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Article: VIBe Scale: Validation of the Intraoperative Bleeding Severity Scale by Spine Surgeons.

Sciubba, Daniel M / Khanna, Nitin / Pennington, Zach / Singh, Rahul K

International journal of spine surgery

2022

Language	English
Publishing date	2022-07-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4599
ISSN	2211-4599
DOI	10.14444/8304
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Article ; Online: Anomalous Diffusion and Lévy Walks Distinguish Active from Inertial Turbulence.

Mukherjee, Siddhartha / Singh, Rahul K / James, Martin / Ray, Samriddhi Sankar

Physical review letters

2021 Volume 127, Issue 11, Page(s) 118001

Abstract: Bacterial swarms display intriguing dynamical states like active turbulence. Now, using a hydrodynamic model, we show that such dense active suspensions manifest superdiffusion, via Lévy walks, which masquerades as a crossover from ballistic to diffusive ...

Abstract	Bacterial swarms display intriguing dynamical states like active turbulence. Now, using a hydrodynamic model, we show that such dense active suspensions manifest superdiffusion, via Lévy walks, which masquerades as a crossover from ballistic to diffusive scaling in measurements of mean-squared displacements, and is tied to the emergence of hitherto undetected oscillatory streaks in the flow. Thus, while laying the theoretical framework of an emergent advantageous strategy in the collective behavior of microorganisms, our Letter underlines the essential differences between active and inertial turbulence.
MeSH term(s)	Bacterial Physiological Phenomena ; Cell Movement/physiology ; Diffusion ; Models, Biological ; Models, Theoretical ; Movement
Language	English
Publishing date	2021-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.118001
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Article ; Online: Toxicopathological impact of sub-lethal concentrations of lead nitrate on the gill of the catfish Heteropneustes fossilis.

Mahapatra, Archisman / Mistri, Arup / Gupta, Priya / Kar, Sumanta / Mittal, Swati / Singh, Rahul K

Acta histochemica

2022 Volume 124, Issue 2, Page(s) 151848

Abstract: In recent studies, fish are heavily used as biomarkers of aquatic pollution, and heavy metals are among the main contributors to water pollution. In the present study, we investigated histopathological changes along with alterations in localization and ... ...

Abstract	In recent studies, fish are heavily used as biomarkers of aquatic pollution, and heavy metals are among the main contributors to water pollution. In the present study, we investigated histopathological changes along with alterations in localization and activity of enzymes alkaline phosphatase (ALP), acid phosphatase (ACP), catalase (CAT), peroxidase (PER) and Na
MeSH term(s)	Animals ; Catfishes/physiology ; Gills ; Lead/toxicity ; Nitrates/toxicity ; Water Pollutants, Chemical/toxicity
Chemical Substances	Nitrates ; Water Pollutants, Chemical ; Lead (2P299V784P) ; lead nitrate (6E5P1699FI)
Language	English
Publishing date	2022-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	77-2
ISSN	1618-0372 ; 0065-1281
ISSN (online)	1618-0372
ISSN	0065-1281
DOI	10.1016/j.acthis.2022.151848
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Article ; Online: Emerging role of miR-320a in lung cancer: a comprehensive review.

Mohanta, Adrija / Kumar, Rajiv R / Singh, Rahul K / Mandal, Surojit / Yadav, Ritu / Khatkar, Rinku / Sharma, Uttam / Uttam, Vivek / Rana, Manjit K / Rana, Amrit Ps / Jain, Aklank

Biomarkers in medicine

2023 Volume 17, Issue 18, Page(s) 767–781

Abstract: A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. ... ...

Abstract	A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. We found that miR-320a modulates levels of diverse cancer-associated molecules and signaling pathways, and is also involved in modulating the immune microenvironment of lung cancer during its pathogenesis. We also discuss how miR-320a encapsulated in exosomes inhibits invasive phenotypes of lung cancer. Therefore, based on the multimodal role of miR-320a in lung cancer development and progression, we believe that miR-320a may be utilized as a potential diagnostic/prognostic marker and therapeutic target for lung cancer patients.
MeSH term(s)	Humans ; Cell Line, Tumor ; Cell Proliferation/genetics ; Lung Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction ; Tumor Microenvironment
Chemical Substances	MicroRNAs ; MIRN320A microRNA, human
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2023-0215
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Article ; Online: Double glassy states and large spontaneous and conventional exchange bias in La

Singh, Prajyoti / Singh, Rahul K / Dixit, Srishti / Patel, Neha / Alam, Mohd / Dan, Sambhab / Jain, A / Anand, K / Gangwar, Vinod K / Singh, Rahul / Joshi, Amish G / Yusuf, S M / Chatterjee, Sandip

Journal of physics. Condensed matter : an Institute of Physics journal

2022 Volume 34, Issue 37

Abstract: The structural and magnetic properties of hole doped double perovskite ... ...

