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  1. Article ; Online: Phytochemical investigation of

    Singhal, Rini / Verma, Shweta / Singh, Vijender

    Natural product research

    2024  , Page(s) 1–7

    Abstract: This study aimed to ensure the quality of the seed as well as determine the phytochemical composition ... ...

    Abstract This study aimed to ensure the quality of the seed as well as determine the phytochemical composition of
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2348673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Investigating antiarthritic potential of polyherbal emulgel.

    Rana, Neha / Gupta, Piyush / Singh, Vijender / Ali, Mohammed

    Journal of Ayurveda and integrative medicine

    2023  Volume 14, Issue 6, Page(s) 100828

    Abstract: Background: Rheumatoid arthritis (RA) is an inflammation of joints with increased cellularity of synovial tissue. Allopathic drugs possess several adverse effects, which have led to increase in the utilization of herbal medicines. Polyherbal emulgel ... ...

    Abstract Background: Rheumatoid arthritis (RA) is an inflammation of joints with increased cellularity of synovial tissue. Allopathic drugs possess several adverse effects, which have led to increase in the utilization of herbal medicines. Polyherbal emulgel resolves the bioavailability issue associated with hydrophobic drugs and can be used effectively in the treatment of RA.
    Objectives: The present study aimed at the formulation of polyherbal emulgel, and evaluation of in vitro anti-inflammatory activity and in vivo antiarthritic activity.
    Methods: Seven emulgels F-1 to F-7 were optimally formulated. In vitro anti-inflammatory activity was determined using protein denaturation method employing Diclofenac sodium as the standard. In antiarthritic study Complete Freund's Adjuvant (CFA) model was used. The various parameters were assessed, like paw volume, body weight, hematological parameters, antioxidant parameters, Rheumatic factor (RF), and histopathological study of ankle joint.
    Results: F-4 and F-7 were found to be optimized formulations as compared to other formulations. The in vitro anti-inflammatory activity was found to be highest in F-4 with IC
    Conclusion: As an anti-inflammatory agent, this newly developed emulgel was found to possess more therapeutic efficacy than commercially available diclofenac sodium.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 0975-9476
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2023.100828
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  3. Article: Caveats of mental healthcare act-2017: Recommendation for amendments.

    Singh, Vijender / Basera, Devendra S / Sutar, Roshan F

    Indian journal of psychiatry

    2023  Volume 65, Issue 1, Page(s) 114–115

    Language English
    Publishing date 2023-01-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_893_21
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2038: Show issues Location:
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  4. Article ; Online: NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α.

    Canalis, Ernesto / Yu, Jungeun / Singh, Vijender / Mocarska, Magda / Schilling, Lauren

    The Journal of biological chemistry

    2023  Volume 299, Issue 12, Page(s) 105372

    Abstract: Notch regulates the immune and inflammatory response and has been associated with the pathogenesis of osteoarthritis in humans and preclinical models of the disease. ... ...

    Abstract Notch regulates the immune and inflammatory response and has been associated with the pathogenesis of osteoarthritis in humans and preclinical models of the disease. Notch2
    MeSH term(s) Animals ; Humans ; Mice ; Chondrocytes/cytology ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Immunoglobulins ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Osteoarthritis/genetics ; Osteoarthritis/metabolism ; Receptor, Notch2/genetics ; Receptor, Notch2/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Inflammation ; Disease Models, Animal ; Chondrogenesis ; Signal Transduction/drug effects ; Protein Domains/immunology ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism ; Gene Deletion ; Gene Expression Regulation/drug effects
    Chemical Substances Immunoglobulins ; Interleukin-6 ; NOTCH2 protein, human ; Receptor, Notch2 ; Tumor Necrosis Factor-alpha ; Immunoglobulin J Recombination Signal Sequence-Binding Protein
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105372
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Mental Health Prevention and Promotion-A Narrative Review.

    Singh, Vijender / Kumar, Akash / Gupta, Snehil

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 898009

    Abstract: Extant literature has established the effectiveness of various mental health promotion and prevention strategies, including novel interventions. However, comprehensive literature encompassing all these aspects and challenges and opportunities in ... ...

