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Article ; Online: Gelatin-based electrospun and lyophilized scaffolds with nano scale feature for bone tissue engineering application: review.

Singh, Yogendra Pratap / Dasgupta, Sudip

Journal of biomaterials science. Polymer edition

2022 Volume 33, Issue 13, Page(s) 1704–1758

Abstract: The rebuilding of the normal functioning of the damaged human body bone tissue is one of the main objectives of bone tissue engineering (BTE). Fabricated scaffolds are mostly treated as artificial supports and as materials for regeneration of neo bone ... ...

Abstract	The rebuilding of the normal functioning of the damaged human body bone tissue is one of the main objectives of bone tissue engineering (BTE). Fabricated scaffolds are mostly treated as artificial supports and as materials for regeneration of neo bone tissues and must closely biomimetic the native extracellular matrix of bone. The materials used for developing scaffolds should be biodegradable, nontoxic, and biocompatible. For the resurrection of bone disorder, specifically natural and synthetic polymers such as chitosan, PCL, gelatin, PGA, PLA, PLGA, etc. meet the requirements for serving their functions as artificial bone substitute materials. Gelatin is one of the potential candidates which could be blended with other polymers or composites to improve its physicochemical, mechanical, and biological performances as a bone graft. Scaffolds are produced by several methods including electrospinning, self-assembly, freeze-drying, phase separation, fiber drawing, template synthesis, etc. Among them, freeze-drying and electrospinning are among the popular, simplest, versatile, and cost-effective techniques. The design and preparation of freeze-dried and electrospun scaffolds are of intense research over the last two decades. Freeze-dried and electrospun scaffolds offer a distinctive architecture at the micro to nano range with desired porosity and pore interconnectivity for selective movement of small biomolecules and play its role as an appropriate matrix very similar to the natural bone extracellular matrix. This review focuses on the properties and functionalization of gelatin-based polymer and its composite in the form of bone scaffolds fabricated primarily using lyophilization and electrospinning technique and their applications in BTE.
MeSH term(s)	Biocompatible Materials ; Bone and Bones ; Gelatin/chemistry ; Humans ; Polyesters/chemistry ; Polymers ; Porosity ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Polyesters ; Polymers ; Gelatin (9000-70-8)
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1014190-x
ISSN	1568-5624 ; 1568-5616 ; 0920-5063
ISSN (online)	1568-5624 ; 1568-5616
ISSN	0920-5063
DOI	10.1080/09205063.2022.2068943
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Zs.A 2931: Show issues

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Article ; Online: Inadequate Completion of Computed Tomography Request Forms of Patients Visiting the Department of Radiology and Imaging in a Tertiary Care Centre.

Sah, Ramswarth / Lohani, Benu / Singh, Yogendra Prasad

JNMA; journal of the Nepal Medical Association

2023 Volume 61, Issue 267, Page(s) 878–881

Abstract: Introduction: From both medical and legal points of view, it is vital that computed tomography request forms should be adequately filled up. It is the responsibility of physicians to collect adequate clinical information that justifies the computed ... ...

Abstract	Introduction: From both medical and legal points of view, it is vital that computed tomography request forms should be adequately filled up. It is the responsibility of physicians to collect adequate clinical information that justifies the computed tomography examination and the ethical responsibility of radiological technologists and radiologists is to perform only the justified radiological examinations. Thus, a properly filled request form is crucial for understanding the clinical problem, using the proper protocol for avoiding unnecessary radiation exposure and providing concise radiological reports. The aim of this study was to find out the prevalence of inadequate completion of computed tomography request forms of patients visiting the Department of Radiology of a tertiary care centre. Methods: This descriptive study was performed in the Department of Radiology from 22 April 2021 to 21 April 2022 after receiving ethical approval from the Institutional Review Committee. Computed tomography request forms from emergency, ward and outpatient Departments were used in the study whereas that from other hospitals and clinics were excluded. A convience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Out of 470 computed tomography examination forms, the prevalence of inadequate computed tomography request forms was 195 (41.49%) (37.03-45.94, 95% Confidence Interval). Conclusions: The prevalence of the inadequacy of completion of computed tomography examination forms was higher than other similar studies done in similar settings. Keywords: audit; computed tomography; form.
MeSH term(s)	Humans ; Tertiary Care Centers ; Radiography ; Tomography, X-Ray Computed ; Radiology ; Outpatients
Language	English
Publishing date	2023-11-01
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
DOI	10.31729/jnma.8327
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Article ; Online: Neuroleptic Malignant Syndrome in a 15-Month-Old Child: A Case Report.

