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  1. Article: Trends and growth of area, production and yield of cotton in punjab and in comparison to India

    Singh, Inder Pal

    Journal of progressive agriculture. 2020 Oct., v. 11, no. 2

    2020  

    Abstract: The present study was conducted on secondary data on cotton crop in respect to area, production and yield from the year 1975–76 to 2017-8 in India as whole and Punjab in particular. The data was collected from the ICAR-Central Institute of Cotton ... ...

    Abstract The present study was conducted on secondary data on cotton crop in respect to area, production and yield from the year 1975–76 to 2017-8 in India as whole and Punjab in particular. The data was collected from the ICAR-Central Institute of Cotton Research. The analysis was done by the simple percentages, growth rates and trends for area, production and yield of cotton in India as whole and Punjab in particular and compared the results of area, production and yield of India and Punjab separately and Punjab in comparison to India. The compound growth rate of cotton area in India was 75.51, 72.51 and 88.71 percent during the period 1975–76 to 1984–85, 1990–91 to 1998–99 and 2004–05 to 2017–18.The compound growth rate of cotton area was increased in almost constant rate during the three different periods. The compound growth rate of cotton area in Punjab was only 6.08, 6.99 and 6.47 percent during the period 1975–76 to 1984–85, 1990–91 to 1998–99 and 2004–05 to 2017–18.The compound growth rate of cotton area was not increased much during the three different periods. It is almost negligible. The compound growth rate of cotton production in India was 63.99, 116.42 and 262.08 percent during the period 1975–76 to 1984–85, 1990–91 to 1998–99 and2004-05 to 2017–18.The compound growth rate of cotton production was increasing continuously during the three different periods.The compound growth rate of cotton production in Punjab was only 12.77, 24.74 and 23.26 percent during the period 1975–76 to 1984–85, 1990–91 to 1998–99 and 2004–05 to 2017–18.The compound growth rate of cotton production was not increased much during the three different periods. The compound growth rate of cotton yield in India was 144.17, 272.33 and 503.94 percent during the period 1975–76 to 1984–85, 1990–91 to 1998–99 and 2004–05 to 2017–18.The compound growth rate of cotton yield was increasing continuously during the three different periods.The compound growth rate of cotton yield in Punjab was 356.80, 603.88and 604.08percent during the period 1975–76 to 198485, 1990–91 to 1998–99 and2004-05 to 2017–18.The compound growth rate of cotton yield was increasing in increasing rate in second period (1990–91 to 1998–99) as compared to first period (1975–76 to 1984–85)..
    Keywords agriculture ; cotton ; India
    Language English
    Dates of publication 2020-10
    Size p. 42-50.
    Publishing place Social Welfare And Integrated Development Society
    Document type Article
    ISSN 2278-0556
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: An adamantyl-caffeoyl-anilide exhibits broad-spectrum antibacterial activity by inhibiting FtsZ assembly and Z-ring formation.

    Bhondwe, Prajakta / Sengar, Neha / Bodiwala, Hardik S / Singh, Inder Pal / Panda, Dulal

    International journal of biological macromolecules

    2024  Volume 259, Issue Pt 2, Page(s) 129255

    Abstract: Several harmful bacteria have evolved resistance to conventional antibiotics due to their extensive usage. FtsZ, a principal bacterial cell division protein, is considered as an important drug target to combat resistance. We identified a caffeoyl anilide ...

