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  1. Article ; Online: Lesbian longings and the question of a queer repertoire in

    Singh, Shailendra Kumar

    Journal of lesbian studies

    2022  Volume 27, Issue 2, Page(s) 160–175

    Abstract: In recent years, there has been an emerging critical discourse in South Asia that examines the changing contours of representational politics that could, in turn, be strategically mobilized to introduce an alternative idiom of same-sex love within a ... ...

    Abstract In recent years, there has been an emerging critical discourse in South Asia that examines the changing contours of representational politics that could, in turn, be strategically mobilized to introduce an alternative idiom of same-sex love within a standard template of heterosexual storytelling. This has been complemented by an evaluation of alternative modes of sexual politics that need not necessarily conform to Western labels or paradigms of queer identities. Taking its cue from such discursive readings, this article demonstrates how Roopa Rao's web series,
    MeSH term(s) Female ; Humans ; Homosexuality, Female ; Sexual and Gender Minorities ; Retrospective Studies ; Sexual Behavior ; Heterosexuality
    Language English
    Publishing date 2022-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2221436-7
    ISSN 1540-3548 ; 1089-4160
    ISSN (online) 1540-3548
    ISSN 1089-4160
    DOI 10.1080/10894160.2022.2119673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6287: Show issues Location:
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  2. Article ; Online: Reply to Jia et al.

    Krishnan, Arunkumar / Singh, Shailendra

    Endoscopy

    2023  Volume 55, Issue 10, Page(s) 974

    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2094-8008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What We Talk About When We Talk About Training in Endoscopic Sleeve Gastroplasty.

    Hadi, Yousaf / Singh, Shailendra

    Digestive diseases and sciences

    2023  Volume 68, Issue 6, Page(s) 2211–2213

    MeSH term(s) Humans ; Gastroplasty ; Endoscopy ; Obesity/surgery ; Treatment Outcome ; Obesity, Morbid/surgery
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07895-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Skin Cancer Image Segmentation Based on Midpoint Analysis Approach.

    Saghir, Uzma / Singh, Shailendra Kumar / Hasan, Moin

    Journal of imaging informatics in medicine

    2024  

    Abstract: Skin cancer affects people of all ages and is a common disease. The death toll from skin cancer rises with a late diagnosis. An automated mechanism for early-stage skin cancer detection is required to diminish the mortality rate. Visual examination with ... ...

    Abstract Skin cancer affects people of all ages and is a common disease. The death toll from skin cancer rises with a late diagnosis. An automated mechanism for early-stage skin cancer detection is required to diminish the mortality rate. Visual examination with scanning or imaging screening is a common mechanism for detecting this disease, but due to its similarity to other diseases, this mechanism shows the least accuracy. This article introduces an innovative segmentation mechanism that operates on the ISIC dataset to divide skin images into critical and non-critical sections. The main objective of the research is to segment lesions from dermoscopic skin images. The suggested framework is completed in two steps. The first step is to pre-process the image; for this, we have applied a bottom hat filter for hair removal and image enhancement by applying DCT and color coefficient. In the next phase, a background subtraction method with midpoint analysis is applied for segmentation to extract the region of interest and achieves an accuracy of 95.30%. The ground truth for the validation of segmentation is accomplished by comparing the segmented images with validation data provided with the ISIC dataset.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2948-2933
    ISSN (online) 2948-2933
    DOI 10.1007/s10278-024-01106-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Flow Cytometry-based Measurement of Reactive Oxygen Species in Cyanobacteria.

    Mondal, Soumila / Singh, Shailendra P

    Bio-protocol

    2022  Volume 12, Issue 10, Page(s) e4417

    Abstract: Cyanobacteria are Gram-negative oxygen-producing photosynthetic bacteria that are useful in the pharmaceutical and biofuel industries. Monitoring of oxidative stress under fluctuating environmental conditions is important for determining the fitness, ... ...