Penugonda, Asha Jyothi / Singh, Yogendra / Kattula, Dheeraj / Bhaskar, Mona

Journal of clinical psychopharmacology

2023 Volume 43, Issue 5, Page(s) 455–456

MeSH term(s)	Humans ; Infant ; Neuroleptic Malignant Syndrome/diagnosis
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001749
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Zs.A 1664: Show issues

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Article ; Online: A Review on Comparison of Allopathic Medicines to other Drug Therapies in the Management of Asthma.

Garg, Ruchika / Piplani, Mona / Upadhayay, Ashutosh / Singh, Yogendra / Bhateja, Pankaj

Infectious disorders drug targets

2023 Volume 24, Issue 2, Page(s) e201023222496

Abstract: Asthma, is a chronic disease of the airways and is characterized by exacerbations of bronchospasm and noticeable airway inflammation. Current asthma therapy has emerged from naturally occurring compounds through rational pharmaceutical advancements, and ... ...

Abstract	Asthma, is a chronic disease of the airways and is characterized by exacerbations of bronchospasm and noticeable airway inflammation. Current asthma therapy has emerged from naturally occurring compounds through rational pharmaceutical advancements, and it is very beneficial. In this review, we have discussed the different drug therapies i.e., Ayurvedic, Homeopathic, Unani, and Allopathic affecting asthma treatment. Allopathic medicines are used as a controller medication for regular maintenance of asthma i.e., long-acting β-agonists, inhaled corticosteroids, anti-leukotriene medicines, and novel biologic agents. Pharmacological research is more important in generating effective, long-lasting, and safe asthma treatments, but it has been difficult to produce new classes of anti-asthmatic therapies. A combination inhaler that contains a long-acting β2-agonist and a corticosteroid is currently the "gold standard" for treating asthma. Allopathic treatments for asthma have been proven effective in reducing the probability of asthma attacks and for improving symptoms along with lung functions as compared to other therapies. The level of asthma management and the possible risk of future worsening are used to determine the treatment's strategies. This review article describes the comparison of allopathic therapy of asthma with homeopathy, ayurvedic and Unani system and gives justification supported by a number of case studies for being allopathic, a better therapy when compared with others.
MeSH term(s)	Humans ; Asthma/drug therapy ; Anti-Asthmatic Agents/therapeutic use ; Adrenal Cortex Hormones/therapeutic use ; Chronic Disease ; Drug Therapy, Combination
Chemical Substances	Anti-Asthmatic Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-10-23
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/0118715265249796231018050521
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Zs.A 5598: Show issues

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Article ; Online: Computational Approaches for the Structure-Based Identification of Novel Inhibitors Targeting Nucleoid-Associated Proteins in Mycobacterium Tuberculosis.

Sunita / Singhvi, Nirjara / Gupta, Vipin / Singh, Yogendra / Shukla, Pratyoosh

Molecular biotechnology

2023 Volume 66, Issue 4, Page(s) 814–823

Abstract: Implementation of computational tools in the identification of novel drug targets for Tuberculosis (TB) has been a promising area of research. TB has been a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) localized primarily on the ... ...