Abstract	The structural and magnetic properties of hole doped double perovskite La
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ac7f74
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Article: Capillary morphogenesis in PEG-collagen hydrogels

Singh, Rahul K / Seliktar, Dror / Putnam, Andrew J

Biomaterials. 2013 Dec., v. 34, no. 37

2013

Abstract: A wide variety of hydrogels have been explored as 3D culture platforms and for applications in tissue engineering. Hydrogels formed from natural extracellular matrix (ECM) proteins readily support the formation of vasculature in vitro, but only a handful ...

Abstract	A wide variety of hydrogels have been explored as 3D culture platforms and for applications in tissue engineering. Hydrogels formed from natural extracellular matrix (ECM) proteins readily support the formation of vasculature in vitro, but only a handful of hydrogels composed of synthetic materials have shown anything comparable. This relative lack of synthetic material options has hindered efforts to better understand how ECM cues direct vascularization. We developed a biosynthetic hydrogel consisting of polyethylene glycol diacrylamide conjugated to macromolecular type-I collagen. Through their acrylamide-based crosslinks, these materials allow for independent control of physical properties and bulk ligand concentration. These hydrogels exhibited hydrolytic stability, but the collagen component retained its susceptibility to enzymatic remodeling. Photoencapsulation of endothelial cells and fibroblasts within this hydrogel material and their subsequent co-culture led to the formation of capillary vessel-like networks with well-defined hollow lumens. Capillary formation was prevented by inhibiting matrix metalloproteinase (MMP) activity, recapitulating the MMP-dependence of vascularization observed in natural hydrogels. These findings validate the utility of this material platform to decipher how the ECM regulates capillary morphogenesis and to support the formation of vascularized tissue constructs for potential applications in regenerative medicine.
Keywords	coculture ; collagen ; crosslinking ; endothelial cells ; extracellular matrix ; fibroblasts ; hydrocolloids ; medicine ; metalloproteinases ; morphogenesis ; physical properties ; polyethylene glycol ; tissue engineering
Language	English
Dates of publication	2013-12
Size	p. 9331-9340.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2013.08.016
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Article ; Online: Capillary morphogenesis in PEG-collagen hydrogels.

Singh, Rahul K / Seliktar, Dror / Putnam, Andrew J

Biomaterials

2013 Volume 34, Issue 37, Page(s) 9331–9340

Abstract	A wide variety of hydrogels have been explored as 3D culture platforms and for applications in tissue engineering. Hydrogels formed from natural extracellular matrix (ECM) proteins readily support the formation of vasculature in vitro, but only a handful of hydrogels composed of synthetic materials have shown anything comparable. This relative lack of synthetic material options has hindered efforts to better understand how ECM cues direct vascularization. We developed a biosynthetic hydrogel consisting of polyethylene glycol diacrylamide conjugated to macromolecular type-I collagen. Through their acrylamide-based crosslinks, these materials allow for independent control of physical properties and bulk ligand concentration. These hydrogels exhibited hydrolytic stability, but the collagen component retained its susceptibility to enzymatic remodeling. Photoencapsulation of endothelial cells and fibroblasts within this hydrogel material and their subsequent co-culture led to the formation of capillary vessel-like networks with well-defined hollow lumens. Capillary formation was prevented by inhibiting matrix metalloproteinase (MMP) activity, recapitulating the MMP-dependence of vascularization observed in natural hydrogels. These findings validate the utility of this material platform to decipher how the ECM regulates capillary morphogenesis and to support the formation of vascularized tissue constructs for potential applications in regenerative medicine.
MeSH term(s)	Biocompatible Materials/chemistry ; Biocompatible Materials/metabolism ; Capillaries/cytology ; Capillaries/physiology ; Cell Line ; Cells, Cultured ; Coculture Techniques ; Collagen Type I/chemistry ; Collagen Type I/metabolism ; Endothelial Cells/cytology ; Fibroblasts/cytology ; Humans ; Hydrogels/chemistry ; Hydrogels/metabolism ; Neovascularization, Physiologic ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/metabolism ; Polymerization ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Collagen Type I ; Hydrogels ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2013-09-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2013.08.016
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Article: Estrogen regulation of brain vasotocin secretion in the catfish Heteropneustes fossilis: An interaction with catecholaminergic system