    Abstract Several harmful bacteria have evolved resistance to conventional antibiotics due to their extensive usage. FtsZ, a principal bacterial cell division protein, is considered as an important drug target to combat resistance. We identified a caffeoyl anilide derivative, (E)-N-(4-(3-(3,4-dihydroxyphenyl)acryloyl)phenyl)-1-adamantylamide (compound 11) as a new antimicrobial agent targeting FtsZ. Compound 11 caused cell elongation in Mycobacterium smegmatis, Bacillus subtilis, and Escherichia coli cells, indicating that it inhibits cell partitioning. Compound 11 inhibited the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ), forming short and thin filaments in vitro. Interestingly, the compound increased the rate of GTP hydrolysis of MsFtsZ. Compound 11 also impeded the assembly of Mycobacterium tuberculosis FtsZ. Fluorescence and absorption spectroscopic analysis suggested that compound 11 binds to MsFtsZ and produces conformational changes in FtsZ. The docking analysis indicated that the compound binds at the interdomain cleft of MsFtsZ. Further, it caused delocalization of the Z-ring in Mycobacterium smegmatis and Bacillus subtilis without affecting DNA segregation. Notably, compound 11 did not inhibit tubulin polymerization, the eukaryotic homolog of FtsZ, suggesting its specificity on bacteria. The evidence indicated that compound 11 exerts its antibacterial effect by impeding FtsZ assembly and has the potential to be developed as a broad-spectrum antimicrobial agent.
    MeSH term(s) Cytoskeletal Proteins/chemistry ; Anti-Bacterial Agents/chemistry ; Cell Division ; Cell Proliferation ; Bacterial Proteins/chemistry
    Chemical Substances Cytoskeletal Proteins ; Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2024-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Simultaneous quantitation of nine carbazole alkaloids from

    Chatterjee, Debanjan / Narzish, Fahima / Borade, Prashant / Singh, Inder Pal

    Natural product research

    2023  , Page(s) 1–9

    Abstract: ... Murraya ... ...

    Abstract Murraya koenigii
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2219819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quality of life in young adults with acne: Results of a cross-sectional study.

    Singh, Inder Pal / Poonia, Kavita / Bajaj, Kanika

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 12, Page(s) 4017–4023

    Abstract: Background: The impact of acne on quality of life (QoL) may vary between patients from different age groups. There are limited data in the literature on QoL of young adults with acne and acne scars.: Objectives: To assess the QoL of young adults (age ...

    Abstract Background: The impact of acne on quality of life (QoL) may vary between patients from different age groups. There are limited data in the literature on QoL of young adults with acne and acne scars.
    Objectives: To assess the QoL of young adults (age 18 to 25) with acne by using dermatology life quality index (DLQI) and Cardiff acne disability index (CADI), to assess the scores of individual items on DLQI and CADI, and to compare the two scales.
    Methods: In this cross-sectional questionnaire study of 1392 subjects with acne, each subject completed two questionnaires: DLQI and CADI. Mean values of DLQI and CADI, and those of individual items on DLQI and CADI were calculated; t-test was used for testing mean values and Spearman's rho coefficient for correlation between two questionnaires.
    Results: Mean DLQI (4.50) and CADI (3.60) scores were low. However, scores were significantly higher in females and in those with acne scars. "Feelings of embarrassment" and "interference with social activities" scored significantly higher for females across both questionnaires. There was no correlation between severity (as well as duration) of acne and HRQoL scores. Spearman's rho coefficient of correlation between DLQI and CADI was 0.71.
    Conclusions: Acne impaired the QoL of young adults, acne scars more so. Females felt worse about their appearance with greater embarrassment and impaired social activities. QoL scores seem to depend on patients' perceptions, which may depend on factors other than objective severity of acne. We found good correlation between the two scales.
    MeSH term(s) Acne Vulgaris ; Adolescent ; Adult ; Cross-Sectional Studies ; Emotions ; Female ; Humans ; Quality of Life ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cisplatin conjugation with an exopolysaccharide extracted from Lactobacillus gasseri potentiates its efficacy and attenuates its toxicity.

    Sharma, Nisha / Kabeer, Shaheen Wasil / Singh, Inder Pal / Tikoo, Kulbhushan

    International journal of biological macromolecules

    2022  

    Abstract: The development of newer cisplatin analogs is constantly being investigated owing to its low solubility, poor pharmacokinetics, and dose-related toxicity. In order to address the limitations of current cisplatin therapy, the present study was undertaken. ...