    Abstract Extant literature has established the effectiveness of various mental health promotion and prevention strategies, including novel interventions. However, comprehensive literature encompassing all these aspects and challenges and opportunities in implementing such interventions in different settings is still lacking. Therefore, in the current review, we aimed to synthesize existing literature on various mental health promotion and prevention interventions and their effectiveness. Additionally, we intend to highlight various novel approaches to mental health care and their implications across different resource settings and provide future directions. The review highlights the (1) concept of preventive psychiatry, including various mental health promotions and prevention approaches, (2) current level of evidence of various mental health preventive interventions, including the novel interventions, and (3) challenges and opportunities in implementing concepts of preventive psychiatry and related interventions across the settings. Although preventive psychiatry is a well-known concept, it is a poorly utilized public health strategy to address the population's mental health needs. It has wide-ranging implications for the wellbeing of society and individuals, including those suffering from chronic medical problems. The researchers and policymakers are increasingly realizing the potential of preventive psychiatry; however, its implementation is poor in low-resource settings. Utilizing novel interventions, such as mobile-and-internet-based interventions and blended and stepped-care models of care can address the vast mental health need of the population. Additionally, it provides mental health services in a less-stigmatizing and easily accessible, and flexible manner. Furthermore, employing decision support systems/algorithms for patient management and personalized care and utilizing the digital platform for the non-specialists' training in mental health care are valuable additions to the existing mental health support system. However, more research concerning this is required worldwide, especially in the low-and-middle-income countries.
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.898009
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  6. Article: Mental Healthcare Act, 2017 (MHCA), from Paper to Clinical Practice in the Mental Health Settings.

    Ghosh, Sanjukta / Gupta, Snehil / Singh, Vijender

    Indian journal of psychological medicine

    2022  Volume 44, Issue 3, Page(s) 315–316

    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2622378-8
    ISSN 0975-1564 ; 0253-7176
    ISSN (online) 0975-1564
    ISSN 0253-7176
    DOI 10.1177/02537176221084045
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  7. Article ; Online: Composition and pharmacological activity of essential oils from two imported

    Alam, Aftab / Singh, Vijender

    Journal of Taibah University Medical Sciences

    2020  Volume 16, Issue 2, Page(s) 231–239

    Abstract: Objective: This work attempted to isolate, identify, and correlate the composition of essential oils (EOs) and pharmacological properties of two imported : Methods: EOs were extracted from Indian and KSA : Results: GC-MS retention times of both ... ...

    Abstract Objective: This work attempted to isolate, identify, and correlate the composition of essential oils (EOs) and pharmacological properties of two imported
    Methods: EOs were extracted from Indian and KSA
    Results: GC-MS retention times of both samples demonstrated 56 bioactive ingredients with different percentages. The principal bioactive compounds in the Indian and Saudi Arabian EO samples were 1,8-cineole (44.24% and 46.22%, respectively), α-terpineol (7.47% and 7.04%, respectively), terpinen-4-ol (5.01% and 4.83%, respectively), geraniol D (4.05% and 3.54%, respectively), and β-pinene (3.38% and 3.98%, respectively). Superior antimicrobial activity against the selected strains was observed for both samples, with an MIC range of 0.5%-1%. Antioxidant assays demonstrated moderate activity in both samples. Moreover, the Indian and Saudi Arabian samples exhibited IC
    Conclusions: The composition of EOs from both samples exhibited similar qualitative but different quantitative variability. No major variations in the pharmacological properties of EOs were observed. More studies are essential for further validation of our study findings.
    Language English
    Publishing date 2020-11-11
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2817396-X
    ISSN 1658-3612 ; 1658-3612
    ISSN (online) 1658-3612
    ISSN 1658-3612
    DOI 10.1016/j.jtumed.2020.10.007
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  8. Article ; Online: Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor.

    Malik, Shipra / Pradeep, Sai Pallavi / Kumar, Vikas / Xiao, Yong / Deng, Yanxiang / Fan, Rong / Vasquez, Juan C / Singh, Vijender / Bahal, Raman

    Cell reports. Medicine

    2024  Volume 5, Issue 1, Page(s) 101354

    Abstract: Targeting oncogenes at the genomic DNA level can open new avenues for precision medicine. Significant efforts are ongoing to target oncogenes using RNA-targeted and protein-targeted platforms, but no progress has been made to target genomic DNA for ... ...

