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Article ; Online: Social Networks in the Dialysis Unit: Can They Influence Patient Behavior?

Singh, Tripti

Kidney360

2021 Volume 2, Issue 3, Page(s) 404–405

MeSH term(s)	Hospital Departments ; Humans ; Renal Dialysis ; Social Networking
Language	English
Publishing date	2021-03-25
Publishing country	United States
Document type	Editorial ; Comment
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000782021
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Article: New Insights Into Pyridoxal Kinase Inhibitors and Their Antileukemic Effects.

Banerjee, Pallabi / Singh, Tripti / Qamar, Imteyaz

Cureus

2023 Volume 15, Issue 11, Page(s) e48176

Abstract: Pyridoxal kinase (PDXK) plays a pivotal role as an essential enzyme in cellular processes. It catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine to generate pyridoxal 5'-phosphate (PLP), the bioactive form of vitamin B6. An ... ...

Abstract	Pyridoxal kinase (PDXK) plays a pivotal role as an essential enzyme in cellular processes. It catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine to generate pyridoxal 5'-phosphate (PLP), the bioactive form of vitamin B6. An intriguing link has emerged between elevated expression levels of PDXK and PLP and various types of carcinomas, including leukemia. Leukemic cells have an increased need for vitamin B6 to sustain their survival and rapid growth, highlighting the potential of targeting PDXK-PLP as a promising therapeutic target in cancer treatment. To discover a novel and promising PDXK inhibitor, we conducted a comprehensive screening of compounds derived from both natural sources and drug-like databases. Our approach involved employing structure-based virtual screening and molecular docking techniques to attenuate the phosphorylation of PLP. Among the top six compounds, ZINC095099376 (referred to as C03) emerged as the most potent inhibitor of PDXK, primarily due to its exceptional binding affinity and remarkable specificity for the target protein. Furthermore, our investigation revealed that compound C03 establishes crucial interactions with key residues within the substrate binding site, indicating that it binds at the same site as the co-crystallized ligand. Remarkably, compound C03 inhibited the endogenous PDXK expression, showed anti-proliferative activity, and triggered an intrinsic pathway for apoptosis via the activation of key apoptotic factors in leukemic cells. In summary, these findings strongly indicate that compound C03 holds promise as a novel inhibitor of PDXK, offering the potential for the development of effective treatments for leukemia.
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.48176
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Article ; Online: Triphasic: Preeclampsia, Systemic Lupus Erythematosus, and Severe Neutropenia With Use of Granulocyte Colony Stimulating Factor in the Partum and Postpartum Period.

Donohue, Sarah / Gomez, Shelby / Singh, Tripti / Garg, Shivani

Arthritis care & research

2023 Volume 75, Issue 10, Page(s) 2036–2043

MeSH term(s)	Female ; Humans ; Pre-Eclampsia/drug therapy ; Neutropenia/chemically induced ; Neutropenia/diagnosis ; Neutropenia/drug therapy ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Granulocyte Colony-Stimulating Factor/adverse effects ; Postpartum Period
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.25138
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Use of CRRT and Plasmapheresis to Treat Simultaneous Iron and Acetaminophen Overdose.

Nye, Rebecca / Singh, Tripti

Blood purification

2021 Volume 51, Issue 3, Page(s) 292–295

Abstract: There is limited information about the prevalence and treatment of concurrent acetaminophen and iron overdose. One case study has suggested that this combination may be lethal. We present a case of fatal intentional acetaminophen and iron overdose and ... ...

Abstract	There is limited information about the prevalence and treatment of concurrent acetaminophen and iron overdose. One case study has suggested that this combination may be lethal. We present a case of fatal intentional acetaminophen and iron overdose and treatment with extracorporeal methods, including continuous venovenous hemofiltration and plasmapheresis, for removal of both toxins.
MeSH term(s)	Acetaminophen ; Continuous Renal Replacement Therapy ; Hemofiltration ; Humans ; Iron ; Plasmapheresis
Chemical Substances	Acetaminophen (362O9ITL9D) ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000517231
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Zs.A 1872: Show issues

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Article: Synergistic Ability of Chitosan and Trichoderma harzianum to Control the Growth and Discolouration of Common Sapstain Fungi of Pinus radiata

Singh, Tripti / Chittenden, Colleen

Forests. 2021 Apr. 27, v. 12, no. 5

2021

Abstract: An environmentally compatible method for controlling sapstain fungi in wood was evaluated, using a combination of chitosan and an albino strain of Trichoderma harzianum, a biological control agent (BCA). The growth and penetration into the wood of the ... ...