    Abstract The development of newer cisplatin analogs is constantly being investigated owing to its low solubility, poor pharmacokinetics, and dose-related toxicity. In order to address the limitations of current cisplatin therapy, the present study was undertaken. Cisplatin conjugation with an exopolysaccharide extracted from Lactobacillus gasseri (LG-EPS) showed remarkably enhanced and selective anticancer activity by targeting tumor cells overexpressing glucose transporter 1 (GLUT1). The EPS-cisplatin complex exhibited a 600-fold increase in aqueous solubility with a better pharmacokinetic profile (longer half-life) in comparison to cisplatin. Cell viability assay and western blotting demonstrated a strong correlation between the cytotoxicity profile and GLUT1 expressions in different cell lines. The concentration of DNA-bound platinum was also found to be significantly higher in EPS-cisplatin-treated cells. Quercetin, a competitive inhibitor of GLUTs, was shown to prevent this selective uptake of EPS-cisplatin complex. Surprisingly, EPS-cisplatin complex showed an exceptionally safer profile (4 times the maximum tolerated dose of cisplatin) in the acute toxicity study and was also more efficacious against the xenograft mice model. The study suggests that this green glycoconjugation can be an effective and safer strategy to broaden the therapeutic potential of anti-cancer drugs in general and cisplatin in particular.
    Language English
    Publishing date 2022-10-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.10.256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Common ringtail possums (<i>Pseudocheirus peregrinus</i>) tolerate high concentrations of unsubstituted B-ring flavanones in their diet

    Beale, Phillipa K. / Foley, William J. / Saraf, Isha / Singh, Inder Pal / Marsh, Karen J.

    Australian mammalogy. 2022, v. 44, no. 3

    2022  

    Abstract: Plant secondary metabolites (PSMs) can influence the consumption of particular plants by herbivores. Unsubstituted B-ring flavanones (UBFs), which are compounds found in the leaves of Eucalyptus species from the Eucalyptus subgenus (common name ... ...

    Abstract Plant secondary metabolites (PSMs) can influence the consumption of particular plants by herbivores. Unsubstituted B-ring flavanones (UBFs), which are compounds found in the leaves of Eucalyptus species from the Eucalyptus subgenus (common name monocalypt), deter feeding by common brushtail possums (Trichosurus vulpecula) when added to artificial diets at concentrations that reflect those found naturally in foliage. We hypothesised that common ringtail possums (Pseudocheirus peregrinus) would tolerate higher UBF concentrations, because, unlike brushtail possums, they regularly eat monocalypt foliage. This proved to be the case; ringtail possums were not deterred by two different UBFs, pinocembrin and flavanone, at concentrations up to 4.7% dry matter, which is substantially higher than the concentrations that deter brushtail possums. These results extend and refine our understanding of how variation in tolerance or susceptibility to eucalypt PSMs affects the diets of sympatric marsupial folivores, potentially reducing competition for food.
    Keywords Eucalyptus ; Trichosurus vulpecula ; common names ; diet ; flavanones ; herbivores ; leaves ; mammalogy ; secondary metabolites ; sympatry
    Language English
    Size p. 347-351.
    Publishing place CSIRO Publishing
    Document type Article
    ISSN 0310-0049
    DOI 10.1071/AM21027
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver.

    Sehgal, Rishabh / Singh, Harsimranjit / Singh, Inder Pal

    European journal of gastroenterology & hepatology

    2020  Volume 32, Issue 4, Page(s) 535–539

    Abstract: Introduction: The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis.: Materials and methods: 105 patients of ascites with liver cirrhosis were ... ...

