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  1. Book ; Online: Optical Coherence Tomography Imaging: Advances in Ophthalmology

    Chhablani, Jay / Singh, Sumit Randhir

    2023  

    Keywords Medicine ; optical coherence tomography ; OCT angiography ; retinal imaging
    Language English
    Size 1 electronic resource (254 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030646029
    ISBN 9783036592510 ; 3036592512
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial Comment on Erectile Dysfunction in Migraine.

    Singh, Sumit

    Annals of Indian Academy of Neurology

    2020  Volume 23, Issue 6, Page(s) 745–746

    Language English
    Publishing date 2020-12-18
    Publishing country India
    Document type Editorial
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_1218_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transition of Care in Celiac Disease.

    Singh, Sumit K / Srivastava, Anshu

    Indian journal of pediatrics

    2023  Volume 90, Issue 11, Page(s) 1142–1148

    Abstract: Celiac disease (CD) is a gluten related disorder which affects all age-groups and occurs in genetically susceptible population after introduction of gluten in diet. The worldwide prevalence of CD is ~1% and it is higher in certain "at-risk groups". The ... ...

    Abstract Celiac disease (CD) is a gluten related disorder which affects all age-groups and occurs in genetically susceptible population after introduction of gluten in diet. The worldwide prevalence of CD is ~1% and it is higher in certain "at-risk groups". The clinical features are variable, ranging from classical diarrhea to an asymptomatic state. Diagnosis requires serology and duodenal histology although a non-biopsy diagnosis is recommended by European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) for a select group of children. Treatment of CD is with a life-long strict gluten free diet (GFD) along with correction of nutritional deficiencies. Regular follow-up to assess compliance and efficacy of GFD is mandatory. Non-responsive CD needs evaluation by a specialist as it can be due to incorrect diagnosis, poor dietary compliance, coexisting conditions like small bowel bacterial overgrowth, pancreatic insufficiency etc. and lastly, refractory CD. Most patients diagnosed as CD in childhood receive no medical or dietary supervision after transition to adulthood and nearly a third are non-compliant to GFD. No requirement of medications, patient's perception of understanding GFD and absence of symptoms with intermittent non-compliance leads to neglect of care after transition. Poor dietary adherence leads to nutritional deficiencies, osteoporosis, fertility issues and risk of malignancy. It is mandatory that the patients know about CD, need of strict GFD, regular follow-up, disease complications, and are capable of communicating with the health-care personnel before transition. Formulating a phased transition care program with joint pediatric and adult clinics is required for a successful transition and improving the long-term outcome.
    MeSH term(s) Adult ; Humans ; Child ; Celiac Disease/diagnosis ; Celiac Disease/therapy ; Patient Transfer ; Glutens/adverse effects ; Diet, Gluten-Free ; Malnutrition/complications ; Patient Compliance
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2023-06-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-023-04611-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Crosstalk-free graphene-liquid elastomer based printed sensors for unobtrusive respiratory monitoring.

    Sharma, Simran / Thapa, Ankur / Singh, Sumit / Mondal, Titash

    Nanoscale

    2024  Volume 16, Issue 7, Page(s) 3498–3509

    Abstract: Flexible strain sensors have garnered attraction in the human healthcare domain. However, caveats like crosstalk and noise associated with the output signal of such a sensor often limit the accuracy. Hence, developing a strain ... ...

    Abstract Flexible strain sensors have garnered attraction in the human healthcare domain. However, caveats like crosstalk and noise associated with the output signal of such a sensor often limit the accuracy. Hence, developing a strain sensor
    MeSH term(s) Humans ; Elastomers ; Wearable Electronic Devices ; Graphite ; Temperature ; Respiration
    Chemical Substances Elastomers ; Graphite (7782-42-5)
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr04774a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.

    Singh, Sumit K / Lee, Kelvin H

    Frontiers in bioengineering and biotechnology

    2022  Volume 9, Page(s) 805788

    Abstract: Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of protein glycosylation. HILIC/MS- ... ...

