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Article ; Online: Novel Approaches for the Treatment of Pulmonary Fibrosis with Emphasis on the Role of Galectin-3 Inhibitors as a Potential Therapeutic Approach.

Mathur, Tanya / Singh, Indu

Current drug research reviews

2023

Abstract: Pulmonary fibrosis is a disease affecting the lungs and the respiratory system that carries along a high fatality rate with no specific therapeutic approaches, making it a disorder sometimes termed as incurable. There have been various researches ... ...

Abstract	Pulmonary fibrosis is a disease affecting the lungs and the respiratory system that carries along a high fatality rate with no specific therapeutic approaches, making it a disorder sometimes termed as incurable. There have been various researches elaborating on the potential treatment and formulation approaches. Therapeutically effective drugs, new molecules, potential drug targets and novel delivery approaches have been identified. Recent findings suggest galectin-3 as a potential target to alleviate the condition by inhibition of the lectin. Certain molecules of galectin-3 have been discovered as promising therapeutic agents. These drug molecules have been administered either orally or through inhalation, and as of now, there is no candidate in the market to pose as a treatment for pulmonary fibrosis. There is a wide window to research and find novel dosage forms for the drug molecules to be presented as an efficacious and tolerable drug therapy against pulmonary fibrosis.
Language	English
Publishing date	2023-12-29
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2589-9783
ISSN (online)	2589-9783
DOI	10.2174/0125899775269970231218100959
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Article ; Online: From Vision Correction to Drug Delivery: Unraveling the Potential of Therapeutic Contact Lens.

Saini, Ankush / Sharma, Mohit / Singh, Indu / Swami, Rajan

Current drug delivery

2024

Abstract: Contact lenses (CLs) have become an essential tool in ocular drug delivery, providing effective treatment options for specific eye conditions. In recent advancements, Therapeutic CLs (TCLs) have emerged as a promising approach for maintaining therapeutic ...

Abstract	Contact lenses (CLs) have become an essential tool in ocular drug delivery, providing effective treatment options for specific eye conditions. In recent advancements, Therapeutic CLs (TCLs) have emerged as a promising approach for maintaining therapeutic drug concentrations on the eye surface. TCLs offer unique attributes, including prolonged wear and a remarkable ability to enhance the bioavailability of loaded medications by more than 50%, thus gaining widespread usage. They have proven beneficial in pain management, medication administration, corneal healing, and protection. To achieve sustained drug delivery from TCLs, researchers are exploring diverse systems, such as polymeric nanoparticulate systems, lipidic systems, and the incorporation of agents like vitamin E or rate-limiting polymers. However, despite breakthrough successes, certain challenges persist, including ensuring drug stability during processing and manufacturing, controlling release kinetics, and biomaterial interaction, reducing protein adhesion, and addressing drug release during packaging and storage etc. While TCLs have shown overall success in treating corneal and ocular surface disorders, careful consideration of potential issues and contraindications is vital. This review offers an insightful perspective on the critical aspects that need to be addressed regarding TCLs, with a specific emphasis on their advantages and limitations.
Language	English
Publishing date	2024-01-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/0115672018270396231213074746
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Article: Fibrinogen, Coagulation, and Ageing.

Donkin, Rebecca / Fung, Yoke Lin / Singh, Indu

Sub-cellular biochemistry

2023 Volume 102, Page(s) 313–342

Abstract: The World Health Organization estimates that the world's population over 60 years of age will nearly double in the next 30 years. This change imposes increasing demands on health and social services with increased disease burden in older people, ... ...

Abstract	The World Health Organization estimates that the world's population over 60 years of age will nearly double in the next 30 years. This change imposes increasing demands on health and social services with increased disease burden in older people, hereafter defined as people aged 60 years or more. An older population will have a greater incidence of cardiovascular disease partly due to higher levels of blood fibrinogen, increased levels of some coagulation factors, and increased platelet activity. These factors lead to a hypercoagulable state which can alter haemostasis, causing an imbalance in appropriate coagulation, which plays a crucial role in the development of cardiovascular diseases. These changes in haemostasis are not only affected by age but also by gender and the effects of hormones, or lack thereof in menopause for older females, ethnicity, other comorbidities, medication interactions, and overall health as we age. Another confounding factor is how we measure fibrinogen and coagulation through laboratory and point-of-care testing and how our decision-making on disease and treatment (including anticoagulation) is managed. It is known throughout life that in normal healthy individuals the levels of fibrinogen and coagulation factors change, however, reference intervals to guide diagnosis and management are based on only two life stages, paediatric, and adult ranges. There are no specific diagnostic guidelines based on reference intervals for an older population. How ageing relates to alterations in haemostasis and the impact of the disease will be discussed in this chapter. Along with the effect of anticoagulation, laboratory testing of fibrinogen and coagulation, future directions, and implications will be presented.
MeSH term(s)	Adult ; Aged ; Child ; Female ; Humans ; Middle Aged ; Aging/metabolism ; Anticoagulants ; Blood Coagulation/physiology ; Blood Coagulation Factors ; Fibrinogen/metabolism
Chemical Substances	Anticoagulants ; Blood Coagulation Factors ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Review
ISSN	0306-0225 ; 0096-8757
ISSN	0306-0225 ; 0096-8757
DOI	10.1007/978-3-031-21410-3_12
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Article ; Online: Association of Erythropoietin Gene Polymorphisms With Type 2 Diabetic Retinopathy in Adult Patients From Northern India.

