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  1. AU="Singh, Riddima"
  2. AU="Sparchez, Zeno"
  3. AU="Thete, Raghavendra"
  4. AU="Sayed, El-Sayed T A"
  5. AU="Lezrek, Mohamed"
  6. AU="Singh, Gautam"
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  1. Article ; Online: Clicking in harmony: exploring the bio-orthogonal overlap in click chemistry.

    Mehak / Singh, Gurleen / Singh, Riddima / Singh, Gurjaspreet / Stanzin, Jigmat / Singh, Harminder / Kaur, Gurpreet / Singh, Jandeep

    RSC advances

    2024  Volume 14, Issue 11, Page(s) 7383–7413

    Abstract: In the quest to scrutinize and modify biological systems, the global research community has continued to explore bio-orthogonal click reactions, a set of reactions exclusively targeting non-native molecules within biological systems. These methodologies ... ...

    Abstract In the quest to scrutinize and modify biological systems, the global research community has continued to explore bio-orthogonal click reactions, a set of reactions exclusively targeting non-native molecules within biological systems. These methodologies have brought about a paradigm shift, demonstrating the feasibility of artificial chemical reactions occurring on cellular surfaces, in the cell cytosol, or within the body - an accomplishment challenging to achieve with the majority of conventional chemical reactions. This review delves into the principles of bio-orthogonal click chemistry, contrasting metal-catalyzed and metal-free reactions of bio-orthogonal nature. It comprehensively explores mechanistic details and applications, highlighting the versatility and potential of this methodology in diverse scientific contexts, from cell labelling to biosensing and polymer synthesis. Researchers globally continue to advance this powerful tool for precise and selective manipulation of biomolecules in complex biological systems.
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00494a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unveiling the ion sensing capabailities of 'click' derived chalcone-tailored 1,2,3-triazolic isomers for Pb(ii) and Cu(ii) ions: DFT analysis.

    Singh, Riddima / Singh, Gurleen / George, Nancy / Singh, Gurjaspreet / Malik, Pooja / Singh, Harminder / Kaur, Gurpreet / Singh, Jandeep

    RSC advances

    2024  Volume 14, Issue 22, Page(s) 15374–15390

    Abstract: In this study, two novel chalcone-derived 1,2,3-triazole-appended positional isomers (probe 6 and probe 9) were ... ...

    Abstract In this study, two novel chalcone-derived 1,2,3-triazole-appended positional isomers (probe 6 and probe 9) were synthesized
    Language English
    Publishing date 2024-05-13
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01471e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review.

    Singh, Gurleen / Majeed, Ather / Singh, Riddima / George, Nancy / Singh, Gurjaspreet / Gupta, Sofia / Singh, Harminder / Kaur, Gurpreet / Singh, Jandeep

    RSC advances

    2023  Volume 13, Issue 5, Page(s) 2912–2936

    Abstract: Copper(i) catalyzed alkyne azide cycloaddition (CuAAC), the quintessential example of 'click chemistry', provides an adaptable and adequate platform for the synthesis of nanogels for sustained drug release at targeted sites because of their better ... ...

    Abstract Copper(i) catalyzed alkyne azide cycloaddition (CuAAC), the quintessential example of 'click chemistry', provides an adaptable and adequate platform for the synthesis of nanogels for sustained drug release at targeted sites because of their better biocompatibility. The coupling of drugs, carried out
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra05592a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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  4. Article ; Online: Cu(i)-catalysed 1,2,3-triazole stitched chalcomer assembly as Pb(ii) and Cu(ii) ion sensor: DFT and docking scrutiny.

    Singh, Riddima / Singh, Gurleen / George, Nancy / Singh, Gurjaspreet / Devi, Anita / Singh, Harminder / Kaur, Gurpreet / Singh, Jandeep

    RSC advances

    2023  Volume 13, Issue 46, Page(s) 32399–32412

    Abstract: Herein, a 1,2,3-triazole derivative (CBT), synthesized using the Copper(i) catalyzed Alkyne Azide Cycloaddition (CuAAC) procedure, based on a chalcone skeleton has been reported, that was implemented as an effective sensor for Pb(ii) and Cu(ii) ions. The ...