    Abstract Introduction: The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis.
    Materials and methods: 105 patients of ascites with liver cirrhosis were randomized into three groups of 35 patients each. Group I was given Spironolactone 100 mg, group II was given Eplerenone 100 mg and group III was given Eplerenone 50 mg. All patients were put on salt-restricted diet (less than or equal to 2 g of sodium) and no loop diuretics were used. Patients were followed after 7 days from the baseline and then biweekly for the period of three months and serial measurements of weight, abdominal girth and incidence of side effects especially gynecomastia, mastalgia, hyperkalemia were recorded. Results were compared. Patients having Child-Turcotte-Pugh score-C, massive ascites, hepatic encephalopathy, Hepatorenal syndrome and ascites due to cardiac, renal, malignant causes were excluded.
    Observations: Difference in mean weight reduction was non significant (P = 0.964) in group I and group II whereas the difference was significant when comparison was made between Group I and III; and Group II and III (P = <0.001, <0.001, respectively). In group I, the incidence of gynecomastia was 14.28% whereas in group II and group III no case of gynecomastia was observed (P <0.001, <0.001). Hyperkalemia was present in one patient (2.8%) in group I whereas no patient developed hyperkalemia in group II and group III (P = >0.05, >0.05).
    Conclusion: Eplerenone and spironolactone are equally effective in management of ascites due to liver cirrhosis but side effect profile of eplerenone scores over Spironolactone.
    MeSH term(s) Adult ; Aged ; Ascites/diet therapy ; Ascites/drug therapy ; Ascites/etiology ; Diet, Sodium-Restricted ; Eplerenone/adverse effects ; Eplerenone/therapeutic use ; Female ; Humans ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Mineralocorticoid Receptor Antagonists/adverse effects ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Spironolactone/adverse effects ; Spironolactone/therapeutic use ; Treatment Outcome
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Spironolactone (27O7W4T232) ; Eplerenone (6995V82D0B)
    Language English
    Publishing date 2020-02-07
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000001678
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  8. Article ; Online: Synthesis and

    Kumar, Sanjay / Shah, Purvi / Tripathi, Siddharth K / Khan, Shabana I / Singh, Inder Pal

    Medicinal chemistry (Shariqah (United Arab Emirates))

    2022  Volume 18, Issue 9, Page(s) 949–969

    Abstract: Background: Quinoline is a well-established nucleus displaying various biological activities. Quinolin-8-ol-containing compounds are reported for antimicrobial as well as antimalarial activity. Hydrazone- and pyrazole-containing compounds are also ... ...

    Abstract Background: Quinoline is a well-established nucleus displaying various biological activities. Quinolin-8-ol-containing compounds are reported for antimicrobial as well as antimalarial activity. Hydrazone- and pyrazole-containing compounds are also reported for antimicrobial activity. In this work, we have synthesized hydrazonomethyl-quinolin-8-ol and pyrazol-3-yl-quinolin-8-ol derivatives retaining quinolin-8-ol along with hydrazone/pyrazole pharmacophores.
    Objective: The objective of this work was to synthesise and evaluate in vitro hydrazonomethylquinolin- 8-ol and pyrazol-3-yl-quinolin-8-ol derivatives for antifungal, antibacterial and antimalarial activity.
    Methods: Designed and synthesized hydrazonomethyl-quinolin-8-ol and pyrazol-3-yl-quinolin-8- ol derivatives were evaluated for antifungal (against Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans), antibacterial (against methicillin resistant Staphylococcus aureus (MRSA), Escherichia Coli, Pseudomonas aeruginosa and Klebsillae pneumoniae) as well as antimalarial (against Plasmodium falciparum D6 and W2 strains) activity.
    Results: Hydrazonomethyl-quinolin-8-ol (15.1-15.28) and pyrazol-3-yl-quinolin-8-ol derivatives (16.1-16.21 and 20.1-20.18) were synthesized in good to moderate yield. One-pot synthesis of pyrazol- 3-yl-quinolin-8-ol derivatives (16.1-16.21 and 20.1-20.18) was achieved. Compounds 15.3, 15.6, 15.7, 15.9-15.14, 15.16-15.19, 15.22 and 15.24 were found more potent compared to reference standard fluconazole (IC
    Conclusion: Most of the 5-hydrazonomethyl-quinolin-8-ol derivatives showed good antifungal activity against C. albicans, A. fumigatus and C. neoformans. Most of the 5-hydrazonomethylquinolin- 8-ol derivatives were found more potent than reference standard fluconazole. These derivatives may be considered as leads for further development of antifungal agents.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Antifungal Agents/pharmacology ; Antimalarials/pharmacology ; Candida albicans ; Cryptococcus neoformans ; Escherichia coli ; Fluconazole ; Hydrazones ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Pyrazoles/pharmacology ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Antifungal Agents ; Antimalarials ; Hydrazones ; Pyrazoles ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2022-03-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-6638
    ISSN (online) 1875-6638
    DOI 10.2174/1573406418666220303144929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quantitative analysis of tiliroside and other flavonoid glycosides in