    Abstract Cyanobacteria are Gram-negative oxygen-producing photosynthetic bacteria that are useful in the pharmaceutical and biofuel industries. Monitoring of oxidative stress under fluctuating environmental conditions is important for determining the fitness, survival, and growth of cyanobacteria in the laboratory as well as in large scale cultivation systems. Here, we provide a protocol developed using unicellular
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by

    Mondal, Soumila / Singh, Shailendra P

    Heliyon

    2022  Volume 8, Issue 10, Page(s) e10776

    Abstract: Thioredoxins (Trxs) and Glutaredoxins (Grxs) regulate several cellular processes by controlling the redox state of their target proteins. Trxs and Grxs belong to thioredoxin superfamily and possess characteristic Trx/Grx fold. Several phylogenetic, ... ...

    Abstract Thioredoxins (Trxs) and Glutaredoxins (Grxs) regulate several cellular processes by controlling the redox state of their target proteins. Trxs and Grxs belong to thioredoxin superfamily and possess characteristic Trx/Grx fold. Several phylogenetic, biochemical and structural studies have contributed to our overall understanding of Trxs and Grxs. However, comparative study of closely related Trxs and Grxs in organisms of all domains of life was missing. Here, we conducted
    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of the Biosensing Capabilities of SiGe Heterojunction Negative Capacitance-Vertical Tunnel Field-Effect Transistor.

    Singh, Shailendra / Agnihotri, Suneet Kumar / Bagga, Navjeet / Samajdar, Dip Prakash

    ACS applied bio materials

    2024  Volume 7, Issue 2, Page(s) 812–826

    Abstract: In this study, a comparison of the negative capacitance vertical tunnel field-effect transistor (NC-VTFET) and VTFET for biosensing applications was conducted. Dielectrically modulated TFET demonstrates better sensitivity than the traditional metal oxide ...

    Abstract In this study, a comparison of the negative capacitance vertical tunnel field-effect transistor (NC-VTFET) and VTFET for biosensing applications was conducted. Dielectrically modulated TFET demonstrates better sensitivity than the traditional metal oxide field effect transistor as a biosensor in label-free biosensing applications. The TFET biosensor, however, has much room for advancement by enhancing its DC characteristics. This research addresses the impact of ferroelectric gate oxide for integration of negative capacitance (NC) effect with the SiGe heterojunction pocket at the source-channel junction to enhance performance for biosensor applications. By putting the NC layer over SiO
    MeSH term(s) Silicon Dioxide ; Electricity ; Oxides ; Temperature
    Chemical Substances Silicon Dioxide (7631-86-9) ; Oxides
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neonatal nephrotic syndrome: all is not gloomy.

    Chetan, Chinmay / Singh, Shailendra Kumar / Patra, Saikat / Gupta, Girish

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Congenital nephrotic syndrome (CNS) is a rare clinical syndrome with a constellation of proteinuria, hypoalbuminaemia and oedema, presenting within 3 months of birth. We present a rare case of neonatal nephrotic syndrome with a probable sepsis induced ... ...

    Abstract Congenital nephrotic syndrome (CNS) is a rare clinical syndrome with a constellation of proteinuria, hypoalbuminaemia and oedema, presenting within 3 months of birth. We present a rare case of neonatal nephrotic syndrome with a probable sepsis induced aetiology. The neonate was referred at day of life 15 with
    MeSH term(s) Infant, Newborn ; Humans ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/diagnosis ; Hypoalbuminemia ; Proteinuria/complications ; Edema/etiology ; Sepsis/complications
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255584
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  9. Article ; Online: New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by in silico amino acid sequence, phylogenetic and comparative structural analyses in organisms of three domains of life

    Mondal, Soumila / Singh, Shailendra P.

    Heliyon. 2022 Oct., v. 8, no. 10 p.e10776-

    2022  

    Abstract: Thioredoxins (Trxs) and Glutaredoxins (Grxs) regulate several cellular processes by controlling the redox state of their target proteins. Trxs and Grxs belong to thioredoxin superfamily and possess characteristic Trx/Grx fold. Several phylogenetic, ... ...