Kaur, Navdeep / Singh, Indu R / Vanita, Vanita

Canadian journal of diabetes

2021 Volume 45, Issue 8, Page(s) 785–791

Abstract: Objectives: Our aim in this study was to determine the association of erythropoietin (EPO) gene polymorphisms with diabetic retinopathy in patients with type 2 diabetes from northern India.: Methods: In this case-control study, we recruited 614 ... ...

Abstract	Objectives: Our aim in this study was to determine the association of erythropoietin (EPO) gene polymorphisms with diabetic retinopathy in patients with type 2 diabetes from northern India. Methods: In this case-control study, we recruited 614 participants, consisting of 302 diabetic retinopathy cases and 312 individuals with confirmed type 2 diabetes without retinopathy as controls. EPO polymorphism analysis was performed in all participants using polymerase chain reaction and direct DNA sequence analysis. Results: The genotype distribution and allele frequency of the c.246+265G>A (rs507392) polymorphism differed significantly (p<0.05) between the retinopathy and control groups. For the -1306C>A (rs1617640) polymorphism, genotype distribution among the 2 groups analyzed differed significantly (p=0.047), but the distribution of allele frequency was not found to be statistically significant (p=0.07). For the c.∗772G>T (rs551238) variant, genotype distribution did not differ significantly when comparing the 2 groups (p=0.062), but allele frequency distribution did differ significantly (p=0.045). For the polymorphisms analyzed, namely rs507392 and rs1617640, a statistically significant association with retinopathy was observed (dominant model: adjusted odds ratio [OR], 2.23; 95% confidence interval [CI], 1.36 to 3.35; p<0.01; codominant model: adjusted OR, 1.45; 95% CI, 1.00 to 2.09; p=0.048). However, no significant association between c.∗772G>T (rs551238) polymorphism and diabetic retinopathy was found. Conclusions: Our findings show 2 polymorphisms (c.246+265G>A [rs507392] and -1306C>A [rs1617640]) in EPO to be risk factors for type 2 diabetic retinopathy in a northern Indian cohort. To our knowledge, this is the first report from India to demonstrate an association between EPO gene polymorphisms and retinopathy.
MeSH term(s)	Case-Control Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/genetics ; Erythropoietin/genetics ; Genotype ; Humans ; India/epidemiology ; Polymorphism, Single Nucleotide
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2021-04-02
Publishing country	Canada
Document type	Journal Article
ISSN	2352-3840
ISSN (online)	2352-3840
DOI	10.1016/j.jcjd.2021.03.008
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Article ; Online: The Potential of Spent Coffee Grounds in Functional Food Development.

Bevilacqua, Elza / Cruzat, Vinicius / Singh, Indu / Rose'Meyer, Roselyn B / Panchal, Sunil K / Brown, Lindsay

Nutrients

2023 Volume 15, Issue 4

Abstract: Coffee is a popular and widely consumed beverage worldwide, with epidemiological studies showing reduced risk of cardiovascular disease, cancers and non-alcoholic fatty liver disease. However, few studies have investigated the health effects of the post- ... ...

Abstract	Coffee is a popular and widely consumed beverage worldwide, with epidemiological studies showing reduced risk of cardiovascular disease, cancers and non-alcoholic fatty liver disease. However, few studies have investigated the health effects of the post-brewing coffee product, spent coffee grounds (SCG), from either hot- or cold-brew coffee. SCG from hot-brew coffee improved metabolic parameters in rats with diet-induced metabolic syndrome and improved gut microbiome in these rats and in humans; further, SCG reduced energy consumption in humans. SCG contains similar bioactive compounds as the beverage including caffeine, chlorogenic acids, trigonelline, polyphenols and melanoidins, with established health benefits and safety for human consumption. Further, SCG utilisation could reduce the estimated 6-8 million tonnes of waste each year worldwide from production of coffee as a beverage. In this article, we explore SCG as a major by-product of coffee production and consumption, together with the potential economic impacts of health and non-health applications of SCG. The known bioactive compounds present in hot- and cold-brew coffee and SCG show potential effects in cardiovascular disease, cancer, liver disease and metabolic disorders. Based on these potential health benefits of SCG, it is expected that foods including SCG may moderate chronic human disease while reducing the environmental impact of waste otherwise dumped in landfill.
MeSH term(s)	Rats ; Humans ; Animals ; Coffee ; Functional Food ; Cardiovascular Diseases ; Caffeine/analysis
Chemical Substances	Coffee ; Caffeine (3G6A5W338E)
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040994
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Article: Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System.

