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Article: Effect of Beam Oscillation on Microstructure and Mechanical Properties of Electron Beam Welded EN25 Steel.

Singh, Vasundhara / Srirangam, Prakash / Roy, Gour Gopal

2023 Volume 16, Issue 7

Abstract: EN25 steels have been found to be applicable in shafts, gears, etc., but welding of EN25 steel was performed using electron beam welding with different oscillation beam diameters varying from 2 mm to 0.5 mm. The present study reports the effect of beam ... ...

Abstract	EN25 steels have been found to be applicable in shafts, gears, etc., but welding of EN25 steel was performed using electron beam welding with different oscillation beam diameters varying from 2 mm to 0.5 mm. The present study reports the effect of beam oscillation on the evolution of nonmetallic inclusions, microstructures, and mechanical properties of EN25 steel. Heat input calculations showed that the application of beam oscillations resulted in significantly lower heat inputs compared to their non-oscillating counterparts. The highest fraction of the retained austenite (9.35%) was observed in a weld prepared with beam oscillation at a 2-mm oscillation diameter, and it decreased to 3.27% at an oscillating diameter of 0.5 mm, and it further reduced to 0.36% for non-oscillating beam cases. Residual stresses were compressive in the fusion zone, irrespective of beam oscillation. Beam oscillation resulted in equiaxed grain in the recenter region of the fusion zone, attributed to heat mixing and the evolution of random texture. The application of beam oscillations resulted in a significant decrease in the size of the nonmetallic inclusions to 0.1-0.5 compared to 5-20 mm in base metal. All tensile samples failed in the base metal, indicating good strength of the weld. Fusion zone hardness (250-670 HNV) and wear properties (COF 0.7 to COF 0.45) improved irrespective of with and without beam oscillation.
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16072717
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D-QSAR and ADMET studies of morpholino-pyrimidine inhibitors of DprE1 from

Tayal, Sonali / Singh, Vasundhara / Bhatnagar, Sonika

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–20

Abstract: DprE1 is involved in the synthesis ... ...

Abstract	DprE1 is involved in the synthesis of
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2294496
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Article: [No title information]

Singh, Vasundhara / Sapehiyia, Varinder / Kad, Goverdhan L.

Synthesis

3013 Volume 2003, Issue 02

Abstract: We have accomplished the oxidation of hydroquinones to quinones in quantitative yields using catalytic quantity of ceric ammonium nitrate doped on various metal-exchanged K-10 clay, as a mild and efficient reagent, by ultrasonic activation. The ... ...

Abstract	We have accomplished the oxidation of hydroquinones to quinones in quantitative yields using catalytic quantity of ceric ammonium nitrate doped on various metal-exchanged K-10 clay, as a mild and efficient reagent, by ultrasonic activation. The exchanged cations examined were Fe 3+, Cu 2+, Ce 4+ and K-10 clay itself. The best results were obtained using Fe 3+ -Mont. K-10 clay.
Keywords	ultrasound ; ceric ammonium nitrate ; hydroquinones ; quinones
Language	English
Publishing date	30131
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2033062-5
ISSN	1437-210X ; 0039-7881
ISSN (online)	1437-210X
ISSN	0039-7881
DOI	10.1055/s-2003-36824
Database	Thieme publisher's database

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Article ; Online: Structure-activity relationships of dihydropyrimidone inhibitors against native and auto-processed human neutrophil elastase.

Singh, Vasundhara / Singh, Nirupma / Pradhan, Amartya / Kumar, Yatender / Bhatnagar, Sonika

Computers in biology and medicine

2023 Volume 161, Page(s) 107004

Abstract: Background: Human neutrophil elastase (HNE) is a key driver of systemic and cardiopulmonary inflammation. Recent studies have established the existence of a pathologically active auto-processed form of HNE with reduced binding affinity against small ... ...