Abstract	Implementation of computational tools in the identification of novel drug targets for Tuberculosis (TB) has been a promising area of research. TB has been a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) localized primarily on the lungs and it has been one of the most successful pathogen in the history of mankind. Extensively arising drug resistivity in TB has made it a global challenge and need for new drugs has become utmost important.The involvement of Nucleoid-Associated Proteins (NAPs) in maintaining the structure of the genomic material and regulating various cellular processes like transcription, DNA replication, repair and recombination makes significant, has opened a new arena to find the drugs targeting Mtb. The current study aims to identify potential inhibitors of NAPs through a computational approach. In the present work we worked on the eight NAPs of Mtb, namely, Lsr2, EspR, HupB, HNS, NapA, mIHF and NapM. The structural modelling and analysis of these NAPs were carried out. Moreover, molecular interaction were checked and binding energy was identified for 2500 FDA-approved drugs that were selected for antagonist analysis to choose novel inhibitors targeting NAPs of Mtb. Drugs including Amikacin, streptomycin, kanamycin, and isoniazid along with eight FDA-approved molecules that were found to be potential novel targets for these mycobacterial NAPs and have an impact on their functions. The potentiality of several anti-tubercular drugs as therapeutic agents identified through computational modelling and simulation unlocks a new gateway for accomplishing the goal to treat TB.
MeSH term(s)	Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/genetics ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Antitubercular Agents/pharmacology ; Antitubercular Agents/chemistry ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/genetics ; Molecular Docking Simulation ; Protein Binding ; Molecular Dynamics Simulation ; Histones
Chemical Substances	Bacterial Proteins ; Antitubercular Agents ; DNA-Binding Proteins ; Lsr2 protein, Mycobacterium tuberculosis ; HupB protein, Mycobacterium tuberculosis ; Histones
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-00710-5
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Zs.A 4031: Show issues

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Article ; Online: Electro-Elastic Modeling of Thermal Spin Transition in Diluted Spin-Crossover Single Crystals.

Affes, Karim / Singh, Yogendra / Boukheddaden, Kamel

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Spin-crossover solids have been studied for many years for their promising applications as optical switches and reversible high-density memories for information storage. This study reports the effect of random metal dilution on the thermal and structural ...

Abstract	Spin-crossover solids have been studied for many years for their promising applications as optical switches and reversible high-density memories for information storage. This study reports the effect of random metal dilution on the thermal and structural properties of a spin-crossover single crystal. The analysis is performed on a 2D rectangular lattice using an electro-elastic model. The lattice is made of sites that can switch thermally between the low-spin and high-spin states, accompanied by local volume changes. The model is solved by Monte Carlo simulations, running on the spin states and atomic positions of this compressible 2D lattice. A detailed analysis of metal dilution on the magneto-structural properties allows us to address the following issues: (i) at low dilution rates, the transition is of the first order; (ii) increasing the concentration of dopant results in a decrease in cooperativity and leads to gradual transformations above a threshold concentration, while incomplete spin transitions are obtained for big dopant sizes. The effects of the metal dilution on the spatiotemporal aspects of the spin transition along the thermal transition and on the low-temperature relaxation of the photo-induced metastable high-spin states are also studied. Significant changes in the organization of the spin states are observed for the thermal transition, where the single-domain nucleation caused by the long-range elastic interactions is replaced by a multi-droplet nucleation. As to the issue of the relaxation curves: their shape transforms from a sigmoidal shape, characteristic of strong cooperative systems, into stretched exponentials for high dilution rates, which is the signature of a disordered system.
MeSH term(s)	Cross-Over Studies ; Monte Carlo Method ; Indicator Dilution Techniques
Language	English
Publishing date	2022-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232213854
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Article ; Online: Harnessing taxonomically diverse and metabolically versatile genus Paracoccus for bioplastic synthesis and xenobiotic biodegradation.

Puri, Akshita / Bajaj, Abhay / Singh, Yogendra / Lal, Rup

Journal of applied microbiology

2022 Volume 132, Issue 6, Page(s) 4208–4224

Abstract: The genus Paracoccus represents a taxonomically diverse group comprising more than 80 novel species isolated from various pristine and polluted environments. The species are characterized as coccoid-shaped Gram-negative bacteria with versatile metabolic ... ...