Singh, Indu / Dhawan, Gagan / Gupta, Seema / Kumar, Pradeep

Frontiers in microbiology

2021 Volume 11, Page(s) 607099

Abstract: The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/ ... ...

Abstract	The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/antibacterial materials and coatings to combat such infections have become a priority, as many infections are caused by indwelling implants (e.g., catheters) as well as improving postsurgical function and outcomes. Pathogenic microorganisms that can exist either in planktonic form or as biofilms in water-carrying pipelines are one of the sources responsible for causing water-borne infections. To combat this, researchers have developed nanotextured surfaces with bactericidal properties mirroring the topographical features of some natural antibacterial materials. Protein-based adhesives, secreted by marine mussels, contain a catecholic amino acid, 3,4-dihydroxyphenylalanine (DOPA), which, in the presence of lysine amino acid, empowers with the ability to anchor them to various surfaces in both wet and saline habitats. Inspired by these features, a novel coating material derived from a catechol derivative, dopamine, known as polydopamine (PDA), has been designed and developed with the ability to adhere to almost all kinds of substrates. Looking at the immense potential of PDA, this review article offers an overview of the recent growth in the field of PDA and its derivatives, especially focusing the promising applications as antibacterial nanocoatings and discussing various antimicrobial mechanisms including reactive oxygen species-mediated antimicrobial properties.
Language	English
Publishing date	2021-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.607099
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Article ; Online: Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells.

Aboonabi, Anahita / Singh, Indu / Rose' Meyer, Roselyn

Chemico-biological interactions

2020 Volume 317, Page(s) 108940

Abstract: Type 2 diabetes is associated with oxidative stress and low-grade inflammation resulting in endothelial dysfunction (ED). This study determined to explore the protective effects of berry-derived anthocyanins (AC) with potent antioxidant and anti- ... ...

Abstract	Type 2 diabetes is associated with oxidative stress and low-grade inflammation resulting in endothelial dysfunction (ED). This study determined to explore the protective effects of berry-derived anthocyanins (AC) with potent antioxidant and anti-inflammatory activities in human diabetic endothelial cells upon oxidative and inflammatory stressors. Cultured healthy human aortic endothelial cells (HAEC) and diabetic human aortic endothelial cells (D-HAEC) exposed to oxidative stress by hydrogen peroxide (H
MeSH term(s)	Anthocyanins/chemistry ; Anthocyanins/pharmacokinetics ; Anthocyanins/pharmacology ; Aorta/cytology ; Caspase 1/genetics ; Caspase 1/metabolism ; Cell Line ; Cell Survival/drug effects ; Cytokines/genetics ; Cytokines/metabolism ; Cytoprotection/drug effects ; Diabetes Mellitus, Type 2 ; Endothelial Cells/drug effects ; Gene Expression Regulation/drug effects ; Humans ; Hydrogen Peroxide/administration & dosage ; Hydrogen Peroxide/toxicity ; Inflammation/chemically induced ; Inflammation/drug therapy ; Male ; Middle Aged ; Molecular Structure ; Oxidative Stress/drug effects ; Reactive Oxygen Species
Chemical Substances	Anthocyanins ; Cytokines ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2020-01-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2020.108940
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Article ; Online: Novel mutation in MKKS/BBS6 linked with arRP and polydactyly in a family of North Indian origin.

Goyal, Shiwali / Singh, Indu R / Vanita, Vanita

Clinical & experimental ophthalmology

2020 Volume 48, Issue 3, Page(s) 343–355

Abstract: Background: To identify the underlying genetic defect in a fourth-generation autosomal recessive retinitis pigmentosa (arRP) family. Detailed family history and clinical data were collected from nine members, including three affected, from an arRP ... ...