    Abstract Herein, a 1,2,3-triazole derivative (CBT), synthesized using the Copper(i) catalyzed Alkyne Azide Cycloaddition (CuAAC) procedure, based on a chalcone skeleton has been reported, that was implemented as an effective sensor for Pb(ii) and Cu(ii) ions. The synthesized CBT was characterized using spectroscopic techniques such as FTIR, NMR (
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05760g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Microwave accelerated green approach for tailored 1,2,3–triazoles via CuAAC

    George, Nancy / Singh, Gurleen / Singh, Riddima / Singh, Gurjaspreet / Anita Devi / Singh, Harminder / Kaura, Guraprīta / Singh, Jandeep

    Sustainable Chemistry and Pharmacy. 2022 Dec., v. 30 p.100824-

    2022  

    Abstract: The persistent deterioration of our environmental assets has initiated ‘a push’ among the scientific community for increased reliance on eco-friendly methodologies minimizing the utilization of hazardous materials. As an outcome, there is a paradigm ... ...

    Abstract The persistent deterioration of our environmental assets has initiated ‘a push’ among the scientific community for increased reliance on eco-friendly methodologies minimizing the utilization of hazardous materials. As an outcome, there is a paradigm shift in the synthetic modules of organic reactions from conventional techniques to the parameters of green principles. Therefore, the demand for microwave (μw) tailored reactions has witnessed substantial and exponential growth in the last two decades. In accordance, the employment of green methodology in Cu(I) catalyzed alkyne-azide cycloaddition reaction (CuAAC) for the synthesis of 1,2,3–triazole derivatives have reared fruitful results with the reduction of synthetic time, superior yields without benign solvents. The use of the microwave technique has been amplified with its implementation of a range of green methodologies by contributing to solvent-less, catalyst-free, use of ionic liquids and aqueous medium. This review puts forward the microwave synthesis of 1,2,3–triazoles through Cu(I) mediated click chemistry.
    Keywords cycloaddition reactions ; green chemistry ; microwave treatment ; Microwave–assisted synthesis ; 1,2,3–triazole ; Click chemistry ; CuAAC ; Sustainability
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ISSN 2352-5541
    DOI 10.1016/j.scp.2022.100824
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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  6. Article ; Online: CuAAC-Derived Selective Fluorescent Probe as a Recognition Agent for Pb(II) and Hg(II): DFT and Docking Studies.

    Singh, Gurleen / George, Nancy / Singh, Riddima / Singh, Gurjaspreet / Kaur, Jashan Deep / Kaur, Gurpreet / Singh, Harminder / Singh, Jandeep

    ACS omega

    2022  Volume 7, Issue 43, Page(s) 39159–39168

    Abstract: Copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended "click" scaffolds with the potential for selective metal ion recognition. Based on " ... ...

    Abstract Copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended "click" scaffolds with the potential for selective metal ion recognition. Based on "click" methodology, this report presents a chemosensor probe (TCT) based on 4-
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c05050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ampyrone appended 1,2,3-triazole as selective fluorescent Cu(II) ion sensor: DFT and docking findings.

    Singh, Gurleen / Lal, Bajrang / Singh, Riddima / George, Nancy / Singh, Gurjaspreet / Diksha / Kaur, Gagandeep / Singh, Harminder / Tittal, Ram Kumar / Kaur, Gurpreet / Singh, Jandeep

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 302, Page(s) 123163

    Abstract: The present report describes the application of the 'Click Chemistry' pathway to synthesize a fluorescent probe (APT) based on ampyrone (4-aminoantipyrine), entailing two benzyl groups as the fluorophores coupled to the antipyrine structure through 1,2,3- ...

    Abstract The present report describes the application of the 'Click Chemistry' pathway to synthesize a fluorescent probe (APT) based on ampyrone (4-aminoantipyrine), entailing two benzyl groups as the fluorophores coupled to the antipyrine structure through 1,2,3-triazole moieties. Infrared spectroscopy (IR), nuclear magnetic resonance (
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.123163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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