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  1. Article ; Online: Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells.

    Singh, Nathan

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  Volume 32, Issue 3, Page(s) 567–568

    MeSH term(s) Humans ; Neoplasms/therapy ; Receptors, Chimeric Antigen/genetics ; T-Lymphocytes ; Immunotherapy, Adoptive
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Neurobiological basis for the application of yoga in drug addiction.

    Singh, Nilkamal

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1373866

    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1373866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Facial shape differences between rats selected for tame and aggressive behaviors

    singh, nandini

    PLOS ONE, 12(4):e0175043

    2017  

    Abstract: Domestication has been consistently accompanied by a suite of traits called the domestication syndrome. These include increased docility, changes in coat coloration, prolonged juvenile behaviors, modified function of adrenal glands and reduced ... ...

    Institution Eberhard Karls Universität Tübingen. Senckenberg Centre for Human Evolution and Palaeoenvironment
    Abstract Domestication has been consistently accompanied by a suite of traits called the domestication syndrome. These include increased docility, changes in coat coloration, prolonged juvenile behaviors, modified function of adrenal glands and reduced craniofacial dimensions. Wilkins et al recently proposed that the mechanistic factor underlying traits that encompass the domestication syndrome was altered neural crest cell (NCC) development. NCC form the precursors to a large number of tissue types including pigment cells, adrenal glands, teeth and the bones of the face. The hypothesis that deficits in NCC development can account for the domestication syndrome was partly based on the outcomes of Dmitri Belyaev’s domestication experiments initially conducted on silver foxes. After generations of selecting for tameness, the foxes displayed phenotypes observed in domesticated species. Belyaev also had a colony of rats selected over 64 generations for either tameness or defensive aggression towards humans. Here we focus on the facial morphology of Belyaev’s tame, ‘domesticated’ rats to test whether: 1) tameness in rats causes craniofacial changes similar to those observed in the foxes; 2) facial shape, i.e. NCC-derived region, is distinct in the tame and aggressive rats. We used computed-tomography scans of rat skulls and landmark-based geometric morphometrics to quantify and analyze the facial skeleton. We found facial shape differences between the tame and aggressive rats that were independent of size and which mirrored changes seen in domesticated animals compared to their wild counterparts. However, there was no evidence of reduced sexual dimorphism in the face of the tame rats. This indicates that not all morphological changes in NCC-derived regions in the rats follow the pattern of shape change reported in domesticated animals or the silver foxes. Thus, certain phenotypic trends that are part of the domestication syndrome might not be consistently present in all experimental animal models.
    Keywords Animal behavior ; Aggression ; Domestic animals ; Foxes ; Face ; Sexual dimorphism ; Phenotypes ; Rats
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article: Inclusion of physical medicine and rehabilitation in the medical curriculum: A step in the right direction.

    Singh, Neha

    The National medical journal of India

    2023  Volume 36, Issue 1, Page(s) 44–48

    Abstract: Background Although physical medicine and rehabilitation (PMR) was first introduced in India in the 1960s, it was not until the 1990s when it was offered as an optional rotation to Indian medical graduates. Lately, with the introduction of a competency- ... ...

    Abstract Background Although physical medicine and rehabilitation (PMR) was first introduced in India in the 1960s, it was not until the 1990s when it was offered as an optional rotation to Indian medical graduates. Lately, with the introduction of a competency-based undergraduate curriculum in 2018, PMR has been included as an essential subject in the medical graduate curriculum, to be implemented from 2019. We aimed to ascertain the importance of incorporating PMR in the medical graduate curriculum while also discussing the awareness about PMR among Indian healthcare professionals. Methods We drafted an online questionnaire-based survey and sent that to participants through cloud-based software. Responses were collected over a period of 4 weeks and a descriptive analysis was performed. Results The initial hypothesis was that most healthcare professionals would be unaware of the scope of PMR as a medical specialty. The results of this study did not support our hypothesis with 96.8% of the participants being familiar with PMR as a medical specialty. In addition, 85% of the participants reported being introduced to PMR either in their medical school or during their residency training and 92% of the participants appreciated the late integration of PMR within the medical graduate curriculum. Conclusions Introduction of medical graduates to PMR would help in bridging the gaps faced by people with disabilities in accessing healthcare facilities. It would also help clinicians from other specialties to collaborate with physiatrists in a more coordinated manner.
    MeSH term(s) Humans ; Physical and Rehabilitation Medicine ; Curriculum ; Internship and Residency ; Clinical Competence ; Health Personnel
    Language English
    Publishing date 2023-08-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.25259/NMJI_704_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Book ; Online ; E-Book: Bio-management of postharvest diseases and mycotoxigenic fungi

    Sharma, Neeta / Bhandari, Avantina S.

    (World Food Preservation Center book series)

    2021  

    Author's details edited by Neeta Sharma and Avantina S. Bhandari
    Series title World Food Preservation Center book series
    Keywords Food crops/Diseases and pests/Biological control ; Mycotoxins ; Toxigenic fungi ; Biological decontamination
    Subject code 632.9
    Language English
    Size 1 Online-Ressource (xvi, 296 Seiten), Illustrationen
    Publisher CRC Press
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020576914
    ISBN 978-1-0001-2385-2 ; 9781498797313 ; 1-0001-2385-5 ; 1498797318
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article: The Top 100 Most-Cited Publications in Musculoskeletal Rehabilitation: A Bibliometric Analysis.