Abstract	Background: To identify the underlying genetic defect in a fourth-generation autosomal recessive retinitis pigmentosa (arRP) family. Detailed family history and clinical data were collected from nine members, including three affected, from an arRP family. Methods: Whole-exome sequencing (WES) was performed on DNA sample of an affected individual IV: 2. Variants obtained by WES were annotated using Ion Reporter Software (ver. 5.2). Potential pathogenic variants detected in an affected member were validated in other affected and unaffected family members by Sanger sequencing. Further 150 ethnically-matched controls were tested for the variant that co-segregated completely with disease in the family, so as to exclude it as a polymorphism. Various web-based bioinformatics tools were also applied to access pathogenic potential of the observed variant. Results: All the three patients had RP with polydactyly of both hands and feet, however, they did not show other symptoms of Bardet-Biedl syndrome (BBS) or McKusick-Kaufmann Syndrome (MKKS). A novel missense mutation, that is, c.518A>C (p.His173Pro) was identified in MKKS/BBS6 that co-segregated completely with the disease phenotype in all the three affected members and was not observed in six unaffected members of the family. Also the c.518A>C change was not observed in 150 ethnically matched controls (300 chromosomes), hence excluding it as a polymorphism. Conclusions: Present study is the second report of identifying a novel mutation in MKKS/BBS6 that is linked with arRP in association with polydactyly, however, with no other signs of BBS or MKKS. These findings further expand the mutation spectrum of MKKS/BBS6 for arRP with polydactyly.
MeSH term(s)	Bardet-Biedl Syndrome ; DNA Mutational Analysis ; Group II Chaperonins/genetics ; Humans ; Mutation ; Pedigree ; Polydactyly ; Retinitis Pigmentosa/genetics
Chemical Substances	MKKS protein, human ; Group II Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2020-02-03
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2014008-3
ISSN	1442-9071 ; 1442-6404
ISSN (online)	1442-9071
ISSN	1442-6404
DOI	10.1111/ceo.13719
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Zs.A 1064: Show issues

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Article ; Online: Design and Characterization of Citronella Oil-Loaded Micro-Emulgel for the Treatment of

Singh, Shambhvi / Chauhan, Shikha Baghel / Gupta, Charu / Singh, Indu / Gupta, Annie / Sharma, Shwetakshi / Kawish, S M / Rahman, Shakilur / Iqbal, Muzaffar

Gels (Basel, Switzerland)

2023 Volume 9, Issue 10

Abstract: The purpose of the current study was to prepare and evaluate a citronella oil-loaded microemulsion-based micro-emulgel for the treatment ... ...

Abstract	The purpose of the current study was to prepare and evaluate a citronella oil-loaded microemulsion-based micro-emulgel for the treatment of
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9100799
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Article ; Online: The association between metabolic syndrome components and the development of atherosclerosis.

Aboonabi, Anahita / Meyer, Roselyn Rose' / Singh, Indu

Journal of human hypertension

2019 Volume 33, Issue 12, Page(s) 844–855

Abstract: Metabolic syndrome (MetS) is a collection of pathological conditions associated with metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the atherosclerotic process with associated clustering of risk factors which can ... ...

Abstract	Metabolic syndrome (MetS) is a collection of pathological conditions associated with metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the atherosclerotic process with associated clustering of risk factors which can increase the risk of atherogenic damage. There is an association between MetS components and the progression of atherosclerosis, which is the leading cause of cardiovascular deaths. This review was undertaken to assess the potential role of metabolic syndrome components, including oxidative stress, hypertension, hyperglycaemia and insulin resistance, obesity, dyslipidemia, chronic inflammation, physical inactivity, and atherogenic diet in the progression of atherosclerosis based on existing research.
MeSH term(s)	Atherosclerosis/blood ; Atherosclerosis/epidemiology ; Atherosclerosis/physiopathology ; Atherosclerosis/therapy ; Biomarkers/blood ; Blood Coagulation ; Blood Glucose/metabolism ; Diet, Atherogenic/adverse effects ; Disease Progression ; Dyslipidemias/blood ; Dyslipidemias/epidemiology ; Dyslipidemias/physiopathology ; Humans ; Hyperglycemia/blood ; Hyperglycemia/epidemiology ; Hyperglycemia/physiopathology ; Hypertension/epidemiology ; Hypertension/physiopathology ; Inflammation/blood ; Inflammation/epidemiology ; Inflammation/physiopathology ; Inflammation Mediators/blood ; Insulin Resistance ; Lipids/blood ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/physiopathology ; Metabolic Syndrome/therapy ; Obesity/blood ; Obesity/epidemiology ; Obesity/physiopathology ; Oxidative Stress ; Prognosis ; Risk Assessment ; Risk Factors ; Sedentary Behavior
Chemical Substances	Biomarkers ; Blood Glucose ; Inflammation Mediators ; Lipids
Language	English
Publishing date	2019-10-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-019-0273-0
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