Chaube, Radha / Singh, Rahul K / Joy, Keerikkattil P

General and Comparative Endocrinology. 2012 Jan. 1, v. 175, no. 1

2012

Abstract: Vasotocin (VT) is a basic neurohypophysial nonapeptide in non-mammalian vertebrates and is involved in diverse functions like osmoregulation, reproduction, metabolism and behavior. In this study, we report that estradiol-17β (E₂) regulates brain and ... ...

Abstract	Vasotocin (VT) is a basic neurohypophysial nonapeptide in non-mammalian vertebrates and is involved in diverse functions like osmoregulation, reproduction, metabolism and behavior. In this study, we report that estradiol-17β (E₂) regulates brain and plasma VT secretion through the involvement of the catecholaminergic (CA) system. To demonstrate this, E₂ level was altered through ovariectomy (OVX, 3weeks) and replacement study with low and high E₂ doses (0.1 and 0.5μg/g body weight). CA activity was inhibited by treatment with α-methylparatyrosine (α-MPT; 250μg/g body weight), a competitive inhibitor of tyrosine hydroxylase. VT was assayed by an enzyme immunoassay method. In the sham group, the low E₂ dose produced 82% and 104% increase, respectively, in brain and plasma VT levels. The high E₂ dose decreased the VT levels significantly. The low E₂ dose decreased brain E₂ but elevated plasma E₂. In the high E₂ group, the E₂ level increased further in both brain and plasma. OVX resulted in a significant inhibition (69% and 25%, respectively) of both brain and plasma VT, which was correlated with low E₂ levels. The low E₂ dose not only reversed the inhibition, but increased the VT level in both brain and plasma in comparison to the sham groups. The high E₂ replacement inhibited VT levels further low in both brain and plasma. The α-MPT treatment inhibited VT levels significantly in both sham and OVX groups. The drug treatment abolished partially the restorative effect of the low E₂ dose in the ovariectomized fish. In the high E₂ dose group, α-MPT decreased brain and plasma VT levels further low compared to the sham+0.5μg E₂ group or OVX+0.5μg E₂ group except the brain VT level, which increased in the OVX+0.5μg E₂ group. It is inferred that E₂ may exert biphasic effects on VT through the mediation of the CA system.
Keywords	Heteropneustes fossilis ; body weight ; brain ; catfish ; drug therapy ; enzyme immunoassays ; metabolism ; osmoregulation ; ovariectomy ; reproduction ; secretion ; tyrosine ; vasotocin
Language	English
Dates of publication	2012-0101
Size	p. 206-213.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2011.11.012
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Article ; Online: Estrogen regulation of brain vasotocin secretion in the catfish Heteropneustes fossilis: an interaction with catecholaminergic system.

