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  1. Article ; Online: Viscoelastic behavior, gelation properties and structural characterization of Deccan hemp seed (Hibiscus cannabinus) protein: Influence of protein and ionic concentrations, pH, and temperature.

    Dash, Dibya Ranjan / Singh, Sushil Kumar / Singha, Poonam

    International journal of biological macromolecules

    2024  Volume 263, Issue Pt 1, Page(s) 130120

    Abstract: This study investigates the viscoelastic behavior, gelling properties, and structural characteristics of Deccan hemp seed protein (DHSP) to overcome limitations in its application in food formulations. Small amplitude oscillatory shear measurements were ... ...

    Abstract This study investigates the viscoelastic behavior, gelling properties, and structural characteristics of Deccan hemp seed protein (DHSP) to overcome limitations in its application in food formulations. Small amplitude oscillatory shear measurements were employed to investigate the impact of protein concentration, pH, ionic concentration, and temperature on DHSP's rheological features. The study revealed that the 20 % protein dispersion had the highest storage modulus (G') and yield stress at 63.96 ± 0.23 Pa and 0.61 Pa, respectively. DHSP dispersion exhibited pseudo-plastic behavior across various conditions. The gelling performance was higher at pH 4 and 8 and at ionic concentration in the range of 0.1 M - 0.5 M. Gelation time and temperature were observed from the temperature ramp test. Structural characterizations, including fluorescence spectroscopy, circular dichroism spectra, FTIR spectra, SEM, AFM images, zeta potential analysis, and DSC, provided insights into DHSP's tertiary and secondary conformation, surface characteristics, and thermal properties. Notably, the study highlighted DHSP's exceptional rheological properties, making it a promising gelling material for the food and nutraceutical industries. The findings also offer new insights into DHSP's structural characteristics, suggesting potential applications in food packaging and product development within the food industry.
    MeSH term(s) Temperature ; Hibiscus ; Cannabis ; Gels ; Hydrogen-Ion Concentration ; Rheology
    Chemical Substances Gels
    Language English
    Publishing date 2024-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130120
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    Zs.B 2374: Show issues Location:
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  2. Article ; Online: Recent Advances in the Development of Near-Infrared Fluorescent Probes for the

    Bajad, Nilesh Gajanan / Kumar, Ashok / Singh, Sushil Kumar

    ACS chemical neuroscience

    2023  Volume 14, Issue 17, Page(s) 2955–2967

    Abstract: The deposition of β-amyloid (Aβ) plaques in the parenchymal and cortical regions of the brain of Alzheimer's disease (AD) patients is considered the foremost pathological hallmark of the disease. The early diagnosis of AD is paramount in order to ... ...

    Abstract The deposition of β-amyloid (Aβ) plaques in the parenchymal and cortical regions of the brain of Alzheimer's disease (AD) patients is considered the foremost pathological hallmark of the disease. The early diagnosis of AD is paramount in order to effective management and treatment of the disease. Developing near-infrared fluorescence (NIRF) probes targeting Aβ species is a potential and attractive approach suitable for the early and timely diagnosis of AD. The advantages of the NIRF probes over other tools include real-time detection, higher sensitivity, resolution, comparatively inexpensive experimental setup, and noninvasive nature. Currently, enormous progress is being observed in the development of NIRF probes for the
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Fluorescent Dyes ; Amyloid beta-Peptides ; Brain/pathology ; Plaque, Amyloid/pathology ; Neuroimaging
    Chemical Substances Fluorescent Dyes ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-08-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00304
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  3. Article: Scilla viridis (Asparagaceae): a century of misinterpretation

    Patil, Sameer / Singh, Sushil Kumar

    Nordic journal of botany. 2021 Apr., v. 39, no. 4

    2021  

    Abstract: Scilla viridis Blatt. & Hallb. has for a long time been treated as an unresolved name based on a single ill‐preserved specimen collected near Khandala, Pune, India, but here we show that it is a synonym of Drimia indica (Roxb.) Jessop. A second‐step ... ...

    Abstract Scilla viridis Blatt. & Hallb. has for a long time been treated as an unresolved name based on a single ill‐preserved specimen collected near Khandala, Pune, India, but here we show that it is a synonym of Drimia indica (Roxb.) Jessop. A second‐step lectotype is designated for Drimia indica (Roxb.) Jessop and a lectotype of Drimia coromandeliana (Roxb.) Lekhak & P.B. Yadav is rectified for errors.
    Keywords Drimia indica ; Scilla ; botany ; lectotypes ; India
    Language English
    Dates of publication 2021-04
    Publishing place Blackwell Publishing Ltd
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 2406507-9
    ISSN 1756-1051 ; 0107-055X
    ISSN (online) 1756-1051
    ISSN 0107-055X
    DOI 10.1111/njb.03018
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  4. Article ; Online: Identification of novel potential cathepsin-B inhibitors through pharmacophore-based virtual screening, molecular docking, and dynamics simulation studies for the treatment of Alzheimer's disease.