Abstract	Background: Human neutrophil elastase (HNE) is a key driver of systemic and cardiopulmonary inflammation. Recent studies have established the existence of a pathologically active auto-processed form of HNE with reduced binding affinity against small molecule inhibitors. Method: AutoDock Vina v1.2.0 and Cresset Forge v10 software were used to develop a 3D-QSAR model for a series of 47 DHPI inhibitors. Molecular Dynamics (MD) simulations were carried out using AMBER v18 to study the structure and dynamics of sc (single-chain HNE) and tcHNE (two-chain HNE). MMPBSA binding free energies of the previously reported clinical candidate BAY 85-8501 and the highly active BAY-8040 were calculated with sc and tcHNE. Results: The DHPI inhibitors occupy the S1 and S2 subsites of scHNE. The robust 3D-QSAR model showed acceptable predictive and descriptive capability with regression coefficient of r Conclusion: SAR insights gained from this study will aid the future development of inhibitors active against both forms of HNE.
MeSH term(s)	Humans ; Leukocyte Elastase/chemistry ; Leukocyte Elastase/metabolism ; Pyrimidinones ; Sulfones ; Molecular Dynamics Simulation ; Quantitative Structure-Activity Relationship ; Molecular Docking Simulation
Chemical Substances	BAY 85-8501 ; Leukocyte Elastase (EC 3.4.21.37) ; Pyrimidinones ; Sulfones
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107004
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Article ; Online: Natural bioactives versus synthetic antibiotics for the attenuation of quorum sensing-regulated virulence factors of

Mangal, Surabhi / Singh, Vasundhara / Chhibber, Sanjay / Harjai, Kusum

Future microbiology

2022 Volume 17, Page(s) 773–787

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biofilms ; Pseudomonas aeruginosa ; Quorum Sensing ; Virulence Factors/genetics
Chemical Substances	Anti-Bacterial Agents ; Virulence Factors
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2021-0199
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Article ; Online: Guaiacol augments quorum quenching potential of ciprofloxacin against Pseudomonas aeruginosa.

Mangal, Surabhi / Chhibber, Sanjay / Singh, Vasundhara / Harjai, Kusum

Journal of applied microbiology

2022 Volume 133, Issue 4, Page(s) 2235–2254

Abstract: Aim: The present study aims to investigate the antimicrobial as well as antivirulence potential and the principle mechanism of action of guaiacol against Pseudomonas aeruginosa.: Methods and results: Quorum sensing inhibition and membrane disruption ... ...

Abstract	Aim: The present study aims to investigate the antimicrobial as well as antivirulence potential and the principle mechanism of action of guaiacol against Pseudomonas aeruginosa. Methods and results: Quorum sensing inhibition and membrane disruption studies were performed to check the effect of guaiacol on the virulence of P. aeruginosa. Production of various virulence factors and biofilm formation was studied at a sub-MIC concentration of guaiacol alone (1/8 MIC) and in combination with ciprofloxacin (1/2 FIC). Guaiacol exhibited synergistic interactions with ciprofloxacin and further reduced the production of all virulence factors and biofilm formation. Using crystal violet (CV) assay and quantification of exopolysaccharide, we observed weak biofilm formation, together with reduced motilities at sub-MIC, which was further visualized by confocal laser microscopy and Field Emission Scanning Electron Microscopy. The antibacterial activity of guaiacol against P. aeruginosa upon 2 × MIC exposure coincided with enhanced membrane permeability leading to disruption and release of cellular material as quantified by CV uptake assay and sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The results demonstrated that sub-MICs of guaiacol in combination with ciprofloxacin can act as a potent alternate compound for attenuation of quorum sensing in P. aeruginosa. Conclusion: The study reports that guaiacol in combination with ciprofloxacin at 1/2 FIC significantly compromised the bacterial growth and motilities alongside inducing quorum quenching potential. This was accompanied by inhibition of biofilm which subsequently decreased EPS production at sub-MIC concentration. Furthermore, guaiacol in combination displayed a severe detrimental effect on bacterial membrane disruption, thereby enhancing cellular material release. Novelty impact statement: For the first time, the potential of guaiacol in combination with ciprofloxacin in attenuation of virulence factors, and biofilm formation in Pseudomonas aeruginosa was described. Results corroborate how plant bioactive in synergism with antibiotics can act as an alternate treatment regime to tackle the menace of drug resistance.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biofilms ; Ciprofloxacin/pharmacology ; Gentian Violet/pharmacology ; Guaiacol/pharmacology ; Pseudomonas aeruginosa ; Quorum Sensing ; Sodium Dodecyl Sulfate/pharmacology ; Virulence Factors
Chemical Substances	Anti-Bacterial Agents ; Virulence Factors ; Sodium Dodecyl Sulfate (368GB5141J) ; Ciprofloxacin (5E8K9I0O4U) ; Guaiacol (6JKA7MAH9C) ; Gentian Violet (J4Z741D6O5)
Language	English
Publishing date	2022-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15787
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Article: Guaiacol augments quorum quenching potential of ciprofloxacin against Pseudomonas aeruginosa

