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  1. Article ; Online: A single centre evaluation of risk prediction models and imaging modalities in acute appendicitis.

    Ashcroft, J / Singh, A A / Rooney, S / Bennett, J / Davies, R J

    Annals of the Royal College of Surgeons of England

    2021  Volume 103, Issue 3, Page(s) 203–207

    Abstract: Introduction: Patients with suspected appendicitis remain a diagnostic challenge. The aim of this study was to validate risk prediction models, and to investigate diagnostic accuracy of ultrasonography and computed tomography (CT) in adults undergoing ... ...

    Abstract Introduction: Patients with suspected appendicitis remain a diagnostic challenge. The aim of this study was to validate risk prediction models, and to investigate diagnostic accuracy of ultrasonography and computed tomography (CT) in adults undergoing appendicectomy.
    Methods: A retrospective case review was performed of patients aged 16-45 years having an appendicectomy between January 2019 and January 2020 at a tertiary referral centre. Primary outcomes were the accuracy of a high risk appendicitis risk score and ultrasonography and CT imaging modalities compared with histological reports following appendicectomy.
    Results: A total of 206 patients (52% female) were included in the study. Removal of a histologically normal appendix was equally likely in men and women (13.1% vs 11.2% respectively, relative risk: 1.17, 95% confidence interval: 0.56-2.44,
    Conclusions: This study suggests that risk prediction models may be useful in both women and men to identify appendicitis. Ultrasonography gave high rates of equivocal results and should not be relied on for the diagnosis of appendicitis. CT is a highly accurate diagnostic tool and could be considered in those at low risk where clinical suspicion remains to reduce negative appendicectomy rates.
    MeSH term(s) Adolescent ; Adult ; Appendectomy ; Appendiceal Neoplasms/pathology ; Appendicitis/diagnostic imaging ; Appendicitis/pathology ; Appendicitis/surgery ; Appendix/pathology ; Clinical Decision Rules ; Diagnostic Errors ; False Positive Reactions ; Female ; Humans ; Male ; Middle Aged ; Neuroendocrine Tumors/pathology ; Patient Readmission ; Retrospective Studies ; Sex Factors ; Tomography, X-Ray Computed ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2021-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2020.7033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Organic aquaculture: Sustainable and superior production

    Singh, A. S. / Devi, M. Shaya / Singh, A. A.

    World aquaculture

    2011  Volume 42, Issue 3, Page(s) 63

    Document type Article
    ZDB-ID 228838-2
    ISSN 1041-5602
    Database Current Contents Nutrition, Environment, Agriculture

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  3. Article: A survey of tuberculosis hospitals in India.

    Singh, A A / Frieden, T R / Khatri, G R / Garg, R

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2004  Volume 8, Issue 10, Page(s) 1255–1259

    Abstract: Setting: Hospitals with beds for tuberculosis (TB) in India.: Objectives: To assess diagnostic and treatment practices at institutions offering secondary or tertiary level care for TB patients, and to determine the resources being used at these ... ...

    Abstract Setting: Hospitals with beds for tuberculosis (TB) in India.
    Objectives: To assess diagnostic and treatment practices at institutions offering secondary or tertiary level care for TB patients, and to determine the resources being used at these institutions.
    Design: Countrywide cross-sectional survey of TB hospitals using a mailed semi-structured questionnaire sent to all 105 hospitals with 100 or more beds and to all State Directorate Health Services.
    Results: The 94 hospitals that returned the questionnaire had 15773 TB beds, one third of the total TB beds in the country. Nearly 1 million patients sought treatment in the TB hospitals and one third were diagnosed with TB; the ratio of smear-positive to smear-negative patients was 1:2.7. Sixty-four per cent of hospitals prescribed unobserved rifampicin in the continuation phase, and 56% of sputum smear-positive patients were hospitalised. The annual expenditure for the TB hospitals was more than the total annual budget for the TB control programme of the country.
    Conclusions: In view of the high number of patients seen and the suboptimal practices observed, urgent steps should be taken to ensure implementation of correct diagnostic and treatment policies in hospitals with TB beds.
    MeSH term(s) Cross-Sectional Studies ; Hospitals, Special/economics ; Hospitals, Special/standards ; Hospitals, Special/utilization ; Humans ; India ; Surveys and Questionnaires ; Tuberculosis/diagnosis ; Tuberculosis/therapy
    Language English
    Publishing date 2004-10
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.