Chaube, Radha / Singh, Rahul K / Joy, Keerikkattil P

General and comparative endocrinology

2012 Volume 175, Issue 1, Page(s) 206–213

Abstract	Vasotocin (VT) is a basic neurohypophysial nonapeptide in non-mammalian vertebrates and is involved in diverse functions like osmoregulation, reproduction, metabolism and behavior. In this study, we report that estradiol-17β (E(2)) regulates brain and plasma VT secretion through the involvement of the catecholaminergic (CA) system. To demonstrate this, E(2) level was altered through ovariectomy (OVX, 3 weeks) and replacement study with low and high E(2) doses (0.1 and 0.5 μg/g body weight). CA activity was inhibited by treatment with α-methylparatyrosine (α-MPT; 250 μg/g body weight), a competitive inhibitor of tyrosine hydroxylase. VT was assayed by an enzyme immunoassay method. In the sham group, the low E(2) dose produced 82% and 104% increase, respectively, in brain and plasma VT levels. The high E(2) dose decreased the VT levels significantly. The low E(2) dose decreased brain E(2) but elevated plasma E(2). In the high E(2) group, the E(2) level increased further in both brain and plasma. OVX resulted in a significant inhibition (69% and 25%, respectively) of both brain and plasma VT, which was correlated with low E(2) levels. The low E(2) dose not only reversed the inhibition, but increased the VT level in both brain and plasma in comparison to the sham groups. The high E(2) replacement inhibited VT levels further low in both brain and plasma. The α-MPT treatment inhibited VT levels significantly in both sham and OVX groups. The drug treatment abolished partially the restorative effect of the low E(2) dose in the ovariectomized fish. In the high E(2) dose group, α-MPT decreased brain and plasma VT levels further low compared to the sham + 0. 5 μg E(2) group or OVX + 0.5 μg E(2) group except the brain VT level, which increased in the OVX+0.5 μg E(2) group. It is inferred that E(2) may exert biphasic effects on VT through the mediation of the CA system.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/metabolism ; Catecholamines/metabolism ; Catfishes/metabolism ; Dose-Response Relationship, Drug ; Estrogens/metabolism ; Estrogens/pharmacology ; Female ; Ovariectomy ; Vasotocin/metabolism ; alpha-Methyltyrosine/pharmacology
Chemical Substances	Catecholamines ; Estrogens ; alpha-Methyltyrosine (658-48-0) ; Vasotocin (W6S6URY8OF)
Language	English
Publishing date	2012-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2011.11.012
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Article ; Online: Characterization of the crosslinking kinetics of multi-arm poly(ethylene glycol) hydrogels formed via Michael-type addition.

Kim, Jiwon / Kong, Yen P / Niedzielski, Steven M / Singh, Rahul K / Putnam, Andrew J / Shikanov, Ariella

Soft matter

2016 Volume 12, Issue 7, Page(s) 2076–2085

Abstract: Tunable properties of multi-arm poly(ethylene glycol) (PEG) hydrogel, crosslinked by Michael-type addition, support diverse applications in tissue engineering. Bioactive modification of PEG is achieved by incorporating integrin binding sequences, like ... ...

Abstract	Tunable properties of multi-arm poly(ethylene glycol) (PEG) hydrogel, crosslinked by Michael-type addition, support diverse applications in tissue engineering. Bioactive modification of PEG is achieved by incorporating integrin binding sequences, like RGD, and crosslinking with tri-functional protease sensitive crosslinking peptide (GCYKNRGCYKNRCG), which compete for the same reactive groups in PEG. This competition leads to a narrow range of conditions that support sufficient crosslinking density to provide structural control. Kinetics of hydrogel formation plays an important role in defining the conditions to form hydrogels with desired mechanical and biological properties, which have not been fully characterized. In this study, we explored how increasing PEG functionality from 4 to 8-arms and the concentration of biological moieties, ranging from 0.5 mM to 3.75 mM, affected the kinetics of hydrogel formation, storage modulus, and swelling after the hydrogels were allowed to form for 15 or 60 minutes. Next, human bone marrow stromal cells were encapsulated and cultured in these modified hydrogels to investigate the combined effect of mechano-biological properties on phenotypes of encapsulated cells. While the molar concentration of the reactive functional groups (-vinyl sulfone) was identical in the conditions comparing 4 and 8-arm PEG, the 8-arm PEG formed faster, allowed a greater degree of modification, and was superior in three-dimensional culture. The degrees of swelling and storage modulus of 8-arm PEG were less affected by the modification compared to 4-arm PEG. These findings suggest that 8-arm PEG allows a more precise control of mechanical properties that could lead to a larger spectrum of tissue engineering applications.
MeSH term(s)	Amino Acid Sequence ; Binding, Competitive ; Cell Line ; Cells, Immobilized ; Cross-Linking Reagents/chemistry ; Cycloaddition Reaction ; Cysteine/pharmacology ; Elastic Modulus ; Humans ; Hydrogels/chemistry ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/drug effects ; Mesenchymal Stromal Cells/physiology ; Molecular Sequence Data ; Peptides/chemistry ; Polyethylene Glycols/chemistry ; Protein Binding ; Temperature ; Time Factors ; Tissue Engineering/methods
Chemical Substances	Cross-Linking Reagents ; Hydrogels ; Peptides ; Polyethylene Glycols (30IQX730WE) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2016-02-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/c5sm02668g
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