Abstract	An environmentally compatible method for controlling sapstain fungi in wood was evaluated, using a combination of chitosan and an albino strain of Trichoderma harzianum, a biological control agent (BCA). The growth and penetration into the wood of the sapstain fungi Ophiostoma piceae, Leptographium procerum, and Sphaeropsis sapinea were assessed in radiata pine wafers treated with chitosan and BCA, both alone and in combination. Several mycological and microscopic techniques were used, including a gfp (green fluorescent protein) transformed strain of O. piceae for assessing the depth of penetration in the wood samples. The synergy between the chitosan and BCA was evident, and for two tested fungi, only the combination of chitosan and BCA afforded protection. The synnemata (recognized by erect conidiogenous cells bearing conidia) was observed on the surface of the wafers inoculated with L. procerum and O. piceae, but the hyphae were unable to penetrate and melanise. The results suggest that the limited ability of chitosan to penetrate deeply into the wood was compensated by the fast growth of T. harzianum in the inner wood.
Keywords	Diplodia pinea ; Leptographium procerum ; Ophiostoma piceae ; Pinus radiata ; Trichoderma harzianum ; albino ; biological control agents ; chitosan ; conidia ; discoloration ; green fluorescent protein ; hyphae ; sapstain fungi ; synnemata ; wood
Language	English
Dates of publication	2021-0427
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f12050542
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Outcomes and mortality of chronic haemodialysis patients in community-based dialysis centres in Singapore during the COVID-19 pandemic.

Teo, Rachel Zui Chih / Yan, Hua / Singh, Tripti / Khan, Behram Ali

Singapore medical journal

2023

Language	English
Publishing date	2023-09-25
Publishing country	India
Document type	Journal Article
ZDB-ID	604319-7
ISSN	2737-5935 ; 0037-5675
ISSN (online)	2737-5935
ISSN	0037-5675
DOI	10.4103/singaporemedj.SMJ-2023-036
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Zs.B 589: Show issues

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Article ; Online: Regional citrate and systemic heparin are adequate to maintain filter half-life for COVID-19 patients on continuous renal replacement therapy.

Chiao, Cassandra / Faust, Hilary / Singh, Tripti

Seminars in dialysis

2022 Volume 35, Issue 4, Page(s) 325–329

Abstract: Introduction: The aim of our study is to compare clotting of CRRT filters in patients with COVID-19-associated AKI versus septic shock-associated AKI.: Methods: Retrospective study of adult ICU patients with COVID-19 compared to those with septic ... ...

Abstract	Introduction: The aim of our study is to compare clotting of CRRT filters in patients with COVID-19-associated AKI versus septic shock-associated AKI. Methods: Retrospective study of adult ICU patients with COVID-19 compared to those with septic shock admitted to a tertiary hospital April-October 2020. Independent t test and chi-square test used to determine statistical significance of CRRT filter clotting between the two groups. Time-to-event data analyzed with Kaplan-Meier curves. Analyses performed on Microsoft Excel and MedCalc. Results: Twenty-seven ICU patients with AKI requiring CRRT were included, 13 with COVID-19 and 14 non-COVID-19 patients with septic shock. The mean half-life of CRRT hemofilter was similar in COVID-19 patients compared to non-COVID-19 patients (27.4 vs. 27.5 h, p = 0.79). The number of CRRT hemofilter changes per day was similar in both groups (0.6 filter changes per day, p = 0.84). However, significantly more patients with COVID-19 were on systemic heparin (69% vs. 13%, p = 0.02). Conclusion: We found that COVID-19 patients with AKI requiring CRRT had similar CRRT hemofilter half-life compared with sepsis-associated AKI patients with use of regional citrate and systemic heparin. Further studies are needed to find which methods of anticoagulation are optimal in patients with COVID-19 infection with AKI requiring CRRT.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/therapy ; Adult ; Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/therapy ; Citrates ; Citric Acid ; Continuous Renal Replacement Therapy ; Half-Life ; Heparin/therapeutic use ; Humans ; Renal Dialysis ; Renal Replacement Therapy/methods ; Retrospective Studies ; Shock, Septic
Chemical Substances	Anticoagulants ; Citrates ; Citric Acid (2968PHW8QP) ; Heparin (9005-49-6)
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.13061
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Zs.A 2879: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Evaluation of Selected Accelerated Above-Ground Durability Testing Methods for Wood after Ten Years Exposure

Singh, Tripti / Page, Dave

Forests. 2020 May 15, v. 11, no. 5

2020

Abstract: Traditional benchmark wood durability testing methods such as stake tests take many years to give conclusive results, and in-ground tests do not always indicate the efficacy of preservatives in above-ground situations. To find test methods that would ... ...