    Abstract Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of protein glycosylation. HILIC/MS-based glycan analysis relies on the library search using Glucose Units (GU) and accurate mass (AM) as the primary search parameters for identification. However, GU-based identifications are gradient-dependent and are not suitable for applications where separation gradients need to be optimized to analyze complex samples or achieve higher throughput. Additionally, the workflow requires calibration curves (using dextran ladder) to be generated for each analysis campaign, which in turn, are used to derive the GU values of the separated glycan species. To overcome this limitation, we employed a two-step strategy for targeted glycan analysis of a mAb expressed in Chinese Hamster Ovary (CHO) cells. The first step is to create a custom library of the glycans of interest independent of GU values (thereby eliminating the need for a calibration curve) and instead uses AM and retention time (RT) as the primary search variables. The second step is to perform targeted glycan screening using the custom-built library. The developed workflow was applied for targeted glycan analysis of a mAb expressed in CHO for 1) cell line selection 2) characterizing the day-wise glycan evolution in a model mAb during a fed-batch culture, 3) assessing the impact of different media conditions on glycosylation, and 4) evaluating the impact of two different process conditions on glycosylation changes in a model mAb grown in a bioreactor. Taken together, the data presented in this study provides insights into the sources of glycan heterogeneity in a model mAb that are seen during its commercial manufacturing.
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.805788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hereditary fructose intolerance: A comprehensive review.

    Singh, Sumit Kumar / Sarma, Moinak Sen

    World journal of clinical pediatrics

    2022  Volume 11, Issue 4, Page(s) 321–329

    Abstract: Hereditary fructose intolerance (HFI) is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3. A fructose load leads to the rapid accumulation of fructose 1-phosphate and ... ...

    Abstract Hereditary fructose intolerance (HFI) is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3. A fructose load leads to the rapid accumulation of fructose 1-phosphate and manifests with its downstream effects. Most commonly children are affected with gastrointestinal symptoms, feeding issues, aversion to sweets and hypoglycemia. Liver manifestations include an asymptomatic increase of transaminases, steatohepatitis and rarely liver failure. Renal involvement usually occurs in the form of proximal renal tubular acidosis and may lead to chronic renal insufficiency. For confirmation, a genetic test is favored over the measurement of aldolase B activity in the liver biopsy specimen. The crux of HFI management lies in the absolute avoidance of foods containing fructose, sucrose, and sorbitol (FSS). There are many dilemmas regarding tolerance, dietary restriction and occurrence of steatohepatitis. Patients with HFI who adhere strictly to FSS free diet have an excellent prognosis with a normal lifespan. This review attempts to increase awareness and provide a comprehensive review of this rare but treatable disorder.
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2219-2808
    ISSN 2219-2808
    DOI 10.5409/wjcp.v11.i4.321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Optical Coherence Tomography Imaging: Advances in Ophthalmology.

    Singh, Sumit Randhir / Chhablani, Jay

    Journal of clinical medicine

    2022  Volume 11, Issue 10

    Abstract: Since its advent in 1991, optical coherence tomography (OCT) has become the most commonly used imaging modality in vitreo-retina practice [ ... ]. ...

    Abstract Since its advent in 1991, optical coherence tomography (OCT) has become the most commonly used imaging modality in vitreo-retina practice [...].
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11102858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?

    Singh, Sumit / Ness, Jayne / Marcus, Lydia

    Journal of neuroradiology = Journal de neuroradiologie

    2023  Volume 50, Issue 4, Page(s) 382–387

    Abstract: Background and purpose: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is increasingly recognized in children. Some children have isolated disease while others relapse. The study evaluates clinical, demographic and imaging ... ...

    Abstract Background and purpose: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is increasingly recognized in children. Some children have isolated disease while others relapse. The study evaluates clinical, demographic and imaging features children with positive anti-MOG antibodies comparing to previously reported findings and correlate patterns on MR imaging with a relapsing course in MOGAD.
    Material and methods: All pediatrics patients with serum anti-MOG antibodies were reviewed. Demographic, clinical, and imaging data were evaluated. Patients with a relapsing course were compared to those with a single event. We assessed initial MR images of the brain, orbits and spine obtained at the onset of clinical symptoms, whether performed at our institution or elsewhere.
    Results: Thirty patients were included, fourteen with a single event and sixteen with more than one clinical event. The mean age was 8.1 years, with a mean follow-up of 58 months (range of 0.67 to 238 months). The relapsing patients had a mean of 3.5 relapses (range 2-12). 55% of patients had long segment optic nerve lesions, 53% of patients had cortical or peripheral white matter lesions, and 46% of patients had thalamic lesions. 43% of patients had spinal cord lesions, with 39% involving the central cord and 26% with long segment involvement. The imaging features between the groups were not statistically significant.
    Conclusion: There were no distinguishing features in relapsing versus non-relapsing patients. In the absence of any predictive characteristics for future relapse, patients should have regular clinical and imaging follow up.
    MeSH term(s) Humans ; Child ; Neuromyelitis Optica ; Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies ; Magnetic Resonance Imaging ; Recurrence
    Chemical Substances Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
    Language English
    Publishing date 2023-01-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 131763-5
    ISSN 1773-0406 ; 0150-9861
    ISSN (online) 1773-0406
    ISSN 0150-9861
    DOI 10.1016/j.neurad.2022.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1062: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Growth inhibitory, immunosuppressive, cytotoxic, and genotoxic effects of γ-terpinene on Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae).

