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  1. Book ; Online ; E-Book: Plant-pest interactions, from molecular mechanisms to chemical ecology

    Singh, Archana / Singh, Indrakant K.

    2021  

    Abstract: As food producers, plants are constantly under attack by insects. Over the course of evolution, plants have not only developed a sophisticated defense apparatus but have also refined biochemical defense mechanisms to protect themselves, thereby ... ...

    Author's details Edited by Indrakant K. Singh and Archana Singh
    Abstract As food producers, plants are constantly under attack by insects. Over the course of evolution, plants have not only developed a sophisticated defense apparatus but have also refined biochemical defense mechanisms to protect themselves, thereby maintaining the ecological balance. Plant-pest interactions induce an elaborate array of reactions involving the release of volatile compounds, effector and signaling molecules, trans-membrane proteins, and a variety of enzymes and hormones. This book offers a comprehensive guide to the strategies that plants employ against insects and other pests to ensure their continued survival. Addressing an important gap in the literature, it shares the latest findings in the field of plant–pest interactions for a broad audience. Providing an overview of the current state of knowledge on plant-pest interactions and their role in the genetic improvement of crops, it offers an essential guide for researchers and professionals in the fields of agriculture, plant pathology, entomology, cell biology, molecular biology and genetics.
    Keywords Plant diseases ; Agricultural pests ; Plants/Insect resistance
    Subject code 581
    Language English
    Size 1 online resource (XX, 464 p. 80 illus., 40 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-2467-X ; 981-15-2466-1 ; 978-981-15-2467-7 ; 978-981-15-2466-0
    DOI 10.1007/978-981-15-2467-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Calcium signaling: an early plant defense response against pests and pathogens.

    Singh, Archana / Gurusamy, Dhandapani / Singh, Indrakant K

    Frontiers in plant science

    2024  Volume 15, Page(s) 1400006

    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1400006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A simulation-based approach to target Zika virus RNA-dependent RNA polymerase with marine compounds for antiviral development.

    Sharma, Pradeep / Moustafa, Mahmoud / Al-Shehri, Mohammed / Alotaibi, Faisal / Bhardwaj, Rima / Singh, Indrakant K

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–11

    Abstract: Despite significant efforts, currently, there is no particular drug available to treat Zika virus (ZIKV) infection, highlighting the urgent need for effective therapeutic interventions. To identify putative inhibitors of the ZIKV RdRp protein's RNA ... ...

    Abstract Despite significant efforts, currently, there is no particular drug available to treat Zika virus (ZIKV) infection, highlighting the urgent need for effective therapeutic interventions. To identify putative inhibitors of the ZIKV RdRp protein's RNA binding function, the present study applied an extensive in-silico drug discovery methodology. The initial phase involved virtual screening using Lipinski's rule of five as a filter, ensuring the selection of molecules with favorable pharmacokinetic properties. This process yielded 238 compounds with promising docking scores, ranging from -6.0 to -7.48 kcal/mol, indicative of their potential binding affinity to the ZIKV RdRp. To refine the selection, these compounds underwent a re-docking process, comparing their binding energies with a reference molecule known for its inhibitory action against RdRp. Remarkably, five compounds, labeled CMNPD30598, CMNPD27464, CMNPD25971, CMNPD27444, and CMNPD16599, demonstrated superior re-docking energies compared to the reference, suggesting a stronger interaction with the RdRp allosteric site. Subsequent molecular dynamics (MD) simulations provided insights into the stability of these complexes over time, reinforcing their potential as RdRp inhibitors. Additionally, the calculation of free binding energies and principal component analysis (PCA) of the free energy landscape offered a deeper understanding of the binding dynamics and energetics. This study not only highlights the utility of marine fungi compounds in antiviral drug discovery but also showcases the power of computational tools in identifying novel therapeutics. The identified compounds represent promising candidates for further experimental validation and development as ZIKV RdRp inhibitors.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2322620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Herbivory-inducible lipid-transfer proteins (LTPs) of

    Negi, Harshita / Saxena, Harshita / Singh, Indrakant K / Singh, Archana

    Journal of biomolecular structure & dynamics

    2023  Volume 41, Issue 22, Page(s) 12863–12879

    Abstract: Lipid-transfer proteins (LTPs) are lipid-binding small proteins, ubiquitously distributed amongst plant kingdom. Apart from their involvement in plant defense, it has also been discovered that they induce allergic reactions in humans. A plethora of LTPs ... ...

