: Our search rendered in total 360 studies and after final screening this resulted in 7 Mendelian randomization (MR) design. According to the MR analysis, increasing Lp(a) level were significantly associated with increased risk of HF (OR 1.064, 95 % CI: 1.043-1.086, I Conclusion: We were able to show that by meta-analysis of MR data, increasing lipoprotein (a) levels are associated with an increased risk of HF. Whether this is due to a direct effect on heart muscle contraction or whether this is due to an increased risk of ischemic cardiac disease remains to be elucidated. |
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| MeSH term(s) | Humans ; Coronary Artery Disease ; Heart Disease Risk Factors ; Heart Failure/epidemiology ; Heart Failure/genetics ; Lipoprotein(a)/genetics ; Mendelian Randomization Analysis |
| Chemical Substances | Lipoprotein(a) ; LPA protein, human |
| Language | English |
| Publishing date | 2024-01-30 |
| Publishing country | Netherlands |
| Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Review |
| ZDB-ID | 441230-8 |
| ISSN | 1535-6280 ; 0146-2806 |
| ISSN (online) | 1535-6280 |
| ISSN | 0146-2806 |
| DOI | 10.1016/j.cpcardiol.2024.102439 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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