    Jangra, Jatin / Bajad, Nilesh Gajanan / Singh, Ravi / Kumar, Ashok / Singh, Sushil Kumar

    Molecular diversity

    2024  

    Abstract: Cathepsin B is a cysteine protease lysosomal enzyme involved in several physiological functions. Overexpression of the enzyme enhances its proteolytic activity and causes the breakdown of amyloid precursor protein (APP) into neurotoxic amyloid β (Aβ), a ... ...

    Abstract Cathepsin B is a cysteine protease lysosomal enzyme involved in several physiological functions. Overexpression of the enzyme enhances its proteolytic activity and causes the breakdown of amyloid precursor protein (APP) into neurotoxic amyloid β (Aβ), a characteristic hallmark of Alzheimer's disease (AD). Therefore, inhibition of the enzyme is a crucial therapeutic aspect for treating the disease. Combined structure and ligand-based drug design strategies were employed in the current study to identify the novel potential cathepsin B inhibitors. Five different pharmacophore models were developed and used for the screening of the ZINC-15 database. The obtained hits were analyzed for the presence of duplicates, interfering PAINS moieties, and structural similarities based on Tanimoto's coefficient. The molecular docking study was performed to screen hits with better target binding affinity. The top seven hits were selected and were further evaluated based on their predicted ADME properties. The resulting best hits, ZINC827855702, ZINC123282431, and ZINC95386847, were finally subjected to molecular dynamics simulation studies to determine the stability of the protein-ligand complex during the run. ZINC123282431 was obtained as the virtual lead compound for cathepsin B inhibition and may be a promising novel anti-Alzheimer agent.
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-024-10821-z
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    Zs.A 4946: Show issues Location:
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  5. Article: Detection and molecular characterization of '

    Singh, Sushil Kumar / Ranebennur, Hemavati / Gupta, Shivani / Pandey, Himanshu / Singh, Vivek / Rao, Govind Pratap

    3 Biotech

    2024  Volume 14, Issue 5, Page(s) 147

    Abstract: In surveys conducted from 2020 to 2022, five leaf samples each from ... ...

    Abstract In surveys conducted from 2020 to 2022, five leaf samples each from symptomatic
    Language English
    Publishing date 2024-05-03
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-024-03995-8
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  6. Article: Comparison of the effect of different desugarization techniques on the functionality of egg white protein hydrolysates

    Asaithambi, Niveditha / Singha, Poonam / Singh, Sushil Kumar

    Applied food research. 2022 Dec., v. 2, no. 2

    2022  

    Abstract: Desugarization is an important technique in industrial egg processing to maintain the color and shelf life of egg white powder. Its effect on proteolysis of egg white protein is essential in understanding the functionality changes in the obtained ... ...

    Abstract Desugarization is an important technique in industrial egg processing to maintain the color and shelf life of egg white powder. Its effect on proteolysis of egg white protein is essential in understanding the functionality changes in the obtained hydrolysate. Two desugarization methods, including yeast fermentation and enzyme desugarization using glucose oxidase are commonly employed in industrial scale egg white processing but the suitable method which can improve egg white protein hydrolysates' functionality has not yet been reported. Thus, the present work compares the physicochemical, functional, and surface properties of egg white protein hydrolysates obtained through both the desugarization methods. Alcalase enzyme (2% w/w) was used for enzyme hydrolysis. The degree of hydrolysis of desugared egg white hydrolysate was higher than the non-desugared samples by 34.5%. The desugared samples (especially yeast fermented) had higher foaming and emulsifying ability than non-desugared samples; however, it showed emulsion activity index and surface hydrophobicity. Compared to native protein, the in-vitro trypsin digestibility of desugared hydrolysate samples was significantly (p<0.05) higher. The antioxidant properties increased with hydrolysis, with yeast desugared hydrolysate samples having the highest antioxidant activity (63.8%).
    Keywords antioxidant activity ; antioxidants ; color ; digestibility ; egg albumen ; eggs ; emulsions ; enzymatic hydrolysis ; fermentation ; food research ; glucose oxidase ; hydrolysates ; hydrolysis ; hydrophobicity ; protein hydrolysates ; proteolysis ; shelf life ; subtilisin ; trypsin ; yeasts
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2772-5022
    DOI 10.1016/j.afres.2022.100152
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  7. Article ; Online: Novel Gastroprotective and Thermostable Cocrystal of Dimethyl Fumarate: Its Preparation, Characterization, and

    Alam, Qadir / Ganeshpurkar, Ankit / Singh, Sushil Kumar / Krishnamurthy, Sairam

    ACS omega

    2023  Volume 8, Issue 29, Page(s) 26218–26230

    Abstract: Crystallization has revolutionized the field of solid-state formulations by modulating the physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl fumarate (DF), an FDA-approved first-line drug for relapsing-remitting ... ...

    Abstract Crystallization has revolutionized the field of solid-state formulations by modulating the physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl fumarate (DF), an FDA-approved first-line drug for relapsing-remitting multiple sclerosis, has a sublimation problem, leading to loss of the drug during its processing. To tackle this problem, DF cocrystal has been prepared by using solvent evaporation technique using nicotinamide as a coformer, which has been chosen based on
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02463
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  8. Article ; Online: Preparation, Characterization, in-vitro and in-vivo Pharmacokinetic Evaluation of Thermostable Dimethyl Fumarate Cocrystals.