    Abstract Targeting oncogenes at the genomic DNA level can open new avenues for precision medicine. Significant efforts are ongoing to target oncogenes using RNA-targeted and protein-targeted platforms, but no progress has been made to target genomic DNA for cancer therapy. Here, we introduce a gamma peptide nucleic acid (γPNA)-based genomic DNA-targeted platform to silence oncogenes in vivo. γPNAs efficiently invade the mixed sequences of genomic DNA with high affinity and specificity. As a proof of concept, we establish that γPNA can inhibit c-Myc transcription in multiple cell lines. We evaluate the in vivo efficacy and safety of genomic DNA targeting in three pre-clinical models. We also establish that anti-transcription γPNA in combination with histone deacetylase inhibitors and chemotherapeutic drugs results in robust antitumor activity in cell-line- and patient-derived xenografts. Overall, this strategy offers a unique therapeutic platform to target genomic DNA to inhibit oncogenes for cancer therapy.
    MeSH term(s) Humans ; Nucleic Acids ; DNA/genetics ; Peptide Nucleic Acids/pharmacology ; Peptide Nucleic Acids/genetics ; RNA ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Nucleic Acids ; DNA (9007-49-2) ; Peptide Nucleic Acids ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101354
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  9. Article: Assessment of memory deficits in psychiatric disorders: A systematic literature review.

    Kushwaha, Anuradha / Basera, Devendra Singh / Kumari, Sangita / Sutar, Roshan Fakirchand / Singh, Vijender / Das, Saikat / Agrawal, Amit

    Journal of neurosciences in rural practice

    2024  Volume 15, Issue 2, Page(s) 182–193

    Abstract: Memory deficits are observed across psychiatric disorders ranging from the prodrome of psychosis to common mental disorders such as anxiety, depression, and dissociative disorders. Memory deficits among patients recovering from psychiatric disorders ... ...

    Abstract Memory deficits are observed across psychiatric disorders ranging from the prodrome of psychosis to common mental disorders such as anxiety, depression, and dissociative disorders. Memory deficits among patients recovering from psychiatric disorders could be directly related to the primary illness or secondary to the adverse effect of a treatment such as Electroconvulsive Therapy (ECT). The trouble in the meaningful integration of working-memory and episodic memory is the most commonly affected domain that requires routine assessments. An update on the recent trends of methods of assessment of memory deficits is the first step towards understanding and correcting these deficits to target optimum recovery. A systematic literature search was conducted from October 2018 to October 2022 to review the recent methods of assessment of memory deficits in psychiatric disorders. The definition of 'Memory deficit' was operationalized as 'selective processes of memory, commonly required for activities of daily living, and affected among psychiatric disorders resulting in subjective distress and dysfunction'. We included 110 studies, most of them being conducted in western countries on patients with schizophrenia. Other disorders included dementia and mild cognitive impairment. Brief Assessment of Cognition in Schizophrenia, Cambridge Automated Neuropsychological Test Battery, California Verbal Learning Test, Trail Making Test Part A and B, Rey Auditory Verbal Learning Test, Wechsler Memory Scale, Wechsler Adults Intelligence Scale-IV were the most common neuropsychological assessments used. Mini-Mental State Examination and Montreal Cognitive Assessment were the most common bedside assessment tools used while Squire Subjective Memory Questionnaire was commonly used to measure ECT-related memory deficits. The review highlights the recent developments in the field of assessment of memory deficits in psychiatric disorders. Findings recommend and emphasize routine assessment of memory deficits among psychiatric disorders in developing countries especially severe mental illnesses. It remains interesting to see the role of standardized assessments in diagnostic systems given more than a decade of research on memory deficits in psychiatric disorders.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP_456_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Case of Factitious Disorder: Red Herring of Psychiatry.

    Sharma, Vatsala / Bhandari, Samrat Singh / Singh, Vijender / Chandra, Anukriti

    Psychiatria Danubina

    2021  Volume 33, Issue 3, Page(s) 371–372

    MeSH term(s) Factitious Disorders/diagnosis ; Humans ; Psychiatry
    Language English
    Publishing date 2021-11-18
    Publishing country Croatia
    Document type Case Reports ; Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
    DOI 10.24869/psyd.2021.371
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    In stock of ZB MED Cologne/Königswinter

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