    Mandoli, A / Singh, A A / Jansen, P W T C / Wierenga, A T J / Riahi, H / Franci, G / Prange, K / Saeed, S / Vellenga, E / Vermeulen, M / Stunnenberg, H G / Martens, J H A

    Leukemia

    2013  Volume 28, Issue 4, Page(s) 770–778

    Abstract: Different mechanisms for CBFβ-MYH11 function in acute myeloid leukemia with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all ... ...

    Abstract Different mechanisms for CBFβ-MYH11 function in acute myeloid leukemia with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of RUNX1 target genes. Here, through genome-wide CBFβ-MYH11-binding site analysis and quantitative interaction proteomics, we found that CBFβ-MYH11 localizes to RUNX1 occupied promoters, where it interacts with TAL1, FLI1 and TBP-associated factors (TAFs) in the context of the hematopoietic transcription factors ERG, GATA2 and PU.1/SPI1 and the coregulators EP300 and HDAC1. Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFβ-MYH11 target genes show increased expression, confirming a role in transcriptional repression. However, the majority of CBFβ-MYH11 target genes, including genes implicated in hematopoietic stem cell self-renewal such as ID1, LMO1 and JAG1, are actively transcribed and repressed upon fusion protein knockdown. Together these results suggest an essential role for CBFβ-MYH11 in regulating the expression of genes involved in maintaining a stem cell phenotype.
    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/physiology ; Binding Sites ; Chromosome Inversion ; Chromosomes, Human, Pair 16 ; Core Binding Factor Alpha 2 Subunit/physiology ; Core Binding Factor beta Subunit/physiology ; GATA2 Transcription Factor/physiology ; Histone Deacetylases/physiology ; Humans ; Leukemia, Myeloid, Acute/genetics ; Myosin Heavy Chains/physiology ; Promoter Regions, Genetic ; Proto-Oncogene Protein c-fli-1/physiology ; Proto-Oncogene Proteins/physiology ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; Transcriptional Activation
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; CBFB protein, human ; Core Binding Factor Alpha 2 Subunit ; Core Binding Factor beta Subunit ; FLI1 protein, human ; GATA2 Transcription Factor ; GATA2 protein, human ; MYH11 protein, human ; Proto-Oncogene Protein c-fli-1 ; Proto-Oncogene Proteins ; RUNX1 protein, human ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; TAL1 protein, human (135471-20-4) ; Histone Deacetylases (EC 3.5.1.98) ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2013-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/leu.2013.257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effectiveness of urban community volunteers in directly observed treatment of tuberculosis patients: a field report from Haryana, North India.

    Singh, A A / Parasher, D / Shekhavat, G S / Sahu, S / Wares, D F / Granich, R

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2004  Volume 8, Issue 6, Page(s) 800–802

    Abstract: A tuberculosis (TB) unit covering a population of 600000 in Gurgaon District of Haryana State, India, where the DOTS-based RNTCP has been implemented since April 2000. Treatment success rate, as recorded in the TB register, of new sputum smear-positive ... ...

    Abstract A tuberculosis (TB) unit covering a population of 600000 in Gurgaon District of Haryana State, India, where the DOTS-based RNTCP has been implemented since April 2000. Treatment success rate, as recorded in the TB register, of new sputum smear-positive patients receiving directly observed treatment (DOT) from community volunteers was comparable with that of patients receiving DOT from government health workers (78% vs. 77%). The proportion of patients with community volunteers increased significantly with time (13% in 2000 to 25% in 2002), even in the absence of financial incentives. In this model of community volunteer involvement in an urban TB control programme, the primary responsibility for returning late patients to treatment was with the staff of the District TB Centre.
    MeSH term(s) Community Health Services ; Developing Countries ; Directly Observed Therapy ; Humans ; India ; Sputum/microbiology ; Treatment Outcome ; Tuberculosis, Pulmonary/drug therapy ; Urban Health Services ; Volunteers/organization & administration
    Language English
    Publishing date 2004-06
    Publishing country France
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A study of dental caries in school children from rural Haryana.

    Singh, A A / Singh, B / Kharbanda, O P / Shukla, D K / Goswami, K / Gupta, S

    Journal of the Indian Society of Pedodontics and Preventive Dentistry

    1999  Volume 17, Issue 1, Page(s) 24–28

    Abstract: The prevalence of dental caries among rural school children (688 boys and 331 girls) in the age group of 12-16 years in Haryana was found to be 39.4%. It was 37.9% in boys and 42.6% in girls. The difference between males and females was statistically not ...