    Abstract Thioredoxins (Trxs) and Glutaredoxins (Grxs) regulate several cellular processes by controlling the redox state of their target proteins. Trxs and Grxs belong to thioredoxin superfamily and possess characteristic Trx/Grx fold. Several phylogenetic, biochemical and structural studies have contributed to our overall understanding of Trxs and Grxs. However, comparative study of closely related Trxs and Grxs in organisms of all domains of life was missing. Here, we conducted in silico comparative structural analysis combined with amino acid sequence and phylogenetic analyses of 65 Trxs and 88 Grxs from 12 organisms of three domains of life to get insights into evolutionary and structural relationship of two proteins. Outcomes suggested that despite diversity in their amino acids composition in distantly related organisms, both Trxs and Grxs strictly conserved functionally and structurally important residues. Also, position of these residues was highly conserved in all studied Trxs and Grxs. Notably, if any substitution occurred during evolution, preference was given to amino acids having similar chemical properties. Trxs and Grxs were found more different in eukaryotes than prokaryotes due to altered helical conformation. The surface of Trxs was negatively charged, while Grxs surface was positively charged, however, the active site was constituted by uncharged amino acids in both proteins. Also, phylogenetic analysis of Trxs and Grxs in three domains of life supported endosymbiotic origins of chloroplast and mitochondria, and suggested their usefulness in molecular systematics. We also report previously unknown catalytic motifs of two proteins, and discuss in detail about effect of abovementioned parameters on overall structural and functional diversity of Trxs and Grxs.
    Keywords active sites ; amino acid sequences ; chloroplasts ; comparative study ; computer simulation ; eukaryotic cells ; functional diversity ; mitochondria ; molecular systematics ; phylogeny ; prokaryotic cells ; thioredoxins ; Glutathione ; Oxidoreductase ; Glutaredoxins ; 3D structure comparison
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e10776
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Prevalence of Hypouricemia and Hyperuricemia and Looking Beyond Serum Uric Acid in Patients with Newly Onset Type 2 Diabetes Mellitus in Eastern Part of Uttar Pradesh: A Cross-sectional Study.

    Singh, Shailendra K / Singh, Rina / Singh, Santosh K

    The Journal of the Association of Physicians of India

    2023  Volume 71, Issue 5, Page(s) 11–12

    Abstract: Introduction: The prevalence of hyperuricemia (HU) and hypouricemia (Hypo-U) is highly variable in different parts of India and there is a lack of data from the Eastern part of Uttar Pradesh. We designed this study in order to know the exact prevalence ... ...

    Abstract Introduction: The prevalence of hyperuricemia (HU) and hypouricemia (Hypo-U) is highly variable in different parts of India and there is a lack of data from the Eastern part of Uttar Pradesh. We designed this study in order to know the exact prevalence of HU and Hypo-U.
    Materials and methods: This is a cross-sectional study conducted in Varanasi. Data were collected from newly onset diabetic patients over a period of 1 year.
    Results: Among the 312 diabetic patients, 12.5 and 19.23% were found to have HU and Hypo-U, respectively. Hypouricemic diabetic patients are phenotypically different. They are characterized by the female sex, higher glycated hemoglobin A1c (GlyHbA1c), higher estimated glomerular filtration rate (eGFR), lower body mass index (BMI), and less insulin resistance.
    Conclusion: The prevalence of HU and Hypo-U is high in newly-onset diabetic patients. Hypouricemic diabetic patients are phenotypically different. Hence routine screening of uric acid is essential for proper diagnosis and appropriate treatment of hypouricemic diabetic patients.
    MeSH term(s) Humans ; Female ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Uric Acid ; Cross-Sectional Studies ; Hyperuricemia/epidemiology ; Prevalence ; Risk Factors
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.5005/japi-11001-0239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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