Abstract	Traditional benchmark wood durability testing methods such as stake tests take many years to give conclusive results, and in-ground tests do not always indicate the efficacy of preservatives in above-ground situations. To find test methods that would shorten the time required for wood evaluation for above-ground end uses, a series of different types of accelerated durability tests were set up. Five types of test: ground proximity, two types of decking, flat panels and double layer, were reassessed after ten years to determine whether the decay rankings given to the various types of preservative had changed over the extended exposure period. Exposure conditions varied between tests, with ground proximity being close to ground, and the double layer test carried out in very wet conditions, while raised decking and flat panel tests were relatively dry. In all of these tests, the preservative retention was 25% of the normal H3 retention. The results indicated that the ground proximity tests gave the fastest and most reliable results. Flat panels contained the next highest decay rates, followed by ground-level decking, double layer and raised decking. The evaluation and comparison of these five test methods after ten years’ field exposure confirmed the trend and relative decay rate that was observed at four-year exposure. The use of a regression model for prediction showed a statistically significant overall relationship between decay scores in 2011 and 2017 (coefficient = 0.14 ± 0.07, d.f. = 345.7, t = 2.038, p = 0.042). When resistance to decay was compared between preservatives, copper-chrome arsenate (CCA)-treated pine and naturally durable spotted gum samples were in better conditions than pine treated with any of the other preservatives.
Keywords	chromated copper arsenate ; durability ; exposure duration ; prediction ; preservatives ; regression analysis ; wood
Language	English
Dates of publication	2020-0515
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f11050559
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Post-COVID green supply chain management of used products: a study towards awareness for vaccination.

Singh, Tripti / Tripathi, Sarvesh / Dwivedi, Ashish / Acevedo-Duque, Ángel

Environmental science and pollution research international

2022 Volume 30, Issue 15, Page(s) 42526–42540

Abstract: In the era of digital media, there is rapid spread of information. During coronavirus (COVID-19) pandemic situation, the government and other administrative bodies were highly dependent on media outlets, as direct contact was not feasible. Visual ... ...

Abstract	In the era of digital media, there is rapid spread of information. During coronavirus (COVID-19) pandemic situation, the government and other administrative bodies were highly dependent on media outlets, as direct contact was not feasible. Visual communication tools are used to spread awareness and encourage people towards vaccination. The circulation of wrong information may lead to confusion, which may cause denying the vaccine. There was a need to know the extent for contribution of visual communication tools for spreading correct information and motivating the society towards vaccination in post COVID times. In the present study, survey questionnaires were framed specific to which media (print or digital) was more effective to deliver the correct information to the targeted audience. The present study objectives to answer the questions through a survey of 312 people of different age groups, and the data was collected about their families. The obtained data was tested through hypothesis, and fact-checked was performed adopting analysis of variance (ANOVA). The results from the study highlighted that different age groups prefer different mediums of communication. The reach and adoption of digital media have tremendously increased, and it helped to achieve the sustainable development goals (SDGs) by efficient green supply chain management (GSCM) of daily plastic and paper wastage during post-pandemic.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Internet ; Communication ; Vaccination
Language	English
Publishing date	2022-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21321-8
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Article: Post-transplant idiopathic immune complex membrano-proliferative glomerulonephritis: Characteristics and outcomes.

Aziz, Fahad / Singh, Tripti / Garg, Neetika / Zhong, Weixiong / Mandelbrot, Didier

Clinical nephrology

2022 Volume 99, Issue 2, Page(s) 69–77

Abstract: Background: There is little published information on the natural history and the treatment of immune complex membrano-proliferative glomerulonephritis (IC-MPGN) of unknown cause in the transplanted kidney.: Materials and methods: From 01/2004 to 12/ ... ...

Abstract	Background: There is little published information on the natural history and the treatment of immune complex membrano-proliferative glomerulonephritis (IC-MPGN) of unknown cause in the transplanted kidney. Materials and methods: From 01/2004 to 12/2018, 41 patients had the diagnosis of post-transplant idiopathic IC-MPGN and were included in the study. Results: The mean age of the cohort at the time of transplant was 50 ± 13 years. The most common presentation was increased proteinuria, followed by kidney dysfunction. Fewer than 50% of patients had hematuria at presentation. 25 patients (61%) had no change in their baseline immunosuppression after the diagnosis of idiopathic IC-MPGN. Eight patients (19.5%) received steroids alone, and 8 patients (19.5%) received rituximab with (7) or without (1) steroids. The patients who received rituximab had better uncensored graft survival than the patients who received no treatment (p = 0.02), but the benefit of steroids compared to no treatment did not reach statistical significance (p = 0.05). The multivariate analysis retained eGFR < 30 mL/min/1.73m Conclusion: To the best of our knowledge, this is the largest clinic-pathological series of post-transplant idiopathic IC-MPGN. Treatment of idiopathic IC-MPGN may be associated with better graft outcomes.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Antigen-Antibody Complex ; Glomerulonephritis/drug therapy ; Glomerulonephritis/complications ; Glomerulonephritis, Membranoproliferative/drug therapy ; Glomerulonephritis, Membranoproliferative/complications ; Kidney/pathology ; Rituximab/therapeutic use ; Kidney Transplantation/adverse effects
Chemical Substances	Antigen-Antibody Complex ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2022-11-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN110991
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