    Singh, Neha

    Indian journal of orthopaedics

    2022  Volume 56, Issue 8, Page(s) 1327–1338

    Abstract: Background: Musculoskeletal conditions are the leading contributor to global healthcare expenditure and with an increase in ageing global population, this number is projected to rise further.: Objectives: To determine the top 100 most-cited studies ... ...

    Abstract Background: Musculoskeletal conditions are the leading contributor to global healthcare expenditure and with an increase in ageing global population, this number is projected to rise further.
    Objectives: To determine the top 100 most-cited studies in field of musculoskeletal rehabilitation and to conduct their bibliometric analysis.
    Design: Scopus was used for identification of studies, published in the field of musculoskeletal rehabilitation over last five decades.
    Methods: Literature search was conducted in February 2021 with final Boolean search phrases being: [(musculoskeletal) and (rehabilitation) and (musculoskeletal rehabilitation)]. In addition to number of citations, data was also collected for other variables such as title of study, topic of discussion, subdivisions of clinical and applied science involved in conduction of study, study design, journal and its impact factor, year of publication, and country where study was conducted.
    Results: The top 100 most-cited articles in musculoskeletal rehabilitation over the last 50 years were published between 1973 and 2015. Total number of citations was 24,366, with an average of 243.66 citations per paper. Highest citation was reported by a paper on treatment of low back pain by Waddell G. The decade of 2000-2009 contributed maximum articles with highest number of publications from journal "Archives of Physical Medicine and Rehabilitation". Most of the publications were from United States and most common topic to feature among these articles was "Strength training".
    Conclusions: This study identifies the top 100 most-cited articles in musculoskeletal rehabilitation and provides insight into its historical trends while serving as a guide for future research.
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 603194-8
    ISSN 0019-5413
    ISSN 0019-5413
    DOI 10.1007/s43465-022-00672-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: SMBE Secretary's Report.

    Singh, Nadia

    Molecular biology and evolution

    2021  Volume 38, Issue 12, Page(s) 5831–5833

    Language English
    Publishing date 2021-11-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msab325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Role of mammalian long non-coding RNAs in normal and neuro oncological disorders.

    Singh, Neetu

    Genomics

    2021  Volume 113, Issue 5, Page(s) 3250–3273

    Abstract: Long non-coding RNAs (lncRNAs) are expressed at lower levels than protein-coding genes but have a crucial role in gene regulation. LncRNA is distinct, they are being transcribed using RNA polymerase II, and their functionality depends on subcellular ... ...

    Abstract Long non-coding RNAs (lncRNAs) are expressed at lower levels than protein-coding genes but have a crucial role in gene regulation. LncRNA is distinct, they are being transcribed using RNA polymerase II, and their functionality depends on subcellular localization. Depending on their niche, they specifically interact with DNA, RNA, and proteins and modify chromatin function, regulate transcription at various stages, forms nuclear condensation bodies and nucleolar organization. lncRNAs may also change the stability and translation of cytoplasmic mRNAs and hamper signaling pathways. Thus, lncRNAs affect the physio-pathological states and lead to the development of various disorders, immune responses, and cancer. To date, ~40% of lncRNAs have been reported in the nervous system (NS) and are involved in the early development/differentiation of the NS to synaptogenesis. LncRNA expression patterns in the most common adult and pediatric tumor suggest them as potential biomarkers and provide a rationale for targeting them pharmaceutically. Here, we discuss the mechanisms of lncRNA synthesis, localization, and functions in transcriptional, post-transcriptional, and other forms of gene regulation, methods of lncRNA identification, and their potential therapeutic applications in neuro oncological disorders as explained by molecular mechanisms in other malignant disorders.
    MeSH term(s) Animals ; Child ; Chromatin ; Cytoplasm/metabolism ; Gene Expression Regulation ; Humans ; Mammals/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger
    Chemical Substances Chromatin ; RNA, Long Noncoding ; RNA, Messenger
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2021.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Society for Molecular Biology and Evolution, Council and Business Meetings, 2020.

    Singh, Nadia

    Molecular biology and evolution

    2021  Volume 38, Issue 4, Page(s) 1691–1693

    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msab016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Modified T cells as therapeutic agents.

    Singh, Nathan

    Hematology. American Society of Hematology. Education Program

    2021  Volume 2021, Issue 1, Page(s) 296–302

    Abstract: Immunotherapy is now a well-established modality in the treatment of cancer. Although several platforms to redirect the immune response exist, the use of genetically modified T cells has garnered particular attention in recent years. This is due, in ... ...

    Abstract Immunotherapy is now a well-established modality in the treatment of cancer. Although several platforms to redirect the immune response exist, the use of genetically modified T cells has garnered particular attention in recent years. This is due, in large part, to their success in the treatment of B-cell malignancies. Adoptively transferred T cells have also demonstrated efficacy in the treatment of systemic viral infections that occur following hematopoietic cell transplantation prior to immune reconstitution. Here we discuss the techniques that enable redirection of T lymphocytes to treat cancer or infection and the current indications for these therapies.
    MeSH term(s) Clinical Trials as Topic ; Humans ; Immunotherapy, Adoptive/methods ; Male ; Middle Aged ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes/immunology ; T-Lymphocytes/transplantation
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2021000262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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