    Alam, Qadir / Ganeshpurkar, Ankit / Singh, Sushil Kumar / Krishnamurthy, Sairam

    Journal of pharmaceutical sciences

    2023  Volume 113, Issue 3, Page(s) 647–658

    Abstract: Dimethyl fumarate (DMF) is an FDA-approved drug for treating relapsing-remitting multiple sclerosis; but it is susceptible to sublimation leading to its loss during processing. Cocrystals can protect against thermal energy via the interaction of DMF with ...

    Abstract Dimethyl fumarate (DMF) is an FDA-approved drug for treating relapsing-remitting multiple sclerosis; but it is susceptible to sublimation leading to its loss during processing. Cocrystals can protect against thermal energy via the interaction of DMF with a coformer via weak forces of interaction. With this hypothesis, we have, for the first time, prepared DMF cocrystals using the solvent evaporation method using coformers like citric acid and succinic acid screened by in-silico predictions and hydrogen bonding properties. Analysis using infra-red (IR), powder x-ray diffraction (PXRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and sublimation evaluation characterized cocrystals and their thermostability. Comparative analysis of the release profile has been done by dissolution and pharmacokinetic study of DMF and its cocrystals. The cocrystals have improved thermal stability and better pharmacological activities than DMF. In the safety and efficacy evaluation of the formulated cocrystals, they were found to be non-cytotoxic, antioxidant, and inhibiting IL-6 and TNF-α in PBMC induced by lipopolysaccharide (LPS). We have obtained cocrystals of DMF with improved thermal stability and better pharmacological activities than DMF.
    MeSH term(s) Dimethyl Fumarate ; Crystallization/methods ; Leukocytes, Mononuclear ; Powder Diffraction ; X-Ray Diffraction ; Calorimetry, Differential Scanning
    Chemical Substances Dimethyl Fumarate (FO2303MNI2)
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.07.001
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  9. Article: Impact of COVID 19 on Dermatology Education.

    Das, Sudip / Singh, Sushil Kumar / Agarwal, Komal

    Indian dermatology online journal

    2022  Volume 13, Issue 6, Page(s) 803–805

    Language English
    Publishing date 2022-10-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/idoj.idoj_562_21
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  10. Article ; Online: Diindolylmethane Ameliorates Ischemic Stroke-Induced Brain Injury by Peripheral and Central Mechanisms.

    Ramakrishna, Kakarla / Singh, Sushil Kumar / Krishnamurthy, Sairam

    Current neurovascular research

    2022  Volume 19, Issue 5, Page(s) 462–475

    Abstract: Introduction: Diindolylmethane (DIM), a major acid condensation product of Indole-3- carbinol, is known to inhibit platelet aggregation and thrombosis. The drugs with antiplatelet and antithrombotic activities are used to treat ischemic stroke.: ... ...

    Abstract Introduction: Diindolylmethane (DIM), a major acid condensation product of Indole-3- carbinol, is known to inhibit platelet aggregation and thrombosis. The drugs with antiplatelet and antithrombotic activities are used to treat ischemic stroke.
    Objective: The present study investigated the role of DIM on platelet aggregation inhibitory properties in middle cerebral artery occluded (MCAO) rats.
    Methods: DIM (12.5, 25, and 50 mg/kg) was orally administered to MCAO rats for 3 days. Platelet aggregation, platelet cyclic adenosine monophosphate (cAMP), reactive oxygen species (ROS), hydrogen peroxide (H2O2), and serum cyclooxygenase (COX-1), thromboxane B2 (TXB2), and prostaglandin E2 (PGE2), and inflammatory markers were estimated. Further brain structural and functional recovery was evaluated by measuring cerebral blood flow, neurological deficits, brain infarction, blood-brain barrier (BBB) leakage, brain water content, and histological abnormalities.
    Results: DIM significantly ameliorated adenosine diphosphate (ADP), collagen, thrombin, and arachidonic acid-induced platelet aggregation by inhibiting COX-1, TXB2, and PGE2 and elevating cAMP. Further, DIM also alleviated platelet-mediated oxidative stress (ROS and H2O2) and reduced the serum inflammatory markers, tumor necrosis factor-α (TNF-α) and interleukin -6 (IL-6), and increased anti-inflammatory cytokine, IL-10, in MCAO rats.
    Conclusion: DIM treatment confers neuroprotection in MCAO rats by inhibition of platelet aggregation, platelet-mediated oxidative stress, and inflammation. Correspondingly, DIM improved cerebral blood flow and reduced neurological deficits, brain infarction, BBB leakage, brain water content, and histopathological abnormalities indicating the preservation of brain structural integrity. Thus, the present study provided preclinical evidence of DIM neuroprotection against ischemic stroke.
    Language English
    Publishing date 2022-11-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2296350-9
    ISSN 1875-5739 ; 1567-2026
    ISSN (online) 1875-5739
    ISSN 1567-2026
    DOI 10.2174/1567202620666221116161128
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