    Abstract Lipid-transfer proteins (LTPs) are lipid-binding small proteins, ubiquitously distributed amongst plant kingdom. Apart from their involvement in plant defense, it has also been discovered that they induce allergic reactions in humans. A plethora of LTPs have been identified in vegetables, fruits, pollens, nuts, and latex, among which Pru p 3, a LTP allergen from peach fruit, is extensively studied and exhibits cross-reactivity with potential allergens from different species. In
    MeSH term(s) Humans ; Allergens/chemistry ; Plant Proteins/chemistry ; Antigens, Plant ; Cicer ; Molecular Docking Simulation ; Herbivory ; Food Hypersensitivity ; Plants ; Lipids
    Chemical Substances Allergens ; Plant Proteins ; Antigens, Plant ; Lipids
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2169353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Regulation of the regulators: Transcription factors controlling biosynthesis of plant secondary metabolites during biotic stresses and their regulation by miRNAs.

    Kajla, Mohini / Roy, Amit / Singh, Indrakant K / Singh, Archana

    Frontiers in plant science

    2023  Volume 14, Page(s) 1126567

    Abstract: Biotic stresses threaten to destabilize global food security and cause major losses to crop yield worldwide. In response to pest and pathogen attacks, plants trigger many adaptive cellular, morphological, physiological, and metabolic changes. One of the ... ...

    Abstract Biotic stresses threaten to destabilize global food security and cause major losses to crop yield worldwide. In response to pest and pathogen attacks, plants trigger many adaptive cellular, morphological, physiological, and metabolic changes. One of the crucial stress-induced adaptive responses is the synthesis and accumulation of plant secondary metabolites (PSMs). PSMs mitigate the adverse effects of stress by maintaining the normal physiological and metabolic functioning of the plants, thereby providing stress tolerance. This differential production of PSMs is tightly orchestrated by master regulatory elements, Transcription factors (TFs) express differentially or undergo transcriptional and translational modifications during stress conditions and influence the production of PSMs. Amongst others, microRNAs, a class of small, non-coding RNA molecules that regulate gene expression post-transcriptionally, also play a vital role in controlling the expression of many such TFs. The present review summarizes the role of stress-inducible TFs in synthesizing and accumulating secondary metabolites and also highlights how miRNAs fine-tune the differential expression of various stress-responsive transcription factors during biotic stress.
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1126567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dhurrin: A naturally occurring phytochemical as a weapon against insect herbivores.

    Yadav, Manisha / Singh, Indrakant K / Singh, Archana

    Phytochemistry

    2022  Volume 205, Page(s) 113483

    Abstract: Dhurrin, a cyanogenic glucoside, is a plant defensive chemical synthesized from aliphatic amino acids and consists of β-d-glucopyranose linked to α-hydroxy nitrile. It is catabolized by the consecutive action of hydroxynitrilase and β-glucosidase to ... ...

    Abstract Dhurrin, a cyanogenic glucoside, is a plant defensive chemical synthesized from aliphatic amino acids and consists of β-d-glucopyranose linked to α-hydroxy nitrile. It is catabolized by the consecutive action of hydroxynitrilase and β-glucosidase to release hydrogen cyanide on tissue disruption during herbivory. These phytoanticipins are widely distributed across various monocot and dicot plants such as Sorghum, Macadamia, Ostrya sp., and many other plant species with ornamental, pharmaceutical, medicinal, and food value. Although repellent properties of dhurrin against herbivores are often reported, less is known about its distribution, metabolism, mode of action against insects, and application for pest control. Herein, we highlight recent updates on dhurrin distribution, biosynthesis, and catabolism along with the cyanide detoxification pathway. Additionally, this article focuses on biological activities of dhurrin against various herbivores and opportunities to explore the utilization of dhurrin as a natural pest control agent and a substitute for chemically synthesized pesticides.
    MeSH term(s) Animals ; Insecta
    Language English
    Publishing date 2022-10-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2022.113483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
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  7. Article ; Online: Deciphering the role of miRNA in reprogramming plant responses to drought stress

    Singh, Archana / Jain, Deepti / Pandey, Jyotsna / Yadav, Manisha / Bansal, Kailash C. / Singh, Indrakant K.

    Critical Reviews in Biotechnology. 2023 May 19, v. 43, no. 4 p.613-627

    2023  

    Abstract: Drought is the most prevalent environmental stress that affects plants’ growth, development, and crop productivity. However, plants have evolved adaptive mechanisms to respond to the harmful effects of drought. They reprogram their: transcriptome, ... ...