    Abstract The prevalence of dental caries among rural school children (688 boys and 331 girls) in the age group of 12-16 years in Haryana was found to be 39.4%. It was 37.9% in boys and 42.6% in girls. The difference between males and females was statistically not significant. A significant increase in prevalence of dental caries with age was observed (i.e. 33.1% in 12-year-old children to 45.8% in 14-year-old children). The mean DMFT per child was found to be 1.03 and DMFT per affected child was 2.6. The mean of D, M and F was found to be 1.0, 0.03 and 0.0 respectively.
    MeSH term(s) Adolescent ; Age Distribution ; Child ; DMF Index ; Dental Caries/epidemiology ; Female ; Humans ; India/epidemiology ; Male ; Prevalence ; Rural Health ; Sex Distribution
    Language English
    Publishing date 1999-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 1425154-1
    ISSN 0970-4388
    ISSN 0970-4388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: New 6-Aryl-2-pyrones from Gentiana pedicellata*.

    Ghosal, S / Singh, A A / Biswas, K

    Planta medica

    1983  Volume 49, Issue 12, Page(s) 240–243

    Abstract: Three new 6-aryl-2-pyrones, viz. pedicellin ( 1), pedicellanin ( 2), and pedicellatin ( 3), have been isolated from the whole plant of GENTIANA PEDICELLATA W ALL., collected when in flower. The compounds have been characterized on the basis of chemical ... ...

    Abstract Three new 6-aryl-2-pyrones, viz. pedicellin ( 1), pedicellanin ( 2), and pedicellatin ( 3), have been isolated from the whole plant of GENTIANA PEDICELLATA W ALL., collected when in flower. The compounds have been characterized on the basis of chemical transformation and comprehensive spectral evidence. This is the first report of occurrence of 6-aryl-2-pyrones in a member of the family Gentianaceae. The other secondary metabolites, e.g. triterpene, secoiridoid, and degraded carotenoid, present in this species are typical of the GENTIANA. 1 and 2 produced significant adaptogenic and anti-stress effects in animal models thereby justifying the use of the title species in popular medicine.
    Language English
    Publishing date 1983-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-2007-969859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: New 6-aryl-2-pyrones from Gentiana pedicellata

    Ghosal, S / Singh, A.A.K / Biswas, K

    Planta medica = journal of medicinal plant research. Dec 1983. v. 49 (4)

    1983  

    Title variant New 6-aryl-2-pyrones from Gentiana pedicellata [isolated from the whole plant when in flowers]
    Keywords plant physiology ; plant biochemistry
    Language English
    Dates of publication 1983-12
    Size p. 240-243., ill.
    Document type Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Transmission of Rhynchosporium oryzae Hashioka and Yokogi by seed

    Singh, A.A / Sen Gupta, P.K

    International rice research newsletter. Apr 1981. v. 6 (2)

    1981  

    Title variant Transmission of Rhynchosporium oryzae Hashioka and Yokogi [rice leaf scald] by seed
    Keywords plant pathogenic fungi ; plant health ; fungal diseases of plants
    Language English
    Dates of publication 1981-04
    Size p. 11., ill.
    Document type Article
    ZDB-ID 406401-x
    ISSN 0115-0944
    ISSN 0115-0944
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: New 6-Aryl-2-pyrones from Gentiana pedicellata*

    Ghosal, Sh. / Singh, A. A. K. / Biswas, K.

    Planta Medica

    1983  Volume 49, Issue 12, Page(s) 240–243

    Abstract: Three new 6-aryl-2-pyrones, viz. pedicellin (1), pedicellanin (2), and pedicellatin (3), have been isolated from the whole plant of GENTIANA PEDICELLATA WALL., collected when in flower. The compounds have been characterized on the basis of chemical ... ...

    Abstract Three new 6-aryl-2-pyrones, viz. pedicellin (1), pedicellanin (2), and pedicellatin (3), have been isolated from the whole plant of GENTIANA PEDICELLATA WALL., collected when in flower. The compounds have been characterized on the basis of chemical transformation and comprehensive spectral evidence. This is the first report of occurrence of 6-aryl-2-pyrones in a member of the family Gentianaceae. The other secondary metabolites, e.g. triterpene, secoiridoid, and degraded carotenoid, present in this species are typical of the GENTIANA. 1 and 2 produced significant adaptogenic and anti-stress effects in animal models thereby justifying the use of the title species in popular medicine.
    Keywords 6-aryl-2-pyrones ; Pedicellin ; Pedicellanin ; Pedicellatin ; Swertiamarin ; (-)-loliolide ; Ursolic acid ; Adaptogenic effect
    Language English
    Publishing date 1983-12-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-2007-969859
    Database Thieme publisher's database

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