Mangal, Surabhi / Chhibber, Sanjay / Singh, Vasundhara / Harjai, Kusum

Journal of applied microbiology. 2022 Oct., v. 133, no. 4

2022

Abstract: AIM: The present study aims to investigate the antimicrobial as well as antivirulence potential and the principle mechanism of action of guaiacol against Pseudomonas aeruginosa. METHODS AND RESULTS: Quorum sensing inhibition and membrane disruption ... ...

Abstract	AIM: The present study aims to investigate the antimicrobial as well as antivirulence potential and the principle mechanism of action of guaiacol against Pseudomonas aeruginosa. METHODS AND RESULTS: Quorum sensing inhibition and membrane disruption studies were performed to check the effect of guaiacol on the virulence of P. aeruginosa. Production of various virulence factors and biofilm formation was studied at a sub‐MIC concentration of guaiacol alone (1/8 MIC) and in combination with ciprofloxacin (1/2 FIC). Guaiacol exhibited synergistic interactions with ciprofloxacin and further reduced the production of all virulence factors and biofilm formation. Using crystal violet (CV) assay and quantification of exopolysaccharide, we observed weak biofilm formation, together with reduced motilities at sub‐MIC, which was further visualized by confocal laser microscopy and Field Emission Scanning Electron Microscopy. The antibacterial activity of guaiacol against P. aeruginosa upon 2 × MIC exposure coincided with enhanced membrane permeability leading to disruption and release of cellular material as quantified by CV uptake assay and sodium dodecyl sulphate‐polyacrylamide gel electrophoresis (SDS‐PAGE). The results demonstrated that sub‐MICs of guaiacol in combination with ciprofloxacin can act as a potent alternate compound for attenuation of quorum sensing in P. aeruginosa. CONCLUSION: The study reports that guaiacol in combination with ciprofloxacin at 1/2 FIC significantly compromised the bacterial growth and motilities alongside inducing quorum quenching potential. This was accompanied by inhibition of biofilm which subsequently decreased EPS production at sub‐MIC concentration. Furthermore, guaiacol in combination displayed a severe detrimental effect on bacterial membrane disruption, thereby enhancing cellular material release. NOVELTY IMPACT STATEMENT: For the first time, the potential of guaiacol in combination with ciprofloxacin in attenuation of virulence factors, and biofilm formation in Pseudomonas aeruginosa was described. Results corroborate how plant bioactive in synergism with antibiotics can act as an alternate treatment regime to tackle the menace of drug resistance.
Keywords	Pseudomonas aeruginosa ; antibacterial properties ; bacterial growth ; biofilm ; ciprofloxacin ; confocal laser scanning microscopy ; drug resistance ; electron microscopy ; exopolysaccharides ; gentian violet ; guaiacol ; mechanism of action ; membrane permeability ; polyacrylamide gel electrophoresis ; synergism ; virulence
Language	English
Dates of publication	2022-10
Size	p. 2235-2254.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15787
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In vivo