Abstract	The genus Paracoccus represents a taxonomically diverse group comprising more than 80 novel species isolated from various pristine and polluted environments. The species are characterized as coccoid-shaped Gram-negative bacteria with versatile metabolic attributes and classified as autotrophs, heterotrophs and/or methylotrophs. The present study highlights the up-to-date global taxonomic diversity and critically discusses the significance of genome analysis for identifying the genomic determinants related to functional attributes mainly bioplastic synthesis and biodegradation potential that makes these isolates commercially viable. The analysis accentuates polyphasic and genomic attributes of Paracoccus spp. which could be harnessed for commercial applications and emphasizes the need of integrating genome-based computational analysis for evolutionary species and functional diversification. The work reflects on the underexplored genetic potential for bioplastic synthesis which can be harnessed using advanced genomic methods. It also underlines the degradation potential and possible use of naturally-occurring pollutant-degrading Paracoccus isolates for the development of a biodegradation system and efficient removal of contaminants. The work contemplates plausible use of such potent isolates to establish the plant-microbe interaction, contributing toward contaminated land reclamation. Overall, the work signifies the need and application of genome analysis to identify and explore the prospective potential of Paracoccus spp. for environmental application toward achieving sustainability.
MeSH term(s)	Bacterial Typing Techniques ; Biodegradation, Environmental ; DNA, Bacterial/genetics ; Fatty Acids/analysis ; Genomics ; Paracoccus/genetics ; Paracoccus/metabolism ; Phylogeny ; Prospective Studies ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Xenobiotics/metabolism
Chemical Substances	DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal, 16S ; Xenobiotics
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15530
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Zs.A 259: Show issues

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Article: Recent developments in systems biology and genetic engineering toward design of vaccines for TB

, Sunita / Singh, Yogendra / Beamer, Gillian / Sun, Xingmin / Shukla, Pratyoosh

Critical reviews in biotechnology. 2022 May 19, v. 42, no. 4

2022

Abstract: Tuberculosis (TB) is one of the most prevalent diseases worldwide. The currently available Bacillus Calmette-Guérin vaccine is not sufficient in protecting against pulmonary TB. Although many vaccines have been evaluated in clinical trials, but none of ... ...

Abstract	Tuberculosis (TB) is one of the most prevalent diseases worldwide. The currently available Bacillus Calmette-Guérin vaccine is not sufficient in protecting against pulmonary TB. Although many vaccines have been evaluated in clinical trials, but none of them yet has proven to be more successful. Thus, new strategies are urgently needed to design more effective TB vaccines. The emergence of new technologies will undoubtedly accelerate the process of vaccine development. This review summarizes the potential and validated applications of emerging technologies, including: systems biology (genomics, proteomics, and transcriptomics), genetic engineering, and other computational tools to discover and develop novel vaccines against TB. It also discussed that the significant implementation of these approaches will play crucial roles in the development of novel vaccines to cure and control TB.
Keywords	BCG vaccine ; biotechnology ; genomics ; proteomics ; transcriptomics ; tuberculosis ; vaccine development
Language	English
Dates of publication	2022-0519
Size	p. 532-547.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1042364-3
ISSN	1549-7801 ; 0738-8551
ISSN (online)	1549-7801
ISSN	0738-8551
DOI	10.1080/07388551.2021.1951649
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2554: Show issues

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Book: Development and change

Singh, Yogendra

(ICSSR research surveys and explorations ; Indian sociology ; / ed. by Yogendra Singh ; Vol. 2)

2014

Series title	ICSSR research surveys and explorations Indian sociology / ed. by Yogendra Singh ; Vol. 2
Language	English
Size	XI, 381 S
Edition	1. ed
Publisher	Oxford Univ. Press
Publishing place	New Delhi
Document type	Book
Note	Includes bibliographical references and index
ISBN	0198092032 ; 9780198092032
Database	Former special subject collection: coastal and deep sea fishing

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Book: Emerging concepts, structure, and change

Singh, Yogendra

(ICSSR research surveys and explorations ; Indian sociology ; / ed. by Yogendra Singh ; Vol. 1)

2014

Series title	ICSSR research surveys and explorations Indian sociology / ed. by Yogendra Singh ; Vol. 1
Language	English
Size	XIII, 457 S
Edition	1. ed
Publisher	Oxford Univ. Press
Publishing place	New Delhi
Document type	Book
Note	Includes bibliographical references and index
ISBN	0198092024 ; 9780198092025
Database	Former special subject collection: coastal and deep sea fishing

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