    Ranjana, Soni / Srivastava, Amit / Goyal, Alok / Singh, Inder Pal / Jachak, Sanjay M

    Natural product research

    2022  Volume 38, Issue 8, Page(s) 1445–1450

    Abstract: A new HPLC-PDA method was developed and validated for simultaneous determination of five phenolic compounds ( ...

    Abstract A new HPLC-PDA method was developed and validated for simultaneous determination of five phenolic compounds (
    MeSH term(s) Quercetin/analysis ; Hippophae/chemistry ; Chromatography, High Pressure Liquid/methods ; Ellagic Acid/analysis ; Flavonoids/chemistry ; Glucosides/analysis ; Glycosides/chemistry ; Plant Leaves/chemistry
    Chemical Substances tiliroside (15M04TXR9M) ; Quercetin (9IKM0I5T1E) ; Ellagic Acid (19YRN3ZS9P) ; Flavonoids ; Glucosides ; Glycosides
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2148244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tetrahydroisoquinolines in therapeutics: a patent review (2010-2015).

    Singh, Inder Pal / Shah, Purvi

    Expert opinion on therapeutic patents

    2017  Volume 27, Issue 1, Page(s) 17–36

    Abstract: Introduction: 1,2,3,4-Tetrahydroisoquinoline (THIQ) is one of the 'privileged scaffolds', commonly found in nature. Initially, this class of compounds was known for its neurotoxicity. Later on, 1-methyl-1,2,3,4-tetrahydroisoquinoline was proved as an ... ...

    Abstract Introduction: 1,2,3,4-Tetrahydroisoquinoline (THIQ) is one of the 'privileged scaffolds', commonly found in nature. Initially, this class of compounds was known for its neurotoxicity. Later on, 1-methyl-1,2,3,4-tetrahydroisoquinoline was proved as an endogeneous Parkinsonism-preventing agent in mammals. The fused THIQs have been studied for their role as anticancer antibiotics. The US FDA approval of the trabectedin for the treatment of soft tissue sarcomas, is a milestone in the anticancer drug discovery. Areas covered: This review covers the patents on various therapeutic activities of the THIQ derivatives in the years between 2010 and 2015. Patents were collected using a thorough search of Espacenet and WIPO databases. The therapeutic areas covered include cancer, malaria, central nervous system (CNS), cardiovascular, metabolic disorders, and so on. This also includes several patents on specific THIQs of clinical importance. Expert opinion: A large number of the THIQ derivatives have been synthesised for various therapeutic activities, with noticeable success in the area of drug discovery for cancer and CNS. They may also prove to be promising candidates for various infectious diseases, such as malaria, tuberculosis, HIV-infection, HSV-infection, leishmaniasis, etc. They can also be developed as novel class of drugs for various therapeutic activities with unique mechanism of action.
    MeSH term(s) Animals ; Antineoplastic Agents, Alkylating/therapeutic use ; Central Nervous System Diseases/drug therapy ; Central Nervous System Diseases/physiopathology ; Dioxoles/therapeutic use ; Drug Design ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Patents as Topic ; Tetrahydroisoquinolines/adverse effects ; Tetrahydroisoquinolines/chemistry ; Tetrahydroisoquinolines/therapeutic use
    Chemical Substances Antineoplastic Agents, Alkylating ; Dioxoles ; Tetrahydroisoquinolines ; 1,2,3,4-tetrahydroisoquinoline (56W89FBX3E) ; trabectedin (ID0YZQ2TCP)
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1186201-4
    ISSN 1744-7674 ; 0962-2594 ; 1354-3776
    ISSN (online) 1744-7674
    ISSN 0962-2594 ; 1354-3776
    DOI 10.1080/13543776.2017.1236084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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