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  1. Article ; Online: Dopingless Negative Capacitance Ferroelectric TFET for Breast Cancer Cells Detection: Design and Sensitivity Analysis.

    Singh, Shradhya / Singh, Sangeeta

    IEEE transactions on ultrasonics, ferroelectrics, and frequency control

    2022  Volume 69, Issue 3, Page(s) 1120–1129

    Abstract: The current research article reports the electrical detection of breast cancer cell lines (MDA-MB-231, Hs578T, T47D, and MCF-7) by deploying dopingless negative capacitance (NC) ferroelectric (FE) tunnel field-effect transistor (DL-FE-TFET). This device ... ...

    Abstract The current research article reports the electrical detection of breast cancer cell lines (MDA-MB-231, Hs578T, T47D, and MCF-7) by deploying dopingless negative capacitance (NC) ferroelectric (FE) tunnel field-effect transistor (DL-FE-TFET). This device has a double dual metal gate and two nanocavities engraved underneath both gate electrodes for higher detection sensitivity. Our work reports the detection of nontumorigenic cell (MCF-10A) and breast cancer cell lines by combining the NC effect of FE material and dopingless technology synergistically. Here, FE material amplifies the applied gate bias intrinsically. The in-depth electrostatic analysis in terms of surface potential, carrier concentration, energy band diagram, drive current, and electric field has been depicted. Variation of the dielectric constant of these breast cancerous cell lines dictates the detection mechanism in our reported biosensor. The sensitivity has been analyzed in terms of drive current, I
    MeSH term(s) Biosensing Techniques ; Breast Neoplasms/diagnostic imaging ; Electric Capacitance ; Electrodes ; Female ; Humans ; Reproducibility of Results
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 1525-8955
    ISSN (online) 1525-8955
    DOI 10.1109/TUFFC.2021.3136099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dual Cavity Dielectric Modulated Ferroelectric Charge Plasma Tunnel FET as Biosensor: For Enhanced Sensitivity.

    Singh, Shradhya / Singh, Sangeeta / Mohammed, Mustafa K A / Wadhwa, Girish

    IEEE transactions on nanobioscience

    2022  Volume 22, Issue 1, Page(s) 182–191

    Abstract: This work reports a biosensor based on the dual cavity dielectric modulated ferroelectric charge plasma Tunnel FET (FE-CP-TFET) with enhanced sensitivity. By incorporating underlap and dielectric modulation phenomena, ultra sensitive, and label-free ... ...

    Abstract This work reports a biosensor based on the dual cavity dielectric modulated ferroelectric charge plasma Tunnel FET (FE-CP-TFET) with enhanced sensitivity. By incorporating underlap and dielectric modulation phenomena, ultra sensitive, and label-free detection of biomolecules is achieved. The cavity is carved underneath the source-gate dielectric for the immobilization of the biomolecules. The ferroelectric (FE) material is used as a gate stack to realize a negative capacitance effect to amplify the low gate voltage. To avoid the issues with metallurgical doping such as random dopant fluctuations (RDFs), ambipolar conduction, and increased thermal budget, the charge plasma concept is deployed. Based on our exhaustive ATLAS 2D TCAD study, the electric field, hole concentration, and energy band diagram of the proposed device are critically analyzed to provide a better insight into the biosensor working mechanism. Here, two different figures-of merits (FOMs) for the proposed biosensor are investigated such as sensitivity and linearity. Sensitivity has been measured in terms of drain current, [Formula: see text] to [Formula: see text] ratio, electric field, and transconductance sensitivity. Linearity analysis of the proposed structure includes [Formula: see text] ratio. The reported biosensor is capable of detecting several biomolecules such as (neutral and charged as well) Streptavidin (2.1), 3-aminopropyltriethoxysilane (APTES) (K =3.57 ), Keratin (K =8 ), T7 (K =6.3 ) and Gelatin (K =12 ). It was observed that the optimized cavity structure demonstrates high drain current sensitivity ( 2.7×10
    MeSH term(s) Biosensing Techniques ; Plasma Gases ; Electricity
    Chemical Substances Plasma Gases
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article
    ISSN 1558-2639
    ISSN (online) 1558-2639
    DOI 10.1109/TNB.2022.3174266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breast-Cancer Biomarker (C-erbB-2) Detection in Saliva/Serum Based on In1-xGaxAs/Si Hetero Junction Dopingless TFET Biosensor.

    Singh, Shradhya / Singh, Navaneet Kumar / Singh, Sangeeta

    IEEE transactions on nanobioscience

    2021  Volume PP

    Abstract: This research article reports the electrical detection of breast-cancer biomarker (C-erbB-2) in saliva/serum based on In1-xGaxAs/Si heterojunction dopingless tunnel FET (HJ-DL-TFET) biosensor for highly sensitive and real-time detection. The work takes ... ...

    Abstract This research article reports the electrical detection of breast-cancer biomarker (C-erbB-2) in saliva/serum based on In1-xGaxAs/Si heterojunction dopingless tunnel FET (HJ-DL-TFET) biosensor for highly sensitive and real-time detection. The work takes into account the interface charge modulation effect in dopingless extended gate heterostructure TFET with embedded nanocavity biosensors for the precise, reliable, and fast detection of antigens present in the body fluids such as saliva in place of blood serum. The reported biosensor is numerically simulated in 2D using the SILVACO ATLAS exhaustive calibrated simulation framework. For the biomolecule immobilization, the proposed biosensor has a dual cavity engraved beneath the dual gate structure. This improves the control of biomolecules over the source-to-channel tunneling rate, as well as the control over the electrical performance parameters of the proposed biosensor. Here, a numerical model for the C-erbB-2 interface charge equivalent is also developed. The analysis of device sensitivity in both saliva and serum environments for various C-erbB-2 concentrations has been carried out. Our study reveals that III-V In1-xGaxAs/Si heterojunction with x composition of 0.2 and extended gate geometry provides an increased tunneling probability, improves the gate control to get a higher ION/IOFF ratio and higher sensitivity. In addition to this, the impact of interface charges corresponding to the different amounts of C-erbB-2 biomarkers on the biosensor sensitivity (in terms of ION/IOFF ratio) yields higher sensitivity of the order of 106.
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article
    ISSN 1558-2639
    ISSN (online) 1558-2639
    DOI 10.1109/TNB.2021.3139345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reliability and sensitivity analysis of double inverted-T nano-cavity label-free Si:HfO

    Singh, Sangeeta / Singh, Shradhya / Mohammed, Mustafa K A / Kishor Jha, Kamal / Loan, Sajad A

    RSC advances

    2022  Volume 12, Issue 42, Page(s) 27179–27188

    Abstract: In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si: ... ...

    Abstract In this work, we propose and simulate an ultrasensitive, label-free, and charge/dielectric modulated Si:HfO
    Language English
    Publishing date 2022-09-26
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra03118c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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