    Abstract Drought is the most prevalent environmental stress that affects plants’ growth, development, and crop productivity. However, plants have evolved adaptive mechanisms to respond to the harmful effects of drought. They reprogram their: transcriptome, proteome, and metabolome that alter their cellular and physiological processes and establish cellular homeostasis. One of the crucial regulatory processes that govern this reprogramming is post-transcriptional regulation by microRNAs (miRNAs). miRNAs are small non-coding RNAs, involved in the downregulation of the target mRNA via translation inhibition/mRNA degradation/miRNA-mediated mRNA decay/ribosome drop off/DNA methylation. Many drought-inducible miRNAs have been identified and characterized in plants. Their main targets are regulatory genes that influence growth, development, osmotic stress tolerance, antioxidant defense, phytohormone-mediated signaling, and delayed senescence during drought stress. Overexpression of drought-responsive miRNAs (Osa-miR535, miR160, miR408, Osa-miR393, Osa-miR319, and Gma-miR394) in certain plants has led to tolerance against drought stress indicating their vital role in stress mitigation. Similarly, knock down (miR166/miR398c) or deletion (miR169 and miR827) of miRNAs has also resulted in tolerance to drought stress. Likewise, engineered Arabidopsis plants with miR165, miR166 using short tandem target mimic strategy, exhibited drought tolerance. Since miRNAs regulate the expression of an array of drought-responsive genes, they can act as prospective targets for genetic manipulations to enhance drought tolerance in crops and achieve sustainable agriculture. Further investigations toward functional characterization of diverse miRNAs, and understanding stress-responses regulated by these miRNAs and their utilization in biotechnological applications is highly recommended.
    Keywords Arabidopsis ; DNA methylation ; antioxidant activity ; biotechnology ; drought ; drought tolerance ; homeostasis ; metabolome ; microRNA ; osmotic stress ; proteome ; ribosomes ; stress tolerance ; sustainable agriculture ; transcriptome ; water stress ; miRNA ; miRNA targets ; translation inhibition ; gene silencing ; drought-tolerance ; biotechnological applications
    Language English
    Dates of publication 2023-0519
    Size p. 613-627.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1042364-3
    ISSN 1549-7801 ; 0738-8551
    ISSN (online) 1549-7801
    ISSN 0738-8551
    DOI 10.1080/07388551.2022.2047880
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2554: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Molecular aspects of plant-pathogen interaction

    Singh, Archana / Singh, Indrakant K

    2018  

    Author's details Archana Singh, Indrakant K. Singh
    Language English
    Size XXIII, 351 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Document type Book
    ISBN 9789811073700 ; 9811073708
    Database Julius Kühn-Institute

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  9. Article ; Online: Metabolomics-driven investigation of plant defense response against pest and pathogen attack.

    Kumari, Megha / Yagnik, Kalpesh Nath / Gupta, Vaishali / Singh, Indrakant K / Gupta, Ravi / Verma, Praveen K / Singh, Archana

    Physiologia plantarum

    2024  Volume 176, Issue 2, Page(s) e14270

    Abstract: The advancement of metabolomics has assisted in the identification of various bewildering characteristics of the biological system. Metabolomics is a standard approach, facilitating crucial aspects of system biology with absolute quantification of ... ...

    Abstract The advancement of metabolomics has assisted in the identification of various bewildering characteristics of the biological system. Metabolomics is a standard approach, facilitating crucial aspects of system biology with absolute quantification of metabolites using minimum samples, based on liquid/gas chromatography, mass spectrometry and nuclear magnetic resonance. The metabolome profiling has narrowed the wide gaps of missing information and has enhanced the understanding of a wide spectrum of plant-environment interactions by highlighting the complex pathways regulating biochemical reactions and cellular physiology under a particular set of conditions. This high throughput technique also plays a prominent role in combined analyses of plant metabolomics and other omics datasets. Plant metabolomics has opened a wide paradigm of opportunities for developing stress-tolerant plants, ensuring better food quality and quantity. However, despite advantageous methods and databases, the technique has a few limitations, such as ineffective 3D capturing of metabolites, low comprehensiveness, and lack of cell-based sampling. In the future, an expansion of plant-pathogen and plant-pest response towards the metabolite architecture is necessary to understand the intricacies of plant defence against invaders, elucidation of metabolic pathway operational during defence and developing a direct correlation between metabolites and biotic stresses. Our aim is to provide an overview of metabolomics and its utilities for the identification of biomarkers or key metabolites associated with biotic stress, devising improved diagnostic methods to efficiently assess pest and pathogen attack and generating improved crop varieties with the help of combined application of analytical and molecular tools.
    MeSH term(s) Metabolomics/methods ; Metabolome/physiology ; Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Plants/metabolism
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 2020837-6
    ISSN 1399-3054 ; 0031-9317
    ISSN (online) 1399-3054
    ISSN 0031-9317
    DOI 10.1111/ppl.14270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Identification and validation of a small molecule targeting ROR1 for the treatment of triple negative breast cancer.

    Gupta, Shradheya R R / Ta, Tram M / Khan, Maryam / Singh, Archana / Singh, Indrakant K / Peethambaran, Bela

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1243763

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1243763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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