    Diksha / Singh, Sumit / Mahajan, Evani / Sohal, Satwinder Kaur

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16472

    Abstract: γ-Terpinene, a monoterpene widely present in essential oils of many medicinal and aromatic plants with numerous biological properties, was evaluated for its insecticidal activity against melon fruit fly, Zeugodacus cucurbitae (Coquillett). Different ... ...

    Abstract γ-Terpinene, a monoterpene widely present in essential oils of many medicinal and aromatic plants with numerous biological properties, was evaluated for its insecticidal activity against melon fruit fly, Zeugodacus cucurbitae (Coquillett). Different concentrations (5, 25, 125, 625, and 3125 ppm) of γ-terpinene along with control were fed to larvae of melon fly. The number of pupae formed and adults emerged declined significantly after treatment. Morphologically deformed adults and pupae were also observed. The developmental duration too prolonged in treated larvae. Food assimilated, mean relative growth rate, larval weight gain, and pupal weight also declined. In the larvae treated with LC
    MeSH term(s) Animals ; Tephritidae/genetics ; Larva ; Cucurbitaceae ; Pupa
    Chemical Substances gamma-terpinene (4YGF4PQP49)
    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43499-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Randomized controlled trials in central serous chorioretinopathy: A review.

    Singh, Sumit Randhir / Goté, John Thomas / Chhablani, Jay

    Eye (London, England)

    2023  Volume 37, Issue 16, Page(s) 3306–3312

    Abstract: Central serous chorioretinopathy (CSCR), a common chorioretinal disease, presents with a myriad of manifestations. Acute CSCR presents with localized neurosensory detachment whereas chronic CSCR may show widespread retinal pigment epithelium (RPE) ... ...

    Abstract Central serous chorioretinopathy (CSCR), a common chorioretinal disease, presents with a myriad of manifestations. Acute CSCR presents with localized neurosensory detachment whereas chronic CSCR may show widespread retinal pigment epithelium (RPE) changes, chronic shallow subretinal fluid, and choroidal neovascularization (CNV) suggestive of a variable natural history leading to suboptimal visual outcomes. Even though multiple treatment options including laser photocoagulation, photodynamic therapy, micropulse laser, anti-vascular endothelial growth factors, and systemic drugs (spironolactone, eplerenone, melatonin, mifepristone) are available, there is an absence of any standardized treatment protocol or gold standard treatment modality. Moreover, their performance compared to observation especially in acute CSCR is still debatable. Compared to other chorioretinal diseases such as age-related macular degeneration, diabetic retinopathy, diabetic macular oedema, and retinal vein occlusion, there is a relative dearth of randomized controlled trials in CSCR. Multiple inconsistencies including reliance on history of disease duration, variable inclusion criteria/disease descriptors/study endpoints, and availability of multiple treatment modalities lead to difficulties in designing RCTs. A consensus-based treatment protocol, therefore, is still elusive. We reviewed the literature and compiled the list of papers published to date, wherein we analyse and compare the inclusion criteria, imaging modalities, study endpoints, study duration, and study results. Correcting these discrepancies and deficiencies will help standardize future study designs, facilitating a next step toward a standardized treatment protocol.
    MeSH term(s) Humans ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/surgery ; Visual Acuity ; Randomized Controlled Trials as Topic ; Eplerenone/therapeutic use ; Spironolactone ; Tomography, Optical Coherence/methods
    Chemical Substances Eplerenone (6995V82D0B) ; Spironolactone (27O7W4T232)
    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Journal Article ; Review ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02509-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 603: Show issues

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