Mangal, Surabhi / Ranot, Nishma / Nosran, Anu / Singh, Vasundhara / Chhibber, Sanjay / Harjai, Kusum

Future microbiology

2023 Volume 18, Page(s) 1339–1351

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Animals ; Mice ; Pseudomonas aeruginosa ; Peritonitis/drug therapy ; Peritonitis/microbiology ; Peritonitis/pathology ; Phenols/pharmacology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology
Chemical Substances	pyochelin (69772-54-9) ; zingerone (4MMW850892) ; Phenols
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2023-0016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Gender Determination from Maxillary Sinus using Computed Tomography Scans - A Radiographic Study.

Jaideepa / Jha, Ashutosh / Mehta, Dhaval N / Singh, Vasundhara / Malawat, Kanchan / Sinha, Shalini

Journal of pharmacy & bioallied sciences

2023 Volume 15, Issue Suppl 2, Page(s) S1010–S1012

Abstract: Aims and objective: Purpose of this research was to check the precision of gender identification using computed tomography (CT) head and neck scans and volumetric analysis of the maxillary sinus.: Materials and methods: For 50 patients (25 females ... ...

Abstract	Aims and objective: Purpose of this research was to check the precision of gender identification using computed tomography (CT) head and neck scans and volumetric analysis of the maxillary sinus. Materials and methods: For 50 patients (25 females and 25 males), left and right maxillary sinus scans were acquired, and linear measurements (width, length, height, and volume) were assessed. Both maxillary sinus measurements' means and standard deviations were computed and contrasted. Results: Males have been found to have considerably larger maxillary sinuses than females. Conclusion: Accurate gender determination is possible with the use of maxillary sinus.
Language	English
Publishing date	2023-07-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_250_23
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Article ; Online: pH-Controlled Efficient Conversion of Hemicellulose to Furfural Using Choline-Based Deep Eutectic Solvents as Catalysts.

Arora, Shalini / Gupta, Neeraj / Singh, Vasundhara

ChemSusChem

2021 Volume 14, Issue 18, Page(s) 3953–3958

Abstract: The valorization of hemicellulose isolated from lignocellulosic biomass (wheat straw, rice husk, and bagasse) to furfural was achieved by pH-controlled acid catalysis using choline-based Brønsted acidic (BA) and natural acidic (NA) deep eutectic solvents ...

Abstract	The valorization of hemicellulose isolated from lignocellulosic biomass (wheat straw, rice husk, and bagasse) to furfural was achieved by pH-controlled acid catalysis using choline-based Brønsted acidic (BA) and natural acidic (NA) deep eutectic solvents (DES) serving both as catalyst and solvent. The effect of pH variation on the catalytic activity of various BADES and NADES prepared in 1 : 1 molar ratio was observed, and choline chloride/p-toluene sulfonic acid (ChCl/p-TSA) was found to be the best with lower pH value of 1.0. The yield of furfural decreased from 85 to 51 % with increase in pH from 1.0 to 3.0. The molar ratio of hydrogen bond donor to acceptor components was varied from 1 : 1 to 1 : 9 to achieve the lowest possible pH values of the DESs and to increase the furfural yield. Further optimization of reaction conditions was also done in terms of DES loading, time of reaction, and temperature using the model DES to achieve higher furfural yield. The best results were obtained using 5 mmol DES at pH 1.0 in 1.5 h at 120 °C. ChCl/p-TSA and ChCl/oxalic acid among BADES and ChCl/levulinic acid among NADES investigated in this work yielding 85 % furfural were found to be most efficient. The reported methodology is advantageous in terms of using bio-based green solvents, mild reaction conditions, and efficient scale-up of the reaction. The DESs were found to be efficiently recyclable up to five consecutive runs for the process.
Language	English
Publishing date	2021-08-19
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202101130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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